CA2632055A1 - Real time binding analysis of antigens on a biosensor surface - Google Patents
Real time binding analysis of antigens on a biosensor surface Download PDFInfo
- Publication number
- CA2632055A1 CA2632055A1 CA002632055A CA2632055A CA2632055A1 CA 2632055 A1 CA2632055 A1 CA 2632055A1 CA 002632055 A CA002632055 A CA 002632055A CA 2632055 A CA2632055 A CA 2632055A CA 2632055 A1 CA2632055 A1 CA 2632055A1
- Authority
- CA
- Canada
- Prior art keywords
- phage
- biosensor
- antibody
- binding
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000427 antigen Substances 0.000 title claims abstract description 68
- 108091007433 antigens Proteins 0.000 title claims abstract description 67
- 102000036639 antigens Human genes 0.000 title claims abstract description 67
- 230000027455 binding Effects 0.000 title claims description 126
- 238000004458 analytical method Methods 0.000 title description 7
- 238000000034 method Methods 0.000 claims abstract description 61
- 108090000623 proteins and genes Proteins 0.000 claims description 66
- 102000004169 proteins and genes Human genes 0.000 claims description 63
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 58
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 58
- 210000004027 cell Anatomy 0.000 claims description 49
- 238000002360 preparation method Methods 0.000 claims description 37
- 230000001413 cellular effect Effects 0.000 claims description 23
- 210000004962 mammalian cell Anatomy 0.000 claims description 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 238000002823 phage display Methods 0.000 claims description 16
- 230000003278 mimic effect Effects 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 11
- 102000018697 Membrane Proteins Human genes 0.000 claims description 10
- 108010052285 Membrane Proteins Proteins 0.000 claims description 10
- 210000004408 hybridoma Anatomy 0.000 claims description 10
- 150000001720 carbohydrates Chemical class 0.000 claims description 9
- 150000003384 small molecules Chemical group 0.000 claims description 9
- 101710132601 Capsid protein Proteins 0.000 claims description 7
- 101710094648 Coat protein Proteins 0.000 claims description 7
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims description 7
- 101710125418 Major capsid protein Proteins 0.000 claims description 7
- 101710141454 Nucleoprotein Proteins 0.000 claims description 7
- 101710083689 Probable capsid protein Proteins 0.000 claims description 7
- 230000003100 immobilizing effect Effects 0.000 claims description 5
- 108091005703 transmembrane proteins Proteins 0.000 claims description 2
- 102000035160 transmembrane proteins Human genes 0.000 claims description 2
- 230000003993 interaction Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 description 58
- 229940079593 drug Drugs 0.000 description 32
- 239000003814 drug Substances 0.000 description 32
- 241000283973 Oryctolagus cuniculus Species 0.000 description 27
- 241000699666 Mus <mouse, genus> Species 0.000 description 25
- 239000000126 substance Substances 0.000 description 22
- 241000700605 Viruses Species 0.000 description 19
- 210000002966 serum Anatomy 0.000 description 19
- 239000000284 extract Substances 0.000 description 18
- 230000009870 specific binding Effects 0.000 description 15
- 235000013336 milk Nutrition 0.000 description 13
- 239000008267 milk Substances 0.000 description 13
- 210000004080 milk Anatomy 0.000 description 13
- 239000000523 sample Substances 0.000 description 13
- 230000001580 bacterial effect Effects 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 230000001225 therapeutic effect Effects 0.000 description 11
- 239000010408 film Substances 0.000 description 10
- 230000003287 optical effect Effects 0.000 description 10
- 108020003175 receptors Proteins 0.000 description 10
- 102000005962 receptors Human genes 0.000 description 10
- 238000002965 ELISA Methods 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 238000012216 screening Methods 0.000 description 9
- 239000000758 substrate Substances 0.000 description 9
- 230000008859 change Effects 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 238000004091 panning Methods 0.000 description 5
