CA2681246A1 - Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer - Google Patents
Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer Download PDFInfo
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- CA2681246A1 CA2681246A1 CA002681246A CA2681246A CA2681246A1 CA 2681246 A1 CA2681246 A1 CA 2681246A1 CA 002681246 A CA002681246 A CA 002681246A CA 2681246 A CA2681246 A CA 2681246A CA 2681246 A1 CA2681246 A1 CA 2681246A1
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89568907P | 2007-03-19 | 2007-03-19 | |
| US60/895,689 | 2007-03-19 | ||
| US91079607P | 2007-04-09 | 2007-04-09 | |
| US60/910,796 | 2007-04-09 | ||
| PCT/US2008/051348 WO2008115610A1 (en) | 2007-03-19 | 2008-01-17 | Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2681246A1 true CA2681246A1 (en) | 2008-09-25 |
Family
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| EP (1) | EP2134358A1 (enExample) |
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| CN (1) | CN101730542A (enExample) |
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| CA (1) | CA2681246A1 (enExample) |
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| US7083787B2 (en) * | 2000-11-15 | 2006-08-01 | Globeimmune, Inc. | Yeast-dendritic cell vaccines and uses thereof |
| AU2003301021C1 (en) * | 2002-12-16 | 2010-02-18 | Globelmmune, Inc. | Yeast-based vaccines as immunotherapy |
| US8343502B2 (en) * | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
| AU2005295317B2 (en) | 2004-10-18 | 2011-10-13 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| US20100034840A1 (en) * | 2005-07-11 | 2010-02-11 | David Apelian | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
| US20070172503A1 (en) * | 2005-12-13 | 2007-07-26 | Mycologics,Inc. | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines |
| CN101448848B (zh) * | 2006-03-27 | 2013-12-04 | 全球免疫股份有限公司 | Ras突变及其相关组合物和方法 |
| JP5570819B2 (ja) | 2007-02-02 | 2014-08-13 | グローブイミューン，インコーポレイテッド | 酵母を含む組成物および酵母を増殖させる方法 |
| US8728489B2 (en) | 2008-09-19 | 2014-05-20 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis C virus infection |
| EP2419126B1 (en) | 2009-04-17 | 2018-01-10 | Globeimmune, Inc. | Combination immunotherapy compositions against cancer and methods |
| JP5913103B2 (ja) | 2009-09-14 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法 |
| EP2651439B1 (en) | 2010-12-17 | 2018-09-19 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| AP2013007110A0 (en) | 2011-02-12 | 2013-09-30 | Globeimmune Inc | Yeast-based therapeutic for chronic hepatitis B infection |
| AU2012228937B2 (en) | 2011-03-17 | 2016-11-03 | Globeimmune, Inc. | Yeast-Brachyury immunotherapeutic compositions |
| BR112013032381B1 (pt) | 2011-06-14 | 2021-01-12 | Globeimmune, Inc. | composições à base de levedura e métodos para o tratamento ou prevenção de infecção pelo vírus da hepatite delta |
| RU2017143985A (ru) | 2011-08-17 | 2019-02-14 | Глоубиммьюн, Инк. | Иммунотерапевтические композиции на основе дрожжей-muc1 и способы их применения |
| EP2864792A1 (en) | 2012-06-26 | 2015-04-29 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| EP2883884A4 (en) * | 2012-08-10 | 2016-08-10 | Kanagawa Prefectural Hospital Organization | ANTIGEN PEPTIDE FROM T790M POINT MUTED SEQUENCE OF THE EPIDERMAL GROWTH FACTOR RECEPTOR |
