CA2664455A1 - Pharmaceutical compositions of aripiprazole - Google Patents
Pharmaceutical compositions of aripiprazole Download PDFInfo
- Publication number
- CA2664455A1 CA2664455A1 CA002664455A CA2664455A CA2664455A1 CA 2664455 A1 CA2664455 A1 CA 2664455A1 CA 002664455 A CA002664455 A CA 002664455A CA 2664455 A CA2664455 A CA 2664455A CA 2664455 A1 CA2664455 A1 CA 2664455A1
- Authority
- CA
- Canada
- Prior art keywords
- aripiprazole
- composition
- hours
- released
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title claims abstract description 380
- 229960004372 aripiprazole Drugs 0.000 title claims abstract description 374
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 303
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 34
- 238000013270 controlled release Methods 0.000 claims abstract description 30
- -1 seed Substances 0.000 claims description 112
- 239000002552 dosage form Substances 0.000 claims description 92
- 238000009472 formulation Methods 0.000 claims description 90
- 238000000034 method Methods 0.000 claims description 62
- 239000003826 tablet Substances 0.000 claims description 50
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 48
- 239000011159 matrix material Substances 0.000 claims description 45
- 230000003204 osmotic effect Effects 0.000 claims description 36
- 239000003814 drug Substances 0.000 claims description 27
- 229940079593 drug Drugs 0.000 claims description 24
- 239000008187 granular material Substances 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 239000002775 capsule Substances 0.000 claims description 21
- 238000000338 in vitro Methods 0.000 claims description 21
- 238000004090 dissolution Methods 0.000 claims description 20
- 230000036470 plasma concentration Effects 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 17
- 238000009792 diffusion process Methods 0.000 claims description 16
- 238000007922 dissolution test Methods 0.000 claims description 15
- 238000001727 in vivo Methods 0.000 claims description 15
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- 239000008188 pellet Substances 0.000 claims description 14
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- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 4
- 206010037423 Pulmonary oedema Diseases 0.000 claims description 3
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- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 2
- YWPHCCPCQOJSGZ-LLVKDONJSA-N (2r)-2-[(2-ethoxyphenoxy)methyl]morpholine Chemical compound CCOC1=CC=CC=C1OC[C@@H]1OCCNC1 YWPHCCPCQOJSGZ-LLVKDONJSA-N 0.000 claims description 2
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 claims description 2
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims description 2
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
- WIHMBLDNRMIGDW-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3h-2-benzofuran-5-carbonitrile;hydron;bromide Chemical compound [Br-].O1CC2=CC(C#N)=CC=C2C1(CCC[NH+](C)C)C1=CC=C(F)C=C1 WIHMBLDNRMIGDW-UHFFFAOYSA-N 0.000 claims description 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 2
- GLQPTZAAUROJMO-UHFFFAOYSA-N 4-(3,4-dimethoxyphenyl)benzaldehyde Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=O)C=C1 GLQPTZAAUROJMO-UHFFFAOYSA-N 0.000 claims description 2
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- 208000022526 Canavan disease Diseases 0.000 claims description 2
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims description 2
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 claims description 2
- 208000026845 Cochlear disease Diseases 0.000 claims description 2
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- 108050004812 Dopamine receptor Proteins 0.000 claims description 2
- 102000015554 Dopamine receptor Human genes 0.000 claims description 2
