MX339671B - Forma oral solida con perfil de liberacion dual que contiene particulas multiples. - Google Patents
Forma oral solida con perfil de liberacion dual que contiene particulas multiples.Info
- Publication number
- MX339671B MX339671B MX2010011409A MX2010011409A MX339671B MX 339671 B MX339671 B MX 339671B MX 2010011409 A MX2010011409 A MX 2010011409A MX 2010011409 A MX2010011409 A MX 2010011409A MX 339671 B MX339671 B MX 339671B
- Authority
- MX
- Mexico
- Prior art keywords
- active agent
- weight
- polymer
- release
- release profile
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 3
- 230000009977 dual effect Effects 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 5
- 229920000642 polymer Polymers 0.000 abstract 5
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- 230000001143 conditioned effect Effects 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000004014 plasticizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
La invención se refiere a una forma sólida prensada para la administración oral de por lo menos un agente activo y capaz de asegurar un mecanismo dual para la liberación del agente activo, por lo que la primera liberación está adaptada al tiempo y la segunda liberación está adaptada al pH, caracterizada en que el agente activo está presente en forma de sistema de partículas múltiples, cuyas partículas múltiples incluyen una base que se compone completa o parcialmente del agente activo y está recubierta con por lo menos una capa que adapta el perfil de liberación del agente activo y que es formada por un material que contiene por lo menos: (i) 25% a 75% en peso, con relación al peso total del recubrimiento, de por lo menos un polímero A que es insoluble en los fluidos gastrointestinales, (ii) 25% a 75% n peso, con relación al peso total del recubrimiento, de por lo menos un polímero B que tiene un valor de pH de solubilización en el intervalo de pH de 5 a 7, y (iii) 0 a 25% en peso, con relación al peso total del recubrimiento, de por lo menos un plastificante, los polímeros A y B están presentes en una relación de peso del polímero B/polímero A que es por lo menos igual a 0.25. La invención también se refiere a un método para preparar esta forma sólida y las partículas múltiples correspondientes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7125008P | 2008-04-18 | 2008-04-18 | |
FR0852627A FR2930147B1 (fr) | 2008-04-18 | 2008-04-18 | Forme orale solide dotee d'un double profil de liberation |
PCT/FR2009/050719 WO2009138642A1 (fr) | 2008-04-18 | 2009-04-17 | Forme orale solide dotee d'un double profil de liberation comprenant des multiparticules |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2010011409A MX2010011409A (es) | 2010-12-02 |
MX339671B true MX339671B (es) | 2016-06-03 |
Family
ID=40110982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010011409A MX339671B (es) | 2008-04-18 | 2009-04-17 | Forma oral solida con perfil de liberacion dual que contiene particulas multiples. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20090291137A1 (es) |
EP (1) | EP2276474B1 (es) |
JP (1) | JP5687185B2 (es) |
KR (1) | KR101380507B1 (es) |
CN (1) | CN102046155A (es) |
AU (1) | AU2009247921B2 (es) |
BR (1) | BRPI0910572B1 (es) |
CA (1) | CA2721232C (es) |
ES (1) | ES2721849T3 (es) |
FR (1) | FR2930147B1 (es) |
IL (1) | IL208572A (es) |
MX (1) | MX339671B (es) |
WO (1) | WO2009138642A1 (es) |
ZA (1) | ZA201007238B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2945947B1 (fr) | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Compositions pharmaceutiques flottantes a liberation controlee |
WO2013156163A1 (en) | 2012-04-19 | 2013-10-24 | Glatt Ag | Taste-masked pharmaceutical compositions containing diclofenac |
WO2016053835A1 (en) * | 2014-09-30 | 2016-04-07 | Dow Global Technologies Llc | Aqueous ethylcellulose dispersions with polymeric additive |
WO2016114812A1 (en) * | 2015-01-12 | 2016-07-21 | Robert Niichel | Layered sustained-release microbeads and methods of making the same |
JP6112696B1 (ja) * | 2015-10-05 | 2017-04-12 | 富山化学工業株式会社 | ソリスロマイシンを含む錠剤 |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
FR3089405A1 (fr) | 2018-12-07 | 2020-06-12 | Urgo Recherche Innovation Et Developpement | Dispositif de retenue et système de contention comprenant un article de contention et un tel dispositif de retenue |