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 4
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 4
- 241000508269 Psidium Species 0.000 description 4
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 238000012482 interaction analysis Methods 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 239000013612 plasmid Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000003255 drug test Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000013537 high throughput screening Methods 0.000 description 3
- 235000014304 histidine Nutrition 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000007783 nanoporous material Substances 0.000 description 3
- 229910052759 nickel Inorganic materials 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000004038 photonic crystal Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 108700012359 toxins Proteins 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 2
- 101100136092 Drosophila melanogaster peng gene Proteins 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 2
- 241001524679 Escherichia virus M13 Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 229940125644 antibody drug Drugs 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000003989 dielectric material Substances 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 150000002411 histidines Chemical class 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000001823 molecular biology technique Methods 0.000 description 2
- 108010087904 neutravidin Proteins 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 230000006916 protein interaction Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000000954 titration curve Methods 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102100027286 Fanconi anemia group C protein Human genes 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 239000005083 Zinc sulfide Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 210000004671 cell-free system Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 210000002726 cyst fluid Anatomy 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000001566 impedance spectroscopy Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000012933 kinetic analysis Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000012092 media component Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 1
- 108700010839 phage proteins Proteins 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 210000004777 protein coat Anatomy 0.000 description 1
- 108020001580 protein domains Proteins 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 210000003370 receptor cell Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- PBCFLUZVCVVTBY-UHFFFAOYSA-N tantalum pentoxide Inorganic materials O=[Ta](=O)O[Ta](=O)=O PBCFLUZVCVVTBY-UHFFFAOYSA-N 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 229910052984 zinc sulfide Inorganic materials 0.000 description 1
- DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
- G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/290,036 US7524625B2 (en) | 2000-10-30 | 2005-11-30 | Real time binding analysis of antigens on a biosensor surface |
| US11/290,036 | 2005-11-30 | ||
| PCT/US2006/045684 WO2007064702A1 (en) | 2005-11-30 | 2006-11-29 | Real time binding analysis of antigens on a biosensor surface |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2632055A1 true CA2632055A1 (en) | 2007-06-07 |
Family
ID=37865867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002632055A Abandoned CA2632055A1 (en) | 2005-11-30 | 2006-11-29 | Real time binding analysis of antigens on a biosensor surface |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7524625B2 (enExample) |
| EP (2) | EP1960791A1 (enExample) |
| JP (1) | JP2009517695A (enExample) |
| CN (1) | CN101336376A (enExample) |
| AU (1) | AU2006320660A1 (enExample) |
| CA (1) | CA2632055A1 (enExample) |
| NZ (1) | NZ569311A (enExample) |
| WO (1) | WO2007064702A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8111401B2 (en) * | 1999-11-05 | 2012-02-07 | Robert Magnusson | Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats |
