CA2698463A1 - Therapeutic kinase modulators - Google Patents

Therapeutic kinase modulators Download PDF

Info

Publication number
CA2698463A1
CA2698463A1 CA2698463A CA2698463A CA2698463A1 CA 2698463 A1 CA2698463 A1 CA 2698463A1 CA 2698463 A CA2698463 A CA 2698463A CA 2698463 A CA2698463 A CA 2698463A CA 2698463 A1 CA2698463 A1 CA 2698463A1
Authority
CA
Canada
Prior art keywords
compound
protein
protein kinase
optionally substituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2698463A
Other languages
English (en)
French (fr)
Inventor
Fabrice Pierre
Mustapha Haddach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cylene Pharmaceuticals Inc
Original Assignee
Cylene Pharmaceuticals, Inc.
Fabrice Pierre
Mustapha Haddach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cylene Pharmaceuticals, Inc., Fabrice Pierre, Mustapha Haddach filed Critical Cylene Pharmaceuticals, Inc.
Publication of CA2698463A1 publication Critical patent/CA2698463A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
CA2698463A 2007-08-31 2008-08-29 Therapeutic kinase modulators Abandoned CA2698463A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96955607P 2007-08-31 2007-08-31
US60/969,556 2007-08-31
PCT/US2008/074820 WO2009097014A2 (en) 2007-08-31 2008-08-29 Therapeutic kinase modulators

Publications (1)

Publication Number Publication Date
CA2698463A1 true CA2698463A1 (en) 2009-08-06

Family

ID=40523789

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2698463A Abandoned CA2698463A1 (en) 2007-08-31 2008-08-29 Therapeutic kinase modulators

Country Status (3)

Country Link
US (1) US7910600B2 (US07910600-20110322-C00062.png)
CA (1) CA2698463A1 (US07910600-20110322-C00062.png)
WO (1) WO2009097014A2 (US07910600-20110322-C00062.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010135571A1 (en) * 2009-05-20 2010-11-25 Cylene Pharmaceuticals, Inc. Novel protein kinase modulators
CN102703456B (zh) * 2012-05-15 2014-04-02 武汉生命之美科技有限公司 DAPK3基因hsa-miR-20a的作用靶位点
CA2925698C (en) 2013-11-28 2021-11-09 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
CN107056819B (zh) * 2017-04-17 2019-08-23 牡丹江医学院 一种预防和治疗心肌缺血的药物及其制备方法
CN111447931B (zh) * 2017-07-31 2024-01-26 加利福尼亚大学董事会 抗癌/抗纤维化化合物
WO2019126730A1 (en) 2017-12-22 2019-06-27 Petra Pharma Corporation Chromenopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
US11071727B2 (en) 2018-01-26 2021-07-27 Northwestern University Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors
TW202112784A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物
CN114957252B (zh) * 2022-07-14 2023-09-05 苏州施安鼎泰生物医药技术有限公司 一种化合物及其制备方法以及药物组合物和在制备eed抑制剂中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL171985C (nl) * 1976-02-10 1983-06-16 Rhone Poulenc Ind Werkwijze voor het bereiden van preparaten met werking tegen schistosomiasis, de aldus verkregen gevormde preparaten en werkwijze voor het bereiden van 1,2-dithioolverbindingen.
JPH09506250A (ja) * 1993-11-23 1997-06-24 ジェネンテク，インコーポレイテッド Ｒｓｅと命名される蛋白チロシンキナーゼ
US5624677A (en) * 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
US6608048B2 (en) * 2000-03-28 2003-08-19 Wyeth Holdings Tricyclic protein kinase inhibitors
CA2330350A1 (en) * 2000-12-05 2002-06-05 Chemokine Therapeutics Corporation Therapeutics for chemokine mediated diseases
US6772081B1 (en) * 2002-05-21 2004-08-03 Data Recognition Corporation Priority system and method for processing standardized tests
US20040126784A1 (en) * 2002-07-12 2004-07-01 Rigel Pharmaceuticals, Incorporated Modulators of cellular proliferation
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
EP1802306A2 (en) * 2004-09-17 2007-07-04 Cylene Pharmaceuticals, Inc. Quinolone analog as cell proliferation inhibitors

Also Published As

Publication number Publication date
WO2009097014A3 (en) 2009-12-30
WO2009097014A2 (en) 2009-08-06
US7910600B2 (en) 2011-03-22
US20090093465A1 (en) 2009-04-09

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140829