CA2692317C - Atmospheric pressure ion source performance enhancement - Google Patents

Atmospheric pressure ion source performance enhancement Download PDF

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Publication number
CA2692317C
CA2692317C CA2692317A CA2692317A CA2692317C CA 2692317 C CA2692317 C CA 2692317C CA 2692317 A CA2692317 A CA 2692317A CA 2692317 A CA2692317 A CA 2692317A CA 2692317 C CA2692317 C CA 2692317C
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CA
Canada
Prior art keywords
solution
electrospray
ionization
source
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2692317A
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English (en)
French (fr)
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CA2692317A1 (en
Inventor
Craig M. Whitehouse
Thomas P. White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PerkinElmer US LLC
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PerkinElmer Health Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by PerkinElmer Health Sciences Inc filed Critical PerkinElmer Health Sciences Inc
Publication of CA2692317A1 publication Critical patent/CA2692317A1/en
Application granted granted Critical
Publication of CA2692317C publication Critical patent/CA2692317C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2692317A 2007-06-01 2008-06-02 Atmospheric pressure ion source performance enhancement Active CA2692317C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93264407P 2007-06-01 2007-06-01
US60/932,644 2007-06-01
PCT/US2008/065513 WO2008151121A1 (en) 2007-06-01 2008-06-02 Atmospheric pressure ion source performance enhancement

Publications (2)

Publication Number Publication Date
CA2692317A1 CA2692317A1 (en) 2008-12-11
CA2692317C true CA2692317C (en) 2017-03-28

Family

ID=40094160

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2692317A Active CA2692317C (en) 2007-06-01 2008-06-02 Atmospheric pressure ion source performance enhancement

Country Status (6)

Country Link
US (2) US7800057B2 (https=)
EP (1) EP2153455B1 (https=)
JP (1) JP5613557B2 (https=)
CN (1) CN101809706B (https=)
CA (1) CA2692317C (https=)
WO (1) WO2008151121A1 (https=)

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* Cited by examiner, † Cited by third party
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US7872225B2 (en) * 2006-08-25 2011-01-18 Perkinelmer Health Sciences, Inc. Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry
USRE44887E1 (en) 2005-05-19 2014-05-13 Perkinelmer Health Sciences, Inc. Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry
EP2153455B1 (en) * 2007-06-01 2020-04-29 PerkinElmer Health Sciences, Inc. Atmospheric pressure ion source performance enhancement
US7919746B2 (en) * 2007-10-16 2011-04-05 Perkinelmer Health Sciences, Inc. Atmospheric pressure ion source performance enhancement
US8217342B2 (en) * 2009-01-14 2012-07-10 Sociedad Europea de Analisis Diferencial de Movilidad Ionizer for vapor analysis decoupling the ionization region from the analyzer
US8063362B1 (en) * 2009-07-09 2011-11-22 The United States Of America As Represented By The Secretary Of The Air Force Ionic liquid membrane for air-to-vacuum sealing and ion transport
CN102221576B (zh) * 2010-04-15 2015-09-16 岛津分析技术研发（上海）有限公司 一种产生、分析离子的方法与装置
IL213522A (en) 2011-06-13 2016-07-31 Kramer Electronics Ltd Install a reversible electric cable extension
CN102568998B (zh) * 2011-12-22 2015-02-18 清华大学 一种非接触式交流电喷雾离子化装置及方法
US10481164B2 (en) * 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
TWI488216B (zh) * 2013-04-18 2015-06-11 國立中山大學 多游離源的質譜游離裝置及質譜分析系統
CN103258711B (zh) * 2013-05-21 2015-07-08 中国科学院上海有机化学研究所 一种溶剂辅助电喷雾离子化装置及使用该装置实现电喷雾离子化的方法
TWI633100B (zh) * 2013-07-19 2018-08-21 半導體能源研究所股份有限公司 有機化合物、發光元件、顯示器模組、照明模組、發光裝置、顯示裝置、照明設備及電子裝置
CN103545166B (zh) * 2013-11-04 2016-01-27 清华大学深圳研究生院 便携式电喷雾离子源装置及质谱仪
MX365638B (es) * 2013-11-15 2019-06-10 Smiths Detection Montreal Inc Fuente de ion de ionizacion de superficie apci concéntrica, guía de ion, y método de uso.
DE112015002780B4 (de) 2014-06-12 2024-05-16 Micromass Uk Limited Sekundäre Elektrospray-Ionisation bei verringertem Druck
GB201410472D0 (en) * 2014-06-12 2014-07-30 Micromass Ltd Secondary electrospray ionization at reduced pressure
CN105632870B (zh) * 2014-10-28 2017-09-15 中国科学院大连化学物理研究所 一种用于质谱的大气压化学电离源
CN104616963B (zh) * 2015-01-30 2017-03-22 昆山禾信质谱技术有限公司 一种等离子体喷雾质谱电离源
EP3391405B1 (en) * 2015-12-18 2021-04-07 DH Technologies Development Pte. Ltd. System for minimizing electrical discharge during esi operation
WO2017154153A1 (ja) * 2016-03-09 2017-09-14 株式会社島津製作所 質量分析装置及び該装置を用いた生体試料の分析方法
EP3550586A1 (en) * 2016-11-29 2019-10-09 Shimadzu Corporation Ionizer and mass spectrometer

