GB2455977A - Multi-reflectron time-of-flight mass spectrometer - Google Patents

Multi-reflectron time-of-flight mass spectrometer Download PDF

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Publication number
GB2455977A
GB2455977A GB0725066A GB0725066A GB2455977A GB 2455977 A GB2455977 A GB 2455977A GB 0725066 A GB0725066 A GB 0725066A GB 0725066 A GB0725066 A GB 0725066A GB 2455977 A GB2455977 A GB 2455977A
Authority
GB
United Kingdom
Prior art keywords
ion mirror
ions
ion
mirror
arrangement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0725066A
Other languages
English (en)
Other versions
GB0725066D0 (en
Inventor
Alexander Makarov
Dmitry E Grinfeld
Mikhail A Monastyrskiy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Fisher Scientific GmbH
Thermo Fisher Scientific Inc
Original Assignee
Thermo Fisher Scientific GmbH
Thermo Fisher Scientific Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0725066A priority Critical patent/GB2455977A/en
Application filed by Thermo Fisher Scientific GmbH, Thermo Fisher Scientific Inc filed Critical Thermo Fisher Scientific GmbH
Publication of GB0725066D0 publication Critical patent/GB0725066D0/en
Priority to EP13161735.9A priority patent/EP2610893B1/en
Priority to JP2010538905A priority patent/JP5282102B2/ja
Priority to CA2710148A priority patent/CA2710148C/en
Priority to EP08865251.6A priority patent/EP2232525B1/en
Priority to EP13161726.8A priority patent/EP2613339B1/en
Priority to PCT/GB2008/004231 priority patent/WO2009081143A2/en
Priority to EP13161743.3A priority patent/EP2610894A3/en
Priority to US12/809,867 priority patent/US8395115B2/en
Publication of GB2455977A publication Critical patent/GB2455977A/en
Priority to US13/790,760 priority patent/US8674293B2/en
Priority to JP2013111128A priority patent/JP5566503B2/ja
Priority to JP2013111127A priority patent/JP5525642B2/ja
Priority to JP2013111126A priority patent/JP5553921B2/ja
Priority to US13/957,776 priority patent/US9082605B2/en
Priority to US14/748,582 priority patent/US9324553B2/en
Priority to US15/131,912 priority patent/US9620350B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/406—Time-of-flight spectrometers with multiple reflections
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/061—Ion deflecting means, e.g. ion gates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/405—Time-of-flight spectrometers characterised by the reflectron, e.g. curved field, electrode shapes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
GB0725066A 2007-12-21 2007-12-21 Multi-reflectron time-of-flight mass spectrometer Withdrawn GB2455977A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB0725066A GB2455977A (en) 2007-12-21 2007-12-21 Multi-reflectron time-of-flight mass spectrometer
EP13161735.9A EP2610893B1 (en) 2007-12-21 2008-12-22 Multireflection time-of-flight mass spectrometer
JP2010538905A JP5282102B2 (ja) 2007-12-21 2008-12-22 多重反射式飛行時間型質量分析器
CA2710148A CA2710148C (en) 2007-12-21 2008-12-22 Multireflection time-of-flight mass spectrometer
EP08865251.6A EP2232525B1 (en) 2007-12-21 2008-12-22 Multireflection time-of-flight mass spectrometer
EP13161726.8A EP2613339B1 (en) 2007-12-21 2008-12-22 Multireflection time-of-flight mass spectrometer
PCT/GB2008/004231 WO2009081143A2 (en) 2007-12-21 2008-12-22 Multiref lection time-of -flight mass spectrometer
EP13161743.3A EP2610894A3 (en) 2007-12-21 2008-12-22 Multireflection time-of-flight mass spectrometer
US12/809,867 US8395115B2 (en) 2007-12-21 2008-12-22 Multireflection time-of-flight mass spectrometer
US13/790,760 US8674293B2 (en) 2007-12-21 2013-03-08 Multireflection time-of-flight mass spectrometer
JP2013111126A JP5553921B2 (ja) 2007-12-21 2013-05-27 多重反射式飛行時間型質量分析器
JP2013111127A JP5525642B2 (ja) 2007-12-21 2013-05-27 多重反射式飛行時間型質量分析器
JP2013111128A JP5566503B2 (ja) 2007-12-21 2013-05-27 多重反射式飛行時間型質量分析器でイオンを反射させる方法
US13/957,776 US9082605B2 (en) 2007-12-21 2013-08-02 Multireflection time-of-flight mass spectrometer
US14/748,582 US9324553B2 (en) 2007-12-21 2015-06-24 Multireflection time-of-flight mass spectrometer
US15/131,912 US9620350B2 (en) 2007-12-21 2016-04-18 Multireflection time-of-flight mass spectrometer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0725066A GB2455977A (en) 2007-12-21 2007-12-21 Multi-reflectron time-of-flight mass spectrometer

