CA2674238A1 - Targeting nbs1-atm interaction to sensitize cancer cells to radiotherapy and chemotherapy - Google Patents

Targeting nbs1-atm interaction to sensitize cancer cells to radiotherapy and chemotherapy Download PDF

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Publication number
CA2674238A1
CA2674238A1 CA002674238A CA2674238A CA2674238A1 CA 2674238 A1 CA2674238 A1 CA 2674238A1 CA 002674238 A CA002674238 A CA 002674238A CA 2674238 A CA2674238 A CA 2674238A CA 2674238 A1 CA2674238 A1 CA 2674238A1
Authority
CA
Canada
Prior art keywords
seq
polypeptide
atm
nbs1
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002674238A
Other languages
English (en)
French (fr)
Inventor
Michael J. Cariveau
Bo Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southern Research Institute
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2674238A1 publication Critical patent/CA2674238A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C07K14/43Sweetening agents, e.g. thaumatin, monellin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002674238A 2006-10-30 2007-10-30 Targeting nbs1-atm interaction to sensitize cancer cells to radiotherapy and chemotherapy Abandoned CA2674238A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86345706P 2006-10-30 2006-10-30
US60/863,457 2006-10-30
PCT/US2007/022886 WO2008054726A2 (en) 2006-10-30 2007-10-30 Targeting nbs1-atm interaction to sensitize cancer cells to radiotherapy and chemotherapy

Publications (1)

Publication Number Publication Date
CA2674238A1 true CA2674238A1 (en) 2008-05-08

Family

ID=39344878

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002674238A Abandoned CA2674238A1 (en) 2006-10-30 2007-10-30 Targeting nbs1-atm interaction to sensitize cancer cells to radiotherapy and chemotherapy

Country Status (9)

Country Link
US (1) US20100120679A1 (https=)
EP (1) EP2091964A2 (https=)
JP (1) JP2010508022A (https=)
KR (1) KR20090102744A (https=)
CN (1) CN101631799A (https=)
AU (1) AU2007314366A1 (https=)
CA (1) CA2674238A1 (https=)
MX (1) MX2009004748A (https=)
WO (1) WO2008054726A2 (https=)

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US8118754B1 (en) 2007-11-15 2012-02-21 Flynn Edward R Magnetic needle biopsy
US9964469B2 (en) 2005-02-28 2018-05-08 Imagion Biosystems, Inc. Magnetic needle separation and optical monitoring
US8841414B1 (en) * 2006-01-27 2014-09-23 University Of Mississippi Medical Center Targeted delivery of therapeutic peptides by thermally responsive biopolymers
US8447379B2 (en) 2006-11-16 2013-05-21 Senior Scientific, LLC Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof
EP2496175A4 (en) 2009-11-06 2014-08-06 Scient Nanomedicine Inc DETECTION, MEASUREMENT, AND IMAGING OF (eg, CANCER) CELLS AND OTHER BIOLOGICAL SUBSTANCES USING TARGETED NANOPARTICLES AND THEIR MAGNETIC PROPERTIES
US10194825B2 (en) 2009-11-06 2019-02-05 Imagion Biosystems Inc. Methods and apparatuses for the localization and treatment of disease such as cancer
MX2013012648A (es) * 2011-04-29 2014-05-27 Kasper Toustrup Metodo para determinar hipoxia clinicamente relevante en cancer.
EP2797617B1 (en) * 2011-12-27 2020-01-22 Sorbonne Université Anti-tumor adjuvant therapy
GB201209517D0 (en) 2012-05-29 2012-07-11 Univ Birmingham Nanoparticles
CN104046644A (zh) * 2013-03-14 2014-09-17 中国科学院上海生命科学研究院 人源化小鼠模型的构建方法和应用
KR101447901B1 (ko) * 2013-04-16 2014-10-16 한양대학교 산학협력단 지방세포 표적 비바이러스성 유전자 전달체
RU2689179C2 (ru) * 2014-02-27 2019-05-24 Конинклейке Филипс Н.В. Медицинский инструмент для высокодозной брахитерапии
US10213284B2 (en) 2015-06-30 2019-02-26 Tela Bio, Inc. Corner-lock stitch patterns
WO2017015421A1 (en) 2015-07-21 2017-01-26 Tela Bio, Inc. Compliance control stitching in substrate materials
EP3448308B1 (en) 2016-04-26 2024-08-14 Tela Bio, Inc. Hernia repair grafts having anti-adhesion barriers
KR101875111B1 (ko) * 2016-04-29 2018-07-09 한국수력원자력 주식회사 저선량 방사선을 이용한 암화유전자 Ras-유도 악성 암화 억제
SG10202107725RA (en) * 2017-02-16 2021-09-29 Firststring Research Inc Composition and methods for preventing radiation injury and promoting tissue regeneration
US11197872B2 (en) 2017-04-21 2021-12-14 Lunella Biotech, Inc. Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
EP3612177A4 (en) 2017-04-21 2021-01-13 Lunella Biotech, Inc. TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY
CA3063450A1 (en) 2017-05-19 2018-11-22 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
PH12019502594A1 (en) 2017-05-19 2020-10-26 Lunella Biotech Inc Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
KR102854338B1 (ko) 2017-06-26 2025-09-03 루넬라 바이오테크 인코포레이티드 미토케토신: 암 세포에서 케톤 대사를 표적화하는 미토콘드리아-기반의 치료제
EP3761963B1 (en) 2018-03-09 2025-01-22 Tela Bio, Inc. Surgical repair graft
US11446130B2 (en) 2019-03-08 2022-09-20 Tela Bio, Inc. Textured medical textiles
US20240335575A1 (en) * 2021-10-20 2024-10-10 Aphios Corporation Method and apparatus for inactivating pathogens in units of whole blood using superparamagnetic nanoparticles coated with chemiluminescence reagents and broad-spectrum anti-viral therapeutics
CN115300449B (zh) * 2022-02-07 2023-06-27 郑州大学第一附属医院 榄香烯在制备抑制肿瘤耐药性的控释制剂中的应用
CN118126155B (zh) * 2024-02-05 2025-04-25 中山大学附属第七医院(深圳) 一种人nbs1蛋白赖氨酸388位点乳酸化抗原、抗体及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077880A (en) * 1997-08-08 2000-06-20 Cordis Corporation Highly radiopaque polyolefins and method for making the same
US7122343B1 (en) * 1998-04-27 2006-10-17 Wisconsin Alumni Research Foundation Methods to alter levels of a DNA repair protein
US7074902B1 (en) * 1998-04-27 2006-07-11 Warf Wisconsin Alumni Research Foundation Antibody specific for a DNA repair protein
US6530944B2 (en) * 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US20030104427A1 (en) * 2001-06-25 2003-06-05 Petrini John H.J. Methods to modulate telomere structure and function

Also Published As

Publication number Publication date
WO2008054726A3 (en) 2009-02-05
CN101631799A (zh) 2010-01-20
AU2007314366A1 (en) 2008-05-08
WO2008054726A2 (en) 2008-05-08
KR20090102744A (ko) 2009-09-30
JP2010508022A (ja) 2010-03-18
MX2009004748A (es) 2009-08-25
EP2091964A2 (en) 2009-08-26
US20100120679A1 (en) 2010-05-13

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20121030