CA2693063A1 - Glycosaminoglycan-antagonising mcp-1 mutants and methods of using same - Google Patents

Glycosaminoglycan-antagonising mcp-1 mutants and methods of using same Download PDF

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Publication number
CA2693063A1
CA2693063A1 CA 2693063 CA2693063A CA2693063A1 CA 2693063 A1 CA2693063 A1 CA 2693063A1 CA 2693063 CA2693063 CA 2693063 CA 2693063 A CA2693063 A CA 2693063A CA 2693063 A1 CA2693063 A1 CA 2693063A1
Authority
CA
Canada
Prior art keywords
mcp
amino acids
mutant protein
protein
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2693063
Other languages
English (en)
French (fr)
Inventor
Andreas Kungl
Anna Maria Piccinini
Christian Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protaffin Biotechnologie AG
Original Assignee
Protaffin Biotechnologie Ag
Andreas Kungl
Anna Maria Piccinini
Christian Weber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protaffin Biotechnologie Ag, Andreas Kungl, Anna Maria Piccinini, Christian Weber filed Critical Protaffin Biotechnologie Ag
Publication of CA2693063A1 publication Critical patent/CA2693063A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
CA 2693063 2007-07-31 2008-07-31 Glycosaminoglycan-antagonising mcp-1 mutants and methods of using same Abandoned CA2693063A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95314007P 2007-07-31 2007-07-31
US60/953,140 2007-07-31
EP07450166.9 2007-09-27
EP07450166A EP2042516A1 (en) 2007-09-27 2007-09-27 Glycosaminoglycan-antagonising MCP-1 mutants and methods of using same
PCT/EP2008/006298 WO2009015884A1 (en) 2007-07-31 2008-07-31 Glycosaminoglycan-antagonising mcp-1 mutants and methods of using same

Publications (1)

Publication Number Publication Date
CA2693063A1 true CA2693063A1 (en) 2009-02-05

Family

ID=38720368

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2693063 Abandoned CA2693063A1 (en) 2007-07-31 2008-07-31 Glycosaminoglycan-antagonising mcp-1 mutants and methods of using same

Country Status (12)

Country Link
US (2) US8337825B2 (ko)
EP (2) EP2042516A1 (ko)
JP (1) JP2010534484A (ko)
KR (1) KR20100049548A (ko)
CN (1) CN101790537A (ko)
AU (1) AU2008282088B2 (ko)
BR (1) BRPI0815043A2 (ko)
CA (1) CA2693063A1 (ko)
EA (1) EA017113B1 (ko)
MX (1) MX2010001111A (ko)
NZ (1) NZ582877A (ko)
WO (1) WO2009015884A1 (ko)

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EA020548B1 (ru) 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
US20120046218A1 (en) * 2009-01-30 2012-02-23 Protaffin Biotechnologie Ag Glycosaminoglycan-antagonising mcp-i mutants and methods of using same
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Also Published As

Publication number Publication date
US8337825B2 (en) 2012-12-25
KR20100049548A (ko) 2010-05-12
US20130150303A1 (en) 2013-06-13
BRPI0815043A2 (pt) 2017-05-23
AU2008282088B2 (en) 2013-10-10
NZ582877A (en) 2012-05-25
JP2010534484A (ja) 2010-11-11
MX2010001111A (es) 2010-03-03
EA017113B1 (ru) 2012-09-28
WO2009015884A1 (en) 2009-02-05
EA201000265A1 (ru) 2010-06-30
CN101790537A (zh) 2010-07-28
EP2042516A1 (en) 2009-04-01
EP2188307A1 (en) 2010-05-26
US20100197583A1 (en) 2010-08-05
AU2008282088A1 (en) 2009-02-05

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Effective date: 20130703

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Effective date: 20150731