CA2723403A1 - Estrogenic extracts for use in treating vaginal and vulvar atrophy - Google Patents

Estrogenic extracts for use in treating vaginal and vulvar atrophy Download PDF

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Publication number
CA2723403A1
CA2723403A1 CA2723403A CA2723403A CA2723403A1 CA 2723403 A1 CA2723403 A1 CA 2723403A1 CA 2723403 A CA2723403 A CA 2723403A CA 2723403 A CA2723403 A CA 2723403A CA 2723403 A1 CA2723403 A1 CA 2723403A1
Authority
CA
Canada
Prior art keywords
extract
composition
cell
mixture
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2723403A
Other languages
English (en)
French (fr)
Inventor
Isaac Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bionovo Inc
Original Assignee
Bionovo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionovo Inc filed Critical Bionovo Inc
Publication of CA2723403A1 publication Critical patent/CA2723403A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2723403A 2008-05-06 2009-05-05 Estrogenic extracts for use in treating vaginal and vulvar atrophy Abandoned CA2723403A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5092508P 2008-05-06 2008-05-06
US61/050,925 2008-05-06
PCT/US2009/042915 WO2009137534A2 (en) 2008-05-06 2009-05-05 Estrogenic extracts for use in treating vaginal and vulvar atrophy

Publications (1)

Publication Number Publication Date
CA2723403A1 true CA2723403A1 (en) 2009-11-12

Family

ID=41265360

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2723403A Abandoned CA2723403A1 (en) 2008-05-06 2009-05-05 Estrogenic extracts for use in treating vaginal and vulvar atrophy

Country Status (6)

Country Link
US (1) US20090304825A1 (https=)
EP (1) EP2310024A4 (https=)
JP (1) JP2011519947A (https=)
AU (1) AU2009244315A1 (https=)
CA (1) CA2723403A1 (https=)
WO (1) WO2009137534A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482029B2 (en) 2005-04-01 2009-01-27 Bionovo, Inc. Composition for treatment of menopause
US20080319051A1 (en) * 2007-06-22 2008-12-25 Bionovo, Inc. Liquiritigenin and derivatives as selective estrogen receptor beta agonists
US20090042818A1 (en) * 2007-06-22 2009-02-12 Bionovo, Inc. Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists
WO2009021196A1 (en) * 2007-08-08 2009-02-12 Bionovo, Inc. Extracts of ligustrum lucidum and uses thereof
JP2010539086A (ja) * 2007-09-07 2010-12-16 バイオノボ・インコーポレーテッド マメ科ファミリーのクズのエストロゲン性抽出物およびその使用
EP2190292A4 (en) * 2007-09-07 2012-12-26 Bionovo Inc ESTROGENWIRKSAME EXTRACTS OF SCUTTELARIA BARBATA D. DON OF THE FAMILY LABIATAE AND ITS USES
AU2008296072A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. Estrogenic extracts of Astragalus membranaceus Fisch.Bge.Var.mongolicus Bge. of the Leguminosae Family and uses thereof
US20090130101A1 (en) * 2007-11-19 2009-05-21 Bionovo, Inc. Anti-cancer therapy with an extract of scutellaria barbata
EP2219659A4 (en) * 2007-11-19 2010-11-17 Bionovo Inc METHODS OF DETECTION AND TREATMENT OF CANCERS USING BARBATA SCUTTELARIA EXTRACT
US20090130118A1 (en) * 2007-11-19 2009-05-21 Bionovo, Inc. Scutellaria barbata extract and combinations for the treatment of cancer
EP2222323A4 (en) * 2007-11-19 2012-07-25 Bionovo Inc PROCESS FOR PREPARING A CLEANED EXTRACT OF SCUTELLARIA BARBATA D. DON
CA2721191A1 (en) * 2008-04-14 2009-10-22 Bionovo, Inc. Calycosin and analogs thereof for the treatment of estrogen receptor beta-mediated diseases
CA2726982A1 (en) * 2008-06-05 2009-12-10 Bionovo, Inc. Method of quantification of multiple bioactives from botanical compositions
US20090312437A1 (en) * 2008-06-06 2009-12-17 Bionovo, Inc., A Delaware Corporation Anthraquinones and Analogs from Rhuem palmatum for Treatment of Estrogen Receptor Beta-Mediated Conditions
AU2009311601A1 (en) * 2008-06-13 2010-05-14 Bionovo, Inc. Nyasol and analogs thereof for the treatment of estrogen receptor beta-mediated diseases
EP2340027A4 (en) * 2008-09-03 2012-04-04 Bionovo Inc METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER
US20130014771A1 (en) * 2011-01-13 2013-01-17 R. J. Reynolds Tobacco Company Tobacco-derived components and materials
CN105037447B (zh) * 2015-06-17 2018-01-16 广东药科大学 牛膝糖聚合物及其制备方法和用途
CN104987340B (zh) * 2015-07-07 2017-06-23 江苏省中国科学院植物研究所 碱蓬黄酮a及其制备方法和用途
KR102168418B1 (ko) * 2019-07-29 2020-10-21 김덕호 황칠나무, 황기 및, 두릅나무 복합 추출물을 포함하는 여성 청결제 조성물

