CA2658559A1 - Induction de reponses immunes cellulaires au virus de la grippe grace a des compositions de peptides et d'acides nucleiques - Google Patents

Induction de reponses immunes cellulaires au virus de la grippe grace a des compositions de peptides et d'acides nucleiques Download PDF

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Publication number
CA2658559A1
CA2658559A1 CA002658559A CA2658559A CA2658559A1 CA 2658559 A1 CA2658559 A1 CA 2658559A1 CA 002658559 A CA002658559 A CA 002658559A CA 2658559 A CA2658559 A CA 2658559A CA 2658559 A1 CA2658559 A1 CA 2658559A1
Authority
CA
Canada
Prior art keywords
epitope
polynucleotide
hla
epitopes
htl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002658559A
Other languages
English (en)
Inventor
Jeffrey L. Alexander
Scott F. Southwood
Pamuk A. Bisel
Mark J. Newman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epimmune Inc
Original Assignee
Pharmexa Inc.
Jeffrey L. Alexander
Scott F. Southwood
Pamuk A. Bisel
Mark J. Newman
Epimmune Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmexa Inc., Jeffrey L. Alexander, Scott F. Southwood, Pamuk A. Bisel, Mark J. Newman, Epimmune Inc. filed Critical Pharmexa Inc.
Publication of CA2658559A1 publication Critical patent/CA2658559A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645—Dendrimers; Multiple antigen peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA002658559A 2006-07-21 2007-07-23 Induction de reponses immunes cellulaires au virus de la grippe grace a des compositions de peptides et d'acides nucleiques Abandoned CA2658559A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83211206P 2006-07-21 2006-07-21
US60/832,112 2006-07-21
PCT/US2007/016529 WO2008039267A2 (fr) 2006-07-21 2007-07-23 Induction de réponses immunes cellulaires au virus de la grippe grâce à des compositions de peptides et d'acides nucléiques

Publications (1)

Publication Number Publication Date
CA2658559A1 true CA2658559A1 (fr) 2008-04-03

Family

ID=39230737

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002658559A Abandoned CA2658559A1 (fr) 2006-07-21 2007-07-23 Induction de reponses immunes cellulaires au virus de la grippe grace a des compositions de peptides et d'acides nucleiques

Country Status (4)

Country Link
EP (1) EP2069376A4 (fr)
AU (1) AU2007300663A1 (fr)
CA (1) CA2658559A1 (fr)
WO (1) WO2008039267A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111277B2 (en) 2016-12-28 2021-09-07 Invvax, Inc. Influenza vaccines