Publications (2)

Publication Number Publication Date
GB0725066D0 GB0725066D0 (en) 2008-01-30
GB2455977A true GB2455977A (en) 2009-07-01

Family

ID=39048622

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0725066A Withdrawn GB2455977A (en) 2007-12-21 2007-12-21 Multi-reflectron time-of-flight mass spectrometer

Country Status (6)

Country Link
US (5) US8395115B2 (enExample)
EP (4) EP2610893B1 (enExample)
JP (4) JP5282102B2 (enExample)
CA (1) CA2710148C (enExample)
GB (1) GB2455977A (enExample)
WO (1) WO2009081143A2 (enExample)

Cited By (31)

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WO2011036472A1 (en) * 2009-09-24 2011-03-31 Edwards Limited Mass spectrometer system
GB2476964A (en) * 2010-01-15 2011-07-20 Anatoly Verenchikov Electrostatic trap mass spectrometer
EP2355129A1 (de) * 2010-01-29 2011-08-10 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Reflektor für ein Flugzeitmassenspektrometer
GB2495127A (en) * 2011-09-30 2013-04-03 Thermo Fisher Scient Bremen Method and apparatus for mass spectrometry
DE112007003188B4 (de) * 2006-12-29 2013-06-06 Thermo Fisher Scientific (Bremen) Gmbh Ionenfalle
EP2615622A4 (en) * 2010-07-09 2014-06-18 Saparqaliyev Aldan Asanovich MASS SPECTROMETRY METHOD AND DEVICE FOR IMPLEMENTING IT
US9082602B2 (en) 2011-10-21 2015-07-14 Shimadzu Corporation Mass analyser providing 3D electrostatic field region, mass spectrometer and methodology
WO2016064398A1 (en) * 2014-10-23 2016-04-28 Leco Corporation A multi-reflecting time-of-flight analyzer
GB2544647A (en) * 2015-11-10 2017-05-24 Micromass Ltd A method of transmitting ions through an aperture
WO2017091501A1 (en) * 2015-11-23 2017-06-01 Micromass Uk Limited Improved ion mirror and ion-optical lens for imaging
US10593533B2 (en) 2015-11-16 2020-03-17 Micromass Uk Limited Imaging mass spectrometer
US10629425B2 (en) 2015-11-16 2020-04-21 Micromass Uk Limited Imaging mass spectrometer
US10741376B2 (en) 2015-04-30 2020-08-11 Micromass Uk Limited Multi-reflecting TOF mass spectrometer
US10950425B2 (en) 2016-08-16 2021-03-16 Micromass Uk Limited Mass analyser having extended flight path
US11049712B2 (en) 2017-08-06 2021-06-29 Micromass Uk Limited Fields for multi-reflecting TOF MS
US11081332B2 (en) 2017-08-06 2021-08-03 Micromass Uk Limited Ion guide within pulsed converters
GB2593056A (en) * 2014-10-23 2021-09-15 Leco Corp A multi-reflecting time-of-flight analyzer
US11205568B2 (en) 2017-08-06 2021-12-21 Micromass Uk Limited Ion injection into multi-pass mass spectrometers
US11211238B2 (en) 2017-08-06 2021-12-28 Micromass Uk Limited Multi-pass mass spectrometer
US11239067B2 (en) 2017-08-06 2022-02-01 Micromass Uk Limited Ion mirror for multi-reflecting mass spectrometers
US11295944B2 (en) 2017-08-06 2022-04-05 Micromass Uk Limited Printed circuit ion mirror with compensation
US11309175B2 (en) 2017-05-05 2022-04-19 Micromass Uk Limited Multi-reflecting time-of-flight mass spectrometers
US11328920B2 (en) 2017-05-26 2022-05-10 Micromass Uk Limited Time of flight mass analyser with spatial focussing
US11342175B2 (en) 2018-05-10 2022-05-24 Micromass Uk Limited Multi-reflecting time of flight mass analyser
US11367608B2 (en) 2018-04-20 2022-06-21 Micromass Uk Limited Gridless ion mirrors with smooth fields
US11587779B2 (en) 2018-06-28 2023-02-21 Micromass Uk Limited Multi-pass mass spectrometer with high duty cycle
US11621156B2 (en) 2018-05-10 2023-04-04 Micromass Uk Limited Multi-reflecting time of flight mass analyser
US11817303B2 (en) 2017-08-06 2023-11-14 Micromass Uk Limited Accelerator for multi-pass mass spectrometers
US11848185B2 (en) 2019-02-01 2023-12-19 Micromass Uk Limited Electrode assembly for mass spectrometer
US11881387B2 (en) 2018-05-24 2024-01-23 Micromass Uk Limited TOF MS detection system with improved dynamic range
US12205813B2 (en) 2019-03-20 2025-01-21 Micromass Uk Limited Multiplexed time of flight mass spectrometer