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- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 208000011688 Generalised anxiety disease Diseases 0.000 claims description 2
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims description 2
- GUTXTARXLVFHDK-UHFFFAOYSA-N Haloperidol decanoate Chemical compound C1CC(OC(=O)CCCCCCCCC)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 GUTXTARXLVFHDK-UHFFFAOYSA-N 0.000 claims description 2
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- 208000001456 Jet Lag Syndrome Diseases 0.000 claims description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims description 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
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- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims description 2
- RMUCZJUITONUFY-UHFFFAOYSA-N Phenelzine Chemical compound NNCCC1=CC=CC=C1 RMUCZJUITONUFY-UHFFFAOYSA-N 0.000 claims description 2
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- 208000010112 Spinocerebellar Degenerations Diseases 0.000 claims description 2
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- 102100036325 Sterol 26-hydroxylase, mitochondrial Human genes 0.000 claims description 2
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- 229960004538 alprazolam Drugs 0.000 claims description 2
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 claims description 2
- 229960003036 amisulpride Drugs 0.000 claims description 2
- NTJOBXMMWNYJFB-UHFFFAOYSA-N amisulpride Chemical compound CCN1CCCC1CNC(=O)C1=CC(S(=O)(=O)CC)=C(N)C=C1OC NTJOBXMMWNYJFB-UHFFFAOYSA-N 0.000 claims description 2
- 229960000836 amitriptyline Drugs 0.000 claims description 2
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 230000001078 anti-cholinergic effect Effects 0.000 claims description 2
- 239000002249 anxiolytic agent Substances 0.000 claims description 2
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- 208000006673 asthma Diseases 0.000 claims description 2
- 150000001557 benzodiazepines Chemical class 0.000 claims description 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims description 2
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- 229960004782 chlordiazepoxide Drugs 0.000 claims description 2
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 claims description 2
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims description 2
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- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 2
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- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 claims description 2
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- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 claims description 2
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- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 claims description 2
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- QSLMDECMDJKHMQ-GSXCWMCISA-N maprotiline Chemical compound C12=CC=CC=C2[C@@]2(CCCNC)C3=CC=CC=C3[C@@H]1CC2 QSLMDECMDJKHMQ-GSXCWMCISA-N 0.000 claims description 2
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- CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical compound C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 claims description 2
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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| PCT/GB2007/003677 WO2008038003A2 (en) | 2006-09-26 | 2007-09-26 | Pharmaceutical compositions of aripiprazole |
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| GB0618879D0 (en) * | 2006-09-26 | 2006-11-01 | Zysis Ltd | Pharmaceutical compositions |
| AP2975A (en) | 2008-07-16 | 2014-09-30 | Richter Gedeon Nyrt | Pharmaceutical formulations containing dopamine receptor ligands |
| US8372808B2 (en) * | 2008-10-31 | 2013-02-12 | Wisconsin Alumni Research Foundation | Suppression of glial fibrillary acidic protein |
