CA2702243C - Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents - Google Patents

Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents Download PDF

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Publication number
CA2702243C
CA2702243C CA2702243A CA2702243A CA2702243C CA 2702243 C CA2702243 C CA 2702243C CA 2702243 A CA2702243 A CA 2702243A CA 2702243 A CA2702243 A CA 2702243A CA 2702243 C CA2702243 C CA 2702243C
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CA
Canada
Prior art keywords
dantrolene sodium
drugs
lyophilized
solution
dantrolene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2702243A
Other languages
English (en)
French (fr)
Other versions
CA2702243A1 (en
Inventor
Ahmad Malkawi
Abeer M. Al-Ghananeem
Patrick Deluca
George A. Digenis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US WORLDMEDS LLC
Original Assignee
US WORLDMEDS LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US WORLDMEDS LLC filed Critical US WORLDMEDS LLC
Publication of CA2702243A1 publication Critical patent/CA2702243A1/en
Application granted granted Critical
Publication of CA2702243C publication Critical patent/CA2702243C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2702243A 2007-10-09 2008-09-05 Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents Active CA2702243C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97862607P 2007-10-09 2007-10-09
US60/978,626 2007-10-09
PCT/US2008/075406 WO2009048698A1 (en) 2007-10-09 2008-09-05 Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents

Publications (2)

Publication Number Publication Date
CA2702243A1 CA2702243A1 (en) 2009-04-16
CA2702243C true CA2702243C (en) 2016-06-21

Family

ID=40316940

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2702243A Active CA2702243C (en) 2007-10-09 2008-09-05 Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents

Country Status (6)

Country Link
US (1) US8975284B2 (Direct)
EP (2) EP2219605B1 (Direct)
JP (1) JP5406197B2 (Direct)
CA (1) CA2702243C (Direct)
ES (1) ES2583804T3 (Direct)
WO (1) WO2009048698A1 (Direct)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080098614A1 (en) * 2006-10-03 2008-05-01 Wyeth Lyophilization methods and apparatuses
WO2009067175A2 (en) 2007-11-16 2009-05-28 Nektar Therapeutics Al, Corporation Oligomer-dantrolene conjugates and related compounds
US20120040970A1 (en) * 2009-04-27 2012-02-16 Al-Ghananeem Abeer M Intranasal delivery system for dantrolene
US20140072525A1 (en) * 2012-09-07 2014-03-13 Gaab, Llc Antimicrobial preparation and methods for making and using the same
US9725429B2 (en) 2013-03-15 2017-08-08 Rosalind Franklin University Of Medicine And Science Furanyl-imine and thiofuranyl-imine compounds for stabilizing ryanodine receptors from aberrant levels of calcium release
JP2016514685A (ja) * 2013-03-15 2016-05-23 ロザリンド フランクリン ユニバーシティー オブ メディスン アンド サイエンス 異常レベルのカルシウム放出からリアノジン受容体を安定化するための化合物
WO2015157212A1 (en) * 2014-04-10 2015-10-15 Us Worldmeds, Llc Stable apomorphine composition and uses thereof
PL3364947T3 (pl) * 2015-10-20 2022-02-07 B. Braun Melsungen Ag Wodna kompozycja zawierająca dantrolen
CA3067457A1 (en) * 2017-06-20 2018-12-27 Tarveda Therapeutics, Inc. Targeted therapeutics
SG11202003452XA (en) 2017-10-20 2020-05-28 Eagle Res Labs Limited Dantrolene prodrugs and methods of their use
WO2019175761A1 (en) * 2018-03-12 2019-09-19 Orbicular Pharmaceutical Technologies Private Limited Ready to use dantrolene compositions
TW202011940A (zh) * 2018-04-05 2020-04-01 美商塔維達治療公司 具有降低量的三級丁醇之藥學組成物
JPWO2020049670A1 (ja) * 2018-09-06 2021-08-12 シミックホールディングス株式会社 ダントロレン水性製剤及びその調製方法
WO2020112932A1 (en) * 2018-11-27 2020-06-04 Eagle Pharmaceuticals, Inc. Use of dantrolene and dantrolene prodrugs to treat radiation exposure
WO2022169582A1 (en) * 2021-02-05 2022-08-11 Uswm, Llc Compositions and methods for clear concentrated parenteral delivery of dantrolene therapeutic agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3415821A (en) * 1965-09-07 1968-12-10 Norwich Pharma Co 1-(5-substituted)furfurylideneamino hydantoins and imidazolidinones
US4543359A (en) 1982-10-01 1985-09-24 Eaton Laboratories, Inc. Treating cardiac arrhythmias with dantrolene sodium
US5145769A (en) 1987-08-21 1992-09-08 Cryolife Inc. Method for cryopreserving blood vessels
US5149621A (en) * 1987-08-21 1992-09-22 Cryolife, Inc. & Medical Univ. Of South Carolina Kit for cryopreserving blood vessels
US5158867A (en) 1987-08-21 1992-10-27 Cryolife Inc. Method for cryopreserving blood vessels
JPH01128923A (ja) * 1987-11-11 1989-05-22 Mikasa Seiyaku Kk 骨格筋弛緩外用剤
US5506231A (en) 1989-03-31 1996-04-09 The Children's Medical Center Corporation Treatment of aids dementia, myelopathy and blindness
WO1994005287A1 (en) * 1992-09-09 1994-03-17 Washington University Prevention or treatment of sepsis with dantrolene or azumolene
JPH06263636A (ja) * 1993-03-12 1994-09-20 Kiyoshi Kataoka 脳または高次神経疾患治療剤
DE69528165T2 (de) 1994-04-21 2003-05-15 Hisamitsu Pharmaceutical Co., Inc. Transdermal verabreichbare grundlage und daraus hergestelltes transdermal verabreichbares arzneimittel
US5597809A (en) * 1994-06-23 1997-01-28 Massachusetts Eye & Ear Infirmary Treatment of optic neuritis
US7758890B2 (en) * 2001-06-23 2010-07-20 Lyotropic Therapeutics, Inc. Treatment using dantrolene
EP1435781A4 (en) * 2001-06-23 2007-06-20 Lyotropic Therapeutics Llc SOLVENT SYSTEM
SI1603513T1 (sl) * 2003-03-04 2021-04-30 Lyotropic Therapeutics, Inc. Sestavki dantrolena
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
AR072777A1 (es) * 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina

Also Published As

Publication number Publication date
JP5406197B2 (ja) 2014-02-05
WO2009048698A9 (en) 2009-11-19
JP2011500570A (ja) 2011-01-06
WO2009048698A1 (en) 2009-04-16
ES2583804T3 (es) 2016-09-22
EP2219605B1 (en) 2015-08-19
CA2702243A1 (en) 2009-04-16
EP2219605A1 (en) 2010-08-25
US8975284B2 (en) 2015-03-10
EP2583670A1 (en) 2013-04-24
US20090093531A1 (en) 2009-04-09
WO2009048698A4 (en) 2013-05-30
US20110015243A2 (en) 2011-01-20

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Effective date: 20130726

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Effective date: 20250305