CA2717511A1 - Modulation de la structure, de l'activite et/ou du taux d'expression d'une enzyme - Google Patents

Modulation de la structure, de l'activite et/ou du taux d'expression d'une enzyme Download PDF

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Publication number
CA2717511A1
CA2717511A1 CA2717511A CA2717511A CA2717511A1 CA 2717511 A1 CA2717511 A1 CA 2717511A1 CA 2717511 A CA2717511 A CA 2717511A CA 2717511 A CA2717511 A CA 2717511A CA 2717511 A1 CA2717511 A1 CA 2717511A1
Authority
CA
Canada
Prior art keywords
modulator
activity
complex
cells
pdh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2717511A
Other languages
English (en)
Inventor
Robert Shorr
Robert Rodriguez
Rajinder Bhasin
Paul Bingham
Lakmal W. Boteju
Zuzana Zachar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2717511A1 publication Critical patent/CA2717511A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2717511A 2008-03-04 2008-03-04 Modulation de la structure, de l'activite et/ou du taux d'expression d'une enzyme Abandoned CA2717511A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/002853 WO2009110859A1 (fr) 2008-03-04 2008-03-04 Modulation de la structure, de l’activité et/ou du taux d’expression d’une enzyme

Publications (1)

Publication Number Publication Date
CA2717511A1 true CA2717511A1 (fr) 2009-09-11

Family

ID=41056265

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2717511A Abandoned CA2717511A1 (fr) 2008-03-04 2008-03-04 Modulation de la structure, de l'activite et/ou du taux d'expression d'une enzyme

Country Status (10)

Country Link
EP (1) EP2260019A4 (fr)
JP (1) JP2011513395A (fr)
KR (1) KR20110004846A (fr)
CN (1) CN102089276A (fr)
AU (1) AU2008352076A1 (fr)
BR (1) BRPI0821176A2 (fr)
CA (1) CA2717511A1 (fr)
IL (1) IL207943A0 (fr)
MX (1) MX2010009673A (fr)
WO (1) WO2009110859A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263653B2 (en) * 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
BRPI0821894A2 (pt) * 2008-04-04 2015-07-21 Robert Shorr Modulador do estado de fosforilação farmaceuticamente aceitável de pelo menos uma enzima e/ou complexo enzimático, ou subunidades das mesma, nas mitocôndrias de células doentes de animais de sangue quente, incluindo seres humanos, método de modulação de pelo menos uma enzima ou um complexo enzimático, ou uma subunidade dos mesmos, em um paciente que apresenta uma doença, uma condição, ou uma síndrome que inclui uma alteração do estado de fosforilação, de pelo menos uma enzima e/ou um complexo enzimático, ou uma subunidade das mesmas, e método para diagnosticar e prever o benefício em um paciente que apresenta sintomas de uma doença, uma condição, ou uma síndrome que incluem uma alteração do estado de fosforilação, de pelo menos uma enzima e/ou complexo enzimático, ou uma subunidade dos mesmos
WO2015195071A1 (fr) 2014-06-19 2015-12-23 Robert Shorr Composés pharmaceutiques
AU2014398232B2 (en) 2014-06-19 2019-11-28 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds
US20220040133A1 (en) * 2018-12-20 2022-02-10 Rafael Pharmaceuticals, Inc. Oral therapy using 6,8-bis-benzylthio-octanoic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5463093A (en) * 1993-11-26 1995-10-31 Garnett; Merrill Palladium complexes and methods for using same in the treatment of tumors or Psoriasis
DE4343593C2 (de) * 1993-12-21 1998-05-20 Asta Medica Ag Verwendung von R-(+)-alpha-Liponsäure, R-(-)-Dihydroliponsäure oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung kompensierter und dekompensierter Insulinresistenz
ES2340488T3 (es) * 1998-10-26 2010-06-04 The Research Foundation Of State University Of New York Sales derivadas del acido lipoico y su utilizacion para el tratamiento de las enfermedades.
US6284786B1 (en) * 1999-02-16 2001-09-04 The Center For The Improvement Of Human Functioning, Int'l., Inc. Treatment of cancer using lipoic acid in combination with ascorbic acid
IT1312060B1 (it) * 1999-04-09 2002-04-04 Antibioticos Spa Uso dell'acido alfa lipoico nel trattamento antimetastatico.
EP1172110A3 (fr) * 2000-07-07 2003-09-17 Basf Aktiengesellschaft Utilisation de l'acide lipoique pour augmenter la biodisponibilité de sels minéraux
US20020071234A1 (en) * 2000-10-25 2002-06-13 George Alexanian Battery powered programmable remote switch controller
WO2006119355A2 (fr) * 2005-05-03 2006-11-09 Albert Einstein College Of Medicine Of Yeshiva University Modulation hypothalamique du metabolisme du glucose chez les mammiferes par l'intermediaire de nutriments
JP5480804B2 (ja) * 2007-04-18 2014-04-23 コーナーストーン ファーマシューティカルズ，インコーポレーテッド リポ酸誘導体を含有する医薬製剤
EP2695614B1 (fr) * 2007-04-18 2017-07-05 Cornerstone Pharmaceuticals, Inc. Dérivés d'acide lipoïque

Also Published As

Publication number Publication date
EP2260019A4 (fr) 2011-08-03
KR20110004846A (ko) 2011-01-14
BRPI0821176A2 (pt) 2015-10-06
AU2008352076A1 (en) 2009-09-11
CN102089276A (zh) 2011-06-08
WO2009110859A1 (fr) 2009-09-11
IL207943A0 (en) 2010-12-30
EP2260019A1 (fr) 2010-12-15
JP2011513395A (ja) 2011-04-28
MX2010009673A (es) 2011-03-15

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130304

FZDE Discontinued

Effective date: 20150929