CA2669207A1 - Anti-angiogenic compounds - Google Patents
Anti-angiogenic compounds Download PDFInfo
- Publication number
- CA2669207A1 CA2669207A1 CA002669207A CA2669207A CA2669207A1 CA 2669207 A1 CA2669207 A1 CA 2669207A1 CA 002669207 A CA002669207 A CA 002669207A CA 2669207 A CA2669207 A CA 2669207A CA 2669207 A1 CA2669207 A1 CA 2669207A1
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- Prior art keywords
- substituted
- unsubstituted
- alkyl
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86536006P | 2006-11-10 | 2006-11-10 | |
| US60/865,360 | 2006-11-10 | ||
| US93983007P | 2007-05-23 | 2007-05-23 | |
| US60/939,830 | 2007-05-23 | ||
| US94532907P | 2007-06-20 | 2007-06-20 | |
| US60/945,329 | 2007-06-20 | ||
| PCT/IE2007/000110 WO2008056346A2 (en) | 2006-11-10 | 2007-11-12 | Anti-angiogenic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2669207A1 true CA2669207A1 (en) | 2008-05-15 |
Family
ID=39364902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002669207A Abandoned CA2669207A1 (en) | 2006-11-10 | 2007-11-12 | Anti-angiogenic compounds |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8288349B2 (OSRAM) |
| EP (2) | EP2368908A3 (OSRAM) |
| JP (2) | JP4897050B2 (OSRAM) |
| KR (2) | KR20120043028A (OSRAM) |
| CN (1) | CN101611053B (OSRAM) |
| AT (1) | ATE520712T1 (OSRAM) |
| AU (1) | AU2007318912B2 (OSRAM) |
| BR (1) | BRPI0718591A2 (OSRAM) |
| CA (1) | CA2669207A1 (OSRAM) |
| DK (1) | DK2089425T3 (OSRAM) |
| IL (1) | IL198581A (OSRAM) |
| MX (1) | MX2009005045A (OSRAM) |
| MY (1) | MY146985A (OSRAM) |
| NO (1) | NO20092203L (OSRAM) |
| NZ (1) | NZ576751A (OSRAM) |
| PL (1) | PL2089425T3 (OSRAM) |
| PT (1) | PT2089425E (OSRAM) |
| WO (1) | WO2008056346A2 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP4897050B2 (ja) * | 2006-11-10 | 2012-03-14 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗血管形成化合物 |
| US20090098130A1 (en) * | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| US8293714B2 (en) * | 2008-05-05 | 2012-10-23 | Covx Technology Ireland, Ltd. | Anti-angiogenic compounds |
| WO2010036930A1 (en) * | 2008-09-26 | 2010-04-01 | Javad Parvizi | Methods and kits for detecting joint infection |
| JP5913307B2 (ja) * | 2010-07-12 | 2016-04-27 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 多機能性抗体複合体 |
| WO2012059873A2 (en) | 2010-11-05 | 2012-05-10 | Covx Technologies Ireland, Ltd. | Anti-diabetic compounds |
| MX358726B (es) | 2011-06-29 | 2018-09-03 | Amgen Inc | Biomarcador predictivo de supervivencia en el tratamiento de carcinoma de celulas renales. |
| EP2793950A2 (en) | 2011-12-20 | 2014-10-29 | Pfizer Inc | Improved processes for preparing peptide conjugates and linkers |
| JP6413127B2 (ja) * | 2012-01-09 | 2018-10-31 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 変異抗体およびそのコンジュゲーション |
| MX350202B (es) | 2012-03-28 | 2017-08-30 | Amgen Inc | Combinaciones de agonistas de receptores de muerte 5 (dr5). |
| CA2913387C (en) * | 2013-06-12 | 2024-05-21 | Pharis Biotec Gmbh | Peptides with antagonistic activities against natural cxcr4 |
| WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| AU2014337555C1 (en) * | 2013-10-15 | 2021-01-28 | Seagen Inc. | PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics |
| US20190004048A1 (en) | 2015-06-26 | 2019-01-03 | Amgen Inc. | Biomarker of Survival in the Treatment of Renal Cell Carcinoma with a VEGFR Inhibitor and an Ang2 Inhibitor |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| TWI852735B (zh) | 2015-12-04 | 2024-08-11 | 美商思進公司 | 四級胺化妥布賴森(tubulysin)化合物之結合物 |
| KR102626498B1 (ko) | 2016-03-25 | 2024-01-19 | 씨젠 인크. | 페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정 |
| US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| ES3066090T3 (en) | 2017-04-28 | 2026-05-11 | Ajinomoto Co Inc | Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3719667A (en) | 1970-08-24 | 1973-03-06 | Lilly Co Eli | Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters |
| US3840556A (en) | 1971-05-28 | 1974-10-08 | Lilly Co Eli | Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5216132A (en) | 1990-01-12 | 1993-06-01 | Protein Design Labs, Inc. | Soluble t-cell antigen receptor chimeric antigens |
| DE69126871T2 (de) | 1990-04-06 | 1998-03-12 | Jolla Cancer Res Found | Verfahren und verbindung zur behandlung von thrombose |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US6080840A (en) | 1992-01-17 | 2000-06-27 | Slanetz; Alfred E. | Soluble T cell receptors |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5733757A (en) | 1995-12-15 | 1998-03-31 | The Scripps Research Institute | Aldolase catalytic antibody |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6326176B1 (en) | 1997-12-18 | 2001-12-04 | The Scripps Research Institute | Aldol condensations by catalytic antibodies |