| US7167615B1 (en) * | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
| US7371562B2 (en) * | 2000-10-30 | 2008-05-13 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US7575939B2 (en) | 2000-10-30 | 2009-08-18 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
| US7524625B2 (en) * | 2000-10-30 | 2009-04-28 | Sru Biosystems, Inc. | Real time binding analysis of antigens on a biosensor surface |
| US7118710B2 (en) | 2000-10-30 | 2006-10-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| AU2006236090B2 (en) * | 2000-10-30 | 2008-01-03 | Sru Biosystems, Inc. | A label-free high-throughput optical technique for detecting biomolecular interactions |
| US7927822B2 (en) | 2002-09-09 | 2011-04-19 | Sru Biosystems, Inc. | Methods for screening cells and antibodies |
| US7309614B1 (en) | 2002-12-04 | 2007-12-18 | Sru Biosystems, Inc. | Self-referencing biodetection method and patterned bioassays |
| US8298780B2 (en) | 2003-09-22 | 2012-10-30 | X-Body, Inc. | Methods of detection of changes in cells |
| CN101072996A (zh) * | 2004-12-10 | 2007-11-14 | 皇家飞利浦电子股份有限公司 | 多点检验设备 |
| AU2006249657B2 (en) * | 2005-04-12 | 2011-02-10 | Sru Biosystems, Inc. | Proteolipid membrane & lipid membrane biosensor |
| US9134307B2 (en) | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
| CN101802611A (zh) | 2007-07-11 | 2010-08-11 | Sru生物系统公司 | 鉴别离子通道调节剂的方法 |
| US8257936B2 (en) | 2008-04-09 | 2012-09-04 | X-Body Inc. | High resolution label free analysis of cellular properties |
| EP2306902A4 (en) * | 2008-07-11 | 2011-08-10 | Sru Biosystems Inc | METHOD FOR IDENTIFYING ION CHANNEL MODULATORS |
| KR101165720B1 (ko) * | 2008-11-18 | 2012-07-18 | 한국전자통신연구원 | 휴대용 광바이오 센서 측정 장치 및 그 측정 방법 |
| KR101123640B1 (ko) | 2008-12-31 | 2012-04-19 | 키스트 유럽 에프게엠베하 | 전기 전도성을 지니게 하는 박테리오파아지의 제조 방법 및상기 제조 방법으로 제조된 박테리오파아지 및 상기 박테리오파아지를 분자 인지 센서로 이용하는 방법 및 상기박테리오파아지를 이용한 분자 인지 센서 |
| KR101123641B1 (ko) | 2008-12-31 | 2012-03-20 | 키스트 유럽 에프게엠베하 | 검출 물질에 특이적으로 반응할 수 있는 분자 인지 물질이 진열된 박테리오파아지의 제조 방법 및 상기 제조 방법으로제조된 박테리오파아지를 미량 검출물을 검출하는데 활용하는 방법 및 상기 박테리오파아지를 이용한 질량 분석장치 |
| US20100273185A1 (en) * | 2009-04-27 | 2010-10-28 | Sru Biosystems, Inc. | Detection of Biased Agonist Activation |
| AU2010248784A1 (en) * | 2009-05-15 | 2011-12-01 | Sru Biosystems, Inc | Detection of changes in cell populations and mixed cell populations |
| US8525237B1 (en) | 2010-10-04 | 2013-09-03 | The Regents Of The University Of California | Electrically conductive polymer nanowires with incorporated viruses |
| WO2013128614A1 (ja) * | 2012-03-01 | 2013-09-06 | 日本精工株式会社 | 標的物質検出装置及び標的物質検出方法 |
| CN103728447B (zh) * | 2014-01-03 | 2016-07-13 | 北京纳晶生物科技有限公司 | 可控量子点位点特异性桥接偶联的抗体标记方法及其应用 |
| US9903816B2 (en) | 2014-12-02 | 2018-02-27 | Infineon Technologies Ag | Photonic crystal sensor structure and a method for manufacturing the same |
| US10656079B2 (en) * | 2016-02-01 | 2020-05-19 | Micro Detect, Inc. | UV solid state detection and methods therefor |
| US11740399B2 (en) * | 2018-02-06 | 2023-08-29 | Raytheon Company | Low cost dispersive optical elements |
| FI3756009T3 (fi) * | 2018-02-23 | 2023-12-01 | Meso Scale Technologies Llc | Menetelmiä antigeeniä sitovien molekyylien seulontaan normalisoimalla antigeeniä sitovan molekyylin pitoisuus |
| CN108956983B (zh) * | 2018-05-07 | 2021-05-07 | 西北工业大学 | 一种以烟草花叶病毒为模板的微传感器可控阵列化制备方法 |
| US12259330B2 (en) * | 2021-09-08 | 2025-03-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Charge-sensitive optical detection of binding kinetics between phage displayed peptide ligands and protein targets |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8423204D0 (en) | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
| EP0226604B1 (de) | 1985-05-29 | 1991-08-21 | Artificial Sensing Instruments ASI AG | Optischer sensor zum selektiven nachweis von substanzen und zum nachweis von brechzahländerungen in messubstanzen |
| SE8804074D0 (sv) * | 1988-11-10 | 1988-11-10 | Pharmacia Ab | Sensorenhet och dess anvaendning i biosensorsystem |
| SE8902043L (sv) * | 1988-11-10 | 1990-05-11 | Pharmacia Ab | Foerfarande foer karakterisering av makromolekyler |