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Publication number Priority date Publication date Assignee Title
EP0655769A1 (en) 1993-11-17 1995-05-31 Hewlett-Packard Company Method and apparatus for preparing an electrospray ion source sample
DE4415480C2 (de) 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI)
US6504149B2 (en) 1998-08-05 2003-01-07 National Research Council Canada Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer
EP1876442A3 (en) 1998-09-17 2008-03-05 Advion BioSciences, Inc. Integrated monolithic microfabricated liquid chromatography system and method
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FI19992070A7 (fi) 1999-09-28 2001-03-29 Carbion Oy Uudet fukosyloidut oligosakkaridit ja menetelmä niiden valmistamiseksi
JP2003520962A (ja) 2000-01-18 2003-07-08 アドビオン バイオサイエンシーズ インコーポレーティッド 分離媒体、複式電気噴霧ノズルシステム、および方法
US6396057B1 (en) 2000-04-18 2002-05-28 Waters Investments Limited Electrospray and other LC/MS interfaces
WO2002066952A2 (en) 2000-10-19 2002-08-29 Target Discovery, Inc Mass defect labeling for the determination of oligomer sequences
US20060079002A1 (en) * 2002-06-07 2006-04-13 Bogdan Gologan System and method for landing of ions on a gas/liquid interface
US7041516B2 (en) * 2002-10-10 2006-05-09 Lsi Logic Corporation Multi chip module assembly
US7544932B2 (en) * 2002-10-21 2009-06-09 The United States Of America, As Represented By The Secretary, Of The Department Of Health And Human Services Contiguous capillary electrospray sources and analytical devices
US7232992B2 (en) * 2004-05-21 2007-06-19 Analytica Of Branford, Inc. Charged droplet sprayers
JP4773150B2 (ja) 2004-07-12 2011-09-14 住友化学株式会社 Ｅｓｉ用カチオン化剤及びそれを用いるｓｅｃ／ｅｓｉｍｓ測定方法
SE0402966D0 (sv) 2004-12-06 2004-12-06 Capture Device Ab A device, methods and interfaces for single and multidimensional separations for characterization and/or identification of molecules by mass spectrometry
US7385192B2 (en) * 2005-02-10 2008-06-10 Bruker Daltonik, Gmbh Laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis
US20060255261A1 (en) * 2005-04-04 2006-11-16 Craig Whitehouse Atmospheric pressure ion source for mass spectrometry
US7872225B2 (en) * 2006-08-25 2011-01-18 Perkinelmer Health Sciences, Inc. Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry
EP2153455B1 (en) 2007-06-01 2020-04-29 PerkinElmer Health Sciences, Inc. Atmospheric pressure ion source performance enhancement
US7919746B2 (en) * 2007-10-16 2011-04-05 Perkinelmer Health Sciences, Inc. Atmospheric pressure ion source performance enhancement

Also Published As

Publication number Publication date
JP2010529435A (ja) 2010-08-26
WO2008151121A1 (en) 2008-12-11
EP2153455A1 (en) 2010-02-17
JP5613557B2 (ja) 2014-10-22
AU2008259894A1 (en) 2008-12-11
CA2692317A1 (en) 2008-12-11
CN101809706A (zh) 2010-08-18
US20090008547A1 (en) 2009-01-08
US20110006198A1 (en) 2011-01-13
US8525105B2 (en) 2013-09-03
US7800057B2 (en) 2010-09-21
EP2153455A4 (en) 2012-12-05
CN101809706B (zh) 2015-12-09
EP2153455B1 (en) 2020-04-29

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