CA2710148C - Multireflection time-of-flight mass spectrometer - Google Patents

Multireflection time-of-flight mass spectrometer Download PDF

Info

Publication number
CA2710148C
CA2710148C CA2710148A CA2710148A CA2710148C CA 2710148 C CA2710148 C CA 2710148C CA 2710148 A CA2710148 A CA 2710148A CA 2710148 A CA2710148 A CA 2710148A CA 2710148 C CA2710148 C CA 2710148C
Authority
CA
Canada
Prior art keywords
ion mirror
ions
ion
mirror
arrangement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2710148A
Other languages
English (en)
French (fr)
Other versions
CA2710148A1 (en
Inventor
Alexander Makarov
Dmitry E. Grinfeld
Mikhail A. Monastyrskiy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Fisher Scientific Bremen GmbH
Original Assignee
Thermo Fisher Scientific Bremen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Fisher Scientific Bremen GmbH filed Critical Thermo Fisher Scientific Bremen GmbH
Publication of CA2710148A1 publication Critical patent/CA2710148A1/en
Application granted granted Critical
Publication of CA2710148C publication Critical patent/CA2710148C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/06Electron- or ion-optical arrangements
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/40Time-of-flight spectrometers
    • H01J49/406Time-of-flight spectrometers with multiple reflections
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/06Electron- or ion-optical arrangements
    • H01J49/061Ion deflecting means, e.g. ion gates
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/40Time-of-flight spectrometers
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/40Time-of-flight spectrometers
    • H01J49/405Time-of-flight spectrometers characterised by the reflectron, e.g. curved field, electrode shapes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2710148A 2007-12-21 2008-12-22 Multireflection time-of-flight mass spectrometer Expired - Fee Related CA2710148C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0725066A GB2455977A (en) 2007-12-21 2007-12-21 Multi-reflectron time-of-flight mass spectrometer
GB0725066.5 2007-12-21
PCT/GB2008/004231 WO2009081143A2 (en) 2007-12-21 2008-12-22 Multiref lection time-of -flight mass spectrometer

Publications (2)

Publication Number Publication Date
CA2710148A1 CA2710148A1 (en) 2009-07-02
CA2710148C true CA2710148C (en) 2017-02-28

Family

ID=39048622

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2710148A Expired - Fee Related CA2710148C (en) 2007-12-21 2008-12-22 Multireflection time-of-flight mass spectrometer

Country Status (6)

