CA2669913C - Endoxifen methods and compositions - Google Patents

Endoxifen methods and compositions Download PDF

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Publication number
CA2669913C
CA2669913C CA2669913A CA2669913A CA2669913C CA 2669913 C CA2669913 C CA 2669913C CA 2669913 A CA2669913 A CA 2669913A CA 2669913 A CA2669913 A CA 2669913A CA 2669913 C CA2669913 C CA 2669913C
Authority
CA
Canada
Prior art keywords
endoxifen
acid
use according
composition
cholesterol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2669913A
Other languages
English (en)
French (fr)
Other versions
CA2669913A1 (en
Inventor
Ateeq Ahmad
Shoukath M. Ali
Moghis U. Ahmad
Saifuddin Sheikh
Imran Ahmad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jina Pharmaceuticals Inc
Original Assignee
Jina Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39492975&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2669913(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jina Pharmaceuticals Inc filed Critical Jina Pharmaceuticals Inc
Publication of CA2669913A1 publication Critical patent/CA2669913A1/en
Application granted granted Critical
Publication of CA2669913C publication Critical patent/CA2669913C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2669913A 2006-11-21 2007-11-21 Endoxifen methods and compositions Active CA2669913C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86042006P 2006-11-21 2006-11-21
US60/860,420 2006-11-21
US86078806P 2006-11-22 2006-11-22
US60/860,788 2006-11-22
PCT/US2007/085443 WO2008070463A2 (en) 2006-11-21 2007-11-21 Endoxifen methods and compositions

Publications (2)

Publication Number Publication Date
CA2669913A1 CA2669913A1 (en) 2008-06-12
CA2669913C true CA2669913C (en) 2012-09-18

Family

ID=39492975

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2669913A Active CA2669913C (en) 2006-11-21 2007-11-21 Endoxifen methods and compositions

Country Status (11)

Country Link
US (2) US9333190B2 (index.php)
EP (1) EP2101731B1 (index.php)
JP (1) JP2010510327A (index.php)
CA (1) CA2669913C (index.php)
DK (1) DK2101731T3 (index.php)
ES (1) ES2665917T3 (index.php)
HU (1) HUE037109T2 (index.php)
IN (1) IN2014MN00139A (index.php)
PL (1) PL2101731T3 (index.php)
PT (1) PT2101731T (index.php)
WO (1) WO2008070463A2 (index.php)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090291134A1 (en) 2006-11-21 2009-11-26 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases
CA2669913C (en) 2006-11-21 2012-09-18 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions
US20120010245A1 (en) * 2008-12-11 2012-01-12 Besins Healthcare Luxembourg Sarl Transdermal pharmaceutical compositions comprising a serm
HUE037863T2 (hu) 2011-04-28 2018-09-28 Oncopeptides Ab Citotoxikus dipeptidek liofilizált készítménye
EP2668945A1 (de) 2012-06-01 2013-12-04 Bayer Technology Services GmbH Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen
BR112015009280B1 (pt) * 2012-10-26 2022-05-31 Oncopeptides Ab Preparação farmacêutica liofilizada de melfalana flufenamida, composição e kit de combinação de partes
CA2992282A1 (en) * 2015-07-14 2017-01-19 Atossa Genetics Inc. Transpapillary methods and compositions for treating breast disorders
DE102015222031A1 (de) 2015-11-10 2017-05-11 Robert Bosch Gesellschaft Für Medizinische Forschung Mbh Synthese von (Z)-Endoxifenhydrochlorid
US20170304232A1 (en) * 2016-04-20 2017-10-26 Northwestern University Endoxifen For Local Transdermal Therapy To The Breast
CN111328280A (zh) 2017-09-11 2020-06-23 阿托萨治疗学公司 制备和使用内昔芬的方法
MX2020002683A (es) * 2017-09-11 2020-09-25 Atossa Therapeutics Inc Composiciones topicas y metodos de tratamiento.
EP3993782A4 (en) * 2019-07-03 2023-08-02 Atossa Therapeutics, Inc. EXTENDED RELEASE ENDOXIFEN COMPOSITIONS
AU2021252229A1 (en) 2020-04-10 2022-10-27 Jina Pharmaceuticals, Inc. Endoxifen for the treatment of bipolar I disorder
CA3185993A1 (en) 2020-04-10 2021-10-14 Jina Pharmaceuticals, Inc. Endoxifen for the treatment of bipolar i disorder
WO2022197989A1 (en) * 2021-03-18 2022-09-22 FormuRx Pharmaceuticals Co., Ltd. Composition and method of preparation for lipid formulations comprising charged lipids
MX2024008643A (es) 2022-01-12 2024-09-25 Atossa Therapeutics Inc Composiciones de (z)-endoxifeno y métodos de enriquecimiento de este.
JP2025514195A (ja) * 2022-04-26 2025-05-02 アトッサ・セラピューティクス・インコーポレイテッド 高用量エンドキシフェン製剤及びその使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817157A1 (de) * 1978-04-17 1979-10-25 Schering Ag Verwendung von antioestrogenen und antigonadotrop wirkenden antiandrogenen zur prophylaxe und therapie der prostatahyperplasie
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
JPH10503769A (ja) * 1994-08-04 1998-04-07 クアドラント ホールディングス ケンブリッジ リミテッド 配合されている分子の制御放出用の固形放出系およびその製造方法
WO1997040679A1 (en) * 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6090407A (en) 1997-09-23 2000-07-18 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
US7968532B2 (en) 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
PT2076244T (pt) 2006-10-10 2017-03-09 Jina Pharmaceuticals Inc Sistemas aquosos para a preparação de compostos farmacêuticos à base de lípidos; composições, métodos e utilizações dos mesmos
WO2008048194A1 (en) 2006-10-20 2008-04-24 Yesilogluj Aysegul Yildiz Use of the protein kinase c inhibitor tamoxifen for the treatment of bipolar disorder
JP2010509355A (ja) 2006-11-06 2010-03-25 ジャイナ ファーマシューティカルズ，インコーポレーテッド グッグルリン脂質の方法および組成物
CA2669913C (en) 2006-11-21 2012-09-18 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions
US20090291134A1 (en) 2006-11-21 2009-11-26 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases
JP5720881B2 (ja) 2011-01-31 2015-05-20 東芝ライテック株式会社 Ｌｅｄランプ点灯装置および照明装置

Also Published As

Publication number Publication date
JP2010510327A (ja) 2010-04-02
CA2669913A1 (en) 2008-06-12
WO2008070463A9 (en) 2008-09-18
ES2665917T3 (es) 2018-04-30
US10376479B2 (en) 2019-08-13
US20160346230A1 (en) 2016-12-01
EP2101731A2 (en) 2009-09-23
US20100112041A1 (en) 2010-05-06
PL2101731T3 (pl) 2018-07-31
WO2008070463A2 (en) 2008-06-12
HUE037109T2 (hu) 2018-08-28
EP2101731B1 (en) 2018-01-31
EP2101731A4 (en) 2011-04-20
PT2101731T (pt) 2018-04-18
DK2101731T3 (en) 2018-04-16
IN2014MN00139A (index.php) 2015-06-19
WO2008070463A3 (en) 2008-11-06
US9333190B2 (en) 2016-05-10

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