CA2657989A1 - Adjuvant-sparing multi-dose influenza vaccination regimen - Google Patents
Adjuvant-sparing multi-dose influenza vaccination regimen Download PDFInfo
- Publication number
- CA2657989A1 CA2657989A1 CA002657989A CA2657989A CA2657989A1 CA 2657989 A1 CA2657989 A1 CA 2657989A1 CA 002657989 A CA002657989 A CA 002657989A CA 2657989 A CA2657989 A CA 2657989A CA 2657989 A1 CA2657989 A1 CA 2657989A1
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- Prior art keywords
- vaccine
- adjuvant
- influenza virus
- dose
- influenza
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940031626 subunit vaccine Drugs 0.000 description 1
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- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
- 229960002766 tetanus vaccines Drugs 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
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- 229960004906 thiomersal Drugs 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 150000003611 tocopherol derivatives Chemical class 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- GLFDLEXFOHUASB-UHFFFAOYSA-N trimethyl(tetradecyl)azanium Chemical class CCCCCCCCCCCCCC[N+](C)(C)C GLFDLEXFOHUASB-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 229940021648 varicella vaccine Drugs 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000007444 viral RNA synthesis Effects 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
- 239000010698 whale oil Substances 0.000 description 1
- 229940126581 whole-virion vaccine Drugs 0.000 description 1
- 241000228158 x Triticosecale Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81466506P | 2006-06-15 | 2006-06-15 | |
| US60/814,665 | 2006-06-15 | ||
| PCT/IB2007/002724 WO2007144772A2 (en) | 2006-06-15 | 2007-06-15 | Adjuvant-sparing multi-dose influenza vaccination regimen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2657989A1 true CA2657989A1 (en) | 2007-12-21 |
Family
ID=38832174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002657989A Abandoned CA2657989A1 (en) | 2006-06-15 | 2007-06-15 | Adjuvant-sparing multi-dose influenza vaccination regimen |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20090220545A1 (https=) |
| EP (1) | EP2032163B1 (https=) |
| JP (2) | JP5566687B2 (https=) |
| KR (1) | KR20090016704A (https=) |
| CN (1) | CN101500603A (https=) |
| AU (1) | AU2007258874B2 (https=) |
| BR (1) | BRPI0713150A8 (https=) |
| CA (1) | CA2657989A1 (https=) |
| CY (1) | CY1114315T1 (https=) |
| DK (1) | DK2032163T3 (https=) |
| EA (1) | EA017441B1 (https=) |
| ES (1) | ES2401484T3 (https=) |
| PL (1) | PL2032163T3 (https=) |
| PT (1) | PT2032163E (https=) |
| SI (1) | SI2032163T1 (https=) |
| WO (1) | WO2007144772A2 (https=) |
| ZA (1) | ZA200810582B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CA2628152C (en) * | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| JP5518041B2 (ja) * | 2008-03-18 | 2014-06-11 | ノバルティス アーゲー | インフルエンザウイルスワクチン抗原の調製における改良 |
| GB0905570D0 (en) * | 2009-03-31 | 2009-05-13 | Novartis Ag | Combined vaccines |
| EP3173097A3 (en) | 2009-02-10 | 2017-07-12 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| KR101176305B1 (ko) * | 2009-10-14 | 2012-08-23 | 웅진코웨이주식회사 | 붉나무 추출물을 포함하는 인플루엔자 바이러스 감염의 예방용 조성물, 상기 조성물을 포함하는 기상필터 및 상기 필터를 포함하는 공기청정기 |
| KR101153630B1 (ko) * | 2009-10-16 | 2012-06-18 | 웅진코웨이주식회사 | 타닌산을 포함하는 인플루엔자 바이러스 감염의 예방용 조성물, 상기 조성물을 포함하는 기상필터 및 상기 필터를 포함하는 공기청정기 |
| US20110126501A1 (en) | 2009-10-16 | 2011-06-02 | Woongjin Coway Co., Ltd. | Composition for prevention of influenza viral infection comprising tannic acid, air filter comprising the same and air cleaning device comprising the filter |
| WO2011102873A1 (en) * | 2010-02-21 | 2011-08-25 | Innovative Bottles, Llc | Biodegradable pharmacy container and safety cap |
| EP2525815B1 (en) * | 2010-01-24 | 2015-02-25 | Novartis AG | Irradiated biodegradable polymer microparticles |
| US8852157B2 (en) | 2010-02-21 | 2014-10-07 | Innovative Bottles, Llc | Disposable items made from bioplastic resins |
| PL2569007T3 (pl) * | 2010-05-11 | 2016-04-29 | Intervet Int Bv | Szczepionka przeciwko Mycoplasma Hyopneumoniae, odpowiednia do podawania w obecności przeciwciał pochodzących od matki |
| WO2012117377A1 (en) * | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| WO2016011343A1 (en) | 2014-07-17 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Her3 peptides and dendritic cell vaccines |