| JP2003516121A (ja) | 1999-09-27 | 2003-05-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 不可逆的に結合するエンジニアリング抗体 |
| US6294374B1 (en) | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
| AU2002319402B2 (en) | 2001-06-28 | 2008-09-11 | Domantis Limited | Dual-specific ligand and its use |
| US20030045477A1 (en) | 2001-07-26 | 2003-03-06 | Fortuna Haviv | Peptides having antiangiogenic activity |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| WO2003059251A2 (en) * | 2001-10-22 | 2003-07-24 | The Scripps Research Institute | Antibody targeting compounds |
| US6737524B2 (en) * | 2002-03-25 | 2004-05-18 | Paul K. Smith | Activated polyethylene glycol compounds |
| EP1600459A3 (en) | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
| JP2006523090A (ja) | 2002-12-27 | 2006-10-12 | ドマンティス リミテッド | リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体 |
| CA2572765C (en) | 2004-07-08 | 2013-05-21 | Amgen Inc. | Compound having improved bioefficiency when administered in a multidose regimen |
| US7442778B2 (en) * | 2004-09-24 | 2008-10-28 | Amgen Inc. | Modified Fc molecules |
| JP4897050B2 (ja) * | 2006-11-10 | 2012-03-14 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗血管形成化合物 |
-
2007
- 2007-11-12 JP JP2009535878A patent/JP4897050B2/ja not_active Expired - Fee Related
- 2007-11-12 BR BRPI0718591-0A patent/BRPI0718591A2/pt not_active IP Right Cessation
- 2007-11-12 MY MYPI20091889A patent/MY146985A/en unknown
- 2007-11-12 EP EP20110170480 patent/EP2368908A3/en not_active Withdrawn
- 2007-11-12 EP EP07827123A patent/EP2089425B1/en not_active Not-in-force
- 2007-11-12 NZ NZ576751A patent/NZ576751A/en not_active IP Right Cessation
- 2007-11-12 AT AT07827123T patent/ATE520712T1/de active
- 2007-11-12 PL PL07827123T patent/PL2089425T3/pl unknown
- 2007-11-12 US US11/938,766 patent/US8288349B2/en not_active Expired - Fee Related
- 2007-11-12 AU AU2007318912A patent/AU2007318912B2/en not_active Ceased
- 2007-11-12 CN CN200780049649.0A patent/CN101611053B/zh not_active Expired - Fee Related
- 2007-11-12 KR KR1020127005049A patent/KR20120043028A/ko not_active Ceased
- 2007-11-12 MX MX2009005045A patent/MX2009005045A/es active IP Right Grant
- 2007-11-12 DK DK07827123.6T patent/DK2089425T3/da active
- 2007-11-12 CA CA002669207A patent/CA2669207A1/en not_active Abandoned
- 2007-11-12 WO PCT/IE2007/000110 patent/WO2008056346A2/en not_active Ceased
- 2007-11-12 PT PT07827123T patent/PT2089425E/pt unknown
- 2007-11-12 KR KR1020097011924A patent/KR101309948B1/ko not_active Expired - Fee Related
-
2009
- 2009-05-05 IL IL198581A patent/IL198581A/en active IP Right Grant
- 2009-06-08 NO NO20092203A patent/NO20092203L/no not_active Application Discontinuation
-
2011
- 2011-12-26 JP JP2011283619A patent/JP2012121886A/ja not_active Ceased
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2012
- 2012-08-13 US US13/584,721 patent/US8912148B2/en not_active Expired - Fee Related
-
2014
- 2014-10-31 US US14/530,444 patent/US20150057431A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4897050B2 (ja) | 2012-03-14 |
| NZ576751A (en) | 2011-10-28 |
| JP2012121886A (ja) | 2012-06-28 |
| US20120301431A1 (en) | 2012-11-29 |
| MX2009005045A (es) | 2009-11-10 |
| KR20120043028A (ko) | 2012-05-03 |
| PL2089425T3 (pl) | 2012-02-29 |
| AU2007318912A1 (en) | 2008-05-15 |
| EP2089425B1 (en) | 2011-08-17 |
| EP2368908A3 (en) | 2011-10-12 |
| CN101611053B (zh) | 2015-06-03 |
| PT2089425E (pt) | 2011-10-17 |
| NO20092203L (no) | 2009-08-10 |
| AU2007318912B2 (en) | 2011-03-03 |
| EP2368908A2 (en) | 2011-09-28 |
| IL198581A0 (en) | 2011-08-01 |
| US8912148B2 (en) | 2014-12-16 |
| WO2008056346B1 (en) | 2008-12-04 |
| KR20090090331A (ko) | 2009-08-25 |
| DK2089425T3 (da) | 2011-10-10 |
| IL198581A (en) | 2015-10-29 |
| CN101611053A (zh) | 2009-12-23 |
| MY146985A (en) | 2012-10-15 |
| BRPI0718591A2 (pt) | 2013-12-03 |
| US20080166364A1 (en) | 2008-07-10 |
| US8288349B2 (en) | 2012-10-16 |
| EP2089425A2 (en) | 2009-08-19 |
| KR101309948B1 (ko) | 2013-09-23 |
| WO2008056346A2 (en) | 2008-05-15 |
| US20150057431A1 (en) | 2015-02-26 |
| WO2008056346A3 (en) | 2008-10-23 |
| JP2010509315A (ja) | 2010-03-25 |
| ATE520712T1 (de) | 2011-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20180112 |