Country Link
US (5) US8395115B2 (enExample)
EP (4) EP2610893B1 (enExample)
JP (4) JP5282102B2 (enExample)
CA (1) CA2710148C (enExample)
GB (1) GB2455977A (enExample)
WO (1) WO2009081143A2 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0620398D0 (en) * 2006-10-13 2006-11-22 Shimadzu Corp Multi-reflecting time-of-flight mass analyser and a time-of-flight mass spectrometer including the time-of-flight mass analyser
GB0626025D0 (en) * 2006-12-29 2007-02-07 Thermo Electron Bremen Gmbh Ion trap
GB2455977A (en) * 2007-12-21 2009-07-01 Thermo Fisher Scient Multi-reflectron time-of-flight mass spectrometer
WO2010008386A1 (en) * 2008-07-16 2010-01-21 Leco Corporation Quasi-planar multi-reflecting time-of-flight mass spectrometer
GB2470599B (en) 2009-05-29 2014-04-02 Thermo Fisher Scient Bremen Charged particle analysers and methods of separating charged particles
GB2470600B (en) 2009-05-29 2012-06-13 Thermo Fisher Scient Bremen Charged particle analysers and methods of separating charged particles
GB2473839B (en) 2009-09-24 2016-06-01 Edwards Ltd Mass spectrometer
GB2476964A (en) * 2010-01-15 2011-07-20 Anatoly Verenchikov Electrostatic trap mass spectrometer
EP2355129B1 (de) * 2010-01-29 2013-01-09 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Reflektor für ein Flugzeitmassenspektrometer
DE112011102315T5 (de) * 2010-07-09 2013-06-20 Aldan Asanovich Sapargaliyev Verfahren der Massenspektrometrie und Einrichtung für seine Ausführung
GB2496991B (en) * 2010-11-26 2015-05-20 Thermo Fisher Scient Bremen Method of mass selecting ions and mass selector
GB201022050D0 (en) * 2010-12-29 2011-02-02 Verenchikov Anatoly Electrostatic trap mass spectrometer with improved ion injection
GB201110662D0 (en) 2011-06-23 2011-08-10 Thermo Fisher Scient Bremen Targeted analysis for tandem mass spectrometry
GB2495899B (en) * 2011-07-04 2018-05-16 Thermo Fisher Scient Bremen Gmbh Identification of samples using a multi pass or multi reflection time of flight mass spectrometer
GB2495127B (en) 2011-09-30 2016-10-19 Thermo Fisher Scient (Bremen) Gmbh Method and apparatus for mass spectrometry
GB201118279D0 (en) 2011-10-21 2011-12-07 Shimadzu Corp Mass analyser, mass spectrometer and associated methods
GB201122178D0 (en) 2011-12-22 2012-02-01 Thermo Fisher Scient Bremen Method of tandem mass spectrometry
GB201201403D0 (en) 2012-01-27 2012-03-14 Thermo Fisher Scient Bremen Multi-reflection mass spectrometer
GB201201405D0 (en) 2012-01-27 2012-03-14 Thermo Fisher Scient Bremen Multi-reflection mass spectrometer
WO2013148181A2 (en) * 2012-03-28 2013-10-03 Ulvac-Phi, Inc. Method and apparatus to provide parallel acquisition of mass spectrometry/mass spectrometry data
CN105009251B (zh) * 2013-03-14 2017-12-22 莱克公司 多反射质谱仪
US9542377B2 (en) * 2013-05-06 2017-01-10 Dropbox, Inc. Note browser
GB2547120B (en) * 2014-10-23 2021-07-07 Leco Corp A multi-reflecting time-of-flight analyzer
GB2593056B (en) * 2014-10-23 2021-12-08 Leco Corp A multi-reflecting time-of-flight analyzer
GB201507363D0 (en) * 2015-04-30 2015-06-17 Micromass Uk Ltd And Leco Corp Multi-reflecting TOF mass spectrometer
GB201519830D0 (en) 2015-11-10 2015-12-23 Micromass Ltd A method of transmitting ions through an aperture
GB201520130D0 (en) 2015-11-16 2015-12-30 Micromass Uk Ltd And Leco Corp Imaging mass spectrometer
GB201520134D0 (en) 2015-11-16 2015-12-30 Micromass Uk Ltd And Leco Corp Imaging mass spectrometer
GB201520540D0 (en) * 2015-11-23 2016-01-06 Micromass Uk Ltd And Leco Corp Improved ion mirror and ion-optical lens for imaging
JP6907226B2 (ja) * 2015-11-30 2021-07-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ 飛行時間質量分析法のためのマルチモードイオンミラープリズム及びエネルギーフィルタリング装置及びシステム
GB201613988D0 (en) 2016-08-16 2016-09-28 Micromass Uk Ltd And Leco Corp Mass analyser having extended flight path
GB2555609B (en) 2016-11-04 2019-06-12 Thermo Fisher Scient Bremen Gmbh Multi-reflection mass spectrometer with deceleration stage
GB2567794B (en) 2017-05-05 2023-03-08 Micromass Ltd Multi-reflecting time-of-flight mass spectrometers
GB2563571B (en) 2017-05-26 2023-05-24 Micromass Ltd Time of flight mass analyser with spatial focussing
GB2563077A (en) 2017-06-02 2018-12-05 Thermo Fisher Scient Bremen Gmbh Mass error correction due to thermal drift in a time of flight mass spectrometer
GB2563604B (en) 2017-06-20 2021-03-10 Thermo Fisher Scient Bremen Gmbh Mass spectrometer and method for time-of-flight mass spectrometry
US11239067B2 (en) 2017-08-06 2022-02-01 Micromass Uk Limited Ion mirror for multi-reflecting mass spectrometers
EP3662502A1 (en) 2017-08-06 2020-06-10 Micromass UK Limited Printed circuit ion mirror with compensation
WO2019030477A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov ACCELERATOR FOR MASS SPECTROMETERS WITH MULTIPASSES
EP3662503A1 (en) 2017-08-06 2020-06-10 Micromass UK Limited Ion injection into multi-pass mass spectrometers
WO2019030473A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov FIELDS FOR SMART REFLECTIVE TOF SM
WO2019030471A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov ION GUIDE INSIDE PULSED CONVERTERS
US11211238B2 (en) 2017-08-06 2021-12-28 Micromass Uk Limited Multi-pass mass spectrometer
GB201806507D0 (en) 2018-04-20 2018-06-06 Verenchikov Anatoly Gridless ion mirrors with smooth fields
GB201807605D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201807626D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201810573D0 (en) 2018-06-28 2018-08-15 Verenchikov Anatoly Multi-pass mass spectrometer with improved duty cycle
WO2020081276A1 (en) 2018-10-19 2020-04-23 Aceleron, Inc. Methods and systems for plasma self-compression
GB201901411D0 (en) 2019-02-01 2019-03-20 Micromass Ltd Electrode assembly for mass spectrometer
GB201903779D0 (en) 2019-03-20 2019-05-01 Micromass Ltd Multiplexed time of flight mass spectrometer
GB2600985B (en) 2020-11-16 2024-10-30 Thermo Fisher Scient Bremen Gmbh Mass spectrometer and method of mass spectrometry
GB2636994A (en) * 2024-01-02 2025-07-09 Thermo Fisher Scient Bremen Gmbh Multi-reflection time-of-flight mass analyser with independent trapping region