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2616328B1 (fr) * 1987-06-12 1990-03-02 Moet Hennessy Rech Composition a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un extrait de murier, ou au moins une flavone, en particulier une kuwanone et composition pharmaceutique, notamment dermatologique, a activite depigmentante, ou anti-inflammatoire, ou cosmetique, l'incorporant
JPH01175942A (ja) * 1987-12-28 1989-07-12 Sanyo Kokusaku Pulp Co Ltd 抗ウイルス性医薬用組成物
JPH0725761A (ja) * 1993-07-09 1995-01-27 Kureha Chem Ind Co Ltd 軟骨保護剤
US5874084A (en) * 1996-07-19 1999-02-23 Yng-Wong; Quing Non Using complex herbal formulations to treat hot flashes
WO1998042363A1 (en) * 1997-03-21 1998-10-01 Shiseido Company, Ltd. Immunopotentiators
MC2441A1 (fr) * 1997-07-31 1998-03-11 Exsymol Sa Composition cosmétique utile notamment pour le blanchiment de la peau et agent inhibiteur de la mélanogénèse comprenant une telle composition cosmétique
FR2784294B1 (fr) * 1998-10-12 2000-11-17 Oreal Composition cosmetique et/ou dermatologique renfermant au moins un extrait de murier, au moins un extrait de scutellaire et au moins un derive d'acide salicylique
US6304825B1 (en) * 1999-01-19 2001-10-16 Xerox Corporation Rotary encoder error compensation system and method for photoreceptor surface motion sensing and control
FR2791573B1 (fr) * 1999-03-30 2003-04-11 Pf Medicament Utilisation d'un extrait de serenoa repens pour la fabrication d'un medicament destine au traitement du cancer de la prostate
NZ514044A (en) * 1999-04-01 2001-09-28 Guorang Hu Herbal compositions and uses for the treatment of allergic reactions
US20020031559A1 (en) * 2000-03-08 2002-03-14 Liang Kin C. Herbal suppositories
DE10031650A1 (de) * 2000-06-29 2002-01-17 Schwabe Willmar Gmbh & Co Verwendung von Extrakten aus Sophora flavescens oder Sophora subprostrata zur Prophylaxe und Therapie von Krankheitszuständen, die durch einen Mangel an Östrogenen oder durch andere hormonelle Dysregulationen verursacht werden
US6238707B1 (en) * 2000-10-11 2001-05-29 Zhang Chun Herbal hormone balance composition
JP2002234835A (ja) * 2001-02-09 2002-08-23 Sangaku Renkei Kiko Kyushu:Kk 血管新生阻害剤
US6551627B1 (en) * 2001-05-03 2003-04-22 Holomed Pharmaceuticals, Ltd. Medicinal herbal compounds for the prevention and treatment of diabetes
KR100456981B1 (ko) * 2001-07-14 2004-11-10 (주) 메드빌 식물추출물을 포함하는 골다공증 예방 또는 치료용 조성물및 그 제조 방법
US6855344B2 (en) * 2001-07-17 2005-02-15 Integrated Chinese Medicine Holdings, Ltd. Compositions and methods for prostate and kidney health and disorders, an herbal preparation
KR20030027208A (ko) * 2001-09-14 2003-04-07 주식회사 바이오딕스 생약을 함유하는 관절염 치료용 조성물 및 그 제조방법
JP2003095971A (ja) * 2001-09-27 2003-04-03 National Institute Of Health & Nutrition 骨粗鬆症治療剤または組成物
US6750248B2 (en) * 2001-11-09 2004-06-15 National University Of Singapore Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof
US20050032882A1 (en) * 2002-03-06 2005-02-10 Sophie Chen Botanical extract compositions and methods of use
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
CA2520532A1 (en) * 2003-03-28 2004-10-14 Nihon University Polynucleotide encoding 2-hydroxyisoflavanone dehydratase and use thereof
US20070122501A1 (en) * 2003-06-27 2007-05-31 Hong Kong University Of Science And Technology Formulations containing astragalus extracts and uses thereof
PL1663103T3 (pl) * 2003-09-08 2012-05-31 Genyous Biomed Int Inc Kompozycje roślinnych ekstraktów do leczenia nowotworu
US20050196409A1 (en) * 2003-09-24 2005-09-08 James Dao Compositions of botanical extracts for treating malignancy-associated changes
US20070122492A1 (en) * 2004-11-18 2007-05-31 Stephen Behr Plant extracts and dermatological uses thereof
