CA2713089C - Compositions and methods for the treatment of viral infections - Google Patents

Compositions and methods for the treatment of viral infections Download PDF

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Publication number
CA2713089C
CA2713089C CA2713089A CA2713089A CA2713089C CA 2713089 C CA2713089 C CA 2713089C CA 2713089 A CA2713089 A CA 2713089A CA 2713089 A CA2713089 A CA 2713089A CA 2713089 C CA2713089 C CA 2713089C
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Prior art keywords
seq
hiv
amino acid
heptad repeat
peptides
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CA2713089A
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English (en)
French (fr)
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CA2713089A1 (en
Inventor
Loren D. Walensky
Gregory H. Bird
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1994155T4 (da) 2006-02-13 2022-07-25 Daiichi Sankyo Co Ltd Polynukleotid- og polypeptidsekvenser involveret i fremgangsmåden med knogleremodellering
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
WO2008045238A2 (en) * 2006-10-05 2008-04-17 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
US8937154B2 (en) 2006-10-05 2015-01-20 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
CA2710964A1 (en) 2007-12-31 2009-09-11 New York University Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices
EP2247606B1 (en) 2008-01-23 2019-08-21 Dana-Farber Cancer Institute, Inc. Compositions and methods for the treatment of viral infections
AU2009244400B2 (en) 2008-05-06 2012-12-20 New York Blood Center Antiviral cell penetrating peptides
AU2009294877C1 (en) 2008-09-22 2015-05-07 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
AU2009316288B2 (en) 2008-11-24 2016-05-19 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
EP3124494B1 (en) 2008-12-09 2019-06-19 Dana-Farber Cancer Institute, Inc. Methods and compositions for specific modulation of mcl-1
WO2010083347A2 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2761568C (en) * 2009-06-18 2020-10-13 Dana-Farber Cancer Institute, Inc. Structured viral peptide compositions and methods of use
GB2471692A (en) * 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats
WO2012065181A2 (en) 2010-11-12 2012-05-18 Dana Farber Cancer Institute, Inc. Cancer therapies and diagnostics
US9029332B2 (en) 2010-12-15 2015-05-12 The Research Foundation For The State University Of New York Cross-linked peptides and proteins, methods of making same, and uses thereof
JP2014515748A (ja) 2011-04-15 2014-07-03 ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド BCL9の安定化されたαへリックスを使用した、癌における調節解除されたWntシグナル伝達の標的化
WO2013102211A2 (en) 2011-12-29 2013-07-04 Walensky Loren D Stabilized antiviral fusion helices
BR112014022958A2 (pt) * 2012-03-20 2017-07-18 Merck Sharp & Dohme peptídeo mimético de gp41, composição imunogênica, e, método para obter uma resposta imune em um hospedeiro mamífero
CN103483428B (zh) * 2012-06-11 2017-05-17 中国人民解放军军事医学科学院毒物药物研究所 抑制hiv感染的小分子‑多肽缀合物
CN104507969A (zh) 2012-07-19 2015-04-08 阿莱斯亚生物疗法股份有限公司 抗siglec-15抗体
AU2014228777B2 (en) 2013-03-15 2018-11-08 Dana-Farber Cancer Institute, Inc. BH4 stabilized peptides and uses thereof
AU2014235039B2 (en) 2013-03-15 2018-10-18 Dana-Farber Cancer Institute, Inc. Stabilized EZH2 peptides
US10087215B2 (en) 2013-03-15 2018-10-02 Dana-Farber Cancer Institute, Inc. Stabilized SOS1 peptides
US9644002B2 (en) 2013-07-25 2017-05-09 Yale University Allosteric modulators of EGFR and constitutively active mutants
US10172961B2 (en) 2014-05-07 2019-01-08 Cornell University Inhibitors of fusion between viral and cell membranes as well as compositions and methods of using them
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
KR20180022971A (ko) 2015-07-02 2018-03-06 다나-파버 캔서 인스티튜트 인크. 안정화된 항미생물성 펩티드
WO2017018595A1 (ko) * 2015-07-28 2017-02-02 동국대학교 산학협력단 이중 스테이플화된 펩타이드 및 이의 용도
AU2016316842C1 (en) 2015-08-28 2021-04-22 Dana-Farber Cancer Institute, Inc. Peptides binding to BFL-1
US20170247423A1 (en) 2016-02-29 2017-08-31 Dana-Farber Cancer Institute, Inc. Stapled intracellular-targeting antimicrobial peptides to treat infection
US11466064B2 (en) 2016-08-26 2022-10-11 Dana-Farber Cancer Institute, Inc. Bcl-w polypeptides and mimetics for treating or preventing chemotherapy-induced peripheral neuropathy and hearing loss
WO2018106937A1 (en) 2016-12-07 2018-06-14 The University Of Chicago Compositions and methods for inhibition of foxp3
JP7305614B2 (ja) 2017-07-19 2023-07-10 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド
KR20200064075A (ko) 2017-09-07 2020-06-05 포그 파마슈티컬스 인코포레이티드 베타-카테닌 기능을 조절하는 제제 및 이의 방법
US11865181B2 (en) 2017-11-03 2024-01-09 Yale University Peptidic materials that traffic efficiently to the cell cytosol and nucleus
JP7575944B2 (ja) 2017-12-15 2024-10-30 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 構造安定化および/またはシステイン反応性noxaペプチドによるアポトーシスタンパク質の選択的標的化
CN108822190B (zh) * 2018-05-23 2021-11-09 中国人民解放军军事科学院军事医学研究院 多肽及其药物组合物和用途
CN113039195A (zh) 2018-08-20 2021-06-25 弗格制药有限公司 肽集合、肽试剂及其使用方法
CA3173973A1 (en) * 2020-03-04 2021-09-10 Dana-Farber Cancer Institute, Inc. Antiviral structurally-stabilized sars-cov-2 peptides and uses thereof
WO2021183463A1 (en) * 2020-03-09 2021-09-16 President And Fellows Of Harvard College Compositions and methods for treating coronavirus
WO2021207517A2 (en) * 2020-04-10 2021-10-14 Sapience Therapeutics, Inc. Modified hr2 peptide inhibitors of coronavirus fusion
US20240131124A1 (en) * 2020-04-22 2024-04-25 Dana-Farber Cancer Institute, Inc. Antiviral structurally-stabilized ace2 helix 1 peptides and uses thereof
EP4228673A4 (en) * 2020-10-14 2024-11-20 The Trustees Of Columbia University In The City Of New York LIPOPEPTIDE FUSION INHIBITORS AS ANTIVIRALS AGAINST SARS-CoV 2
CN116801908A (zh) * 2020-10-14 2023-09-22 丹娜法伯癌症研究院 用于降解病毒和宿主蛋白的嵌合缀合物和使用方法
US11479582B2 (en) 2020-10-16 2022-10-25 King Faisal University Anti-SARS-CoV-2 fusion peptides
WO2022098848A1 (en) * 2020-11-05 2022-05-12 Dana-Farber Cancer Institute, Inc. Antiviral structurally-stabilized ebolavirus peptides and uses thereof
WO2022140591A1 (en) * 2020-12-22 2022-06-30 The University Of Chicago Blockade of sars-cov-2 infection using hydrocarbon stapled peptides
EP4453245A4 (en) * 2021-12-23 2025-12-31 Mammoth Biosciences Inc DOSING IMPROVEMENTS BASED ON A PROGRAMMABLE NUCLEASE

