CA2670345A1 - Thrombopoietin mimetics - Google Patents

Thrombopoietin mimetics Download PDF

Info

Publication number
CA2670345A1
CA2670345A1 CA002670345A CA2670345A CA2670345A1 CA 2670345 A1 CA2670345 A1 CA 2670345A1 CA 002670345 A CA002670345 A CA 002670345A CA 2670345 A CA2670345 A CA 2670345A CA 2670345 A1 CA2670345 A1 CA 2670345A1
Authority
CA
Canada
Prior art keywords
compound
substituted
alkyl
hydroxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002670345A
Other languages
English (en)
French (fr)
Inventor
Jeffrey R. Spencer
Juha Punnonen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STATegics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2670345A1 publication Critical patent/CA2670345A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002670345A 2006-12-01 2007-11-30 Thrombopoietin mimetics Abandoned CA2670345A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86196306P 2006-12-01 2006-12-01
US60/861,963 2006-12-01
PCT/US2007/086186 WO2008070583A2 (en) 2006-12-01 2007-11-30 Thrombopoietin mimetics

Publications (1)

Publication Number Publication Date
CA2670345A1 true CA2670345A1 (en) 2008-06-12

Family

ID=39493014

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002670345A Abandoned CA2670345A1 (en) 2006-12-01 2007-11-30 Thrombopoietin mimetics

Country Status (6)

Country Link
US (2) US7786159B2 (enExample)
EP (1) EP2086551A4 (enExample)
JP (1) JP2010511631A (enExample)
AU (1) AU2007329464A1 (enExample)
CA (1) CA2670345A1 (enExample)
WO (1) WO2008070583A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
EP2086551A4 (en) * 2006-12-01 2011-06-08 Stategics Inc Thrombopoietin mimetics
WO2010129738A1 (en) * 2009-05-07 2010-11-11 Glaxosmithkline Llc Method of treating thrombocytopenia
US8476249B2 (en) 2009-05-07 2013-07-02 Glaxosmithkline Llc Method of treating thrombocytopenia
CN101921232A (zh) * 2009-06-11 2010-12-22 上海恒瑞医药有限公司 双环取代吡唑酮偶氮类衍生物的盐,其制备方法及其在医药上的应用
WO2012121958A2 (en) * 2011-03-08 2012-09-13 Glaxosmithkline Llc Combination
WO2013072921A2 (en) * 2011-09-13 2013-05-23 Glenmark Generics Limited Process for preparation of substituted 3'-hydrazino-biphenyl-3-carboxylic acid compounds
EP2780322B1 (en) 2011-11-14 2018-05-16 Ligand Pharmaceuticals, Inc. Methods and compositions associated with the granulocyte colony-stimulating factor receptor
JP6150374B2 (ja) * 2012-11-15 2017-06-21 国立大学法人弘前大学 放射線被ばく治療剤及び放射線被ばく治療方法
WO2014150252A1 (en) 2013-03-15 2014-09-25 Ligand Pharmaceuticals Incorporated Methods of treatment associated with the granulocyte colony-stimulating factor receptor
CN104257928A (zh) * 2014-10-20 2015-01-07 王艳萍 一种治疗软组织损伤疼痛综合症的中药制剂
JP7481252B2 (ja) 2017-07-26 2024-05-10 ヤンセン ファーマシューティカ エヌ．ベー． 標的放射線治療誘発性血管完全性を保護する方法
KR20210141460A (ko) * 2019-01-25 2021-11-23 잔센파마슈티카엔.브이. 방사선 및/또는 방사선 모방체 치료와 함께 간 손상을 완화하고 간 비대, 재생 및 세포 생착을 촉진하는 방법
WO2024249284A2 (en) * 2023-05-26 2024-12-05 Ipsen Pharma S.A.S. Bax activators and use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE634840A (enExample) * 1961-08-10
US3141772A (en) * 1963-08-09 1964-07-21 Polaroid Corp Photographic products, processes and compositions employing azo dye developers
DE1182432B (de) * 1962-04-26 1964-11-26 Basf Ag Verfahren zur Herstellung von thermoplastischen farbigen makromolekularen Stoffen
US3666746A (en) * 1969-06-25 1972-05-30 Gaf Corp Pyrrolidonylphenyl azo dyestuffs
US5132189A (en) * 1989-09-07 1992-07-21 Fuji Electric Co., Ltd. Photoconductor for electrophotography
JPH04128767A (ja) * 1990-09-19 1992-04-30 Fuji Electric Co Ltd 電子写真用感光体
WO2001009256A1 (en) * 1999-07-29 2001-02-08 Mitsui Chemicals, Inc. Yellow compound and water-based ink-jet recording ink containing the compound
ES2256038T3 (es) * 1999-09-10 2006-07-16 Smithkline Beecham Corporation Mimeticos de trombopoyetina.
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
JP4562523B2 (ja) 2002-06-06 2010-10-13 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー トロンボポエチン疑似体
WO2005118551A2 (en) 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
ATE486859T1 (de) * 2004-10-25 2010-11-15 Ligand Pharm Inc Verbindungen modulierende thrombopoietinaktivität und verfahren
US7226575B2 (en) * 2004-11-30 2007-06-05 Chevron U.S.A. Inc. Boron-containing molecular sieve CHA
KR20080080305A (ko) * 2005-11-23 2008-09-03 리간드 파마슈티칼스 인코포레이티드 트롬보포이에틴 활성 조절 화합물 및 이의 조절 방법
AU2006336506B2 (en) 2006-01-13 2012-06-28 Pharmacyclics Llc Inhibitors of tyrosine kinases and uses thereof
EP2086551A4 (en) 2006-12-01 2011-06-08 Stategics Inc Thrombopoietin mimetics

Also Published As

Publication number Publication date
WO2008070583A3 (en) 2008-08-14
EP2086551A4 (en) 2011-06-08
US20080139621A1 (en) 2008-06-12
AU2007329464A1 (en) 2008-06-12
US8143287B2 (en) 2012-03-27
US20100323965A1 (en) 2010-12-23
JP2010511631A (ja) 2010-04-15
US7786159B2 (en) 2010-08-31
EP2086551A2 (en) 2009-08-12
WO2008070583A2 (en) 2008-06-12

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20121130