CA2656295A1 - Methods, mixtures, kits and compositions pertaining to analyte determination - Google Patents

Methods, mixtures, kits and compositions pertaining to analyte determination Download PDF

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Publication number
CA2656295A1
CA2656295A1 CA002656295A CA2656295A CA2656295A1 CA 2656295 A1 CA2656295 A1 CA 2656295A1 CA 002656295 A CA002656295 A CA 002656295A CA 2656295 A CA2656295 A CA 2656295A CA 2656295 A1 CA2656295 A1 CA 2656295A1
Authority
CA
Canada
Prior art keywords
independently
substituted
hydrogen
analyte
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002656295A
Other languages
English (en)
French (fr)
Inventor
Subhasish Purkayastha
Subhakar Dey
Scott B. Daniels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2656295A1 publication Critical patent/CA2656295A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002656295A 2006-06-30 2007-06-29 Methods, mixtures, kits and compositions pertaining to analyte determination Abandoned CA2656295A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81751306P 2006-06-30 2006-06-30
US60/817,513 2006-06-30
US11/770,212 US7906341B2 (en) 2006-06-30 2007-06-28 Methods, mixtures, kits and compositions pertaining to analyte determination
US11/770,212 2007-06-28
PCT/US2007/072503 WO2008005846A2 (en) 2006-06-30 2007-06-29 Methods, mixtures, kits and compositions pertaining to analyte determination

Publications (1)

Publication Number Publication Date
CA2656295A1 true CA2656295A1 (en) 2008-01-10

Family

ID=38752488

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002656295A Abandoned CA2656295A1 (en) 2006-06-30 2007-06-29 Methods, mixtures, kits and compositions pertaining to analyte determination

Country Status (6)

Country Link
US (1) US7906341B2 (cg-RX-API-DMAC7.html)
EP (1) EP2041105A2 (cg-RX-API-DMAC7.html)
JP (2) JP5548447B2 (cg-RX-API-DMAC7.html)
AU (1) AU2007269232A1 (cg-RX-API-DMAC7.html)
CA (1) CA2656295A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008005846A2 (cg-RX-API-DMAC7.html)

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US20050148087A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
US7972867B2 (en) * 2005-04-06 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites by mass spectrometry
US7972868B2 (en) 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
WO2010099108A2 (en) * 2009-02-24 2010-09-02 Mayo Foundation For Medical Education And Research Multiplexing derivatized anayltes using mass spectroscopy
ES2890501T3 (es) 2009-03-02 2022-01-20 Massachusetts Inst Technology Métodos y productos para la creación de perfiles enzimáticos in vivo
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
US8034627B2 (en) 2009-12-03 2011-10-11 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
WO2011072152A1 (en) * 2009-12-11 2011-06-16 Quest Diagnostics Investments Incorporated Mass spectrometry of steroidal compounds in multiplex samples
WO2011072168A1 (en) 2009-12-11 2011-06-16 Quest Diagnostics Investments Incorporated Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d
WO2011075530A1 (en) * 2009-12-15 2011-06-23 Dh Technologies Development Pte. Ltd. Analysis of amino acids and amine-containing compounds using tagging reagents and lc-ms workflow
WO2011146521A2 (en) * 2010-05-17 2011-11-24 The Uab Research Foundation A general mass spectrometry assay using continuously eluting co-fractionating reporters of mass spectrometry detection efficiency
EP3950704A1 (en) 2011-03-15 2022-02-09 Massachusetts Institute Of Technology Multiplexed detection with isotope-coded reporters
US9388132B2 (en) 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
US9129783B2 (en) * 2012-04-05 2015-09-08 Micromass Uk Limited MS/MS analysis using ECD or ETD fragmentation
CN102944604B (zh) * 2012-07-18 2015-02-18 中国科学院上海有机化学研究所 哌嗪基嘧啶类同位素标记试剂的用途
WO2014066284A1 (en) 2012-10-22 2014-05-01 President And Fellows Of Harvard College Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry
US9366678B2 (en) 2012-10-25 2016-06-14 Wisconsin Alumni Research Foundation Neutron encoded mass tags for analyte quantification
ES2828985T3 (es) 2013-06-07 2021-05-28 Massachusetts Inst Technology Detección basada en la afinidad de biomarcadores sintéticos codificados por ligando
GB201521903D0 (en) * 2015-12-11 2016-01-27 Electrophoretics Ltd Isorbaric mass labels
WO2017177115A1 (en) 2016-04-08 2017-10-12 Massachusetts Institute Of Technology Methods to specifically profile protease activity at lymph nodes
EP3452407B1 (en) 2016-05-05 2024-04-03 Massachusetts Institute Of Technology Methods and uses for remotely triggered protease activity measurements
WO2017210427A1 (en) 2016-06-03 2017-12-07 President And Fellows Of Harvard College Techniques for high throughput targeted proteomic analysis and related systems and methods
JP7051871B2 (ja) 2016-12-23 2022-04-11 エフ．ホフマン－ラ ロシュ アーゲー 分析系におけるプロセス中に試薬を同定するための方法
EP3559657B1 (en) * 2016-12-23 2025-06-18 Roche Diagnostics GmbH Method for identifying a reagent during a process in an analysis system
EP3607085A1 (en) 2017-04-07 2020-02-12 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
US11054428B2 (en) 2018-03-05 2021-07-06 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
US12173349B2 (en) 2018-09-25 2024-12-24 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
EP3911753A1 (en) 2019-01-17 2021-11-24 Massachusetts Institute of Technology Sensors for detecting and imaging of cancer metastasis
WO2023013047A1 (ja) * 2021-08-06 2023-02-09 株式会社島津製作所 ペプチド分析方法及びペプチド分析装置
CN114019062B (zh) * 2022-01-05 2022-03-25 河北欣港药业有限公司 一种利福平中有关物质的检测方法

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US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
CZ217698A3 (cs) * 1996-04-08 1998-12-16 Glaxo Group Limited Způsob sledování průběhu reakce
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US6270976B1 (en) * 1998-09-15 2001-08-07 Brax Group Limited Characterizing nucleic acid by mass spectrometry
US7183116B2 (en) * 2001-05-14 2007-02-27 The Institute For Systems Biology Methods for isolation and labeling of sample molecules
US7132295B2 (en) * 2001-11-09 2006-11-07 Bayer Aktiengesellschaft Isotopically coded affinity markers 3
US7473535B2 (en) 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
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US8975404B2 (en) 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same

Also Published As

Publication number Publication date
JP2010249838A (ja) 2010-11-04
US7906341B2 (en) 2011-03-15
JP5548447B2 (ja) 2014-07-16
AU2007269232A1 (en) 2008-01-10
JP2009543069A (ja) 2009-12-03
WO2008005846A3 (en) 2008-03-06
EP2041105A2 (en) 2009-04-01
WO2008005846A2 (en) 2008-01-10
US20080241955A1 (en) 2008-10-02

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20130702