| WO2010146872A1 (ja) * | 2009-06-19 | 2010-12-23 | 株式会社メドレックス | アリピプラゾールと有機酸を有効成分とする外用剤組成物 |
| CN102670553A (zh) * | 2011-03-14 | 2012-09-19 | 北京天衡药物研究院 | 盐酸文拉法辛渗透泵控释片 |
| US9066949B2 (en) | 2011-03-21 | 2015-06-30 | James Conour | Compositions and methods for the treatment of catatonia |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| WO2013175508A2 (en) | 2012-05-24 | 2013-11-28 | Medreich Limited | Stable pharmaceutical composition of aripiprazole |
| CA2905501A1 (en) * | 2013-03-15 | 2014-09-18 | Ameritox, Ltd. | Methods of monitoring for adherence to aripiprazole therapy |
| CN103393594A (zh) * | 2013-08-22 | 2013-11-20 | 万特制药(海南)有限公司 | 一种新的阿立哌唑的制剂组合物 |
| US10525057B2 (en) * | 2013-09-24 | 2020-01-07 | Otsuka Pharmaceutical Co., Ltd. | Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function |
| CN103536594A (zh) * | 2013-10-21 | 2014-01-29 | 江苏亚虹医药科技有限公司 | G蛋白偶联受体拮抗剂在用于制备治疗谷氨酸受体高表达肿瘤药物中的用途 |
| US20190070174A1 (en) * | 2016-03-10 | 2019-03-07 | The Regents Of The University Of Michigan | Methods of treating neurodegenerative diseases |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| HUP1700253A1 (hu) | 2017-06-13 | 2019-01-28 | Richter Gedeon Nyrt | Szilárd orális gyógyszerkészítmények |
| WO2019113084A1 (en) | 2017-12-05 | 2019-06-13 | Sunovion Pharmaceuticals Inc. | Crystal forms and production methods thereof |
| CN118593482A (zh) | 2017-12-05 | 2024-09-06 | 赛诺维信制药公司 | 非外消旋混合物及其用途 |
| CN110025572A (zh) * | 2018-01-11 | 2019-07-19 | 四川科伦药物研究院有限公司 | 月桂酰阿立哌唑混悬剂及其制备方法 |
| JP7059444B2 (ja) * | 2018-05-04 | 2022-04-25 | コリア インスティチュート オブ レディオロジカル アンド メディカル サイエンシズ | アリピプラゾールを有効成分として含有する放射線敏感性増進用組成物 |
| US12138363B2 (en) * | 2018-10-04 | 2024-11-12 | École Polytechnique Fédérale de Lausanne | Cross-linkable polymer, hydrogel, and method of preparation thereof |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| MX2021014774A (es) * | 2019-06-04 | 2022-02-03 | Sunovion Pharmaceuticals Inc | Formulaciones de liberacion modificada y usos de las mismas. |
| EP4271381A4 (en) * | 2020-12-31 | 2024-12-11 | Lake O'Hara LLC | METHODS OF TREATMENT OF PSYCHIATRIC DISORDERS WITH BREXPIPRAZOLE IN OBESE PATIENTS |
| KR102525213B1 (ko) | 2021-01-13 | 2023-04-25 | 아주대학교산학협력단 | Qr 코드가 적용된 구강붕해필름 및 3d 프린팅 기술을 이용한 이의 제조방법 |
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| US5178878A (en) * | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
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| US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
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| MY129350A (en) | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
| EP1397145B1 (en) | 2001-06-19 | 2006-09-06 | Norbert Müller | Use of cox-2 inhibitors for the treatment of schizophrenia, or tic disorders |
| SE0102887D0 (sv) | 2001-08-29 | 2001-08-29 | Astrazeneca Ab | New formulation |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| FR2834212B1 (fr) | 2001-12-27 | 2004-07-09 | Besins Int Belgique | Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques |
| MXPA04007752A (es) | 2002-02-08 | 2005-06-17 | Abbott Lab | Terapia de combinacion para tratamiento de esquizofrenia. |
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| US20040127489A1 (en) | 2002-07-29 | 2004-07-01 | David Pickar | Novel antipsychotic combination therapies and compositions useful therein |
| EP1551393A4 (en) | 2002-07-30 | 2010-06-16 | Peter Migaly | COMBINATION OF THERAPY FOR DEPRESSION, PREVENTION OF SUICIDE AND VARIOUS MEDICAL AND PSYCHIATRIC DISORDERS |
| DE60327225D1 (de) | 2002-08-20 | 2009-05-28 | Bristol Myers Squibb Co | Aripiprazol-komplex-formulierung und verfahren |
| US7038085B2 (en) | 2002-10-25 | 2006-05-02 | Collegium Pharmaceutical, Inc. | Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof |
| WO2004083183A1 (en) | 2003-03-21 | 2004-09-30 | Hetero Drugs Limited | Novel crystalline forms of aripiprazole |
