CA2638734A1 - Inhibiteurs de la reponse aux proteines non depliees et procedes d'utilisation - Google Patents
Inhibiteurs de la reponse aux proteines non depliees et procedes d'utilisation Download PDFInfo
- Publication number
- CA2638734A1 CA2638734A1 CA002638734A CA2638734A CA2638734A1 CA 2638734 A1 CA2638734 A1 CA 2638734A1 CA 002638734 A CA002638734 A CA 002638734A CA 2638734 A CA2638734 A CA 2638734A CA 2638734 A1 CA2638734 A1 CA 2638734A1
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- Prior art keywords
- hydrogen
- pharmaceutical composition
- compound
- alkyl
- xbp
- Prior art date
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77745806P | 2006-02-27 | 2006-02-27 | |
| US60/777,458 | 2006-02-27 | ||
| PCT/US2007/062917 WO2007101224A2 (fr) | 2006-02-27 | 2007-02-27 | Inhibiteurs de la reponse aux proteines non depliees et procedes d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2638734A1 true CA2638734A1 (fr) | 2007-09-07 |
Family
ID=38459802
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002638735A Abandoned CA2638735A1 (fr) | 2006-02-27 | 2007-02-27 | Procedes permettant d'identifier les inhibiteurs de reponse aux proteines depliees |
| CA002638734A Abandoned CA2638734A1 (fr) | 2006-02-27 | 2007-02-27 | Inhibiteurs de la reponse aux proteines non depliees et procedes d'utilisation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002638735A Abandoned CA2638735A1 (fr) | 2006-02-27 | 2007-02-27 | Procedes permettant d'identifier les inhibiteurs de reponse aux proteines depliees |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8372861B2 (fr) |
| EP (1) | EP1999303A4 (fr) |
| AU (2) | AU2007220039A1 (fr) |
| CA (2) | CA2638735A1 (fr) |
| WO (2) | WO2007101225A2 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007101225A2 (fr) | 2006-02-27 | 2007-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Procedes permettant d'identifier les inhibiteurs de reponse aux proteines depliees |
| WO2008154484A1 (fr) * | 2007-06-08 | 2008-12-18 | Mannkind Corporation | Inhibiteurs d'ire-1a |
| EP2391372A4 (fr) * | 2009-01-30 | 2013-07-03 | Bayer Healthcare Llc | Méthodes de traitement de cancer positif aux récepteurs oestrogéniques par inhibition de la protéine de liaison à la boîte x 1 (xbp1) |
| CA2780149C (fr) | 2009-11-03 | 2019-06-18 | Mannkind Corporation | Inhibiteurs de l'ire-1.alpha. |
| US20120028933A1 (en) | 2010-07-28 | 2012-02-02 | Baust John M | Cell Culture Media Supplement and Method of Molecular Stress Control |
| WO2012064774A1 (fr) | 2010-11-10 | 2012-05-18 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibiteur spécifique de l'endonucléase ire1 alpha ayant une activité cytotoxique |
| WO2012109238A2 (fr) | 2011-02-07 | 2012-08-16 | President And Fellows Of Harvard College | Procédés d'augmentation des réponses immunitaires à l'aide d'agents qui se lient directement à ire-1 et activent ire-1 |
| US9359299B2 (en) | 2011-04-04 | 2016-06-07 | Georgetown University | Small molecules for treating breast cancer |
| JP2014512008A (ja) * | 2011-04-13 | 2014-05-19 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 炎症性腸疾患の処置のためのスクリーニング法および薬学的組成物 |
| WO2013134774A1 (fr) * | 2012-03-09 | 2013-09-12 | Cornell University | Modulation de la croissance du cancer du sein par modulation de l'activité de la xbp1 |
| US9296994B2 (en) | 2012-04-23 | 2016-03-29 | Imba-Institut Für Molekulare Biotechnologie Gmbh | Archease as RNA ligaes complex member |
| AU2013323426A1 (en) | 2012-09-26 | 2015-04-23 | The Regents Of The University Of California | Modulation of ire1 |
| EP3632208A1 (fr) | 2013-06-13 | 2020-04-08 | Biomatrica, INC. | Stabilisation de cellules |
| DK3049521T3 (en) | 2013-09-25 | 2019-04-23 | Univ Cornell | Compounds for inducing antitumor immunity and methods thereof |
| US9447054B2 (en) * | 2014-01-15 | 2016-09-20 | Korea Institute Of Radiological & Medical Sciences | Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient |
| KR101643281B1 (ko) * | 2014-01-15 | 2016-08-11 | 한국원자력의학원 | 벤조[ｄ]옥사졸 유도체를 유효성분으로 함유하는 항암활성 보조제 |
| CA2938311C (fr) | 2014-02-03 | 2023-03-07 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de ror-gamma a base de dihydropyrrolopyridine |
| WO2015178770A1 (fr) * | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions pour le traitement du cancer |