| US5216680A (en) | 1991-07-11 | 1993-06-01 | Board Of Regents, The University Of Texas System | Optical guided-mode resonance filter |
| JP3335189B2 (ja) * | 1992-01-31 | 2002-10-15 | 理化学研究所 | 領域指定突然変異導入法 |
| GB9314991D0 (en) | 1993-07-20 | 1993-09-01 | Sandoz Ltd | Mechanical device |
| WO1996038726A1 (en) | 1995-05-30 | 1996-12-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Covalently immobilized phospholipid bilayers on solid surfaces |
| GB9602542D0 (en) | 1996-02-08 | 1996-04-10 | Fisons Plc | Analytical device |
| US5666197A (en) | 1996-08-21 | 1997-09-09 | Polaroid Corporation | Apparatus and methods employing phase control and analysis of evanescent illumination for imaging and metrology of subwavelength lateral surface topography |
| JP2001504213A (ja) | 1996-08-29 | 2001-03-27 | ツェプトゼンス アクチエンゲゼルシャフト | 化学的／生化学的な光センサ |
| DE59811600D1 (de) | 1997-09-10 | 2004-07-29 | Artificial Sensing Instr Asi A | Optischer sensor und optisches verfahren zur charakterisierung einer chemischen und/oder biochemischen substanz |
| US6346376B1 (en) | 1998-06-03 | 2002-02-12 | Centre Suisse D'electronique Et De Mictotechnique Sa | Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes |
| US6846906B1 (en) | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| US6684007B2 (en) | 1998-10-09 | 2004-01-27 | Fujitsu Limited | Optical coupling structures and the fabrication processes |
| EP1031828B1 (en) | 1999-02-25 | 2006-09-13 | C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa | Integrated-optical sensor and method for integrated-optically sensing a substance |
| US6771376B2 (en) | 1999-07-05 | 2004-08-03 | Novartis Ag | Sensor platform, apparatus incorporating the platform, and process using the platform |
| HK1046438B (en) | 1999-07-05 | 2007-05-04 | Novartis Ag | Process of using a sensor platform |
| ATE244883T1 (de) | 1999-09-15 | 2003-07-15 | Suisse Electronique Microtech | Integriert-optischer sensor |
| US6541071B1 (en) | 2000-03-23 | 2003-04-01 | Corning Incorporated | Method for fabricating supported bilayer-lipid membranes |
| AU2001257074A1 (en) | 2000-04-18 | 2001-10-30 | Wayne State University | System to detect protein-protein interactions |
| AU2001274068A1 (en) | 2000-06-02 | 2001-12-11 | Zeptosens Ag | Kit and method for determining a plurality of analytes |
| US7312043B2 (en) | 2000-07-10 | 2007-12-25 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| US20040219619A1 (en) | 2000-07-21 | 2004-11-04 | Ester Fernandez-Salas | Methods of identifying compounds that alter toxin persistence and/or protease activity |
| US7524625B2 (en) | 2000-10-30 | 2009-04-28 | Sru Biosystems, Inc. | Real time binding analysis of antigens on a biosensor surface |
| US7070987B2 (en) | 2000-10-30 | 2006-07-04 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US7306827B2 (en) | 2000-10-30 | 2007-12-11 | Sru Biosystems, Inc. | Method and machine for replicating holographic gratings on a substrate |
| US7118710B2 (en) | 2000-10-30 | 2006-10-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US7575939B2 (en) | 2000-10-30 | 2009-08-18 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
| CN1200738C (zh) | 2000-10-30 | 2005-05-11 | 阿托芬德利公司 | 具有可控变色速度的热熔融湿度指示剂粘合剂组合物 |
| US7142296B2 (en) | 2000-10-30 | 2006-11-28 | Sru Biosystems, Inc. | Method and apparatus for detecting biomolecular interactions |
| US7202076B2 (en) | 2000-10-30 | 2007-04-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US7371562B2 (en) | 2000-10-30 | 2008-05-13 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US6951715B2 (en) | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
| US20030113766A1 (en) | 2000-10-30 | 2003-06-19 | Sru Biosystems, Llc | Amine activated colorimetric resonant biosensor |
| US7101660B2 (en) | 2000-10-30 | 2006-09-05 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
| US7217574B2 (en) | 2000-10-30 | 2007-05-15 | Sru Biosystems, Inc. | Method and apparatus for biosensor spectral shift detection |
| US7175980B2 (en) | 2000-10-30 | 2007-02-13 | Sru Biosystems, Inc. | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities |
