CA2660814C - Promedicaments hydrosolubles charges positivement contenant des acides aryl- et heteroarylpropioniques et dotes d'une tres grande vitesse de penetration cutanee - Google Patents
Promedicaments hydrosolubles charges positivement contenant des acides aryl- et heteroarylpropioniques et dotes d'une tres grande vitesse de penetration cutanee Download PDFInfo
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- CA2660814C CA2660814C CA2660814A CA2660814A CA2660814C CA 2660814 C CA2660814 C CA 2660814C CA 2660814 A CA2660814 A CA 2660814A CA 2660814 A CA2660814 A CA 2660814A CA 2660814 C CA2660814 C CA 2660814C
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- Prior art keywords
- diethylaminoethyl
- compound
- acoh
- methyl
- negative ion
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
De nouveaux promédicaments chargés positivement contenant des acides aryl- et hétéroarylpropioniques représentés par la formule générale (1) "Structure 1" et par la formule générale (2) "Structure 2" ont été mis au point et synthétisés. Les composés représentés par la formule générale (1) "Structure 1" et par la formule générale (2) "Structure 2" indiquées ci-dessus peuvent être préparés à partir de dérivés fonctionnels de naproxène, suprofène, acide .alpha.-méthyl-(p-chlorobenzoyl)-5-méthoxy-2-méthylindole 3-acétique, flurbiprofène, carprofène, pranoprofène, benoxaprofène, alminoprofène, acide tiaprofénique, pirprofène, zaltoprofène, bermoprofène, loxoprofène, indoprofène, fenclorac, oxaprozine, fenbufène, orpanoxine, kétorolac, clidanac et les composés apparentés, (par exemple les halogénures d'acides ou les anhydrides mixtes), par réaction avec des alcools, thiols, ou amines appropriés. Ces promédicaments renferment des groupes amino à charge positive qui non seulement augmentent de façon importante la solubilité de ces médicaments, mais encore se lient à la charge négative sur le groupe de tête phosphate de membrane et poussent le promédicament dans le cytosol. Les résultats suggèrent que les promédicaments se diffusent à travers la peau humaine de 100-130 fois plus vite que leurs médicaments parents. Pris par la voie orale, les naproxène, suprofène, acide .alpha.-méthyl-(p-chlorobenzoyl)-5-méthoxy-2-méthylindole 3-acétique, flurbiprofène, carprofène, pranoprofène, benoxaprofène, alminoprofène, acide tiaprofénique, pirprofène, zaltoprofène, bermoprofène, loxoprofène, indoprofène, fenclorac, oxaprozine, fenbufène, orpanoxine, kétorolac, clidanac, et composés apparentés atteignent le taux de plasma de pic en 2-4 heures. Pris par la voie transdermique, les promédicaments ne prennent qu'environ 40-50 minutes pour atteindre le taux de plasma de pic. Dans le plasma, plus de 90% desdits promédicaments peuvent reprendre leur forme de médicament en quelques minutes. Les promédicaments peuvent être utilisés médicalement pour traiter n'importe quelles conditions répondant à un traitement par analgésiques anti-inflammatoires non stéroïdiens NSAIA chez l'homme ou chez l'animal. Les promédicaments peuvent être administrés par voie orale autant que par voie transdermique dans toute thérapeutique et permettetn d'éviter la plupart des effets secondaires des NSAIA, plus particulièrement les troubles gastro-intestinaux tels que la dyspepsie, les saignements gastro-duodénaux, les ulcères gastriques et la gastrite. Les systèmes d'administration transdermique contrôlée des promédicaments permettent aux naproxène, suprofène, acide .alpha.-méthyl-(p-chlorobenzoyl)-5-méthoxy-2-methylindole 3-acétique, flurbiprofène, carprofène, pranoprofène, benoxaprofène, alminoprofène, acide tiaprofénique, pirprofène, zaltoprofène, bermoprofène, loxoprofène, indoprofène, fenclorac, oxaprozine, fenbufène, orpanoxine, kétorolac, clidanac et composés apparentés d'atteindre des taux thérapeutiques sanguins constants permettant d'optimiser l'efficacité et de réduire les effets secondaires des NSAIA. En outre, l'administration transdermique desdits promédicaments permet d'administrer la médication beaucoup plus facilement, notamment aux enfants.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2006/052815 WO2008020270A1 (fr) | 2006-08-15 | 2006-08-15 | Promédicaments hydrosolubles chargés positivement contenant des acides aryl- et hétéroarylpropioniques et dotés d'une très grande vitesse de pénétration cutanée |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2660814A1 CA2660814A1 (fr) | 2008-02-21 |
CA2660814C true CA2660814C (fr) | 2017-07-18 |
Family
ID=39081992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2660814A Active CA2660814C (fr) | 2006-08-15 | 2006-08-15 | Promedicaments hydrosolubles charges positivement contenant des acides aryl- et heteroarylpropioniques et dotes d'une tres grande vitesse de penetration cutanee |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2054384A4 (fr) |
