CA2628924C - Mass spectrometer - Google Patents
Mass spectrometer Download PDFInfo
- Publication number
- CA2628924C CA2628924C CA2628924A CA2628924A CA2628924C CA 2628924 C CA2628924 C CA 2628924C CA 2628924 A CA2628924 A CA 2628924A CA 2628924 A CA2628924 A CA 2628924A CA 2628924 C CA2628924 C CA 2628924C
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- 150000002500 ions Chemical class 0.000 claims abstract description 1125
- 238000013467 fragmentation Methods 0.000 claims abstract description 366
- 238000006062 fragmentation reaction Methods 0.000 claims abstract description 366
- 238000006243 chemical reaction Methods 0.000 claims abstract description 245
- 238000010494 dissociation reaction Methods 0.000 claims abstract description 50
- 230000005593 dissociations Effects 0.000 claims abstract description 50
- 238000000034 method Methods 0.000 claims abstract description 45
- 238000001211 electron capture detection Methods 0.000 claims abstract description 36
- 238000001077 electron transfer detection Methods 0.000 claims abstract description 36
- 238000004949 mass spectrometry Methods 0.000 claims abstract description 19
- 239000002243 precursor Substances 0.000 claims description 507
- 239000012634 fragment Substances 0.000 claims description 223
- 238000005040 ion trap Methods 0.000 claims description 32
- 239000003153 chemical reaction reagent Substances 0.000 claims description 18
- 238000001360 collision-induced dissociation Methods 0.000 claims description 14
- 230000005855 radiation Effects 0.000 claims description 12
- 238000011144 upstream manufacturing Methods 0.000 claims description 12
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 10
- -1 daughter Substances 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 7
- 230000001133 acceleration Effects 0.000 claims description 6
- 230000015556 catabolic process Effects 0.000 claims description 6
- 238000006731 degradation reaction Methods 0.000 claims description 6
- 238000003795 desorption Methods 0.000 claims description 6
- 230000005684 electric field Effects 0.000 claims description 6
- 238000001976 enzyme digestion Methods 0.000 claims description 6
- 238000010265 fast atom bombardment Methods 0.000 claims description 6
- 238000009616 inductively coupled plasma Methods 0.000 claims description 6
- 238000001698 laser desorption ionisation Methods 0.000 claims description 6
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 5
- 230000005405 multipole Effects 0.000 claims description 5
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 3
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 3
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 3
- 238000000451 chemical ionisation Methods 0.000 claims description 3
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- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 2
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 claims description 2
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- 239000007789 gas Substances 0.000 description 16
- 238000005259 measurement Methods 0.000 description 16
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 15
- 235000021240 caseins Nutrition 0.000 description 15
- 239000012491 analyte Substances 0.000 description 14
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
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- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
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- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 3
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- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 3
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
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- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 3
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- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 238000002545 neutral loss scan Methods 0.000 description 2
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- 229920002527 Glycogen Polymers 0.000 description 1
- 102000002068 Glycopeptides Human genes 0.000 description 1
- 108010015899 Glycopeptides Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- ILZZTQYNTRWQSJ-UHFFFAOYSA-N Phe-Phe-Val-Ala-Pro-Phe-Pro-Glu-Val-Phe-Gly-Lys Natural products CC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(N)Cc2ccccc2)C(=O)NC(C)C(=O)N3CCCC3C(=O)NC(Cc4ccccc4)C(=O)N5CCCC5C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(Cc6ccccc6)C(=O)NCC(=O)NC(CCCCN)C(=O)O ILZZTQYNTRWQSJ-UHFFFAOYSA-N 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/0068—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with a surface, e.g. surface induced dissociation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Composite Materials (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2835314A CA2835314A1 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/286,141 US20060151689A1 (en) | 2002-07-24 | 2005-11-23 | Mass spectrometer |
GB0523806.8 | 2005-11-23 | ||
GBGB0523806.8A GB0523806D0 (en) | 2005-11-23 | 2005-11-23 | Mass spectrometer |