| US7023544B2 (en) | 2000-10-30 | 2006-04-04 | Sru Biosystems, Inc. | Method and instrument for detecting biomolecular interactions |
| US7264973B2 (en) | 2000-10-30 | 2007-09-04 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant optical biosensor |
| US20030092075A1 (en) | 2000-10-30 | 2003-05-15 | Sru Biosystems, Llc | Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors |
| US7153702B2 (en) | 2000-10-30 | 2006-12-26 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
| DE60234131D1 (de) | 2001-08-01 | 2009-12-03 | Cellomics Inc | Neue fusionsproteine und molekulare bindungsassays |
| US7267993B2 (en) | 2001-11-07 | 2007-09-11 | Auburn University | Phage ligand sensor devices and uses thereof |
| US7927822B2 (en) | 2002-09-09 | 2011-04-19 | Sru Biosystems, Inc. | Methods for screening cells and antibodies |
| US7863052B2 (en) | 2005-08-11 | 2011-01-04 | Sru Biosystems, Inc. | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor |
| CA2501648A1 (en) * | 2002-10-15 | 2004-04-29 | Regents Of The University Of Minnesota | Assays to detect or quantify bacterial or viral pathogens and contaminants |
| US20040091397A1 (en) | 2002-11-07 | 2004-05-13 | Corning Incorporated | Multiwell insert device that enables label free detection of cells and other objects |
| US7309614B1 (en) | 2002-12-04 | 2007-12-18 | Sru Biosystems, Inc. | Self-referencing biodetection method and patterned bioassays |
| WO2005012909A1 (en) | 2003-03-04 | 2005-02-10 | Auburn University | Methods of forming monolayers of phage-derived products and uses thereof |
| EP1613965A2 (en) * | 2003-04-10 | 2006-01-11 | Kent J. Voorhees | Apparatus and method for detecting microscopic living organisms using bacteriophage |
| US7497992B2 (en) | 2003-05-08 | 2009-03-03 | Sru Biosystems, Inc. | Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers |
| US8298780B2 (en) | 2003-09-22 | 2012-10-30 | X-Body, Inc. | Methods of detection of changes in cells |
| AU2004290375A1 (en) | 2003-11-06 | 2005-05-26 | Sru Biosystems, Inc. | High-density amine-functionalized surface |
| US6990259B2 (en) | 2004-03-29 | 2006-01-24 | Sru Biosystems, Inc. | Photonic crystal defect cavity biosensor |
| US20060003372A1 (en) | 2004-06-28 | 2006-01-05 | Sru Biosystems, Inc. | Integration of direct binding label-free biosensors with mass spectrometry for functional and structural characterization of molecules |
| DE102004052510A1 (de) | 2004-10-21 | 2006-04-27 | Wilhelm Stahlecker Gmbh | Luftdüsenspinnmaschine |
| US7803619B2 (en) | 2004-11-24 | 2010-09-28 | Geneprotech, Inc. | Embryoid body-based screen |
| AU2006249657B2 (en) | 2005-04-12 | 2011-02-10 | Sru Biosystems, Inc. | Proteolipid membrane & lipid membrane biosensor |
| US7162125B1 (en) | 2005-06-23 | 2007-01-09 | Sru Biosystems, Inc. | Optimized grating based biosensor and substrate combination |
| US7197198B2 (en) | 2005-06-23 | 2007-03-27 | Sru Biosystems, Inc. | Biosensor substrate structure for reducing the effects of optical interference |
| US7521769B2 (en) | 2005-07-08 | 2009-04-21 | Sru Biosystems, Inc. | Photonic crystal biosensor structure and fabrication method |
| US7479404B2 (en) | 2005-07-08 | 2009-01-20 | The Board Of Trustees Of The University Of Illinois | Photonic crystal biosensor structure and fabrication method |
| US7483127B1 (en) | 2005-08-08 | 2009-01-27 | Sru Biosystems, Inc. | Method and apparatus for generating an image of biomolecular sensor target area |
| US7790406B2 (en) | 2005-08-11 | 2010-09-07 | Sru Biosystems, Inc | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor |
| CA2656162A1 (en) | 2006-07-07 | 2008-01-17 | The Board Of Trustees Of The University Of Illinois | Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio |
| WO2008055080A2 (en) | 2006-10-31 | 2008-05-08 | Sru Biosystems, Inc. | Method for blocking non-specific protein binding on a functionalized surface |
| NZ576760A (en) | 2006-11-09 | 2011-10-28 | Univ Illinois | Photonic crystal based biosensor based on a microfluidic device |
| US7628085B2 (en) | 2006-11-17 | 2009-12-08 | Sru Biosystems, Inc. | Simultaneous aspirator and dispenser for multiwell plates and similar devices |