| SI3207043T1 (sl) | 2014-10-14 | 2019-04-30 | Vitae Pharmaceuticals, Inc. | Dihidropirolopiridinovi inhibitorji za ROR-gama |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| JP2018500388A (ja) * | 2014-11-18 | 2018-01-11 | ラットガーズ、ザ ステート ユニバーシティ オブ ニュージャージー | 代謝疾患及び癌の治療のための、新規ミトコンドリアアンカップラー |
| US10301261B2 (en) | 2015-08-05 | 2019-05-28 | Vitae Pharmaceuticals, Llc | Substituted indoles as modulators of ROR-gamma |
| CN108463458B (zh) | 2015-11-20 | 2022-02-01 | 生命医药有限责任公司 | ROR-γ的调节剂 |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| WO2017201313A1 (fr) | 2016-05-18 | 2017-11-23 | Shengkan Jin | Nouveaux découplants mitochondriaux pour le traitement de maladies métaboliques et du cancer |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
| WO2018145080A1 (fr) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions et procédés de modulation de l'activité de la déshydrogénase à chaîne courte |
| US10392367B2 (en) | 2017-06-01 | 2019-08-27 | Quentis Therapeutics, Inc. | IRE1 small molecule inhibitors |
| JP7126084B2 (ja) | 2017-06-01 | 2022-08-26 | コーネル ユニバーシティー | Ｉｒｅ１小分子阻害薬 |
| WO2019018975A1 (fr) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de ror gamma |
| WO2019023207A1 (fr) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de rorƴ |
| EP3728639B1 (fr) * | 2017-12-20 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédé de sélection d'une thérapie basée sur un inhibiteur de ire1 pour un patient souffrant d'un cancer |
| JP7357009B2 (ja) * | 2018-06-01 | 2023-10-05 | プロメガ コーポレイション | Ｏｐｌｏｐｈｏｒｕｓルシフェラーゼ由来生物発光性複合体の阻害剤 |
| CN109574920B (zh) * | 2018-12-25 | 2022-03-04 | 药大制药有限公司 | 3-腈基-6环丙基吡啶类ido1抑制剂及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4172896A (en) * | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
| GB9217295D0 (en) * | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
| GB9315856D0 (en) * | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
| US5541231A (en) * | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
| US5358970A (en) * | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
| EP0882128A1 (fr) * | 1996-02-23 | 1998-12-09 | Ariad Pharmaceuticals, Inc. | Essai a base de cellules |
| US5958703A (en) * | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
| JP2002501892A (ja) * | 1998-01-29 | 2002-01-22 | セプラコア インコーポレーテッド | 光学的に純粋な（−）−ビュープロピオンの薬学的使用 |
| US20030049701A1 (en) * | 2000-09-29 | 2003-03-13 | Muraca Patrick J. | Oncology tissue microarrays |
| US7666587B2 (en) * | 2002-04-12 | 2010-02-23 | New York University | Method of screening test substances for treating or preventing a disease mediated by plasma cells |
| US20040170622A1 (en) * | 2002-08-30 | 2004-09-02 | President And Fellows Of Harvard College | Methods and compositions for modulating XBP-1 activity |
| CN101031293A (zh) * | 2004-05-06 | 2007-09-05 | 普莱希科公司 | Pde4b抑制剂及其应用 |
| JP2008533018A (ja) * | 2005-03-09 | 2008-08-21 | シェーリング コーポレイション | ＫＳＰキネシン活性を阻害するための縮合チエノ［２，３−ｂ］ピリジン化合物および縮合チアゾロ［５，４−ｂ］ピリジン化合物 |
| WO2007101225A2 (fr) | 2006-02-27 | 2007-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Procedes permettant d'identifier les inhibiteurs de reponse aux proteines depliees |
-
2007
- 2007-02-27 WO PCT/US2007/062918 patent/WO2007101225A2/fr active Application Filing
- 2007-02-27 AU AU2007220039A patent/AU2007220039A1/en not_active Abandoned
- 2007-02-27 WO PCT/US2007/062917 patent/WO2007101224A2/fr active Application Filing
- 2007-02-27 CA CA002638735A patent/CA2638735A1/fr not_active Abandoned
- 2007-02-27 AU AU2007220040A patent/AU2007220040A1/en not_active Abandoned
- 2007-02-27 CA CA002638734A patent/CA2638734A1/fr not_active Abandoned
- 2007-02-27 EP EP07757587A patent/EP1999303A4/fr not_active Withdrawn
- 2007-02-27 US US12/280,793 patent/US8372861B2/en not_active Expired - Fee Related
- 2007-02-27 US US12/280,794 patent/US20090291857A1/en not_active Abandoned
-
2013
- 2013-02-11 US US13/764,200 patent/US20130150399A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007220040A1 (en) | 2007-09-07 |
| WO2007101225A3 (fr) | 2009-04-02 |
| EP1999303A4 (fr) | 2010-09-08 |
| CA2638735A1 (fr) | 2007-09-07 |
| WO2007101224A3 (fr) | 2008-10-16 |
| US20090291857A1 (en) | 2009-11-26 |
| US8372861B2 (en) | 2013-02-12 |
| EP1999303A2 (fr) | 2008-12-10 |
| WO2007101225A2 (fr) | 2007-09-07 |
| US20130150399A1 (en) | 2013-06-13 |
| US20090312362A1 (en) | 2009-12-17 |
| WO2007101224A2 (fr) | 2007-09-07 |
| AU2007220039A1 (en) | 2007-09-07 |
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