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GB0620398D0 (en) * 2006-10-13 2006-11-22 Shimadzu Corp Multi-reflecting time-of-flight mass analyser and a time-of-flight mass spectrometer including the time-of-flight mass analyser
GB2455977A (en) * 2007-12-21 2009-07-01 Thermo Fisher Scient Multi-reflectron time-of-flight mass spectrometer
WO2010008386A1 (en) * 2008-07-16 2010-01-21 Leco Corporation Quasi-planar multi-reflecting time-of-flight mass spectrometer
GB2470599B (en) 2009-05-29 2014-04-02 Thermo Fisher Scient Bremen Charged particle analysers and methods of separating charged particles
GB2470600B (en) 2009-05-29 2012-06-13 Thermo Fisher Scient Bremen Charged particle analysers and methods of separating charged particles
GB2496991B (en) * 2010-11-26 2015-05-20 Thermo Fisher Scient Bremen Method of mass selecting ions and mass selector
GB201022050D0 (en) * 2010-12-29 2011-02-02 Verenchikov Anatoly Electrostatic trap mass spectrometer with improved ion injection
GB201110662D0 (en) 2011-06-23 2011-08-10 Thermo Fisher Scient Bremen Targeted analysis for tandem mass spectrometry
GB2495899B (en) * 2011-07-04 2018-05-16 Thermo Fisher Scient Bremen Gmbh Identification of samples using a multi pass or multi reflection time of flight mass spectrometer
GB201122178D0 (en) 2011-12-22 2012-02-01 Thermo Fisher Scient Bremen Method of tandem mass spectrometry
GB201201403D0 (en) 2012-01-27 2012-03-14 Thermo Fisher Scient Bremen Multi-reflection mass spectrometer
GB201201405D0 (en) 2012-01-27 2012-03-14 Thermo Fisher Scient Bremen Multi-reflection mass spectrometer
WO2013148181A2 (en) * 2012-03-28 2013-10-03 Ulvac-Phi, Inc. Method and apparatus to provide parallel acquisition of mass spectrometry/mass spectrometry data
CN105009251B (zh) * 2013-03-14 2017-12-22 莱克公司 多反射质谱仪
US9542377B2 (en) * 2013-05-06 2017-01-10 Dropbox, Inc. Note browser
JP6907226B2 (ja) * 2015-11-30 2021-07-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ 飛行時間質量分析法のためのマルチモードイオンミラープリズム及びエネルギーフィルタリング装置及びシステム
GB2555609B (en) 2016-11-04 2019-06-12 Thermo Fisher Scient Bremen Gmbh Multi-reflection mass spectrometer with deceleration stage
GB2563077A (en) 2017-06-02 2018-12-05 Thermo Fisher Scient Bremen Gmbh Mass error correction due to thermal drift in a time of flight mass spectrometer
GB2563604B (en) 2017-06-20 2021-03-10 Thermo Fisher Scient Bremen Gmbh Mass spectrometer and method for time-of-flight mass spectrometry
WO2020081276A1 (en) 2018-10-19 2020-04-23 Aceleron, Inc. Methods and systems for plasma self-compression
GB2600985B (en) 2020-11-16 2024-10-30 Thermo Fisher Scient Bremen Gmbh Mass spectrometer and method of mass spectrometry
GB2636994A (en) * 2024-01-02 2025-07-09 Thermo Fisher Scient Bremen Gmbh Multi-reflection time-of-flight mass analyser with independent trapping region

