CA2721232C - Forme orale solide dotee d'un double profil de liberation comprenant des multiparticules - Google Patents

Forme orale solide dotee d'un double profil de liberation comprenant des multiparticules Download PDF

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Publication number
CA2721232C
CA2721232C CA2721232A CA2721232A CA2721232C CA 2721232 C CA2721232 C CA 2721232C CA 2721232 A CA2721232 A CA 2721232A CA 2721232 A CA2721232 A CA 2721232A CA 2721232 C CA2721232 C CA 2721232C
Authority
CA
Canada
Prior art keywords
microparticles
coating
copolymer
weight
methacrylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2721232A
Other languages
English (en)
French (fr)
Other versions
CA2721232A1 (fr
Inventor
Florence Guimberteau
Anne-Sophie Daviaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Ireland Ltd
Original Assignee
Flamel Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Ireland Ltd filed Critical Flamel Ireland Ltd
Publication of CA2721232A1 publication Critical patent/CA2721232A1/fr
Application granted granted Critical
Publication of CA2721232C publication Critical patent/CA2721232C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
CA2721232A 2008-04-18 2009-04-17 Forme orale solide dotee d'un double profil de liberation comprenant des multiparticules Active CA2721232C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7125008P 2008-04-18 2008-04-18
FR0852627 2008-04-18
FR0852627A FR2930147B1 (fr) 2008-04-18 2008-04-18 Forme orale solide dotee d'un double profil de liberation
US61/071,250 2008-04-18
PCT/FR2009/050719 WO2009138642A1 (fr) 2008-04-18 2009-04-17 Forme orale solide dotee d'un double profil de liberation comprenant des multiparticules

Publications (2)

Publication Number Publication Date
CA2721232A1 CA2721232A1 (fr) 2009-11-19
CA2721232C true CA2721232C (fr) 2016-03-29

Family

ID=40110982

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2721232A Active CA2721232C (fr) 2008-04-18 2009-04-17 Forme orale solide dotee d'un double profil de liberation comprenant des multiparticules

Country Status (14)

Country Link
US (1) US20090291137A1 (enExample)
EP (1) EP2276474B1 (enExample)
JP (1) JP5687185B2 (enExample)
KR (1) KR101380507B1 (enExample)
CN (1) CN102046155A (enExample)
AU (1) AU2009247921B2 (enExample)
BR (1) BRPI0910572B1 (enExample)
CA (1) CA2721232C (enExample)
ES (1) ES2721849T3 (enExample)
FR (1) FR2930147B1 (enExample)
IL (1) IL208572A (enExample)
MX (1) MX339671B (enExample)
WO (1) WO2009138642A1 (enExample)
ZA (1) ZA201007238B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945947B1 (fr) 2009-05-29 2011-07-29 Flamel Tech Sa Compositions pharmaceutiques flottantes a liberation controlee
EP2704689B1 (en) 2012-04-19 2018-11-28 Glatt AG Taste-masked pharmaceutical compositions containing diclofenac
BR112017005525A2 (pt) * 2014-09-30 2017-12-05 Dow Global Technologies Llc dispersões de etilcelulose aquosas com aditivo polimérico
EP3244881A4 (en) * 2015-01-12 2018-08-15 Nano Pharmaceutical Laboratories LLC Layered sustained-release microbeads and methods of making the same
JP6112696B1 (ja) * 2015-10-05 2017-04-12 富山化学工業株式会社 ソリスロマイシンを含む錠剤
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
FR3089406B1 (fr) 2018-12-07 2020-11-20 Urgo Rech Innovation Et Developpement Dispositif de retenue et système de contention comprenant un article de contention et un tel dispositif de retenue
FR3089405A1 (fr) 2018-12-07 2020-06-12 Urgo Recherche Innovation Et Developpement Dispositif de retenue et système de contention comprenant un article de contention et un tel dispositif de retenue
KR20220008824A (ko) 2019-04-17 2022-01-21 컴퍼스 패쓰파인더 리미티드 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE66933B1 (en) * 1990-01-15 1996-02-07 Elan Corp Plc Controlled absorption naproxen formulation for once-daily administration
EP0653935B1 (en) * 1992-08-05 2002-05-08 F.H. FAULDING & CO. LIMITED Pelletised pharmaceutical composition
US5260069A (en) * 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5458888A (en) * 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
JPH0826977A (ja) * 1994-07-19 1996-01-30 Tanabe Seiyaku Co Ltd 溶出制御型経口製剤
TW580397B (en) * 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
US8545880B2 (en) * 1999-02-26 2013-10-01 Andrx Pharmaceuticals, Llc Controlled release oral dosage form
US6627223B2 (en) * 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems
US6991807B2 (en) * 2000-02-24 2006-01-31 Advancis Pharmaceutical, Corp. Antibiotic composition
US7223421B2 (en) * 2000-06-30 2007-05-29 Mcneil-Ppc, Inc. Teste masked pharmaceutical particles
US6500457B1 (en) * 2000-08-14 2002-12-31 Peirce Management, Llc Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US7939102B2 (en) * 2002-06-07 2011-05-10 Torrent Pharmaceuticals Ltd. Controlled release formulation of lamotrigine
US7294347B2 (en) * 2004-06-21 2007-11-13 Council Of Scientific And Industrial Research Coating compositions for bitterness inhibition
US20060263429A1 (en) * 2005-05-20 2006-11-23 Hengsheng Feng Compressible mixture, compressed pharmaceutical compositions, and method of preparation thereof
KR20070021806A (ko) * 2005-08-19 2007-02-23 (주)아모레퍼시픽 α1-수용체 차단제의 서방형 펠렛제제 및 이의 제조 방법
GB0517205D0 (en) * 2005-08-22 2005-09-28 Novartis Ag Organic compounds
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
NZ575171A (en) * 2006-08-31 2012-04-27 Aptalis Pharmatech Inc Drug delivery systems comprising solid solutions of weakly basic drugs

Also Published As

Publication number Publication date
KR20110005876A (ko) 2011-01-19
FR2930147B1 (fr) 2013-02-08
FR2930147A1 (fr) 2009-10-23
MX339671B (es) 2016-06-03
CN102046155A (zh) 2011-05-04
EP2276474B1 (fr) 2019-03-06
ZA201007238B (en) 2011-06-29
AU2009247921A1 (en) 2009-11-19
JP5687185B2 (ja) 2015-03-18
ES2721849T3 (es) 2019-08-05
IL208572A0 (en) 2010-12-30
JP2011518139A (ja) 2011-06-23
BRPI0910572A2 (enExample) 2017-08-08
CA2721232A1 (fr) 2009-11-19
KR101380507B1 (ko) 2014-04-11
IL208572A (en) 2016-02-29
WO2009138642A1 (fr) 2009-11-19
US20090291137A1 (en) 2009-11-26
EP2276474A1 (fr) 2011-01-26
AU2009247921B2 (en) 2013-09-05
MX2010011409A (es) 2010-12-02
BRPI0910572B1 (pt) 2021-10-13

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