FR3089406B1 (fr) | 2018-12-07 | 2020-11-20 | Urgo Rech Innovation Et Developpement | Dispositif de retenue et système de contention comprenant un article de contention et un tel dispositif de retenue |
WO2020212948A1 (en) | 2019-04-17 | 2020-10-22 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE66933B1 (en) * | 1990-01-15 | 1996-02-07 | Elan Corp Plc | Controlled absorption naproxen formulation for once-daily administration |
WO1994003160A1 (en) * | 1992-08-05 | 1994-02-17 | F.H. Faulding & Co. Limited | Pelletised pharmaceutical composition |
US5260069A (en) * | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
US5458888A (en) * | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
JPH0826977A (ja) * | 1994-07-19 | 1996-01-30 | Tanabe Seiyaku Co Ltd | 溶出制御型経口製剤 |
TW580397B (en) * | 1997-05-27 | 2004-03-21 | Takeda Chemical Industries Ltd | Solid preparation |
US8545880B2 (en) * | 1999-02-26 | 2013-10-01 | Andrx Pharmaceuticals, Llc | Controlled release oral dosage form |
US6627223B2 (en) * | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
US6991807B2 (en) * | 2000-02-24 | 2006-01-31 | Advancis Pharmaceutical, Corp. | Antibiotic composition |
US7223421B2 (en) * | 2000-06-30 | 2007-05-29 | Mcneil-Ppc, Inc. | Teste masked pharmaceutical particles |
US6500457B1 (en) * | 2000-08-14 | 2002-12-31 | Peirce Management, Llc | Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent |
EP1258241A1 (en) * | 2001-05-16 | 2002-11-20 | BIOPROGRESS S.p.A. | Method of increasing the bioavailability of nimesulide |
FR2830447B1 (fr) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
US7939102B2 (en) * | 2002-06-07 | 2011-05-10 | Torrent Pharmaceuticals Ltd. | Controlled release formulation of lamotrigine |
US7294347B2 (en) * | 2004-06-21 | 2007-11-13 | Council Of Scientific And Industrial Research | Coating compositions for bitterness inhibition |
US20060263429A1 (en) * | 2005-05-20 | 2006-11-23 | Hengsheng Feng | Compressible mixture, compressed pharmaceutical compositions, and method of preparation thereof |
KR20070021806A (ko) * | 2005-08-19 | 2007-02-23 | (주)아모레퍼시픽 | α1-수용체 차단제의 서방형 펠렛제제 및 이의 제조 방법 |
GB0517205D0 (en) * | 2005-08-22 | 2005-09-28 | Novartis Ag | Organic compounds |
FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
MX370905B (es) * | 2006-08-31 | 2020-01-09 | Adare Pharmaceuticals Inc | Sistema de distribucion de farmacos, que comprenden soluciones solidas de farmacos debilmente basicos. |
-
2008
- 2008-04-18 FR FR0852627A patent/FR2930147B1/fr active Active
-
2009
- 2009-04-17 US US12/425,875 patent/US20090291137A1/en not_active Abandoned
- 2009-04-17 BR BRPI0910572-7A patent/BRPI0910572B1/pt active IP Right Grant
- 2009-04-17 JP JP2011504516A patent/JP5687185B2/ja active Active
- 2009-04-17 CN CN2009801202525A patent/CN102046155A/zh active Pending
- 2009-04-17 AU AU2009247921A patent/AU2009247921B2/en active Active
- 2009-04-17 WO PCT/FR2009/050719 patent/WO2009138642A1/fr active Application Filing
- 2009-04-17 CA CA2721232A patent/CA2721232C/fr active Active
- 2009-04-17 MX MX2010011409A patent/MX339671B/es active IP Right Grant
- 2009-04-17 EP EP09745961.4A patent/EP2276474B1/fr active Active
- 2009-04-17 KR KR1020107025760A patent/KR101380507B1/ko not_active IP Right Cessation
- 2009-04-17 ES ES09745961T patent/ES2721849T3/es active Active
-
2010
- 2010-10-07 IL IL208572A patent/IL208572A/en not_active IP Right Cessation
- 2010-10-11 ZA ZA2010/07238A patent/ZA201007238B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2721232A1 (fr) | 2009-11-19 |
KR101380507B1 (ko) | 2014-04-11 |
BRPI0910572B1 (pt) | 2021-10-13 |
CA2721232C (fr) | 2016-03-29 |
WO2009138642A1 (fr) | 2009-11-19 |
BRPI0910572A2 (es) | 2017-08-08 |
IL208572A0 (en) | 2010-12-30 |
CN102046155A (zh) | 2011-05-04 |
FR2930147A1 (fr) | 2009-10-23 |
AU2009247921B2 (en) | 2013-09-05 |
EP2276474B1 (fr) | 2019-03-06 |
EP2276474A1 (fr) | 2011-01-26 |
IL208572A (en) | 2016-02-29 |
ZA201007238B (en) | 2011-06-29 |
FR2930147B1 (fr) | 2013-02-08 |
KR20110005876A (ko) | 2011-01-19 |
AU2009247921A1 (en) | 2009-11-19 |
ES2721849T3 (es) | 2019-08-05 |
JP2011518139A (ja) | 2011-06-23 |
JP5687185B2 (ja) | 2015-03-18 |
US20090291137A1 (en) | 2009-11-26 |
MX2010011409A (es) | 2010-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: FLAMEL IRELAND LIMITED |
|
FG | Grant or registration |