| US20080240543A1 (en) | 2007-03-30 | 2008-10-02 | Wolfgang Ernst Gustav Budach | Calibration and normalization method for biosensors |
| JP2010525334A (ja) | 2007-04-19 | 2010-07-22 | エス アール ユー バイオシステムズ，インコーポレイテッド | 固定化された標的と直接結合する小分子を検出するためにバイオセンサーを使用する方法 |
| CN101802611A (zh) | 2007-07-11 | 2010-08-11 | Sru生物系统公司 | 鉴别离子通道调节剂的方法 |
| US9134307B2 (en) | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
| US8268637B2 (en) | 2008-01-11 | 2012-09-18 | The Board Of Trustees Of The University Of Illinois | Label-free biosensors based upon distributed feedback laser |
| US20090213910A1 (en) * | 2008-02-25 | 2009-08-27 | Grant Stephen J | Code Power Estimation for MIMO Signals |
| WO2009114133A1 (en) | 2008-03-10 | 2009-09-17 | The J. David Gladstone Institutes | Cells and assays for use in detecting long qt syndrome |
| US8257936B2 (en) | 2008-04-09 | 2012-09-04 | X-Body Inc. | High resolution label free analysis of cellular properties |
| EP2304500A1 (en) | 2008-06-04 | 2011-04-06 | SRU Biosystems, Inc. | Detection of promiscuous small submicrometer aggregates |
| US20100008826A1 (en) | 2008-07-10 | 2010-01-14 | Sru Biosystems, Inc. | Biosensors featuring confinement of deposited material and intra-well self-referencing |
| EP2306902A4 (en) | 2008-07-11 | 2011-08-10 | Sru Biosystems Inc | METHOD FOR IDENTIFYING ION CHANNEL MODULATORS |
| KR20110118706A (ko) | 2009-02-02 | 2011-10-31 | 에스알유 바이오시스템즈, 인코포레이티드 | 비표지 바이오센서들의 조명 및 검출을 위한 효율적인 광학 배열 및 비표지 이미징에서 간섭 무늬들을 감소시키기 위한 방법 |
| AU2010248784A1 (en) | 2009-05-15 | 2011-12-01 | Sru Biosystems, Inc | Detection of changes in cell populations and mixed cell populations |
-
2005
- 2005-11-30 US US11/290,036 patent/US7524625B2/en not_active Expired - Lifetime
-
2006
- 2006-11-29 JP JP2008543421A patent/JP2009517695A/ja active Pending
- 2006-11-29 AU AU2006320660A patent/AU2006320660A1/en not_active Abandoned
- 2006-11-29 CA CA002632055A patent/CA2632055A1/en not_active Abandoned
- 2006-11-29 EP EP06838572A patent/EP1960791A1/en not_active Withdrawn
- 2006-11-29 CN CNA2006800520052A patent/CN101336376A/zh active Pending
- 2006-11-29 EP EP11170906A patent/EP2383580A1/en not_active Withdrawn
- 2006-11-29 NZ NZ569311A patent/NZ569311A/en unknown
- 2006-11-29 WO PCT/US2006/045684 patent/WO2007064702A1/en not_active Ceased
-
2009
- 2009-03-12 US US12/402,629 patent/US8293542B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007064702A1 (en) | 2007-06-07 |
| US20060148100A1 (en) | 2006-07-06 |
| US7524625B2 (en) | 2009-04-28 |
| EP1960791A1 (en) | 2008-08-27 |
| EP2383580A1 (en) | 2011-11-02 |
| NZ569311A (en) | 2011-10-28 |
| US8293542B2 (en) | 2012-10-23 |
| JP2009517695A (ja) | 2009-04-30 |
| CN101336376A (zh) | 2008-12-31 |
| AU2006320660A1 (en) | 2007-06-07 |
| US20090176658A1 (en) | 2009-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8293542B2 (en) | Real time binding analysis of antigens on a biosensor surface | |
| Concepcion et al. | Label-free detection of biomolecular interactions using BioLayer interferometry for kinetic characterization | |
| US7264973B2 (en) | Label-free methods for performing assays using a colorimetric resonant optical biosensor | |
| US7153702B2 (en) | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor | |
| US7300803B2 (en) | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor | |
| US7534578B1 (en) | Self-referencing biodetection method and patterned bioassays | |
| US8257936B2 (en) | High resolution label free analysis of cellular properties | |
| US9778267B2 (en) | Methods for identifying modulators of ion channels | |
| US20060003372A1 (en) | Integration of direct binding label-free biosensors with mass spectrometry for functional and structural characterization of molecules | |
| US7875434B2 (en) | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor | |
| US20100015721A1 (en) | Detection of Promiscuous Small Submicrometer Aggregates | |
| JP2001504219A (ja) | 植物の病気を診断するためのバイオセンサーの使用 | |
| US9851350B2 (en) | Nanohole sensor chip with reference sections | |
| CN120112542A (zh) | 针对亨廷顿舞蹈症的早期诊断的多肽探针和试剂盒 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |
Effective date: 20131129 |