CA2703283C - Method for treating hematopoietic neoplasms - Google Patents
Method for treating hematopoietic neoplasms Download PDFInfo
- Publication number
- CA2703283C CA2703283C CA2703283A CA2703283A CA2703283C CA 2703283 C CA2703283 C CA 2703283C CA 2703283 A CA2703283 A CA 2703283A CA 2703283 A CA2703283 A CA 2703283A CA 2703283 C CA2703283 C CA 2703283C
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- Prior art keywords
- compound
- combretastatin
- cells
- chem
- cell
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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Landscapes
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- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
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| US60/989,786 | 2007-11-21 | ||
| PCT/US2008/084427 WO2009067706A1 (en) | 2007-11-21 | 2008-11-21 | Method for treating hematopoietic neoplasms |
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| CA2703283A1 CA2703283A1 (en) | 2009-05-28 |
| CA2703283C true CA2703283C (en) | 2016-01-12 |
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| EP (1) | EP2219451B1 (https=) |
| JP (1) | JP5302328B2 (https=) |
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| WO2012088438A1 (en) * | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
| CN104276960B (zh) * | 2014-09-26 | 2016-09-28 | 安徽省逸欣铭医药科技有限公司 | 盐酸他喷他多和塞来昔布共晶及其组合物和制备方法 |
| EP3337495A4 (en) * | 2015-08-18 | 2019-04-10 | Mateon Therapeutics, Inc. | USE OF VDA TO ENHANCE IMMUNOMODULATION THERAPIES AGAINST TUMORS |
| US11478445B2 (en) * | 2017-10-25 | 2022-10-25 | Bionomics Ltd. | Method for treating acute myeloid leukemia |
| WO2020150326A1 (en) * | 2019-01-15 | 2020-07-23 | Ptc Therapeutics, Inc. | Method for treating an acute myeloid leukemia |
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| US4996237A (en) | 1987-01-06 | 1991-02-26 | Arizona Board Of Regents | Combretastatin A-4 |
| US4940726A (en) | 1989-04-26 | 1990-07-10 | Arizona Board Of Regents | Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2 |
| GB9106177D0 (en) | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
| US5430062A (en) | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
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| TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
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| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| WO1999034788A1 (en) | 1998-01-09 | 1999-07-15 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Synthesis of phenstatin and prodrugs thereof |
| JP2002500227A (ja) | 1998-01-09 | 2002-01-08 | アリゾナ ボード オブ リーゼンツ | コンブレタスタチンａ−４プロドラッグとそのトランス異性体 |
| GB2334256A (en) | 1998-02-12 | 1999-08-18 | Univ Montfort | Hydroxylation activated prodrugs |
| AU3109199A (en) | 1998-03-25 | 1999-10-18 | Large Scale Biology Corporation | Benzoates derivatives for inhibiting angiogenesis |
| US6433012B1 (en) | 1998-03-25 | 2002-08-13 | Large Scale Biology Corp. | Method for inhibiting inflammatory disease |
| ES2267255T3 (es) | 1998-04-03 | 2007-03-01 | Ajinomoto Co., Inc. | Agentes antitumorales. |
| AU5227999A (en) | 1998-07-27 | 2000-02-21 | Abbott Laboratories | Substituted oxazolines as antiproliferative agents |
| AU2190700A (en) | 1998-12-17 | 2000-07-03 | Tularik Inc. | Tubulin-binding agents |
| GB9903403D0 (en) | 1999-02-16 | 1999-04-07 | Angiogene Pharm Ltd | Substituted stilbene compounds with vascular damaging activity |
| GB9903404D0 (en) | 1999-02-16 | 1999-04-07 | Angiogene Pharm Ltd | Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis |
| WO2000048606A1 (en) | 1999-02-18 | 2000-08-24 | Oxigene, Inc. | Compositions and methods for use in targeting vascular destruction |
| CO5170498A1 (es) | 1999-05-28 | 2002-06-27 | Abbott Lab | Biaril sulfonamidas son utiles como inhibidores de proliferacion celular |
| US6201001B1 (en) | 1999-08-02 | 2001-03-13 | Abbott Laboratories | Imidazole antiproliferative agents |
| GB9918912D0 (en) | 1999-08-12 | 1999-10-13 | Angiogene Pharm Ltd | New stilbenes with vascular damaging activity |
| US6849656B1 (en) | 1999-09-17 | 2005-02-01 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
| WO2001068654A2 (en) * | 2000-03-10 | 2001-09-20 | Baylor University | Tubulin binding ligands and corresponding prodrug constructs |
| GB0007401D0 (en) | 2000-03-27 | 2000-05-17 | Cancer Res Campaign Tech | Substituted chalcones as therapeeutic compounds |
| US6777578B2 (en) | 2000-04-27 | 2004-08-17 | Arizona Board Of Regents | Hydroxyphenstatin and the prodrugs thereof |
| US7078552B2 (en) * | 2000-04-27 | 2006-07-18 | Arizona Board Of Regents | Combretastatin A-1 phosphate and combretastatin B-1 phosphate prodrugs |
| DE60107234T2 (de) | 2000-05-09 | 2005-10-27 | Arizona Board of Regents, acting for and on behalf of Arizona State University, Tempe | Antitubulinanordnung und zellenwachstumshemmstoff "dioxostatin" |
