CA2682195A1 - Aminopyrimidines useful as kinase inhibitors - Google Patents
Aminopyrimidines useful as kinase inhibitors Download PDFInfo
- Publication number
- CA2682195A1 CA2682195A1 CA002682195A CA2682195A CA2682195A1 CA 2682195 A1 CA2682195 A1 CA 2682195A1 CA 002682195 A CA002682195 A CA 002682195A CA 2682195 A CA2682195 A CA 2682195A CA 2682195 A1 CA2682195 A1 CA 2682195A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- optionally substituted
- brs
- mhz
- dmso
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91901407P | 2007-03-20 | 2007-03-20 | |
| US60/919,014 | 2007-03-20 | ||
| US94677807P | 2007-06-28 | 2007-06-28 | |
| US60/946,778 | 2007-06-28 | ||
| PCT/US2008/057465 WO2008115973A2 (en) | 2007-03-20 | 2008-03-19 | Aminopyrimidines useful as kinase inhibitors |
Publications (1)
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|---|---|
| CA2682195A1 true CA2682195A1 (en) | 2008-09-25 |
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|---|---|---|---|
| CA002682195A Abandoned CA2682195A1 (en) | 2007-03-20 | 2008-03-19 | Aminopyrimidines useful as kinase inhibitors |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100137305A1 (enExample) |
| EP (1) | EP2142537A2 (enExample) |
| JP (2) | JP2010522194A (enExample) |
| CN (1) | CN101675041A (enExample) |
| AU (1) | AU2008228963A1 (enExample) |
| CA (1) | CA2682195A1 (enExample) |
| MX (1) | MX2009010037A (enExample) |
| WO (1) | WO2008115973A2 (enExample) |
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| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| DK1318997T3 (da) | 2000-09-15 | 2006-09-25 | Vertex Pharma | Pyrazolforbindelser der er nyttige som proteinkinase-inhibitorer |
| WO2004072029A2 (en) | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| TW200734327A (en) | 2005-11-03 | 2007-09-16 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
| WO2008057940A1 (en) | 2006-11-02 | 2008-05-15 | Vertex Pharmaceuticals Incorporated | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
| WO2008077086A1 (en) | 2006-12-19 | 2008-06-26 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
| EP2134709A1 (en) | 2007-03-09 | 2009-12-23 | Vertex Pharmaceuticals, Inc. | Aminopyridines useful as inhibitors of protein kinases |
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| CA2982890C (en) | 2015-04-17 | 2023-08-22 | Ludwig Institute For Cancer Research Ltd | Plk4 inhibitors |
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| BR112019001921A2 (pt) | 2016-08-01 | 2019-05-14 | Aptinyx Inc. | moduladores do receptor nmda de espiro-lactama e seus usos |
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| US11578072B2 (en) * | 2018-01-31 | 2023-02-14 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
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| MX2022007265A (es) | 2019-12-20 | 2022-09-09 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| US11780843B2 (en) | 2020-03-31 | 2023-10-10 | Nuevolution A/S | Compounds active towards nuclear receptors |
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| HUP0400639A3 (en) * | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| ES2289279T3 (es) * | 2002-03-15 | 2008-02-01 | Vertex Pharmaceuticals Incorporated | Composiciones utiles como inhibidores de proteinquinasas. |
| MY141867A (en) * | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| CN101675041A (zh) * | 2007-03-20 | 2010-03-17 | 沃泰克斯药物股份有限公司 | 用作激酶抑制剂的氨基嘧啶类化合物 |
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2008
- 2008-03-19 CN CN200880014717A patent/CN101675041A/zh active Pending
- 2008-03-19 WO PCT/US2008/057465 patent/WO2008115973A2/en not_active Ceased
- 2008-03-19 MX MX2009010037A patent/MX2009010037A/es not_active Application Discontinuation
- 2008-03-19 AU AU2008228963A patent/AU2008228963A1/en not_active Abandoned
- 2008-03-19 JP JP2009554707A patent/JP2010522194A/ja active Pending
- 2008-03-19 EP EP08732458A patent/EP2142537A2/en not_active Withdrawn
- 2008-03-19 CA CA002682195A patent/CA2682195A1/en not_active Abandoned
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2009
- 2009-09-18 US US12/562,181 patent/US20100137305A1/en not_active Abandoned
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2013
- 2013-08-30 JP JP2013179892A patent/JP2013237703A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101675041A (zh) | 2010-03-17 |
| JP2013237703A (ja) | 2013-11-28 |
| MX2009010037A (es) | 2009-11-05 |
| EP2142537A2 (en) | 2010-01-13 |
| US20100137305A1 (en) | 2010-06-03 |
| AU2008228963A1 (en) | 2008-09-25 |
| WO2008115973A3 (en) | 2008-12-04 |
| JP2010522194A (ja) | 2010-07-01 |
| WO2008115973A2 (en) | 2008-09-25 |
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| FZDE | Discontinued |
Effective date: 20140319 |