CA2707400A1 - Method for treating bone fracture with anti-sclerostin antibodies - Google Patents

Method for treating bone fracture with anti-sclerostin antibodies Download PDF

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Publication number
CA2707400A1
CA2707400A1 CA2707400A CA2707400A CA2707400A1 CA 2707400 A1 CA2707400 A1 CA 2707400A1 CA 2707400 A CA2707400 A CA 2707400A CA 2707400 A CA2707400 A CA 2707400A CA 2707400 A1 CA2707400 A1 CA 2707400A1
Authority
CA
Canada
Prior art keywords
seq
nos
cdr
cdr sequences
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2707400A
Other languages
English (en)
French (fr)
Inventor
Hua Zhu Ke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2707400A1 publication Critical patent/CA2707400A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2707400A 2007-12-14 2008-12-15 Method for treating bone fracture with anti-sclerostin antibodies Abandoned CA2707400A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1391707P 2007-12-14 2007-12-14
US61/013,917 2007-12-14
PCT/US2008/086864 WO2009079471A1 (en) 2007-12-14 2008-12-15 Method for treating bone fracture with anti-sclerostin antibodies

Publications (1)

Publication Number Publication Date
CA2707400A1 true CA2707400A1 (en) 2009-06-25

Family

ID=40394322

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2707400A Abandoned CA2707400A1 (en) 2007-12-14 2008-12-15 Method for treating bone fracture with anti-sclerostin antibodies

Country Status (11)

Country Link
US (1) US20110044978A1 (enExample)
EP (2) EP2628486A3 (enExample)
JP (1) JP2011506483A (enExample)
KR (1) KR20100101656A (enExample)
CN (1) CN101896201A (enExample)
AU (1) AU2008338464A1 (enExample)
BR (1) BRPI0819688A2 (enExample)
CA (1) CA2707400A1 (enExample)
EA (1) EA201070740A1 (enExample)
MX (1) MX2010006519A (enExample)
WO (1) WO2009079471A1 (enExample)

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ES2639020T3 (es) 1998-11-27 2017-10-25 Ucb Pharma S.A. Composiciones y métodos para incrementar la mineralización de la substancia ósea
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US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
AR068767A1 (es) 2007-10-12 2009-12-02 Novartis Ag Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
SMT202000095T1 (it) * 2010-05-14 2020-03-13 Amgen Inc Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
AU2011325134B2 (en) 2010-11-05 2014-10-23 Novartis Ag Methods of treating rheumatoid arthritis using IL-17 antagonists
JP2014509588A (ja) 2011-03-01 2014-04-21 アムジエン・インコーポレーテツド 二特異性結合剤
US9145457B2 (en) 2011-03-25 2015-09-29 Amgen Inc. Sclerostin antibody crystals and formulations thereof
US20140056912A1 (en) 2011-04-29 2014-02-27 Novartis Ag Methods of treating squamous cell carcinoma
ES2667554T3 (es) 2011-08-04 2018-05-11 Amgen Inc. Método para el tratamiento de los defectos de espacio óseo
GEP201606523B (en) * 2011-09-22 2016-08-10 Exelixis Inc Method for treating osteoporosis
KR20190120401A (ko) * 2011-12-28 2019-10-23 암젠 인크 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법
JP6770312B2 (ja) * 2012-07-05 2020-10-14 ユセベ ファルマ ソシエテ アノニム 骨疾患の治療
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
WO2014118705A1 (en) 2013-01-31 2014-08-07 Novartis Ag Methods of treating chronic kidney disease-mineral and bone disorder using sclerostin antagonists
WO2014155278A2 (en) 2013-03-26 2014-10-02 Novartis Ag Methods of treating autoimmune diseases using il-17 antagonists
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
WO2016145961A1 (zh) * 2015-03-13 2016-09-22 江苏恒瑞医药股份有限公司 抗硬骨素抗体、其抗原结合片段及其医药用途
CN105581795A (zh) * 2016-02-26 2016-05-18 金哲 一种利用磁共振成像监测骨折愈合及研究相关病理生理过程的骨折固定动物模型及其应用
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
US10961305B2 (en) 2016-12-21 2021-03-30 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
EP3774879B1 (en) 2018-03-30 2026-01-28 Amgen Inc. C-terminal antibody variants
CN110862969B (zh) * 2019-11-28 2021-08-24 扬州大学 分泌抗cfp-10抗体的杂交瘤细胞株、其抗体及其应用

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Also Published As

Publication number Publication date
KR20100101656A (ko) 2010-09-17
EA201070740A1 (ru) 2010-12-30
BRPI0819688A2 (pt) 2015-06-16
EP2227256A1 (en) 2010-09-15
CN101896201A (zh) 2010-11-24
EP2628486A3 (en) 2013-10-30
AU2008338464A1 (en) 2009-06-25
WO2009079471A1 (en) 2009-06-25
US20110044978A1 (en) 2011-02-24
MX2010006519A (es) 2010-10-15
EP2628486A2 (en) 2013-08-21
JP2011506483A (ja) 2011-03-03

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Effective date: 20141216