CA2663044C - Quinolone carboxylic acids, derivatives thereof, and methods of making and using same - Google Patents

Quinolone carboxylic acids, derivatives thereof, and methods of making and using same Download PDF

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Publication number
CA2663044C
CA2663044C CA2663044A CA2663044A CA2663044C CA 2663044 C CA2663044 C CA 2663044C CA 2663044 A CA2663044 A CA 2663044A CA 2663044 A CA2663044 A CA 2663044A CA 2663044 C CA2663044 C CA 2663044C
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Prior art keywords
groups
formula
group
substituted
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2663044A
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English (en)
French (fr)
Other versions
CA2663044A1 (en
Inventor
Arthur E. Harms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Lomb Inc
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Bausch and Lomb Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch and Lomb Inc filed Critical Bausch and Lomb Inc
Publication of CA2663044A1 publication Critical patent/CA2663044A1/en
Application granted granted Critical
Publication of CA2663044C publication Critical patent/CA2663044C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2663044A 2006-10-06 2007-09-24 Quinolone carboxylic acids, derivatives thereof, and methods of making and using same Expired - Fee Related CA2663044C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84992406P 2006-10-06 2006-10-06
US60/849,924 2006-10-06
PCT/US2007/079304 WO2008045673A2 (en) 2006-10-06 2007-09-24 Quinolone carboxylic acids, derivatives thereof, processes for its preparation and its use as antibacterial agents

Publications (2)

Publication Number Publication Date
CA2663044A1 CA2663044A1 (en) 2008-04-17
CA2663044C true CA2663044C (en) 2012-07-24

Family

ID=39186175

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2663044A Expired - Fee Related CA2663044C (en) 2006-10-06 2007-09-24 Quinolone carboxylic acids, derivatives thereof, and methods of making and using same

Country Status (12)

Country Link
US (1) US8227597B2 (https=)
EP (1) EP2074111A2 (https=)
JP (1) JP2010505861A (https=)
KR (1) KR20090061029A (https=)
CN (1) CN101522662A (https=)
AU (1) AU2007307995B2 (https=)
BR (1) BRPI0717513A2 (https=)
CA (1) CA2663044C (https=)
MX (1) MX2009003313A (https=)
SG (1) SG172744A1 (https=)
TW (1) TWI383978B (https=)
WO (1) WO2008045673A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252783B2 (en) * 2007-01-24 2012-08-28 Bausch & Lomb Incorporated Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US20080200442A1 (en) * 2007-02-16 2008-08-21 Srini Venkatesh Compositions and Methods for Treating, Reducing, Ameliorating, or Preventing Infections of the Ear or Upper Respiratory Tract
US8415342B2 (en) * 2008-10-29 2013-04-09 Bausch & Lomb Incorporated Besifloxacin ophthalmic composition for the treatment or control of infection
MX2011005117A (es) 2008-11-15 2011-10-21 Rib X Pharmaceuticals Inc Composiciones antimicrobianas.
US8481526B2 (en) * 2009-03-25 2013-07-09 Bausch & Lomb Incorporated Fluoroquinolone carboxylic acid molecular crystals
CN101759629B (zh) * 2009-12-22 2012-01-11 北大方正集团有限公司 西他沙星中间体的制备方法
CN101974578B (zh) * 2010-10-21 2014-06-11 杭州师范大学 一种复合酶催化水解制备喹诺酮类羧酸中间体的方法
CN102659761B (zh) * 2012-04-27 2017-10-10 常州市亚邦医药研究所有限公司 盐酸贝西沙星的制备方法
CN104327107A (zh) * 2013-10-17 2015-02-04 广东东阳光药业有限公司 一种氟喹诺酮类抗菌药物的制备方法
WO2016120813A1 (en) 2015-01-28 2016-08-04 Mankind Research Centre Fluoroquinolone carboxylic acid compounds and use thereof for the preparation of besifloxacin hydrochloride

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1086735A (en) * 1977-11-03 1980-09-30 John C. Danilewicz Piperidino-quinazolines
JPS606684A (ja) * 1983-06-24 1985-01-14 Hokuriku Seiyaku Co Ltd ７−ホモピペラジン置換−６，８−ジフルオロ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体
CA1283112C (en) 1986-01-20 1991-04-16 Tsutomu Irikura Process for the preparation of quinolonecarboxylic acid derivatives
JPS63132885A (ja) * 1986-11-25 1988-06-04 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
JPS63196579A (ja) * 1987-02-09 1988-08-15 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
JPS63196580A (ja) * 1987-02-09 1988-08-15 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
WO1993024460A1 (en) * 1992-05-26 1993-12-09 Ss Pharmaceutical Co., Ltd. 5-aminoquinolonecarboxylic acid derivative and antibacterial containing the same as active ingredient
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
TW301607B (https=) * 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
FR2706459B1 (fr) * 1993-06-17 1995-08-04 Bouchara Sa Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent.
CZ84199A3 (cs) * 1996-09-13 1999-11-17 Schering Corporation Nové, tricyklické piperidinylové sloučeniny použitelné jako inhibitory farnesylprotein transferasy
US6685958B2 (en) 2001-04-25 2004-02-03 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US6699492B2 (en) 1999-03-31 2004-03-02 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
JP4612301B2 (ja) * 2003-12-26 2011-01-12 広栄化学工業株式会社 １−アルキル−４−アミノメチルピペリジンの製造法
DE102004035203A1 (de) * 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone

Also Published As

Publication number Publication date
WO2008045673A2 (en) 2008-04-17
SG172744A1 (en) 2011-07-28
BRPI0717513A2 (pt) 2013-11-19
EP2074111A2 (en) 2009-07-01
MX2009003313A (es) 2009-04-09
TWI383978B (zh) 2013-02-01
US20120157447A1 (en) 2012-06-21
AU2007307995B2 (en) 2013-01-17
CA2663044A1 (en) 2008-04-17
US8227597B2 (en) 2012-07-24
CN101522662A (zh) 2009-09-02
TW200827348A (en) 2008-07-01
AU2007307995A1 (en) 2008-04-17
JP2010505861A (ja) 2010-02-25
KR20090061029A (ko) 2009-06-15
WO2008045673A3 (en) 2008-05-29

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