CA2686033A1 - Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof - Google Patents

Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof Download PDF

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Publication number
CA2686033A1
CA2686033A1 CA002686033A CA2686033A CA2686033A1 CA 2686033 A1 CA2686033 A1 CA 2686033A1 CA 002686033 A CA002686033 A CA 002686033A CA 2686033 A CA2686033 A CA 2686033A CA 2686033 A1 CA2686033 A1 CA 2686033A1
Authority
CA
Canada
Prior art keywords
methylpyrrolidine
methyl
tartrate
pyrrolidin
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002686033A
Other languages
English (en)
French (fr)
Inventor
Michael Christie
Joseph J. Petraitis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2686033A1 publication Critical patent/CA2686033A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Cosmetics (AREA)
CA002686033A 2007-05-03 2008-05-02 Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof Abandoned CA2686033A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92735607P 2007-05-03 2007-05-03
US60/927,356 2007-05-03
PCT/US2008/005702 WO2008137087A1 (en) 2007-05-03 2008-05-02 Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof

Publications (1)

Publication Number Publication Date
CA2686033A1 true CA2686033A1 (en) 2008-11-13

Family

ID=39688886

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002686033A Abandoned CA2686033A1 (en) 2007-05-03 2008-05-02 Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof

Country Status (14)

Country Link
EP (1) EP2152669A1 (esLanguage)
JP (1) JP5698887B2 (esLanguage)
KR (1) KR20100017565A (esLanguage)
CN (1) CN101679237A (esLanguage)
AU (1) AU2008248168B2 (esLanguage)
BR (1) BRPI0810330A2 (esLanguage)
CA (1) CA2686033A1 (esLanguage)
EA (1) EA019031B1 (esLanguage)
IL (1) IL201627A (esLanguage)
MX (1) MX2009011787A (esLanguage)
NZ (1) NZ580948A (esLanguage)
UA (1) UA99913C2 (esLanguage)
WO (1) WO2008137087A1 (esLanguage)
ZA (1) ZA200907643B (esLanguage)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY148634A (en) 2006-07-25 2013-05-15 Cephalon Inc Pyridazinone derivatives
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
JP5539230B2 (ja) * 2008-01-30 2014-07-02 セファロン、インク． ヒスタミンｈ３アンタゴニスト活性を有する置換ピリダジン誘導体
EP3237408B1 (en) * 2014-12-23 2018-10-31 Cephalon, Inc. Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives
BR112021003061A2 (pt) * 2018-09-07 2021-05-11 Sanofi processo para a preparação do 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metila

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329974A1 (de) 1983-08-19 1985-02-28 Bayer Ag, 5090 Leverkusen Herstellung von hydrierten nitrilkautschuken
DE3433392A1 (de) 1984-09-12 1986-03-20 Bayer Ag, 5090 Leverkusen Hydrierung nitrilgruppenhaltiger ungesaettigter polymerer
FR2714849B1 (fr) 1994-01-13 1996-04-05 Inst Francais Du Petrole Procédé de préparation d'un catalyseur d'hydrogénation soluble en phase liquide organique.
DE4403479A1 (de) 1994-02-04 1995-08-10 Basf Ag Verfahren zur Herstellung von Hydroxylammoniumsalzen
WO2004024707A2 (en) * 2002-09-16 2004-03-25 Abbott Laboratories Process for preparing amine type substituted benzofurans
US7153889B2 (en) 2002-11-12 2006-12-26 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
WO2005085307A1 (ja) 2004-03-08 2005-09-15 Japan Science And Technology Agency 高分子担持金属クラスター組成物
US7145005B2 (en) 2004-05-12 2006-12-05 Abbott Laboratories 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation
BRPI0511778A (pt) 2004-06-02 2008-01-15 Hoffmann La Roche derivados da naftalina úteis como ligantes do receptor 3 da histamina
WO2006059778A1 (ja) 2004-12-01 2006-06-08 Banyu Pharmaceutical Co., Ltd. 置換ピリドン誘導体
CA2592353A1 (en) 2004-12-17 2006-06-22 Janssen Pharmaceutica, N.V. Tetrahydroisoquinoline compounds for treatment of cns disorders
CN101107231A (zh) 2005-01-21 2008-01-16 先灵公司 用作组胺h3拮抗剂的咪唑和苯并咪唑衍生物
WO2006103045A1 (en) 2005-03-31 2006-10-05 Ucb Pharma S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
GB0514812D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
CN101296902A (zh) 2005-10-27 2008-10-29 Ucb医药有限公司 包含内酰胺或内酰胺衍生部分的化合物、制备它们的方法和它们的用途
EP1988777B1 (en) 2006-02-09 2011-09-21 Athersys, Inc. Pyrazoles for the treatment of obesity and other cns disorders
WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
US20090163482A1 (en) 2006-03-13 2009-06-25 Mchardy Stanton Furst Tetralines antagonists of the h-3 receptor
WO2008005338A1 (en) 2006-06-29 2008-01-10 Arena Pharmaceuticals, Inc. Modulators of the histamine h3-receptor useful for the treatment of disorders related thereto
MY148634A (en) 2006-07-25 2013-05-15 Cephalon Inc Pyridazinone derivatives

Also Published As

Publication number Publication date
MX2009011787A (es) 2009-11-13
WO2008137087A1 (en) 2008-11-13
JP5698887B2 (ja) 2015-04-08
ZA200907643B (en) 2014-03-26
EA200971019A1 (ru) 2010-04-30
CN101679237A (zh) 2010-03-24
EA019031B1 (ru) 2013-12-30
IL201627A0 (en) 2010-05-31
IL201627A (en) 2014-06-30
BRPI0810330A2 (pt) 2014-10-14
KR20100017565A (ko) 2010-02-16
UA99913C2 (ru) 2012-10-25
NZ580948A (en) 2011-04-29
JP2010526142A (ja) 2010-07-29
EP2152669A1 (en) 2010-02-17
AU2008248168B2 (en) 2013-03-21
AU2008248168A1 (en) 2008-11-13

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130319

FZDE Discontinued

Effective date: 20160504