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3025764C2 (de) * 1980-07-08 1984-04-19 Hermann Prof. Dr. 6301 Fernwald Wollnik Laufzeit-Massenspektrometer
JPS6229049A (ja) * 1985-07-31 1987-02-07 Hitachi Ltd 質量分析計
SU1725289A1 (ru) 1989-07-20 1992-04-07 Институт Ядерной Физики Ан Казсср Врем пролетный масс-спектрометр с многократным отражением
DE4408489C2 (de) * 1994-03-14 1997-07-31 Frank Dr Strehle Massenspektrometer
US6013913A (en) * 1998-02-06 2000-01-11 The University Of Northern Iowa Multi-pass reflectron time-of-flight mass spectrometer
US6674069B1 (en) * 1998-12-17 2004-01-06 Jeol Usa, Inc. In-line reflecting time-of-flight mass spectrometer for molecular structural analysis using collision induced dissociation
DE10005698B4 (de) * 2000-02-09 2007-03-01 Bruker Daltonik Gmbh Gitterloses Reflektor-Flugzeitmassenspektrometer für orthogonalen Ioneneinschuss
US6657190B2 (en) * 2001-06-20 2003-12-02 University Of Northern Iowa Research Foundation Variable potential ion guide for mass spectrometry
US7196324B2 (en) * 2002-07-16 2007-03-27 Leco Corporation Tandem time of flight mass spectrometer and method of use
GB2390935A (en) * 2002-07-16 2004-01-21 Anatoli Nicolai Verentchikov Time-nested mass analysis using a TOF-TOF tandem mass spectrometer
GB2403063A (en) * 2003-06-21 2004-12-22 Anatoli Nicolai Verentchikov Time of flight mass spectrometer employing a plurality of lenses focussing an ion beam in shift direction
US7385187B2 (en) 2003-06-21 2008-06-10 Leco Corporation Multi-reflecting time-of-flight mass spectrometer and method of use
EP1759402B1 (en) * 2004-05-21 2015-07-08 Craig M. Whitehouse Rf surfaces and rf ion guides
JP5357538B2 (ja) * 2005-03-22 2013-12-04 レコ コーポレイション 等時性湾曲イオンインタフェースを備えた多重反射型飛行時間質量分析計
WO2007044696A1 (en) * 2005-10-11 2007-04-19 Leco Corporation Multi-reflecting time-of-flight mass spectrometer with orthogonal acceleration
GB0605089D0 (en) * 2006-03-14 2006-04-26 Micromass Ltd Mass spectrometer
DE112007000931B4 (de) * 2006-04-13 2014-05-22 Thermo Fisher Scientific (Bremen) Gmbh Ionenenergiestreuungsreduzierung für ein Massenspektrometer
GB0620398D0 (en) * 2006-10-13 2006-11-22 Shimadzu Corp Multi-reflecting time-of-flight mass analyser and a time-of-flight mass spectrometer including the time-of-flight mass analyser
GB0620963D0 (en) * 2006-10-20 2006-11-29 Thermo Finnigan Llc Multi-channel detection
GB0624677D0 (en) 2006-12-11 2007-01-17 Shimadzu Corp A co-axial time-of-flight mass spectrometer
GB0712252D0 (en) * 2007-06-22 2007-08-01 Shimadzu Corp A multi-reflecting ion optical device
GB2455977A (en) * 2007-12-21 2009-07-01 Thermo Fisher Scient Multi-reflectron time-of-flight mass spectrometer

Also Published As

Publication number Publication date
US20130313424A1 (en) 2013-11-28
JP5525642B2 (ja) 2014-06-18
JP5282102B2 (ja) 2013-09-04
US9620350B2 (en) 2017-04-11
CA2710148A1 (en) 2009-07-02
JP2013175481A (ja) 2013-09-05
US8674293B2 (en) 2014-03-18
JP2013179083A (ja) 2013-09-09
EP2613339B1 (en) 2016-11-16
US9082605B2 (en) 2015-07-14
JP5553921B2 (ja) 2014-07-23
EP2610893B1 (en) 2017-02-01
US9324553B2 (en) 2016-04-26
EP2610894A3 (en) 2013-07-17
EP2610893A2 (en) 2013-07-03
EP2610894A2 (en) 2013-07-03
JP2011507205A (ja) 2011-03-03
US20110017907A1 (en) 2011-01-27
US8395115B2 (en) 2013-03-12
JP5566503B2 (ja) 2014-08-06
EP2232525B1 (en) 2014-04-16
EP2613339A1 (en) 2013-07-10
US20150294849A1 (en) 2015-10-15
WO2009081143A2 (en) 2009-07-02
US20160233076A1 (en) 2016-08-11
EP2232525A2 (en) 2010-09-29
WO2009081143A3 (en) 2010-03-25
EP2610893A3 (en) 2013-07-10
US20130187043A1 (en) 2013-07-25
GB2455977A (en) 2009-07-01
GB0725066D0 (en) 2008-01-30
JP2013179084A (ja) 2013-09-09

Similar Documents

Publication Publication Date Title
CA2710148C (en) Multireflection time-of-flight mass spectrometer
US10964520B2 (en) Multi-reflection mass spectrometer
JP6596103B2 (ja) 多重反射型tof質量分光計およびtof質量分析方法
US11587779B2 (en) Multi-pass mass spectrometer with high duty cycle
US6348688B1 (en) Tandem time-of-flight mass spectrometer with delayed extraction and method for use
WO2018033494A1 (en) Mass analyser having extended flight path

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20131220

MKLA Lapsed

Effective date: 20201222