| BR0110877A (pt) * | 2000-05-15 | 2003-03-11 | Celgene Corp | Métodos de tratamento de câncer primário, de aumento da dosagem de um inibidor de topoisomerase, de redução ou prevenção de um efeito adverso associado com quimioterapia e com terapia de radiação, de aumento da eficácia terapêutica de um inibidor de topoisomerase, e de proteção de um paciente canceroso dos efeitos adversos associados com a administração de uma droga anti-câncer, composição farmacêutica, forma de dosagem, e, kit para uso no tratamento de câncer |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| US6720323B2 (en) | 2000-07-07 | 2004-04-13 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| AU2001296215A1 (en) * | 2000-07-17 | 2002-01-30 | Oxi-Gene, Inc. | Efficient method of synthesizing combretastatin a-4 prodrugs |
| GB0019944D0 (en) | 2000-08-15 | 2000-09-27 | Angiogene Pharm Ltd | Compositions with vascular damaging activity |
| US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| AU2002216228A1 (en) | 2000-12-21 | 2002-07-01 | Cancer Research Ventures Limited | Substituted stilbenes, their reactions and anticancer activity |
| US7037906B1 (en) | 2000-12-22 | 2006-05-02 | Oxigene, Inc. | Methods for modulating tumor growth and metastasis |
| CA2432792C (en) * | 2000-12-22 | 2012-04-03 | Bristol-Myers Squibb Company | Methods for modulating tumor growth and metastasis |
| US20020183266A1 (en) * | 2001-03-15 | 2002-12-05 | Aventis Pharma, S.A. | Combination comprising combretastatin and anticancer agents |
| GB2377469B (en) | 2001-07-13 | 2005-07-06 | Prismo Ltd | Method and apparatus for laying a traffic calming surface |
| CA2463902A1 (en) | 2001-10-26 | 2003-05-01 | Oxigene, Inc. | Functionalized stilbene derivatives as improved vascular targeting agents |
| GB0126889D0 (en) | 2001-11-08 | 2002-01-02 | Paterson Inst For Cancer Res | Compounds and their uses |
| JP2005514450A (ja) | 2001-12-21 | 2005-05-19 | アリゾナ ボード オブ リーゼンツ | コンブレタスタチンａ−２プロドラッグの合成 |
| WO2003082271A2 (en) | 2002-04-03 | 2003-10-09 | Astrazeneca Ab | Indole derivatives having anti-angiogenetic activity |
| US7358236B1 (en) * | 2002-06-21 | 2008-04-15 | Oxigene, Inc. | Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents |
| US20040024696A1 (en) | 2002-08-02 | 2004-02-05 | Federico Alves | System for automatically transferring funds |
| TW549690U (en) | 2002-11-13 | 2003-08-21 | Tekcon Electronics Corp | Electrical card connector |
| CA2516078C (en) | 2003-02-28 | 2014-04-29 | Oxigene, Inc. | Catechol compositions and use thereof |
| ITRM20030355A1 (it) | 2003-07-18 | 2005-01-19 | Sigma Tau Ind Farmaceuti | Composti ad attivita' citotossica derivati della combretastatina. |
| EP1896391B1 (en) | 2005-06-14 | 2015-08-12 | Baylor University | Combretastatin analogs with tubulin binding activity |
| DK2219451T3 (en) | 2007-11-21 | 2015-01-12 | Oxigene Inc | A method for the treatment of hematopoietic neoplasms |
-
2008
- 2008-11-21 DK DK08851754.5T patent/DK2219451T3/en active
- 2008-11-21 CA CA2703283A patent/CA2703283C/en not_active Expired - Fee Related
- 2008-11-21 US US12/276,197 patent/US20090192098A1/en not_active Abandoned
- 2008-11-21 PL PL08851754T patent/PL2219451T3/pl unknown
- 2008-11-21 US US12/276,064 patent/US20090264382A1/en not_active Abandoned
- 2008-11-21 ES ES08851754.5T patent/ES2529434T3/es active Active
- 2008-11-21 PT PT88517545T patent/PT2219451E/pt unknown
- 2008-11-21 AU AU2008326251A patent/AU2008326251B2/en not_active Ceased
- 2008-11-21 SI SI200831365T patent/SI2219451T1/sl unknown
- 2008-11-21 WO PCT/US2008/084427 patent/WO2009067706A1/en not_active Ceased
- 2008-11-21 EP EP08851754.5A patent/EP2219451B1/en not_active Not-in-force
- 2008-11-21 JP JP2010535108A patent/JP5302328B2/ja not_active Expired - Fee Related
- 2008-11-21 HR HRP20150040AT patent/HRP20150040T1/hr unknown
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2011
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-
2015
- 2015-05-14 US US14/712,537 patent/US20150246064A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120270831A1 (en) | 2012-10-25 |
| US9040500B2 (en) | 2015-05-26 |
| JP5302328B2 (ja) | 2013-10-02 |
| EP2219451A4 (en) | 2011-01-19 |
| SI2219451T1 (sl) | 2015-02-27 |
| ES2529434T3 (es) | 2015-02-20 |
| US20150246064A1 (en) | 2015-09-03 |
| AU2008326251A1 (en) | 2009-05-28 |
| US20090192098A1 (en) | 2009-07-30 |
| WO2009067706A1 (en) | 2009-05-28 |
| DK2219451T3 (en) | 2015-01-12 |
| EP2219451B1 (en) | 2014-11-12 |
| US20090264382A1 (en) | 2009-10-22 |
| PT2219451E (pt) | 2015-02-09 |
| PL2219451T3 (pl) | 2015-04-30 |
| EP2219451A1 (en) | 2010-08-25 |
| JP2011504510A (ja) | 2011-02-10 |
| AU2008326251B2 (en) | 2014-03-06 |
| CA2703283A1 (en) | 2009-05-28 |
| HRP20150040T1 (hr) | 2015-02-27 |
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