JP (1) | JP5424880B2 (fr) |
CN (1) | CN101506161B (fr) |
AU (1) | AU2006347391B2 (fr) |
CA (1) | CA2660814C (fr) |
HK (1) | HK1137425A1 (fr) |
WO (1) | WO2008020270A1 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
PT2041068T (pt) * | 2006-07-18 | 2017-02-17 | Techfields Biochem Co Ltd | Pró-fármacos solúveis em água positivamente carregados de ibuprofeno com taxa de penetração de pele muito rápida |
JP5378219B2 (ja) | 2006-10-02 | 2013-12-25 | テックフィールズ バイオケム カンパニー リミテッド | 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ |
AU2006350707A1 (en) | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
CA2671938C (fr) | 2006-12-10 | 2017-10-17 | Chongxi Yu | Systemes d'administration transdermique de beta-lactamines |
EP3181132A1 (fr) | 2007-01-15 | 2017-06-21 | Chongxi Yu | Promédicaments positivement chargés solubles dans l'eau de rétinoïdes et de composés semblables à des rétinoïdes ayant des vitesses de pénétration dans la peau très élevées |
PL2115140T3 (pl) | 2007-01-31 | 2017-03-31 | Yu | Dodatnio naładowane rozpuszczalne w wodzie proleki 1H-imidazo[4,5-c]chinolino-4-amin i powiązane związki o bardzo wysokich wskaźnikach penetracji przez skórę |
CN101687792B (zh) * | 2007-06-04 | 2016-03-02 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其医药用途 |
RU2630577C2 (ru) * | 2008-12-04 | 2017-09-11 | Чунси ЮЙ | Композиции интенсивного проникновения и их применение |
EP2427475B1 (fr) | 2009-05-08 | 2020-11-04 | Techfields Biochem Co., Ltd. | Compositions promédicamenteuses à pénétration élevée de peptides et de composés apparentés à des peptides |
US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
AU2013262320B2 (en) | 2012-05-16 | 2018-02-22 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
CN105143174B (zh) * | 2013-03-15 | 2021-01-12 | 苏州泰飞尔医药有限公司 | 治疗帕金森疾病的新型高穿透力药物及其药物组合物 |
JP5940036B2 (ja) * | 2013-10-08 | 2016-06-29 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
US11242319B2 (en) | 2014-11-05 | 2022-02-08 | Flexus Biosciences, Inc. | Immunoregulatory agents |
US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
JP6290947B2 (ja) * | 2016-02-05 | 2018-03-07 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
WO2019210223A1 (fr) | 2018-04-26 | 2019-10-31 | Adt Pharmaceuticals, Llc | Indènes, indanes, azaindènes, azaindanes anticancéreux, compositions pharmaceutiques et utilisations |
CN114746394B (zh) * | 2020-09-09 | 2024-02-02 | 南京海融医药科技股份有限公司 | 一种芳基丙酸衍生物、药物组合物及其制备方法和应用 |
CN117916219A (zh) * | 2021-07-06 | 2024-04-19 | 石家庄迪斯凯威医药科技有限公司 | 一类抗膀胱癌的季胺盐化合物及其应用 |
CN115850289B (zh) * | 2021-09-24 | 2023-10-24 | 石家庄迪斯凯威医药科技有限公司 | 一种新型普拉洛芬衍生物及其药物组合物和用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1593024A (fr) * | 1968-09-18 | 1970-05-25 | ||
CA1012159A (en) * | 1972-06-27 | 1977-06-14 | Michael Marx | Dialkylaminoalkyl esters of 2-(6-methoxy-2-naphthyl) propionic acid and the pharmaceutically acceptable salts thereof |
US3896145A (en) * | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
ZA738203B (en) * | 1972-10-24 | 1975-05-28 | Janssen Pharmaceutica Nv | Aroyl-substituted phenylacetic acid derivatives |
JPS5826744B2 (ja) * | 1975-12-24 | 1983-06-04 | ヒサミツセイヤク カブシキガイシヤ | シンキナプロピオンサン エステルユウドウタイノセイゾウホウ |
IT1090782B (it) * | 1977-11-30 | 1985-06-26 | Menarini Sas | 2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi |
JPS58126846A (ja) * | 1982-01-22 | 1983-07-28 | Kaken Pharmaceut Co Ltd | プロピオン酸アミノアルキルエステル誘導体、その製法およびそれを有効成分とする消炎、鎮痛剤 |
AU1508988A (en) * | 1987-04-27 | 1988-10-27 | Syntex Pharmaceuticals International Ltd. | Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs |
IT1317826B1 (it) * | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
ITMI20010395A1 (it) * | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
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2006
- 2006-08-15 WO PCT/IB2006/052815 patent/WO2008020270A1/fr active Application Filing
- 2006-08-15 CN CN2006800556054A patent/CN101506161B/zh active Active
- 2006-08-15 AU AU2006347391A patent/AU2006347391B2/en not_active Ceased
- 2006-08-15 JP JP2009524242A patent/JP5424880B2/ja not_active Expired - Fee Related
- 2006-08-15 CA CA2660814A patent/CA2660814C/fr active Active
- 2006-08-15 EP EP06795662A patent/EP2054384A4/fr active Pending
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2010
- 2010-01-28 HK HK10100928.5A patent/HK1137425A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN101506161B (zh) | 2013-11-13 |
JP2010500989A (ja) | 2010-01-14 |
JP5424880B2 (ja) | 2014-02-26 |
AU2006347391A1 (en) | 2008-02-21 |
CA2660814A1 (fr) | 2008-02-21 |
HK1137425A1 (en) | 2010-07-30 |
EP2054384A4 (fr) | 2010-11-03 |
WO2008020270A1 (fr) | 2008-02-21 |
EP2054384A1 (fr) | 2009-05-06 |
CN101506161A (zh) | 2009-08-12 |
AU2006347391B2 (en) | 2013-03-07 |
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