CA2658915A1 - Coating composition comprising starch - Google Patents
Coating composition comprising starch Download PDFInfo
- Publication number
- CA2658915A1 CA2658915A1 CA002658915A CA2658915A CA2658915A1 CA 2658915 A1 CA2658915 A1 CA 2658915A1 CA 002658915 A CA002658915 A CA 002658915A CA 2658915 A CA2658915 A CA 2658915A CA 2658915 A1 CA2658915 A1 CA 2658915A1
- Authority
- CA
- Canada
- Prior art keywords
- starch
- formulation
- film
- composition according
- forming agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229920002472 Starch Polymers 0.000 title claims abstract description 69
- 235000019698 starch Nutrition 0.000 title claims abstract description 69
- 239000008107 starch Substances 0.000 title claims abstract description 63
- 239000008199 coating composition Substances 0.000 title claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 83
- 238000009472 formulation Methods 0.000 claims abstract description 45
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 28
- 239000012736 aqueous medium Substances 0.000 claims abstract description 21
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- 208000019399 Colonic disease Diseases 0.000 claims abstract description 6
- 238000003745 diagnosis Methods 0.000 claims abstract description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 39
- 238000000576 coating method Methods 0.000 claims description 38
- 239000006185 dispersion Substances 0.000 claims description 38
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- 239000011248 coating agent Substances 0.000 claims description 30
- 239000001856 Ethyl cellulose Substances 0.000 claims description 26
- 210000001072 colon Anatomy 0.000 claims description 26
- 229920001249 ethyl cellulose Polymers 0.000 claims description 26
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 24
- 239000004480 active ingredient Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 16
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- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
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- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
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- 229960004110 olsalazine Drugs 0.000 description 1
- QQBDLJCYGRGAKP-FOCLMDBBSA-N olsalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=C(C(O)=CC=2)C(O)=O)=C1 QQBDLJCYGRGAKP-FOCLMDBBSA-N 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960002407 prednisolone sodium metasulphobenzoate Drugs 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 239000003340 retarding agent Substances 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- RWFZSORKWFPGNE-VDYYWZOJSA-M sodium;3-[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]carbonylbenzenesulfonate Chemical compound [Na+].O=C([C@@]1(O)CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)[C@@H](O)C[C@@]21C)COC(=O)C1=CC=CC(S([O-])(=O)=O)=C1 RWFZSORKWFPGNE-VDYYWZOJSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Paints Or Removers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0614933.0 | 2006-07-27 | ||
| GB0614933A GB0614933D0 (en) | 2006-07-27 | 2006-07-27 | Composition |
| GB0617215A GB0617215D0 (en) | 2006-09-01 | 2006-09-01 | Composition |
| GB0617215.9 | 2006-09-01 | ||
| PCT/GB2007/050428 WO2008012573A1 (en) | 2006-07-27 | 2007-07-20 | Coating composition comprising starch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2658915A1 true CA2658915A1 (en) | 2008-01-31 |
Family
ID=38698207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002658915A Abandoned CA2658915A1 (en) | 2006-07-27 | 2007-07-20 | Coating composition comprising starch |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090285863A1 (enExample) |
| EP (1) | EP2046306B8 (enExample) |
| JP (1) | JP2009544684A (enExample) |
| AT (1) | ATE553755T1 (enExample) |
| AU (1) | AU2007279036A1 (enExample) |
| BR (1) | BRPI0715362A2 (enExample) |
| CA (1) | CA2658915A1 (enExample) |
| MX (1) | MX2009001085A (enExample) |
| RU (1) | RU2440104C2 (enExample) |
| WO (1) | WO2008012573A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009105409A2 (en) * | 2008-02-19 | 2009-08-27 | Mc Neil-Ppc, Inc. | Dip coated compositions containing a starch having a high amylose content |
| EP2179727B1 (en) | 2008-10-27 | 2013-05-29 | Roquette Freres | Water insoluble polymer: modified starch derivative-based film coatings for colon targeting |
| GB2567493B (en) * | 2017-10-13 | 2019-12-18 | Altus Formulation Inc | Starch-based release modifying excipients and pharmaceutical compositions derived therefrom |
| GB201905940D0 (en) * | 2019-04-29 | 2019-06-12 | Intract Pharma Ltd | 5-aminolevulinic acid for the local treatment of inflammatory bowel disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3034592B2 (ja) * | 1990-11-20 | 2000-04-17 | わかもと製薬株式会社 | 経口用固形製剤及びその製造法 |
| GB9722426D0 (en) * | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| US6514526B1 (en) * | 1998-03-27 | 2003-02-04 | Valtion Teknillinen Tutkimuskeskus | Coated starch capsules and a process for producing them |
| FR2785539B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Particules enrobees d'ibuprofene cristallin granule |
| EP1137011B1 (en) * | 2000-03-21 | 2008-12-10 | STMicroelectronics S.r.l. | String programmable nonvolatile memory with NOR architecture |
| GB0203421D0 (en) * | 2002-02-13 | 2002-04-03 | Alizyme Therapeutics Ltd | Composition |
| US6703044B1 (en) * | 2002-10-25 | 2004-03-09 | Dexcel Pharma Tech, Ltd | Venlafaxine formulations |
| JP5649784B2 (ja) * | 2006-02-07 | 2015-01-07 | エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ | 組成物、基材を組成物でコーティングする方法、被覆基材、製品、フィルム、ペレット、タブレット及びカプセル |
-
2007
- 2007-07-20 AT AT07789340T patent/ATE553755T1/de active
- 2007-07-20 RU RU2009106260/15A patent/RU2440104C2/ru not_active IP Right Cessation
- 2007-07-20 WO PCT/GB2007/050428 patent/WO2008012573A1/en not_active Ceased
- 2007-07-20 EP EP07789340A patent/EP2046306B8/en active Active
- 2007-07-20 JP JP2009521350A patent/JP2009544684A/ja not_active Withdrawn
- 2007-07-20 BR BRPI0715362-7A patent/BRPI0715362A2/pt not_active IP Right Cessation
- 2007-07-20 AU AU2007279036A patent/AU2007279036A1/en not_active Abandoned
- 2007-07-20 CA CA002658915A patent/CA2658915A1/en not_active Abandoned
- 2007-07-20 US US12/375,149 patent/US20090285863A1/en not_active Abandoned
- 2007-07-20 MX MX2009001085A patent/MX2009001085A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2046306B1 (en) | 2012-04-18 |
| WO2008012573A1 (en) | 2008-01-31 |
| RU2009106260A (ru) | 2010-09-10 |
| MX2009001085A (es) | 2009-03-23 |
| RU2440104C2 (ru) | 2012-01-20 |
| BRPI0715362A2 (pt) | 2013-06-18 |
| JP2009544684A (ja) | 2009-12-17 |
| ATE553755T1 (de) | 2012-05-15 |
| EP2046306B8 (en) | 2012-06-27 |
| US20090285863A1 (en) | 2009-11-19 |
| EP2046306A1 (en) | 2009-04-15 |
| AU2007279036A1 (en) | 2008-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20130722 |