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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EA017957B1 (ru) 2007-06-25 2013-04-30 Дзе Администрейторс Оф Дзе Тьюлейн Эдьюкейшнл Фанд Композиции и способы, ингибирующие грипп
DK2173376T3 (en) * 2007-08-02 2015-06-29 Biondvax Pharmaceuticals Ltd Multimeric multi-epitope influenza vaccines
EP2296688A2 (fr) * 2007-10-26 2011-03-23 Glykos Finland Oy Vaccin peptidique contre le virus de la grippe
FI20080333A0 (fi) * 2008-05-02 2008-05-02 Glykos Finland Oy Influenssaviruksen nukleiinihappoja ja peptidejä
EP2353610A4 (fr) * 2008-11-19 2013-12-11 Avi Mex S A De C V Lab Vaccin recombinant à vecteur viral inactivé
US8282938B2 (en) * 2008-11-28 2012-10-09 National Institute Of Infectious Diseases Immunogenic compositions comprising liposomes and an influenza PB2 CTL epitope obtained from the highly pathogenic H5N1 strain
WO2010086294A2 (fr) 2009-01-28 2010-08-05 Epimmune Inc. Polypeptides de liaison de pan-dr et leurs utilisations
CA2750922A1 (fr) * 2009-01-28 2010-08-05 Antigen Express, Inc. Peptides hybrides li-key modulant la reponse immunitaire a la grippe
CN101792745B (zh) 2009-02-04 2014-09-17 中国科学院生物物理研究所 流感病毒聚合酶亚基pa氨基端多肽的表达纯化及pa氨基端多肽的晶体结构
CN101565455B (zh) * 2009-05-25 2012-03-14 中国科学院微生物研究所 禽流感h5n1病毒的ctl表位多肽及其应用
CA2761733C (fr) * 2009-06-01 2019-01-08 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Reactifs et procedes de detection de proteines du virus de la grippe
US8865182B2 (en) 2009-07-31 2014-10-21 Paxvax, Inc. Adenoviral-based vectors
CA2775720A1 (fr) * 2009-09-30 2011-04-07 Saint Louis University Peptides declenchant des reponses hetero sous-typiques des lymphocytes t contre la grippe
CN102153621B (zh) * 2010-02-12 2014-07-02 广东省疾病预防控制中心 新型甲型h1n1流感na蛋白b细胞表位及其应用
EP2536747B1 (fr) 2010-02-19 2017-09-27 Université de Liège Un polynucleotide pour l'utilisation dans les traitements de maldies induites par des virus influenza a virus, codant pour une proteine modifiee, cette proteine modifiee et un animal transgénique exprimant un gène codant pour cette protéine modifiée
WO2011138032A2 (fr) * 2010-05-05 2011-11-10 Artemev, Timur Vaccins antigrippaux universels et leurs procédés de production
WO2012040127A1 (fr) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Analogues nucléotidiques substitués
CA2828068C (fr) 2011-02-22 2019-03-19 Biondvax Pharmaceuticals Ltd. Polypeptides multimeres multi-epitopes utilises dans des vaccins contre la grippe saisonniere et pandemique
US20140302124A1 (en) * 2011-10-19 2014-10-09 Immunotape, Inc. Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of INFLUENZA VIRUS INFECTION
CA2860234A1 (fr) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Analogues de nucleotide phosphorothioate substitue
WO2013093514A2 (fr) * 2011-12-23 2013-06-27 Retroscreen Virology Ltd Vaccins - peptides
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
MX2015008847A (es) * 2013-01-10 2015-10-30 Novartis Ag Composiciones inmunogenicas de virus de influenza y usos de las mismas.
CN103333224B (zh) * 2013-05-10 2015-03-25 中国农业科学院哈尔滨兽医研究所 禽流感病毒ns1蛋白b细胞抗原表位多肽及其应用
WO2015186721A1 (fr) * 2014-06-03 2015-12-10 国立研究開発法人農業・食品産業技術総合研究機構 Anticorps ou fragment d'anticorps comprenant une région variable de celui-ci, polypeptide antigénique et utilisations de ceux-ci
CN106589105B (zh) * 2017-01-23 2020-09-15 中国医科大学 Hla-a2限制性ecm1特异性的ctl表位肽及其应用
US11517617B2 (en) 2017-09-08 2022-12-06 The University Of Melbourne Methods and compositions for preventing influenza infection
EP3851120A4 (fr) * 2018-09-11 2022-04-27 Shanghai Public Health Clinical Center Immunogène pour vaccin à large spectre contre la grippe, et application de celui-ci
EP4168428A1 (fr) * 2020-06-19 2023-04-26 Intervet International B.V. Vaccin contre le virus de la grippe porcine comprenant une construction d'acide nucléique codant pour des antigènes de lignées de virus spécifiques
JP2023530134A (ja) * 2020-06-19 2023-07-13 インターベット インターナショナル ベー． フェー． ウイルスの別々のノイラミニダーゼ抗原をエンコードする第１、第２および第３の核酸配列を含む核酸構築物を含むブタインフルエンザａウイルスワクチン
WO2022032274A1 (fr) * 2020-08-02 2022-02-10 Richard Ascione Compositions de vaccins contre les virus de la grippe et méthodes d'utilisation
JP2023541807A (ja) * 2020-08-25 2023-10-04 ジェネンテック， インコーポレイテッド Ｍｈｃｉペプチド結合の特徴づけのためのアッセイおよび試薬
CN116410271A (zh) * 2023-03-13 2023-07-11 华南农业大学 H5n1亚型aiv mhc b1限制性t细胞表位肽及其应用

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Publication number Priority date Publication date Assignee Title
US7572620B2 (en) * 2005-01-11 2009-08-11 Wisconsin Alumni Research Foundation H3 equine influenza A virus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111277B2 (en) 2016-12-28 2021-09-07 Invvax, Inc. Influenza vaccines
US11739127B2 (en) 2016-12-28 2023-08-29 Invvax, Inc. Influenza vaccines

Also Published As

Publication number Publication date
AU2007300663A1 (en) 2008-04-03
WO2008039267A3 (fr) 2008-12-31
EP2069376A2 (fr) 2009-06-17
EP2069376A4 (fr) 2013-10-16
WO2008039267A2 (fr) 2008-04-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20140723