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271198B1 (en) 1996-11-06 2001-08-07 Genentech, Inc. Constrained helical peptides and methods of making same
AU745101B2 (en) * 1996-11-06 2002-03-14 Genentech Inc. Constrained helical peptides and methods of making same
AU2604200A (en) 1999-01-08 2000-07-24 Panacos Pharmaceuticals, Inc. Methods of eliciting broadly neutralizing antibodies targeting hiv-1 gp41
US20060241027A1 (en) * 2002-02-07 2006-10-26 Hans-Peter Hauser Hiv inhibiting proteins
WO2005034842A2 (en) * 2003-05-19 2005-04-21 Progenics Pharmaceuticals, Inc. Peptides useful as hiv fusion inhibitors
EP1680443B9 (en) * 2003-11-05 2014-09-03 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
EP1708734A4 (en) 2004-01-07 2009-06-17 Trimeris Inc PEPTIDES DERIVED FROM HIV GP41 HR2 AND THEIR USE IN THERAPY TO INHIBIT THE TRANSMISSION OF HUMAN IMMUNODICIENCY VIRUS
WO2006121809A2 (en) * 2005-05-06 2006-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibition of membrane fusion proteins
CA2700925C (en) * 2007-09-26 2016-08-23 Dana Farber Cancer Institute Methods and compositions for modulating bcl-2 family polypeptides
WO2009042895A2 (en) 2007-09-26 2009-04-02 Dana-Farber Cancer Institute, Inc. Reagents for inducing an immune response
EP2247606B1 (en) 2008-01-23 2019-08-21 Dana-Farber Cancer Institute, Inc. Compositions and methods for the treatment of viral infections

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