| WO2014186047A1 (en) | 2013-03-19 | 2014-11-20 | Globeimmune, Inc. | Yeast-based immunotherapy for chordoma |
| WO2014160747A2 (en) | 2013-03-26 | 2014-10-02 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human immunodeficiency virus infection |
| TWI654200B (zh) | 2013-08-30 | 2019-03-21 | 環球免疫公司 | 治療或預防結核病的組合物及方法 |
| KR102409372B1 (ko) | 2014-04-11 | 2022-06-16 | 글로브이뮨 | 효모 면역 요법 및 타입 i 인터페론 감도 |
| WO2017023840A1 (en) | 2015-08-03 | 2017-02-09 | Globeimmune, Inc. | Modified yeast-brachyury immunotherapeutic compositions |
| RS67172B1 (sr) * | 2016-03-31 | 2025-09-30 | Biontech Us Inc | Neoantigeni i postupci za njihovu upotrebu |
| JP7457642B2 (ja) | 2017-04-03 | 2024-03-28 | ビオンテック ユーエス インコーポレイテッド | タンパク質抗原およびその使用 |
| TW201930340A (zh) | 2017-12-18 | 2019-08-01 | 美商尼恩醫療公司 | 新抗原及其用途 |
| CN119818663A (zh) | 2018-05-15 | 2025-04-15 | 全球免疫公司 | 用于诱导细胞免疫应答的重组酵母裂解物 |
| CA3103983A1 (en) | 2018-06-19 | 2019-12-26 | Biontech Us Inc. | Neoantigens and uses thereof |
| CN112687354B (zh) * | 2019-01-29 | 2022-07-12 | 杭州纽安津生物科技有限公司 | 针对靶向药物PI3K、AKT、mTOR通路的激酶抑制剂的多肽疫苗组合及其设计方法 |
| CN116536402B (zh) * | 2023-03-08 | 2025-06-24 | 华中科技大学同济医学院附属协和医院 | Arms-pcr法检测bcr-abl融合基因abl激酶区的核酸组合物、试剂盒 |
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| JP5570819B2 (ja) * | 2007-02-02 | 2014-08-13 | グローブイミューン，インコーポレイテッド | 酵母を含む組成物および酵母を増殖させる方法 |
| US8728489B2 (en) | 2008-09-19 | 2014-05-20 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis C virus infection |
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| JP5913103B2 (ja) | 2009-09-14 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法 |
| JP2013522302A (ja) | 2010-03-14 | 2013-06-13 | グローブイミューン，インコーポレイテッド | 酵母系免疫療法を使用した感染症の薬理ゲノミクス及び治療反応性ガイド治療 |
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2008
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- 2008-01-17 BR BRPI0809247-8A patent/BRPI0809247A2/pt not_active IP Right Cessation
- 2008-01-17 KR KR1020097021695A patent/KR20100015661A/ko not_active Ceased
- 2008-01-17 MX MX2009010066A patent/MX2009010066A/es active IP Right Grant
- 2008-01-17 JP JP2009554603A patent/JP5579451B2/ja active Active
- 2008-01-17 US US12/531,876 patent/US8501167B2/en not_active Expired - Fee Related
- 2008-01-17 CA CA002681246A patent/CA2681246A1/en not_active Abandoned
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- 2008-01-17 RU RU2009138327/15A patent/RU2505313C2/ru not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2010522180A (ja) | 2010-07-01 |
| RU2505313C2 (ru) | 2014-01-27 |
| KR20100015661A (ko) | 2010-02-12 |
| IL201039A0 (en) | 2010-05-17 |
| WO2008115610A1 (en) | 2008-09-25 |
| US8501167B2 (en) | 2013-08-06 |
| CN101730542A (zh) | 2010-06-09 |
| AU2008229295B2 (en) | 2014-05-22 |
| JP2014156467A (ja) | 2014-08-28 |
| US20100111912A1 (en) | 2010-05-06 |
| RU2009138327A (ru) | 2011-04-27 |
| MX2009010066A (es) | 2009-10-12 |
| EP2134358A1 (en) | 2009-12-23 |
| NZ580444A (en) | 2012-02-24 |
| BRPI0809247A2 (pt) | 2014-09-09 |
| JP5579451B2 (ja) | 2014-08-27 |
| AU2008229295A1 (en) | 2008-09-25 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20140115 |
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| FZDE | Discontinued |
Effective date: 20160715 |