CA2684220A1 - Systeme de radiosynthese microfluidique pour biomarqueurs de tomographie par emission de positrons - Google Patents

Systeme de radiosynthese microfluidique pour biomarqueurs de tomographie par emission de positrons Download PDF

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Publication number
CA2684220A1
CA2684220A1 CA002684220A CA2684220A CA2684220A1 CA 2684220 A1 CA2684220 A1 CA 2684220A1 CA 002684220 A CA002684220 A CA 002684220A CA 2684220 A CA2684220 A CA 2684220A CA 2684220 A1 CA2684220 A1 CA 2684220A1
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CA
Canada
Prior art keywords
chip
reaction chamber
reactor
reagents
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002684220A
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English (en)
Inventor
Arkadij M. Elizarov
Carroll Edward Ball
Jianzhong Zhang
Hartmuth Kolb
R. Michael Van Dam
Lawrence Diener
Sean Ford
Reza Miraghaie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Medical Solutions USA Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/895,636 external-priority patent/US7741121B2/en
Application filed by Individual filed Critical Individual
Publication of CA2684220A1 publication Critical patent/CA2684220A1/fr
Abandoned legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B81MICROSTRUCTURAL TECHNOLOGY
    • B81BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00Devices without movable or flexible elements, e.g. microcapillary devices
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00783Laminate assemblies, i.e. the reactor comprising a stack of plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00824Ceramic
    • B01J2219/00826Quartz
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00831Glass
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00833Plastic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00858Aspects relating to the size of the reactor
    • B01J2219/0086Dimensions of the flow channels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00873Heat exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00891Feeding or evacuation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00905Separation
    • B01J2219/00907Separation using membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00905Separation
    • B01J2219/00909Separation using filters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00952Sensing operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00952Sensing operations
    • B01J2219/00954Measured properties
    • B01J2219/00959Flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00952Sensing operations
    • B01J2219/00954Measured properties
    • B01J2219/00961Temperature
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00952Sensing operations
    • B01J2219/00954Measured properties
    • B01J2219/00963Pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00986Microprocessor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0099Cleaning

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Saccharide Compounds (AREA)
CA002684220A 2007-04-12 2008-04-14 Systeme de radiosynthese microfluidique pour biomarqueurs de tomographie par emission de positrons Abandoned CA2684220A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US92308607P 2007-04-12 2007-04-12
US60/923,086 2007-04-12
US92340707P 2007-04-13 2007-04-13
US60/923,407 2007-04-13
US11/895,636 2007-08-23
US11/895,636 US7741121B2 (en) 2006-08-24 2007-08-23 System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices
US1082208P 2008-01-11 2008-01-11
US61/010,822 2008-01-11
PCT/US2008/060267 WO2008128201A1 (fr) 2007-04-12 2008-04-14 Système de radiosynthèse microfluidique pour biomarqueurs de tomographie par émission de positrons

Publications (1)

Publication Number Publication Date
CA2684220A1 true CA2684220A1 (fr) 2008-10-23

Family

ID=39589259

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002684220A Abandoned CA2684220A1 (fr) 2007-04-12 2008-04-14 Systeme de radiosynthese microfluidique pour biomarqueurs de tomographie par emission de positrons

Country Status (6)