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WO2007044696A1 (en) * 2005-10-11 2007-04-19 Leco Corporation Multi-reflecting time-of-flight mass spectrometer with orthogonal acceleration

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Cited By (49)

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Publication number Priority date Publication date Assignee Title
DE112007003188B4 (de) * 2006-12-29 2013-06-06 Thermo Fisher Scientific (Bremen) Gmbh Ionenfalle
WO2011036472A1 (en) * 2009-09-24 2011-03-31 Edwards Limited Mass spectrometer system
US8716658B2 (en) 2009-09-24 2014-05-06 Edwards Limited Mass spectrometer system
GB2476964A (en) * 2010-01-15 2011-07-20 Anatoly Verenchikov Electrostatic trap mass spectrometer
EP2355129A1 (de) * 2010-01-29 2011-08-10 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Reflektor für ein Flugzeitmassenspektrometer
US8314381B2 (en) 2010-01-29 2012-11-20 Helmholtz-Zentrum Geesthacht Zentrum für Material-und Küstenforschung GmbH Reflector for a time-of-flight mass spectrometer
EP2615622A4 (en) * 2010-07-09 2014-06-18 Saparqaliyev Aldan Asanovich MASS SPECTROMETRY METHOD AND DEVICE FOR IMPLEMENTING IT
GB2495127A (en) * 2011-09-30 2013-04-03 Thermo Fisher Scient Bremen Method and apparatus for mass spectrometry
US9209005B2 (en) 2011-09-30 2015-12-08 Thermo Fisher Scientific (Bremen) Gmbh Method and apparatus for mass spectrometry
US10186411B2 (en) 2011-09-30 2019-01-22 Thermo Fisher Scientific (Bremen) Gmbh Method and apparatus for mass spectrometry
GB2495127B (en) * 2011-09-30 2016-10-19 Thermo Fisher Scient (Bremen) Gmbh Method and apparatus for mass spectrometry
US9082602B2 (en) 2011-10-21 2015-07-14 Shimadzu Corporation Mass analyser providing 3D electrostatic field region, mass spectrometer and methodology
WO2016064398A1 (en) * 2014-10-23 2016-04-28 Leco Corporation A multi-reflecting time-of-flight analyzer
GB2593056B (en) * 2014-10-23 2021-12-08 Leco Corp A multi-reflecting time-of-flight analyzer
GB2547120A (en) * 2014-10-23 2017-08-09 Leco Corp A multi-reflecting time-of-flight analyzer
CN107078019A (zh) * 2014-10-23 2017-08-18 莱克公司 多反射飞行时间分析仪
US10163616B2 (en) 2014-10-23 2018-12-25 Leco Corporation Multi-reflecting time-of-flight analyzer
GB2593056A (en) * 2014-10-23 2021-09-15 Leco Corp A multi-reflecting time-of-flight analyzer
CN107078019B (zh) * 2014-10-23 2019-05-03 莱克公司 多反射飞行时间分析仪
GB2547120B (en) * 2014-10-23 2021-07-07 Leco Corp A multi-reflecting time-of-flight analyzer
DE112014007095B4 (de) * 2014-10-23 2021-02-18 Leco Corporation Multireflektierender Flugzeitanalysator
US10741376B2 (en) 2015-04-30 2020-08-11 Micromass Uk Limited Multi-reflecting TOF mass spectrometer
GB2544647A (en) * 2015-11-10 2017-05-24 Micromass Ltd A method of transmitting ions through an aperture
DE102016121522B4 (de) 2015-11-10 2023-05-25 Micromass Uk Limited Verfahren zum Durchlassen von Ionen durch eine Apertur
GB2544647B (en) * 2015-11-10 2020-06-17 Micromass Ltd A method of transmitting ions through an aperture
US10629425B2 (en) 2015-11-16 2020-04-21 Micromass Uk Limited Imaging mass spectrometer
US10593533B2 (en) 2015-11-16 2020-03-17 Micromass Uk Limited Imaging mass spectrometer
