AU2001296215A1 - Efficient method of synthesizing combretastatin a-4 prodrugs - Google Patents

Efficient method of synthesizing combretastatin a-4 prodrugs

Info

Publication number
AU2001296215A1
AU2001296215A1 AU2001296215A AU9621501A AU2001296215A1 AU 2001296215 A1 AU2001296215 A1 AU 2001296215A1 AU 2001296215 A AU2001296215 A AU 2001296215A AU 9621501 A AU9621501 A AU 9621501A AU 2001296215 A1 AU2001296215 A1 AU 2001296215A1
Authority
AU
Australia
Prior art keywords
prodrugs
efficient method
combretastatin
synthesizing
synthesizing combretastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001296215A
Inventor
Jonathan Gale
Reem Haider
John Hoare
Faye Seyedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxi Gene Inc
Original Assignee
Oxi Gene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxi Gene Inc filed Critical Oxi Gene Inc
Publication of AU2001296215A1 publication Critical patent/AU2001296215A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AU2001296215A 2000-07-17 2001-07-17 Efficient method of synthesizing combretastatin a-4 prodrugs Abandoned AU2001296215A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21876600P 2000-07-17 2000-07-17
US60/218,766 2000-07-17
PCT/US2001/022403 WO2002006279A1 (en) 2000-07-17 2001-07-17 Efficient method of synthesizing combretastatin a-4 prodrugs

Publications (1)

Publication Number Publication Date
AU2001296215A1 true AU2001296215A1 (en) 2002-01-30

Family

ID=22816425

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001296215A Abandoned AU2001296215A1 (en) 2000-07-17 2001-07-17 Efficient method of synthesizing combretastatin a-4 prodrugs

Country Status (3)

Country Link
US (1) US6743937B2 (en)
AU (1) AU2001296215A1 (en)
WO (1) WO2002006279A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576084B2 (en) * 2001-10-12 2009-08-18 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
WO2003059855A1 (en) 2001-12-21 2003-07-24 Arizona Board Of Regents Synthesis of combretastatin a-2 prodrugs
WO2003086414A1 (en) * 2002-04-10 2003-10-23 Arizona Board Of Regents Structural modification of resveratrol: sodium resverastatin phosphate
GB0306907D0 (en) * 2003-03-26 2003-04-30 Angiogene Pharm Ltd Boireductively-activated prodrugs
CN100343216C (en) * 2004-05-25 2007-10-17 浙江大德药业集团有限公司 Synthesis of Combretastatin A-4 supported by polymer
EP1792927B1 (en) 2004-09-22 2013-03-06 Nippon Kayaku Kabushiki Kaisha Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
CN1312161C (en) * 2005-04-30 2007-04-25 中国科学院广州化学研究所 3-hydroxy-4,3',4',5'-tetromethoxy bibenzyl phosphate and its composition, prepn and application
FR2895735B1 (en) 2005-12-30 2008-04-18 Ecopack France IMPROVED POCKET VALVE
WO2007111211A1 (en) 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
RU2447095C2 (en) 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся High-molecular weight conjugate of podophyllotoxins
WO2008010463A1 (en) 2006-07-19 2008-01-24 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of combretastatin
WO2008041610A1 (en) * 2006-10-03 2008-04-10 Nippon Kayaku Kabushiki Kaisha Compound of resorcinol derivative with polymer
JP5503872B2 (en) 2006-11-06 2014-05-28 日本化薬株式会社 Polymer derivatives of nucleic acid antimetabolites
WO2008056654A1 (en) 2006-11-08 2008-05-15 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
CN101808651B (en) 2007-09-28 2013-03-27 日本化药株式会社 Polymer conjugate of steroid
CA2703283C (en) 2007-11-21 2016-01-12 Oxigene, Inc. Method for treating hematopoietic neoplasms
CN101977631A (en) * 2008-03-18 2011-02-16 日本化药株式会社 Polymer conjugate of physiologically active substance
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
EP2431403B1 (en) 2009-05-15 2016-09-28 Nipponkayaku Kabushikikaisha Polymer conjugate of bioactive substance having hydroxy group
NZ597573A (en) * 2009-07-02 2013-10-25 Oxigene Inc Combretastatins for prevention of posterior capsule opacification
WO2011036674A1 (en) * 2009-09-24 2011-03-31 Inogent Laboratories Private Limited A new process for the preparation of olmesartan medoxomil
FR2953518B1 (en) * 2009-12-03 2012-01-20 Sanofi Aventis PROCESS FOR PREPARING A COMBRETASTATIN DERIVATIVE
WO2012067138A1 (en) 2010-11-17 2012-05-24 日本化薬株式会社 Novel polymer derivative of cytidine metabolism antagonist
RU2623426C2 (en) 2011-09-11 2017-06-26 Ниппон Каяку Кабусики Кайся Method of obtaining a block copolymer
CN103102254B (en) * 2013-02-06 2015-08-26 浙江新赛科药业有限公司 The synthetic method of a kind of Pterostilene
CN104892668B (en) * 2015-05-12 2017-03-29 上海大学 Prodrug and preparation method thereof before combretastatin analog water solublity
EP3337495A4 (en) 2015-08-18 2019-04-10 Mateon Therapeutics, Inc. Use of vdas to enhance immunomodulating therapies against tumors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670193A (en) * 1986-05-12 1987-06-02 E. R. Squibb & Sons, Inc. Process for preparing phosphonic acids
US4996237A (en) 1987-01-06 1991-02-26 Arizona Board Of Regents Combretastatin A-4
CA1338645C (en) 1987-01-06 1996-10-15 George R. Pettit Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins"
GB9106177D0 (en) 1991-03-22 1991-05-08 Aston Molecules Ltd Substituted diphenylethylenes and analogues or derivatives thereof
US5561122A (en) 1994-12-22 1996-10-01 Arizona Board Of Regents Acting On Behalf Of Arizona State University Combretastatin A-4 prodrug
WO1999035150A1 (en) 1998-01-09 1999-07-15 Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University Synthesis of combretastatin a-4 prodrugs and trans-isomers thereo f

Also Published As

Publication number Publication date
WO2002006279A1 (en) 2002-01-24
US6743937B2 (en) 2004-06-01
WO2002006279A8 (en) 2002-02-14
US20020119951A1 (en) 2002-08-29
WO2002006279A9 (en) 2003-04-03
WO2002006279A3 (en) 2002-04-18

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