CA2642813A1 - Inhibitors of histone deacetylase - Google Patents

Inhibitors of histone deacetylase Download PDF

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Publication number
CA2642813A1
CA2642813A1 CA002642813A CA2642813A CA2642813A1 CA 2642813 A1 CA2642813 A1 CA 2642813A1 CA 002642813 A CA002642813 A CA 002642813A CA 2642813 A CA2642813 A CA 2642813A CA 2642813 A1 CA2642813 A1 CA 2642813A1
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CA
Canada
Prior art keywords
amino
phenyl
benzamide
oxoethyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002642813A
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English (en)
French (fr)
Inventor
Jonathan B. Grimm
Jed L. Hubbs
Thomas Miller
Karin M. Otte
Phieng Siliphaivanh
Matthew G. Stanton
Kevin Wilson
David Witter
Hua Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CA2642813A1 publication Critical patent/CA2642813A1/en
Abandoned legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

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CA002642813A 2006-02-28 2007-02-23 Inhibitors of histone deacetylase Abandoned CA2642813A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77771406P 2006-02-28 2006-02-28
US60/777,714 2006-02-28
PCT/US2007/004724 WO2007100657A2 (en) 2006-02-28 2007-02-23 Inhibitors of histone deacetylase

Publications (1)

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CA2642813A1 true CA2642813A1 (en) 2007-09-07

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CA002642813A Abandoned CA2642813A1 (en) 2006-02-28 2007-02-23 Inhibitors of histone deacetylase

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US (1) US8168658B2 (enExample)
EP (1) EP1991226B1 (enExample)
JP (1) JP2009528354A (enExample)
AU (1) AU2007221207A1 (enExample)
CA (1) CA2642813A1 (enExample)
WO (1) WO2007100657A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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US8017321B2 (en) 2004-01-23 2011-09-13 The Regents Of The University Of Colorado, A Body Corporate Gefitinib sensitivity-related gene expression and products and methods related thereto
WO2005117553A2 (en) 2004-05-27 2005-12-15 The Regents Of The University Of Colorado Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
WO2009002495A1 (en) * 2007-06-27 2008-12-31 Merck & Co., Inc. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8461189B2 (en) * 2007-06-27 2013-06-11 Merck Sharp & Dohme Corp. Pyridyl derivatives as histone deacetylase inhibitors
MX2010008021A (es) * 2008-01-29 2010-08-04 Hoffmann La Roche Nuevos derivados de n-(2-amino-fenil)-amida.
AU2009228931B2 (en) 2008-03-27 2013-05-23 Janssen Pharmaceutica Nv Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
CA2724003A1 (en) 2008-05-16 2009-11-19 F. Hoffmann-La Roche Ag Novel n-(2-amino-phenyl)-acrylamides
KR20110028262A (ko) 2008-05-23 2011-03-17 산텐 세이야꾸 가부시키가이샤 우레아 구조를 갖는 신규 티오펜디아민 유도체
CA2735593C (en) 2008-09-03 2017-08-15 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
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