US11/286,141 | 2005-11-23 | ||
PCT/GB2006/004362 WO2007060421A2 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2835314A Division CA2835314A1 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2628924A1 CA2628924A1 (en) | 2007-05-31 |
CA2628924C true CA2628924C (en) | 2017-09-05 |
Family
ID=35601028
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2835314A Abandoned CA2835314A1 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
CA2628924A Active CA2628924C (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2835314A Abandoned CA2835314A1 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1952422A2 (de) |
JP (1) | JP4959712B2 (de) |
CA (2) | CA2835314A1 (de) |
GB (4) | GB0523806D0 (de) |
WO (1) | WO2007060421A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201122178D0 (en) | 2011-12-22 | 2012-02-01 | Thermo Fisher Scient Bremen | Method of tandem mass spectrometry |
WO2014080493A1 (ja) * | 2012-11-22 | 2014-05-30 | 株式会社島津製作所 | タンデム四重極型質量分析装置 |
US9352020B2 (en) | 2013-03-15 | 2016-05-31 | Mead Johnson Nutrition Company | Reducing proinflammatory response |
US8889633B2 (en) | 2013-03-15 | 2014-11-18 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof |
US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
US9138455B2 (en) | 2013-03-15 | 2015-09-22 | Mead Johnson Nutrition Company | Activating adiponectin by casein hydrolysate |
CN104345107B (zh) * | 2013-07-24 | 2016-08-17 | 上海科倍斯生物科技有限公司 | 一种乳或乳制品中牛乳血清白蛋白定量检测试剂盒 |
WO2015162426A1 (en) | 2014-04-23 | 2015-10-29 | Micromass Uk Limited | Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences |
GB201407123D0 (en) * | 2014-04-23 | 2014-06-04 | Micromass Ltd | Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences |
JP7326324B2 (ja) * | 2018-04-10 | 2023-08-15 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 質量分析における抗体のトップダウン分析 |
CN114829927A (zh) * | 2019-10-10 | 2022-07-29 | 詹森生物科技公司 | 用于质谱蛋白质分析的材料和方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3300602B2 (ja) * | 1996-06-20 | 2002-07-08 | 株式会社日立製作所 | 大気圧イオン化イオントラップ質量分析方法及び装置 |
JP2000241390A (ja) * | 1999-02-17 | 2000-09-08 | Japan Atom Energy Res Inst | 中性種の解離を用いる電荷逆転質量分析法 |
US6545268B1 (en) * | 2000-04-10 | 2003-04-08 | Perseptive Biosystems | Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis |
CA2340150C (en) * | 2000-06-09 | 2005-11-22 | Micromass Limited | Methods and apparatus for mass spectrometry |
DE60210056T2 (de) * | 2001-03-22 | 2006-11-16 | Syddansk Universitet | Massenspektrometrisches Verfahren mit Elektroneneinfang durch Ionen und Massenspektrometer zum Durchführen des Verfahrens |
US6744040B2 (en) * | 2001-06-13 | 2004-06-01 | Bruker Daltonics, Inc. | Means and method for a quadrupole surface induced dissociation quadrupole time-of-flight mass spectrometer |
GB0121172D0 (en) * | 2001-08-31 | 2001-10-24 | Shimadzu Res Lab Europe Ltd | A method for dissociating ions using a quadrupole ion trap device |
JP4161125B2 (ja) * | 2002-04-24 | 2008-10-08 | 滋雄 早川 | 質量分析法および質量分析装置 |
CA2643534C (en) * | 2002-05-31 | 2011-08-02 | Analytica Of Branford, Inc. | Fragmentation methods for mass spectrometry |
GB2390935A (en) * | 2002-07-16 | 2004-01-21 | Anatoli Nicolai Verentchikov | Time-nested mass analysis using a TOF-TOF tandem mass spectrometer |
GB0305796D0 (en) * | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
AU2002952747A0 (en) * | 2002-11-18 | 2002-12-05 | Ludwig Institute For Cancer Research | Method for analysing peptides |
GB2402260B (en) * | 2003-05-30 | 2006-05-24 | Thermo Finnigan Llc | All mass MS/MS method and apparatus |
JP4275545B2 (ja) * | 2004-02-17 | 2009-06-10 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
EP1723416B1 (de) * | 2004-03-12 | 2010-09-01 | University Of Virginia Patent Foundation | Elektronentransferdissoziation zur biopolymer-sequenzanalyse |
-
2005
- 2005-11-23 GB GBGB0523806.8A patent/GB0523806D0/en not_active Ceased
-
2006
- 2006-11-23 EP EP06808640A patent/EP1952422A2/de not_active Withdrawn
- 2006-11-23 GB GB0623376A patent/GB2435713B/en active Active
- 2006-11-23 JP JP2008541816A patent/JP4959712B2/ja not_active Expired - Fee Related
- 2006-11-23 CA CA2835314A patent/CA2835314A1/en not_active Abandoned
- 2006-11-23 WO PCT/GB2006/004362 patent/WO2007060421A2/en active Application Filing
- 2006-11-23 GB GB0801093A patent/GB2443571B/en active Active
- 2006-11-23 GB GB0816195A patent/GB2451962B/en active Active
- 2006-11-23 CA CA2628924A patent/CA2628924C/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP4959712B2 (ja) | 2012-06-27 |
GB0816195D0 (en) | 2008-10-15 |
GB2451962A (en) | 2009-02-18 |
JP2009516842A (ja) | 2009-04-23 |
GB2443571A (en) | 2008-05-07 |
GB0801093D0 (en) | 2008-02-27 |
GB2435713B (en) | 2010-06-16 |
CA2835314A1 (en) | 2007-05-31 |
WO2007060421A2 (en) | 2007-05-31 |
WO2007060421A3 (en) | 2008-05-08 |
EP1952422A2 (de) | 2008-08-06 |
GB0523806D0 (en) | 2006-01-04 |
GB0623376D0 (en) | 2007-01-03 |
GB2443571B (en) | 2010-05-12 |
CA2628924A1 (en) | 2007-05-31 |
GB2451962B (en) | 2010-02-17 |
GB2435713A (en) | 2007-09-05 |
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