US10636646B2 (en) 2015-11-23 2020-04-28 Micromass Uk Limited Ion mirror and ion-optical lens for imaging
GB2563743A (en) * 2015-11-23 2018-12-26 Micromass Ltd Improved ion mirror and ion-optical lens for imaging
WO2017091501A1 (en) * 2015-11-23 2017-06-01 Micromass Uk Limited Improved ion mirror and ion-optical lens for imaging
GB2563743B (en) * 2015-11-23 2023-03-08 Micromass Ltd Improved ion mirror and ion-optical lens for imaging
US10950425B2 (en) 2016-08-16 2021-03-16 Micromass Uk Limited Mass analyser having extended flight path
US11309175B2 (en) 2017-05-05 2022-04-19 Micromass Uk Limited Multi-reflecting time-of-flight mass spectrometers
US11328920B2 (en) 2017-05-26 2022-05-10 Micromass Uk Limited Time of flight mass analyser with spatial focussing
US11081332B2 (en) 2017-08-06 2021-08-03 Micromass Uk Limited Ion guide within pulsed converters
US11756782B2 (en) 2017-08-06 2023-09-12 Micromass Uk Limited Ion mirror for multi-reflecting mass spectrometers
US11239067B2 (en) 2017-08-06 2022-02-01 Micromass Uk Limited Ion mirror for multi-reflecting mass spectrometers
US11211238B2 (en) 2017-08-06 2021-12-28 Micromass Uk Limited Multi-pass mass spectrometer
US11817303B2 (en) 2017-08-06 2023-11-14 Micromass Uk Limited Accelerator for multi-pass mass spectrometers
US11295944B2 (en) 2017-08-06 2022-04-05 Micromass Uk Limited Printed circuit ion mirror with compensation
US11049712B2 (en) 2017-08-06 2021-06-29 Micromass Uk Limited Fields for multi-reflecting TOF MS
US11205568B2 (en) 2017-08-06 2021-12-21 Micromass Uk Limited Ion injection into multi-pass mass spectrometers
US11367608B2 (en) 2018-04-20 2022-06-21 Micromass Uk Limited Gridless ion mirrors with smooth fields
US11621156B2 (en) 2018-05-10 2023-04-04 Micromass Uk Limited Multi-reflecting time of flight mass analyser
US11342175B2 (en) 2018-05-10 2022-05-24 Micromass Uk Limited Multi-reflecting time of flight mass analyser
US11881387B2 (en) 2018-05-24 2024-01-23 Micromass Uk Limited TOF MS detection system with improved dynamic range
US11587779B2 (en) 2018-06-28 2023-02-21 Micromass Uk Limited Multi-pass mass spectrometer with high duty cycle
US11848185B2 (en) 2019-02-01 2023-12-19 Micromass Uk Limited Electrode assembly for mass spectrometer
US12205813B2 (en) 2019-03-20 2025-01-21 Micromass Uk Limited Multiplexed time of flight mass spectrometer

Also Published As

Publication number Publication date
US20130313424A1 (en) 2013-11-28
JP5525642B2 (ja) 2014-06-18
JP5282102B2 (ja) 2013-09-04
US9620350B2 (en) 2017-04-11
CA2710148A1 (en) 2009-07-02
JP2013175481A (ja) 2013-09-05
US8674293B2 (en) 2014-03-18
JP2013179083A (ja) 2013-09-09
EP2613339B1 (en) 2016-11-16
US9082605B2 (en) 2015-07-14
JP5553921B2 (ja) 2014-07-23
CA2710148C (en) 2017-02-28
EP2610893B1 (en) 2017-02-01
US9324553B2 (en) 2016-04-26
EP2610894A3 (en) 2013-07-17
EP2610893A2 (en) 2013-07-03
EP2610894A2 (en) 2013-07-03
JP2011507205A (ja) 2011-03-03
US20110017907A1 (en) 2011-01-27
US8395115B2 (en) 2013-03-12
JP5566503B2 (ja) 2014-08-06
EP2232525B1 (en) 2014-04-16
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US20150294849A1 (en) 2015-10-15
WO2009081143A2 (en) 2009-07-02
US20160233076A1 (en) 2016-08-11
EP2232525A2 (en) 2010-09-29
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