CA2630666A1 - Jasmonate derivatives, pharmaceutical compositions and methods of use thereof - Google Patents

Jasmonate derivatives, pharmaceutical compositions and methods of use thereof Download PDF

Info

Publication number
CA2630666A1
CA2630666A1 CA002630666A CA2630666A CA2630666A1 CA 2630666 A1 CA2630666 A1 CA 2630666A1 CA 002630666 A CA002630666 A CA 002630666A CA 2630666 A CA2630666 A CA 2630666A CA 2630666 A1 CA2630666 A1 CA 2630666A1
Authority
CA
Canada
Prior art keywords
cancer
unsubstituted
carcinoma
substituted
leukemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002630666A
Other languages
English (en)
French (fr)
Inventor
Max Herzberg
Adrian Harel
Christian Mang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEPAL PHARMA Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2630666A1 publication Critical patent/CA2630666A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CA002630666A 2005-12-07 2006-12-07 Jasmonate derivatives, pharmaceutical compositions and methods of use thereof Abandoned CA2630666A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US74287505P 2005-12-07 2005-12-07
US60/742,875 2005-12-07
US77258206P 2006-02-13 2006-02-13
US60/772,582 2006-02-13
US83066606P 2006-07-14 2006-07-14
US60/830,666 2006-07-14
PCT/IL2006/001409 WO2007066337A2 (en) 2005-12-07 2006-12-07 Jasmonate derivatives, pharmaceutical compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2630666A1 true CA2630666A1 (en) 2007-06-14

Family

ID=38123294

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002630666A Abandoned CA2630666A1 (en) 2005-12-07 2006-12-07 Jasmonate derivatives, pharmaceutical compositions and methods of use thereof

Country Status (7)

Country Link
US (1) US8247439B2 (https=)
EP (1) EP1968959A2 (https=)
JP (1) JP2009520692A (https=)
AU (1) AU2006322845A1 (https=)
BR (1) BRPI0619551A2 (https=)
CA (1) CA2630666A1 (https=)
WO (1) WO2007066337A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012114196A1 (pt) 2011-02-25 2012-08-30 Nanocare Technologies, Inc. Formulação farmacêutica compreendendo compostos da família dos jasmonatos
US8883220B2 (en) 2011-09-16 2014-11-11 Nanocare Technologies, Inc. Compositions of jasmonate compounds
US10314918B2 (en) 2014-12-31 2019-06-11 Nanocare Technologies, Inc. Jasmonate derivatives and compositions thereof

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9284274B2 (en) 2005-12-07 2016-03-15 Ramot At Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
CA2657375A1 (en) * 2006-07-10 2008-01-17 Ramot At Tel-Aviv University Ltd. Combination methods of treating cancer
WO2008111088A2 (en) 2007-03-15 2008-09-18 Ramot At Tel-Aviv University Ltd. Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases
WO2009120826A1 (en) * 2008-03-27 2009-10-01 Wyeth 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof
US9284252B2 (en) 2009-06-09 2016-03-15 Sepal Pharma Ltd. Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
WO2017168416A1 (en) 2016-03-28 2017-10-05 Vidac Pharma Ltd. Stable pharmaceutical compositions for topical administration and uses thereof
US11266639B2 (en) 2016-11-07 2022-03-08 Vidac Pharma Ltd. Use of hexokinase 2/mitochondria-detaching compounds for treating hexokinase-2 (HK2)-expressing cancers
WO2018083704A1 (en) 2016-11-07 2018-05-11 Vidac Pharma Ltd. Use of hexokinase 2/mitochondria-detaching compounds for activating immune responses
WO2019135243A1 (en) * 2018-01-07 2019-07-11 Vidac Pharma Ltd Methods for preparation of jasmonate compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63122669A (ja) 1986-10-25 1988-05-26 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 複素環状液晶化合物
US5476945A (en) * 1992-11-17 1995-12-19 Fuji Photo Film Co., Ltd. Water-soluble methine derivatives of thiazole
US5637484A (en) 1993-11-15 1997-06-10 Mitsui Petrochemical Industries, Ltd. Method of producing a taxane-type diterpene and a method of obtaining cultured cells which produce the taxane-type diterpene at a high rate
JPH07308196A (ja) 1994-05-18 1995-11-28 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
WO2002076439A2 (en) * 2001-03-23 2002-10-03 The Board Of Trustees Of The University Of Illinois Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
US6469061B1 (en) * 2001-04-04 2002-10-22 Ramot University Authority For Applied Research And Industrial Development Limited Jasmonate pharmaceutical composition for treatment of cancer
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
JP2006516254A (ja) * 2003-01-06 2006-06-29 イーライ・リリー・アンド・カンパニー Pparモジュレータとしての縮合ヘテロ環誘導体
WO2005054172A2 (en) * 2003-12-02 2005-06-16 Ramot At Tel-Aviv University Ltd. Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012114196A1 (pt) 2011-02-25 2012-08-30 Nanocare Technologies, Inc. Formulação farmacêutica compreendendo compostos da família dos jasmonatos
US8883220B2 (en) 2011-09-16 2014-11-11 Nanocare Technologies, Inc. Compositions of jasmonate compounds
US9592305B2 (en) 2011-09-16 2017-03-14 Nanocare Technologies, Inc. Compositions of jasmonate compounds and methods of use
US10328155B2 (en) 2011-09-16 2019-06-25 Nanocare Technologies, Inc. Compositions of jasmonate compounds and methods of use
US10314918B2 (en) 2014-12-31 2019-06-11 Nanocare Technologies, Inc. Jasmonate derivatives and compositions thereof