| US20050032811A1 (en) | 2003-08-06 | 2005-02-10 | Josiah Brown | Methods for administering aripiprazole |
| US6987111B2 (en) | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
| WO2005048979A2 (en) * | 2003-10-06 | 2005-06-02 | Torrent Pharmaceuticals Limited | Pharmaceutical composition having casing with multiple micro tablets |
| CA2542836A1 (en) | 2003-10-21 | 2005-05-12 | Alpharma, Inc. | Pharmaceutical formulations containing quetiapine |
| BRPI0415531B8 (pt) * | 2003-10-23 | 2021-05-25 | Otsuka Pharma Co Ltd | formulação de aripiprazol injetável estéril de liberação controlada e método para a sua preparação |
| DE10353196A1 (de) * | 2003-11-13 | 2005-06-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix |
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| WO2005058835A2 (en) | 2003-12-16 | 2005-06-30 | Teva Pharmaceutical Industries Ltd. | Methods of preparing aripiprazole crystalline forms |
| WO2005082370A1 (en) | 2004-01-29 | 2005-09-09 | Pfizer Products Inc. | Combinations of an atypical antipsychotic and an aminomethylpyridyloxymethyl/benzisoxazole azabicyclic derivatives for treating cns disorders |
| CA2563743A1 (en) | 2004-04-22 | 2005-11-03 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for the treatment of sexual disorders ii |
| EP1753460A2 (en) | 2004-05-11 | 2007-02-21 | Pfizer Products Inc. | Combination of atypical antipsychotics and 5-ht1b receptor antagonists |
| TWI338583B (en) | 2004-05-20 | 2011-03-11 | Otsuka Pharma Co Ltd | Solid pharmaceutical formulation |
| WO2006000222A2 (en) | 2004-06-24 | 2006-01-05 | H. Lundbeck A/S | The combination of an antipsychotic and a glycine transporter type i inhibitor for the treatment of schizophrenia |
| WO2006012237A2 (en) | 2004-06-25 | 2006-02-02 | Shanghai Institute Of Pharmaceutical Industry | Aripiprazole crystaline forms and associated methods |
| GB0417702D0 (en) | 2004-08-09 | 2004-09-08 | Merck Sharp & Dohme | New uses |
| WO2006053780A1 (en) | 2004-11-18 | 2006-05-26 | Synthon B.V. | Crystalline aripiprazole solvates |
| CA2590802A1 (en) | 2004-12-20 | 2006-06-29 | Collegium Pharmaceutical, Inc. | Pharmaceutical compositions for sleep disorders |
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| EP2783688A1 (en) | 2005-03-17 | 2014-10-01 | Synhton B.V. | Pharmaceutical tablets of crystalline type ii aripiprazole |
| WO2007004061A1 (en) | 2005-04-15 | 2007-01-11 | Medichem, S.A. | Syntheses and preparations of polymorphs of crystalline aripiprazole |
| HUP0500683A3 (en) | 2005-07-14 | 2009-03-30 | Egis Gyogyszergyar Nyilvanosan | New arylpiprazole salts for producing pharmaceutical composition |
| CA2622758A1 (en) | 2005-09-15 | 2007-03-29 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
| DE602006006536D1 (de) | 2006-01-05 | 2009-06-10 | Teva Pharma | Trockene Aripiprazolformulierungen |
| DE602006004694D1 (de) | 2006-01-05 | 2009-02-26 | Teva Pharma | Feuchtgranulierungsmethode zur Herstellung pharmazeutischer Aripiprazolzusammensetzungen |
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Also Published As
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| US8575172B2 (en) | 2013-11-05 |
| DK2066325T3 (da) | 2012-04-30 |
| JP2010504950A (ja) | 2010-02-18 |
| AU2007301742A1 (en) | 2008-04-03 |
| US20100004262A1 (en) | 2010-01-07 |
| ATE540680T1 (de) | 2012-01-15 |
| PT2066325E (pt) | 2012-04-13 |
| EP2066325A2 (en) | 2009-06-10 |
| WO2008038003A2 (en) | 2008-04-03 |
| IL197574A0 (en) | 2009-12-24 |
| ES2395119T3 (es) | 2013-02-08 |
| AU2007301742B2 (en) | 2013-05-02 |
| WO2008038003A3 (en) | 2008-06-26 |
| KR20090065514A (ko) | 2009-06-22 |
| EP2066325B1 (en) | 2012-01-11 |
| GB0618879D0 (en) | 2006-11-01 |
| US20140044786A1 (en) | 2014-02-13 |
| IL197574A (en) | 2012-07-31 |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150928 |