CA2717511A1 - Modulation of enzymatic structure, activity, and/or expression level - Google Patents
Modulation of enzymatic structure, activity, and/or expression level Download PDFInfo
- Publication number
- CA2717511A1 CA2717511A1 CA2717511A CA2717511A CA2717511A1 CA 2717511 A1 CA2717511 A1 CA 2717511A1 CA 2717511 A CA2717511 A CA 2717511A CA 2717511 A CA2717511 A CA 2717511A CA 2717511 A1 CA2717511 A1 CA 2717511A1
- Authority
- CA
- Canada
- Prior art keywords
- modulator
- activity
- complex
- cells
- pdh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2008/002853 WO2009110859A1 (en) | 2008-03-04 | 2008-03-04 | Modulation of enzymatic structure, activity, and/or expression level |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2717511A1 true CA2717511A1 (en) | 2009-09-11 |
Family
ID=41056265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2717511A Abandoned CA2717511A1 (en) | 2008-03-04 | 2008-03-04 | Modulation of enzymatic structure, activity, and/or expression level |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP2260019A4 (zh) |
JP (1) | JP2011513395A (zh) |
KR (1) | KR20110004846A (zh) |
CN (1) | CN102089276A (zh) |
AU (1) | AU2008352076A1 (zh) |
BR (1) | BRPI0821176A2 (zh) |
CA (1) | CA2717511A1 (zh) |
IL (1) | IL207943A0 (zh) |
MX (1) | MX2010009673A (zh) |
WO (1) | WO2009110859A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8263653B2 (en) * | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
WO2009123597A1 (en) * | 2008-04-04 | 2009-10-08 | Robert Shorr | Pharmaceutical composition |
AU2014398233B2 (en) | 2014-06-19 | 2019-11-28 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
ES2819175T3 (es) | 2014-06-19 | 2021-04-15 | Rafael Pharmaceuticals Inc | Compuestos farmacéuticos |
TW202038930A (zh) * | 2018-12-20 | 2020-11-01 | 美商拉斐爾製藥公司 | 使用6,8-雙-苄硫基-辛酸之口服療法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5463093A (en) * | 1993-11-26 | 1995-10-31 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis |
DE4343593C2 (de) * | 1993-12-21 | 1998-05-20 | Asta Medica Ag | Verwendung von R-(+)-alpha-Liponsäure, R-(-)-Dihydroliponsäure oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung kompensierter und dekompensierter Insulinresistenz |
MXPA01004152A (es) * | 1998-10-26 | 2002-06-04 | Univ New York State Res Found | Derivados de acido lipoico y su uso en el tratamiento de enfermedades. |
US6284786B1 (en) * | 1999-02-16 | 2001-09-04 | The Center For The Improvement Of Human Functioning, Int'l., Inc. | Treatment of cancer using lipoic acid in combination with ascorbic acid |
IT1312060B1 (it) * | 1999-04-09 | 2002-04-04 | Antibioticos Spa | Uso dell'acido alfa lipoico nel trattamento antimetastatico. |
EP1172110A3 (de) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen |
US20020071234A1 (en) * | 2000-10-25 | 2002-06-13 | George Alexanian | Battery powered programmable remote switch controller |
WO2006119355A2 (en) * | 2005-05-03 | 2006-11-09 | Albert Einstein College Of Medicine Of Yeshiva University | Mammalian hypothalamic nutrient modulation of glucose metabolism |
AU2008242827B2 (en) * | 2007-04-18 | 2014-06-05 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
KR101644192B1 (ko) * | 2007-04-18 | 2016-07-29 | 코너스톤 파마슈티칼스, 인크. | 리포산 유도체 |
-
2008
- 2008-03-04 MX MX2010009673A patent/MX2010009673A/es unknown
- 2008-03-04 CA CA2717511A patent/CA2717511A1/en not_active Abandoned
- 2008-03-04 EP EP08726395A patent/EP2260019A4/en not_active Withdrawn
- 2008-03-04 WO PCT/US2008/002853 patent/WO2009110859A1/en active Application Filing
- 2008-03-04 AU AU2008352076A patent/AU2008352076A1/en not_active Abandoned
- 2008-03-04 KR KR1020107022085A patent/KR20110004846A/ko not_active Application Discontinuation
- 2008-03-04 JP JP2010549618A patent/JP2011513395A/ja active Pending
- 2008-03-04 BR BRPI0821176A patent/BRPI0821176A2/pt not_active IP Right Cessation
- 2008-03-04 CN CN2008801288127A patent/CN102089276A/zh active Pending
-
2010
- 2010-09-02 IL IL207943A patent/IL207943A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2010009673A (es) | 2011-03-15 |
AU2008352076A1 (en) | 2009-09-11 |
EP2260019A1 (en) | 2010-12-15 |
CN102089276A (zh) | 2011-06-08 |
IL207943A0 (en) | 2010-12-30 |
JP2011513395A (ja) | 2011-04-28 |
EP2260019A4 (en) | 2011-08-03 |
KR20110004846A (ko) | 2011-01-14 |
WO2009110859A1 (en) | 2009-09-11 |
BRPI0821176A2 (pt) | 2015-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Hashemi et al. | Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells | |
Gan et al. | Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity | |
CA2720396A1 (en) | Pharmaceutical composition | |
CA2638735A1 (en) | Methods to identify inhibitors of the unfolded protein response | |
An et al. | Synthesis and biological evaluation of selenium-containing 4-anilinoquinazoline derivatives as novel antimitotic agents | |
WO2009025781A1 (en) | Activators of pyruvate kinase m2 and methods of treating disease | |
JP2014512337A (ja) | スチルベン類似体およびがんを処置する方法 | |
Sandoval-Acuña et al. | Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates | |
Lee et al. | 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression | |
CA2717511A1 (en) | Modulation of enzymatic structure, activity, and/or expression level | |
Liu et al. | Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition | |
Li et al. | Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations | |
US20170218003A1 (en) | Pharmaceutical compounds | |
US10526357B2 (en) | Pharmaceutical compounds | |
AU2013364387B2 (en) | Pharmaceutical compounds | |
CA2829654C (en) | Small molecules that replace or agonize p53 function | |
Oh et al. | Selective targeting of cancer cells using a hydrogen peroxide-activated Hsp90 inhibitor | |
Lee et al. | Concurrent induction of apoptosis and necroptosis in apigenin‑treated malignant mesothelioma cells: Reversal of Warburg effect through Akt inhibition and p53 upregulation | |
WO2010110887A1 (en) | Fatty acids | |
JP2010527328A (ja) | 金属トリアングロ化合物およびその使用方法 | |
US11352382B2 (en) | Mito-lonidamine, compositions and methods of use | |
Szlachcikowska et al. | Role of Ciminalum-4-thiazolidinone Hybrids in Molecular NF-κB Dependent Pathways |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20130304 |
|
FZDE | Discontinued |
Effective date: 20150929 |