CA2676061C - Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof - Google Patents

Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof Download PDF

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Publication number
CA2676061C
CA2676061C CA2676061A CA2676061A CA2676061C CA 2676061 C CA2676061 C CA 2676061C CA 2676061 A CA2676061 A CA 2676061A CA 2676061 A CA2676061 A CA 2676061A CA 2676061 C CA2676061 C CA 2676061C
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CA
Canada
Prior art keywords
compound
formula
polymorph
pharmaceutical composition
tiacumicins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2676061A
Other languages
English (en)
French (fr)
Other versions
CA2676061A1 (en
Inventor
Yu-Hung Chiu
Tessie Mary Che
Alex Romero
Yoshi Ichikawa
Youe-Kong Shue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38661942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2676061(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Priority to CA2880860A priority Critical patent/CA2880860A1/en
Publication of CA2676061A1 publication Critical patent/CA2676061A1/en
Application granted granted Critical
Publication of CA2676061C publication Critical patent/CA2676061C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
CA2676061A 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof Active CA2676061C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2880860A CA2880860A1 (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88195007P 2007-01-22 2007-01-22
US60/881,950 2007-01-22
US11/831,886 US7378508B2 (en) 2007-01-22 2007-07-31 Polymorphic crystalline forms of tiacumicin B
US11/831,886 2007-07-31
PCT/US2008/000735 WO2008091554A1 (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2880860A Division CA2880860A1 (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Publications (2)

Publication Number Publication Date
CA2676061A1 CA2676061A1 (en) 2008-07-31
CA2676061C true CA2676061C (en) 2016-01-19

Family

ID=38661942

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2676061A Active CA2676061C (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
CA2880860A Withdrawn CA2880860A1 (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2880860A Withdrawn CA2880860A1 (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Country Status (23)

Country Link
US (5) US7378508B2 (enExample)
EP (3) EP3412678B1 (enExample)
JP (2) JP5468388B2 (enExample)
KR (2) KR20150006082A (enExample)
CN (2) CN101663312B (enExample)
BR (1) BRPI0806878A2 (enExample)
CA (2) CA2676061C (enExample)
CY (1) CY1120358T1 (enExample)
DK (1) DK2125850T3 (enExample)
ES (2) ES2821384T3 (enExample)
HR (1) HRP20180912T1 (enExample)
HU (2) HUE039395T2 (enExample)
IL (2) IL199984A0 (enExample)
LT (1) LT2125850T (enExample)
MX (2) MX2009007730A (enExample)
NZ (2) NZ578697A (enExample)
PL (2) PL3412678T3 (enExample)
PT (2) PT3412678T (enExample)
RU (1) RU2478643C2 (enExample)
SI (1) SI2125850T1 (enExample)
TR (1) TR201810589T4 (enExample)
TW (2) TWI453015B (enExample)
WO (1) WO2008091554A1 (enExample)

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JP5113978B2 (ja) * 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
US7906489B2 (en) * 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
ES2713954T3 (es) * 2004-05-14 2019-05-24 Merck Sharp & Dohme Tratamiento de enfermedades asociadas al uso de antibióticos
US7935377B2 (en) * 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
MX2010000465A (es) * 2007-07-12 2010-08-30 Tragara Pharmaceuticals Inc Metodos y composiciones para el tratamiento de cancer, tumores y alteraciones relacionadas con tumores.
TWI523654B (zh) 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法
EP2531197B1 (en) * 2010-02-05 2017-05-17 Tragara Pharmaceuticals, Inc. Solid state forms of macrocyclic kinase inhibitors
WO2011146624A2 (en) * 2010-05-18 2011-11-24 Optimer Pharmaceuticals, Inc. Methods of treating recurring bacterial infection
WO2012106722A2 (en) * 2011-02-04 2012-08-09 Optimer Pharmaceuticals, Inc. Treatment of bacterial infections
US20150157653A1 (en) * 2012-03-16 2015-06-11 Optimer Pharmaceuticals, Inc. Prevention of Clostridium Difficile Infection in High Risk Patients
US8722863B2 (en) 2012-05-10 2014-05-13 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
WO2013170142A1 (en) 2012-05-10 2013-11-14 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
JO3464B1 (ar) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
ZA201401683B (en) 2013-03-08 2017-06-28 Cipla Ltd Pharmaceutical compositions for rectal administration
CN103275152B (zh) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 一种高纯度非达霉素的制备方法
CN103275153B (zh) * 2013-06-27 2016-03-23 华北制药集团新药研究开发有限责任公司 一种非达霉素晶体的制备方法
CN104560766B (zh) 2013-10-16 2017-07-28 浙江海正药业股份有限公司 一种游动放线菌菌株及其应用
US20150141356A1 (en) * 2013-11-15 2015-05-21 Optimer Pharmaceuticals, Inc. Treatment of Clostridium Difficile Infection in High Risk Patients
US9862740B2 (en) 2014-02-25 2018-01-09 Olon S.P.A. Process for preparing novel forms of tiacumicin B
WO2015127955A1 (en) 2014-02-25 2015-09-03 Olon S.P.A. A new polymorph of tiacumicin b and process for preparation thereof
CA2940902C (en) * 2014-03-18 2022-10-25 Xellia Pharmaceuticals Aps Polymorphs and solid states of tiacumicin b
KR20160149288A (ko) 2014-05-09 2016-12-27 아스텔라스 파마 유럽 리미티드 치료 요법 티아큐미신 화합물
US20150329582A1 (en) * 2014-05-13 2015-11-19 Jef DeBrabander Small molecule compounds selective against gram-negative bacterial infections
CN104098637B (zh) 2014-07-09 2017-01-04 浙江海正药业股份有限公司 一种纯化非达霉素的方法
MA41689A (fr) * 2014-10-15 2017-08-22 Bioxcel Corp Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine
JP2018519344A (ja) 2015-07-03 2018-07-19 アステラス ファーマ ユーロープ リミテッド チアクマイシン化合物の新規の投薬レジメン
CN112190589A (zh) * 2020-11-17 2021-01-08 首都医科大学附属北京胸科医院 非达霉素在制备抑制鸟分枝杆菌活性的产品中的应用