Country Link
EP (1) EP2134461A1 (fr)
JP (1) JP2010531295A (fr)
KR (1) KR101176710B1 (fr)
CN (1) CN102083525A (fr)
CA (1) CA2684220A1 (fr)
WO (1) WO2008128201A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7741121B2 (en) 2006-08-24 2010-06-22 Siemens Medical Solutions Usa, Inc. System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices
JP5309312B2 (ja) 2007-11-01 2013-10-09 Jfeテクノス株式会社 マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法
US20100093098A1 (en) * 2008-10-14 2010-04-15 Siemens Medical Solutions Nonflow-through appratus and mehod using enhanced flow mechanisms
US8110148B2 (en) 2008-11-06 2012-02-07 Siemens Medical Solutions Usa, Inc. Apparatus and method using rotary flow distribution mechanisms
JP5438351B2 (ja) * 2009-03-30 2014-03-12 Jfeテクノス株式会社 マイクロチップを用いたpet用標識化合物の調剤方法及び装置
JP5431764B2 (ja) * 2009-03-30 2014-03-05 Jfeテクノス株式会社 マイクロチップを用いたフッ素f−18標識化合物の製造方法及び装置
US8273300B2 (en) 2009-07-09 2012-09-25 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
US8435454B2 (en) 2009-07-09 2013-05-07 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
US20110202177A1 (en) * 2010-02-15 2011-08-18 Siemens Medical Solutions Usa, Inc. Intuitive Graphical User Interface for Carrying Out Chemical Reactions
KR101347747B1 (ko) * 2011-05-13 2014-01-06 성균관대학교산학협력단 열 용융 밸브를 포함하는 방사성 화합물 합성장치
WO2012157920A2 (fr) * 2011-05-13 2012-11-22 성균관대학교 산학협력단 Système de synthèse de composés radioactifs comprenant une unité de régulation de température
KR101288866B1 (ko) * 2011-05-13 2013-07-23 성균관대학교산학협력단 방사성 화합물 합성을 위한 원격제어시스템
KR101293158B1 (ko) * 2011-05-13 2013-08-12 성균관대학교산학협력단 방사성 화합물 합성모듈
KR101288867B1 (ko) * 2011-05-13 2013-07-23 성균관대학교산학협력단 온도조절유닛을 포함하는 방사성 화합물 합성 시스템
US20130004414A1 (en) * 2011-06-30 2013-01-03 General Electric Company Devices and methods for reducing radiolysis of radioisotopes
EP2562150B1 (fr) 2011-08-26 2014-10-15 FutureChemistry Holding B.V. Procédé et dispositif pour la production de radiomarqueurs pour animaux domestiques
CN104011802B (zh) * 2011-09-30 2016-09-07 通用电气健康护理有限公司 合成器诊断盒模拟器
ITTO20120996A1 (it) * 2012-11-16 2014-05-17 Consiglio Nazionale Ricerche Procedimento e impianto per la produzione di radiotraccianti pet 18f-fluorurati
WO2014102944A1 (fr) * 2012-12-26 2014-07-03 株式会社日立製作所 Réacteur pour le marquage d'une molécule biologique et appareil à réaction et procédé de réaction l'utilisant chacun
US9907867B2 (en) 2013-09-26 2018-03-06 General Electric Company Systems, methods and apparatus for manufacturing radioisotopes
GB201405591D0 (en) 2014-03-28 2014-05-14 Ge Healthcare Ltd Heatseal
KR101689321B1 (ko) * 2014-05-30 2017-01-02 성균관대학교산학협력단 방사성 화합물 합성 장치용 인터페이스 및 그의 조작방법
KR101903695B1 (ko) * 2016-11-28 2018-10-04 가천대학교 산학협력단 고온 불활성 기체를 이용한 불소-18 화합물 합성장치
CN109254018B (zh) * 2018-09-11 2021-12-07 华中科技大学同济医学院附属协和医院 一种放射性药物的药物代谢动力学成像检测系统
EP3972655A4 (fr) * 2019-05-22 2022-07-06 The Regents of University of California Radiosynthétiseur de microgouttelettes ultra-compact automatisé

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WO2005066100A1 (fr) * 2003-12-24 2005-07-21 Ge Healthcare Limited Procedes permettant de synthetiser, par marquage des isotopes du carbone, des cetones et des amines au moyen de reactions de couplage suzuki utilisant un monoxyde d'isotope du carbone
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EP1981636A4 (fr) * 2006-02-03 2010-06-09 California Inst Of Techn Procede et structure microfluidique dotee d'un joint elastomere permeable aux gaz

Also Published As

Publication number Publication date
JP2010531295A (ja) 2010-09-24
KR20100005216A (ko) 2010-01-14
CN102083525A (zh) 2011-06-01
WO2008128201A1 (fr) 2008-10-23
KR101176710B1 (ko) 2012-08-23
EP2134461A1 (fr) 2009-12-23

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Legal Events

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EEER Examination request
FZDE Discontinued

Effective date: 20141205