CA2653472A1 - Novel lapachone compounds and methods of use thereof - Google Patents

Novel lapachone compounds and methods of use thereof Download PDF

Info

Publication number
CA2653472A1
CA2653472A1 CA002653472A CA2653472A CA2653472A1 CA 2653472 A1 CA2653472 A1 CA 2653472A1 CA 002653472 A CA002653472 A CA 002653472A CA 2653472 A CA2653472 A CA 2653472A CA 2653472 A1 CA2653472 A1 CA 2653472A1
Authority
CA
Canada
Prior art keywords
compound
dione
spiro
substituted
oxathiine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002653472A
Other languages
English (en)
French (fr)
Inventor
Mark Ashwell
Manish Tandon
Jean-Marc Lapierre
Syed Ali
David Vensel
Chiang J. Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arqule Inc
Original Assignee
Arqule, Inc.
Mark Ashwell
Manish Tandon
Jean-Marc Lapierre
Syed Ali
David Vensel
Chiang J. Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule, Inc., Mark Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, David Vensel, Chiang J. Li filed Critical Arqule, Inc.
Publication of CA2653472A1 publication Critical patent/CA2653472A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002653472A 2006-05-26 2006-08-21 Novel lapachone compounds and methods of use thereof Abandoned CA2653472A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80886106P 2006-05-26 2006-05-26
US60/808,861 2006-05-26
PCT/US2006/032660 WO2007139569A1 (en) 2006-05-26 2006-08-21 Novel lapachone compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2653472A1 true CA2653472A1 (en) 2007-12-06

Family

ID=37845346

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002653472A Abandoned CA2653472A1 (en) 2006-05-26 2006-08-21 Novel lapachone compounds and methods of use thereof

Country Status (4)

Country Link
EP (1) EP2035435A1 (ja)
JP (1) JP2009538298A (ja)
CA (1) CA2653472A1 (ja)
WO (1) WO2007139569A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009051752A1 (en) * 2007-10-16 2009-04-23 Arqule, Inc. Novel lapachone compounds and methods of use thereof
CN102186809A (zh) * 2008-08-14 2011-09-14 拜尔农作物科学股份公司 杀虫性的4-苯基-1h-吡唑
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds
JP2023533187A (ja) * 2020-07-10 2023-08-02 ナディアンバイオ・リミテッド ナフトキノンベースの化合物及び免疫チェックポイント阻害剤を、活性成分として含む、がんを防止又は処置するための医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061142A1 (en) * 1999-04-14 2000-10-19 Dana-Farber Cancer Institute, Inc. Method and composition for the treatment of cancer
EP1567515A4 (en) * 2002-11-18 2008-04-23 Arqule Inc NEW LAPACHONE COMPOUNDS AND METHODS FOR THE APPLICATION
WO2006128120A2 (en) * 2005-05-26 2006-11-30 Arqule, Inc. Novel lapachone compounds and methods of use thereof

Also Published As

Publication number Publication date
EP2035435A1 (en) 2009-03-18
JP2009538298A (ja) 2009-11-05
WO2007139569A1 (en) 2007-12-06

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20130821