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JP2000072760A (ja) 1998-06-19 2000-03-07 Ajinomoto Co Inc 新規シストチアゾール類縁体
JP2000053514A (ja) 1998-08-06 2000-02-22 Aquas Corp レジオネラ属細菌が生産する殺菌性物質、これを用いた殺菌剤、水処理剤、スライム抑制剤、及びこれらの製造方法
JP2000239266A (ja) 1999-02-17 2000-09-05 Ajinomoto Co Inc 新規ポリエン系抗生物質
DE60114865T2 (de) 2000-04-28 2006-07-27 Kosan Biosciences, Inc., Hayward Heterologe herstellung von polyketiden
WO2002032427A1 (en) 2000-10-20 2002-04-25 Galephar M/F Stable oral formulation containing benzimidazole derivative
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ES2713954T3 (es) * 2004-05-14 2019-05-24 Merck Sharp & Dohme Tratamiento de enfermedades asociadas al uso de antibióticos
US7378508B2 (en) 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
BRPI0519890A2 (pt) * 2005-01-31 2009-03-31 Optimer Pharmaceuticals Inc macrociclos de 18 elementos e seus análogos
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TWI523654B (zh) 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法

Also Published As

Publication number Publication date
IL220255A0 (en) 2012-07-31
CA2676061A1 (en) 2008-07-31
RU2478643C2 (ru) 2013-04-10
EP2468761A1 (en) 2012-06-27
US20130252914A1 (en) 2013-09-26
KR20150006082A (ko) 2015-01-15
MX348083B (es) 2017-05-25
NZ578697A (en) 2012-08-31
AU2008209580A1 (en) 2008-07-31
US20100081800A1 (en) 2010-04-01
EP2125850A1 (en) 2009-12-02
DK2125850T3 (en) 2018-07-30
US20080194497A1 (en) 2008-08-14
CN101663312A (zh) 2010-03-03
KR20090117924A (ko) 2009-11-16
US7378508B2 (en) 2008-05-27
EP3412678B1 (en) 2020-08-19
HRP20180912T1 (hr) 2018-07-27
JP2013241440A (ja) 2013-12-05
PT2125850T (pt) 2018-07-11
TWI453015B (zh) 2014-09-21
PL2125850T3 (pl) 2018-08-31
HUE039395T2 (hu) 2018-12-28
CN102746353A (zh) 2012-10-24
US8859510B2 (en) 2014-10-14
TW200840562A (en) 2008-10-16
US20090163428A1 (en) 2009-06-25
US7863249B2 (en) 2011-01-04
WO2008091554A1 (en) 2008-07-31
PL3412678T3 (pl) 2020-12-14
BRPI0806878A2 (pt) 2014-06-24
CY1120358T1 (el) 2019-07-10
EP2125850B1 (en) 2018-05-30
SI2125850T1 (en) 2018-08-31
TWI425942B (zh) 2014-02-11
HUE052444T2 (hu) 2021-05-28
LT2125850T (lt) 2018-08-10
MX2009007730A (es) 2009-08-07
TR201810589T4 (tr) 2018-08-27
ES2676308T3 (es) 2018-07-18
JP2010516681A (ja) 2010-05-20
CA2880860A1 (en) 2008-07-31
RU2009131727A (ru) 2011-02-27
EP3412678A1 (en) 2018-12-12
JP5468388B2 (ja) 2014-04-09
PT3412678T (pt) 2020-09-29
IL199984A0 (en) 2010-04-15
US20070259949A1 (en) 2007-11-08
NZ601347A (en) 2013-11-29
US8883986B2 (en) 2014-11-11
CN101663312B (zh) 2013-10-23
TW201350114A (zh) 2013-12-16
JP5764168B2 (ja) 2015-08-12
ES2821384T3 (es) 2021-04-26

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