| WO2016068333A1 (ja) * | 2014-10-30 | 2016-05-06 | 中外製薬株式会社 | シリンジキャップを具備した、針付プレフィルドシリンジ製剤 |
| US10406290B2 (en) | 2015-02-03 | 2019-09-10 | Merz Pharma Gmbh & Co. Kgaa | Botulinum toxin prefilled plastic syringe |
| US11013795B2 (en) | 2015-06-26 | 2021-05-25 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| CA2992925A1 (en) * | 2015-07-17 | 2017-01-26 | The Trustees Of The University Of Pennsylvania | Identification of immunogenic mhc class ii peptides for immune-based therapy |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| WO2019121513A1 (en) | 2017-12-18 | 2019-06-27 | Intervet International B.V. | Swine influenza a virus vaccine |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990001947A1 (en) | 1988-08-25 | 1990-03-08 | The Liposome Company, Inc. | Affinity associated vaccine |
| AU631377B2 (en) * | 1988-08-25 | 1992-11-26 | Liposome Company, Inc., The | Affinity associated vaccine |
| GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
| DE10012370A1 (de) * | 2000-03-14 | 2001-09-27 | Chiron Behring Gmbh & Co | Adjuvans für Vakzinen |
| DK1635863T3 (da) * | 2003-06-17 | 2010-11-22 | Mannkind Corp | Sammensætninger til udløsning, forbedring og opretholdelse af immunresponser mod MHC-klasse-i-begrænsede epitoper til profylaktiske eller terapeutiske formål |
| JP5600375B2 (ja) * | 2004-03-09 | 2014-10-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | インフルエンザウイルスワクチン |
| AR054020A1 (es) | 2005-03-23 | 2007-05-30 | Glaxosmithkline Biolog Sa | Nuevo uso |
| AU2006310338A1 (en) * | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Adminstration routes for priming/boosting with influenza vaccines |
| TWI457133B (zh) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
-
2007
- 2007-06-15 WO PCT/IB2007/002724 patent/WO2007144772A2/en not_active Ceased
- 2007-06-15 BR BRPI0713150A patent/BRPI0713150A8/pt not_active Application Discontinuation
- 2007-06-15 DK DK07804945.9T patent/DK2032163T3/da active
- 2007-06-15 SI SI200731201T patent/SI2032163T1/sl unknown
- 2007-06-15 EP EP07804945A patent/EP2032163B1/en not_active Revoked
- 2007-06-15 JP JP2009514931A patent/JP5566687B2/ja active Active
- 2007-06-15 AU AU2007258874A patent/AU2007258874B2/en active Active
- 2007-06-15 ES ES07804945T patent/ES2401484T3/es active Active
- 2007-06-15 EA EA200970013A patent/EA017441B1/ru not_active IP Right Cessation
- 2007-06-15 CA CA002657989A patent/CA2657989A1/en not_active Abandoned
- 2007-06-15 US US12/304,919 patent/US20090220545A1/en not_active Abandoned
- 2007-06-15 CN CNA2007800273327A patent/CN101500603A/zh active Pending
- 2007-06-15 PL PL07804945T patent/PL2032163T3/pl unknown
- 2007-06-15 KR KR1020087030382A patent/KR20090016704A/ko not_active Ceased
- 2007-06-15 PT PT78049459T patent/PT2032163E/pt unknown
-
2008
- 2008-12-12 ZA ZA200810582A patent/ZA200810582B/xx unknown
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2011
- 2011-09-19 US US13/236,538 patent/US8808686B2/en active Active
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2013
- 2013-02-25 CY CY20131100167T patent/CY1114315T1/el unknown
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2014
- 2014-02-28 JP JP2014037950A patent/JP5981951B2/ja active Active
- 2014-07-08 US US14/326,299 patent/US9901630B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200810582B (en) | 2009-09-30 |
| EA200970013A1 (ru) | 2009-06-30 |
| JP5566687B2 (ja) | 2014-08-06 |
| WO2007144772A3 (en) | 2008-03-27 |
| KR20090016704A (ko) | 2009-02-17 |
| US9901630B2 (en) | 2018-02-27 |
| US20090220545A1 (en) | 2009-09-03 |
| CY1114315T1 (el) | 2016-08-31 |
| US20120039934A1 (en) | 2012-02-16 |
| US20140370053A1 (en) | 2014-12-18 |
| EP2032163A2 (en) | 2009-03-11 |
| EP2032163B1 (en) | 2013-01-23 |
| CN101500603A (zh) | 2009-08-05 |
| DK2032163T3 (da) | 2013-03-25 |
| SI2032163T1 (sl) | 2013-05-31 |
| EA017441B1 (ru) | 2012-12-28 |
| US8808686B2 (en) | 2014-08-19 |
| AU2007258874B2 (en) | 2013-11-14 |
| HK1129205A1 (en) | 2009-11-20 |
| JP2009539965A (ja) | 2009-11-19 |
| JP5981951B2 (ja) | 2016-08-31 |
| WO2007144772A2 (en) | 2007-12-21 |
| JP2014098038A (ja) | 2014-05-29 |
| BRPI0713150A2 (pt) | 2012-03-27 |
| AU2007258874A1 (en) | 2007-12-21 |
| PL2032163T3 (pl) | 2013-06-28 |
| ES2401484T3 (es) | 2013-04-22 |
| BRPI0713150A8 (pt) | 2017-08-22 |
| PT2032163E (pt) | 2013-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20181206 |