BRPI0619551A2 - derivados de jasmonato aprimorados, composições farmacêuticas e métodos de uso dos mesmos - Google Patents

derivados de jasmonato aprimorados, composições farmacêuticas e métodos de uso dos mesmos Download PDF

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Publication number
BRPI0619551A2
BRPI0619551A2 BRPI0619551-2A BRPI0619551A BRPI0619551A2 BR PI0619551 A2 BRPI0619551 A2 BR PI0619551A2 BR PI0619551 A BRPI0619551 A BR PI0619551A BR PI0619551 A2 BRPI0619551 A2 BR PI0619551A2
Authority
BR
Brazil
Prior art keywords
cancer
unsubstituted
formula
substituted
carcinoma
Prior art date
Application number
BRPI0619551-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Max Herzberg
Adrian Harel
Christian Mang
Original Assignee
Sepal Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepal Pharma Ltd filed Critical Sepal Pharma Ltd
Publication of BRPI0619551A2 publication Critical patent/BRPI0619551A2/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
BRPI0619551-2A 2005-12-07 2006-12-07 derivados de jasmonato aprimorados, composições farmacêuticas e métodos de uso dos mesmos BRPI0619551A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US74287505P 2005-12-07 2005-12-07
US60/742.875 2005-12-07
US77258206P 2006-02-13 2006-02-13
US60/772.582 2006-02-13
US83066606P 2006-07-14 2006-07-14
US60/830.666 2006-07-14
PCT/IL2006/001409 WO2007066337A2 (en) 2005-12-07 2006-12-07 Jasmonate derivatives, pharmaceutical compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0619551A2 true BRPI0619551A2 (pt) 2011-10-04

Family

ID=38123294

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0619551-2A BRPI0619551A2 (pt) 2005-12-07 2006-12-07 derivados de jasmonato aprimorados, composições farmacêuticas e métodos de uso dos mesmos

Country Status (7)

Country Link
US (1) US8247439B2 (https=)
EP (1) EP1968959A2 (https=)
JP (1) JP2009520692A (https=)
AU (1) AU2006322845A1 (https=)
BR (1) BRPI0619551A2 (https=)
CA (1) CA2630666A1 (https=)
WO (1) WO2007066337A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9284274B2 (en) 2005-12-07 2016-03-15 Ramot At Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
CA2657375A1 (en) * 2006-07-10 2008-01-17 Ramot At Tel-Aviv University Ltd. Combination methods of treating cancer
WO2008111088A2 (en) 2007-03-15 2008-09-18 Ramot At Tel-Aviv University Ltd. Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases
WO2009120826A1 (en) * 2008-03-27 2009-10-01 Wyeth 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof
US9284252B2 (en) 2009-06-09 2016-03-15 Sepal Pharma Ltd. Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
US20140220132A1 (en) 2011-02-25 2014-08-07 José E. Fehr Pereira Lopes Pharmaceutical Formulation Comprising Compounds of the Jasmonate Family
WO2013040556A1 (en) 2011-09-16 2013-03-21 Nanocare Technologies, Inc. Compositions of jasmonate compounds and methods of use
CA2971870A1 (en) * 2014-12-31 2016-07-07 Nanocare Technologies, Inc. Jasmonate derivatives and compositions thereof
WO2017168416A1 (en) 2016-03-28 2017-10-05 Vidac Pharma Ltd. Stable pharmaceutical compositions for topical administration and uses thereof
US11266639B2 (en) 2016-11-07 2022-03-08 Vidac Pharma Ltd. Use of hexokinase 2/mitochondria-detaching compounds for treating hexokinase-2 (HK2)-expressing cancers
WO2018083704A1 (en) 2016-11-07 2018-05-11 Vidac Pharma Ltd. Use of hexokinase 2/mitochondria-detaching compounds for activating immune responses
WO2019135243A1 (en) * 2018-01-07 2019-07-11 Vidac Pharma Ltd Methods for preparation of jasmonate compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63122669A (ja) 1986-10-25 1988-05-26 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 複素環状液晶化合物
US5476945A (en) * 1992-11-17 1995-12-19 Fuji Photo Film Co., Ltd. Water-soluble methine derivatives of thiazole
US5637484A (en) 1993-11-15 1997-06-10 Mitsui Petrochemical Industries, Ltd. Method of producing a taxane-type diterpene and a method of obtaining cultured cells which produce the taxane-type diterpene at a high rate
JPH07308196A (ja) 1994-05-18 1995-11-28 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
WO2002076439A2 (en) * 2001-03-23 2002-10-03 The Board Of Trustees Of The University Of Illinois Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
US6469061B1 (en) * 2001-04-04 2002-10-22 Ramot University Authority For Applied Research And Industrial Development Limited Jasmonate pharmaceutical composition for treatment of cancer
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
JP2006516254A (ja) * 2003-01-06 2006-06-29 イーライ・リリー・アンド・カンパニー Pparモジュレータとしての縮合ヘテロ環誘導体
WO2005054172A2 (en) * 2003-12-02 2005-06-16 Ramot At Tel-Aviv University Ltd. Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof

Also Published As

Publication number Publication date
AU2006322845A1 (en) 2007-06-14
JP2009520692A (ja) 2009-05-28
WO2007066337A2 (en) 2007-06-14
US20090197927A1 (en) 2009-08-06
US8247439B2 (en) 2012-08-21
EP1968959A2 (en) 2008-09-17
WO2007066337A3 (en) 2007-11-15
CA2630666A1 (en) 2007-06-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.