Also Published As

Publication number Publication date
AU2006322845A1 (en) 2007-06-14
JP2009520692A (ja) 2009-05-28
WO2007066337A2 (en) 2007-06-14
US20090197927A1 (en) 2009-08-06
BRPI0619551A2 (pt) 2011-10-04
US8247439B2 (en) 2012-08-21
EP1968959A2 (en) 2008-09-17
WO2007066337A3 (en) 2007-11-15

Similar Documents

Publication Publication Date Title
JP2013199483A (ja) ジャスモネートの化学的誘導体、医薬組成物及びこれらの使用方法
AU2007282080B2 (en) Isoform-selective HDAC inhibitors
US12162868B2 (en) Piperazine derivatives, pharmaceutical compositions and methods of use thereof
US8247439B2 (en) Jasmonate derivatives, pharmaceutical compositions and methods of use thereof
CN105111271B (zh) 一种熊果酸-阿司匹林偶联物及其在制备预防肿瘤转移药物中的应用
EP2924042A1 (en) Bis- -carboline compound and preparation method, pharmaceutical composition and use thereof
CN112707833B (zh) 组蛋白去乙酰酶抑制剂及其制备和应用
CN103304573B (zh) 石蒜碱类化合物在制备抗肿瘤药物的应用
US9284274B2 (en) Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
JP4933683B1 (ja) 細胞毒性特性及び/または抗血管新生特性を有する新規なレチノイド誘導体
CN103864720B (zh) 苯丙烯酸类法尼基硫代水杨酸衍生物及制备方法和用途
CN104945333B (zh) 紫苏醇类似物及其制备和应用
CN103450198B (zh) 咪唑并吡啶并咪唑-3-取代乙酸苄酯、其合成、抗肿瘤活性及应用
JP6021847B2 (ja) 扁平上皮ガン及び肝ガンの抑制剤とされるスチルベノイド化合物及びその用途
CN110049768A (zh) 酚噻嗪衍生物及其使用方法
IL229418A (en) Derivatives of gasmont, pharmaceutical preparations and their use
CN107325030A (zh) 一类新型反式芪类抗肿瘤剂
EP3194360B1 (en) 4-oxo-n-(4-hydroxyphenyl)retinamide derivatives as therapeutic agents for the treatment of cancer
JP2011513259A (ja) 細胞増殖の阻害剤、及びそれらの使用
CN104945336A (zh) 紫苏酸甲酯含氮衍生物及其制备和应用

Legal Events

Date Code Title Description
FZDE Discontinued