US20050118290A1 (en) * 2003-12-02 2005-06-02 University Of Singapore Compositions and method for treatment of steroid/nuclear receptor-mediated diseases
US20050208159A1 (en) * 2004-03-16 2005-09-22 Kang Kyung S Phytoestrogenic composition comprising an extract of chinese licorice root, liquiritin or isoliquiritin
WO2005107747A2 (en) * 2004-05-06 2005-11-17 Bioresponse, Llc Diindolymethane formulations for the treatment of leiomyomas
EP1815014B1 (en) * 2004-11-05 2012-03-21 Genomic Health, Inc. Molecular indicators of breast cancer prognosis and prediction of treatment response
KR100589050B1 (ko) * 2004-11-23 2006-06-14 인하대학교 산학협력단 황기 추출물 및 그로부터 분리한 이소플라보노이드계화합물을 유효성분으로 하는 관절염 예방 및 치료용 조성물
NZ555316A (en) * 2004-12-09 2009-08-28 Merck & Co Inc Estrogen receptor modulators
US20060134243A1 (en) * 2004-12-17 2006-06-22 Bionovo, Inc. Method of using extracts of epimedium species
CA2588566A1 (en) * 2004-12-17 2006-06-22 Bionovo, Inc. Estrogenic extracts of morus alba and uses thereof
TW200621273A (en) * 2004-12-21 2006-07-01 Golden Biotechnology Corp A composition for effectively inhibiting prostate cancer cell growth and hypertrophy of the prostate, and a preparing method thereof
US7482029B2 (en) * 2005-04-01 2009-01-27 Bionovo, Inc. Composition for treatment of menopause
EP1907858A4 (en) * 2005-06-13 2009-04-08 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
US7700136B2 (en) * 2005-11-14 2010-04-20 Bionovo, Inc. Scutellaria barbata extract for the treatment of cancer
HUE030390T2 (en) * 2005-12-21 2017-05-29 Janssen Pharmaceutica Nv Triazolopyridazines as tyrosine kinase modulators
CN100475253C (zh) * 2006-02-22 2009-04-08 陈耀明 一种治疗不孕症、月经不调、痛经、内分泌失调及骨质疏松的药物
KR100760384B1 (ko) * 2006-02-22 2007-09-19 경희대학교 산학협력단 황기 추출물을 포함하는 혈관형성 촉진 및 골유합 효과를갖는 골절의 예방 및 치료용 조성물
CN100488525C (zh) * 2006-08-04 2009-05-20 北京化工大学 一种治疗女性更年期综合症的药物及制备方法
US7381432B2 (en) * 2006-09-19 2008-06-03 Jose Angel Olalde Menopause disorder synergistic phyto-nutraceutical composition
CN1961744A (zh) * 2006-12-08 2007-05-16 富天桂 一种保健食品
US20090042818A1 (en) * 2007-06-22 2009-02-12 Bionovo, Inc. Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists
US20080319051A1 (en) * 2007-06-22 2008-12-25 Bionovo, Inc. Liquiritigenin and derivatives as selective estrogen receptor beta agonists
WO2009021196A1 (en) * 2007-08-08 2009-02-12 Bionovo, Inc. Extracts of ligustrum lucidum and uses thereof
AU2008296072A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. Estrogenic extracts of Astragalus membranaceus Fisch.Bge.Var.mongolicus Bge. of the Leguminosae Family and uses thereof
AU2008296176A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. Estrogenic extracts of Asparagus conchinchinensis (Lour.) Merr of the Liliaceae Family and uses thereof
JP2010539086A (ja) * 2007-09-07 2010-12-16 バイオノボ・インコーポレーテッド マメ科ファミリーのクズのエストロゲン性抽出物およびその使用
CA2721191A1 (en) * 2008-04-14 2009-10-22 Bionovo, Inc. Calycosin and analogs thereof for the treatment of estrogen receptor beta-mediated diseases
CA2726982A1 (en) * 2008-06-05 2009-12-10 Bionovo, Inc. Method of quantification of multiple bioactives from botanical compositions
US20090312437A1 (en) * 2008-06-06 2009-12-17 Bionovo, Inc., A Delaware Corporation Anthraquinones and Analogs from Rhuem palmatum for Treatment of Estrogen Receptor Beta-Mediated Conditions
AU2009311601A1 (en) * 2008-06-13 2010-05-14 Bionovo, Inc. Nyasol and analogs thereof for the treatment of estrogen receptor beta-mediated diseases

Also Published As

Publication number Publication date
JP2011519947A (ja) 2011-07-14
WO2009137534A2 (en) 2009-11-12
AU2009244315A1 (en) 2009-11-12
EP2310024A2 (en) 2011-04-20
EP2310024A4 (en) 2012-07-25
US20090304825A1 (en) 2009-12-10
WO2009137534A3 (en) 2010-02-18

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20140203