CA2628747C - Combinations of hormone therapy agents and metalloprotease inhibitors for the treatment of cancer - Google Patents

Combinations of hormone therapy agents and metalloprotease inhibitors for the treatment of cancer Download PDF

Info

Publication number
CA2628747C
CA2628747C CA2628747A CA2628747A CA2628747C CA 2628747 C CA2628747 C CA 2628747C CA 2628747 A CA2628747 A CA 2628747A CA 2628747 A CA2628747 A CA 2628747A CA 2628747 C CA2628747 C CA 2628747C
Authority
CA
Canada
Prior art keywords
cancer
hormone therapy
patient
hormone
term
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2628747A
Other languages
English (en)
French (fr)
Other versions
CA2628747A1 (en
Inventor
Jordan S. Fridman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Holdings Corp
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CA2628747A1 publication Critical patent/CA2628747A1/en
Application granted granted Critical
Publication of CA2628747C publication Critical patent/CA2628747C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2628747A 2005-11-22 2006-11-21 Combinations of hormone therapy agents and metalloprotease inhibitors for the treatment of cancer Active CA2628747C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73891905P 2005-11-22 2005-11-22
US60/738,919 2005-11-22
PCT/US2006/045151 WO2007062093A2 (en) 2005-11-22 2006-11-21 Combination therapy for the treatment of cancer comprising a metalloprotease inhibitor

Publications (2)

Publication Number Publication Date
CA2628747A1 CA2628747A1 (en) 2007-05-31
CA2628747C true CA2628747C (en) 2014-01-21

Family

ID=37994504

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2628747A Active CA2628747C (en) 2005-11-22 2006-11-21 Combinations of hormone therapy agents and metalloprotease inhibitors for the treatment of cancer

Country Status (5)

Country Link
US (1) US8324194B2 (enExample)
EP (1) EP1951242A2 (enExample)
JP (1) JP5256042B2 (enExample)
CA (1) CA2628747C (enExample)
WO (1) WO2007062093A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8088737B2 (en) 2003-04-04 2012-01-03 Incyte Corporation Compositions, methods and kits relating to Her-2 cleavage
WO2004096139A2 (en) 2003-04-24 2004-11-11 Incyte Corporation Aza spiro alkane derivatives as inhibitors of metalloproteases
MXPA06004191A (es) 2003-10-17 2007-01-19 Incyte Corp Hidroxamatos ciclicos sustituidos en la forma inhibidores de metaloproteinasas de matriz.
WO2007016597A2 (en) * 2005-07-29 2007-02-08 The Regents Of The University Of California Targeting tnf-alpha converting enzyme (tace)-dependent growth factor shedding in cancer therapy
WO2007143600A2 (en) 2006-06-05 2007-12-13 Incyte Corporation Sheddase inhibitors combined with cd30-binding immunotherapeutics for the treatment of cd30 positive diseases
SG186656A1 (en) 2007-12-14 2013-01-30 Bristol Myers Squibb Co Binding molecules to the human ox40 receptor
WO2010141543A1 (en) * 2009-06-02 2010-12-09 Targeted Molecular Diagnostics, Llc Methods for the detection and quantitation of the p95 component of her2/neu (erbb2)
WO2011083391A2 (en) 2010-01-05 2011-07-14 Pfizer Inc. Biomarkers for anti-igf-ir cancer therapy
MX337040B (es) 2010-09-09 2016-02-09 Pfizer Moleculas de union a 4-1bb.
GB201116092D0 (en) 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
ES2620668T3 (es) 2012-03-02 2017-06-29 Genentech, Inc. Derivados de amidas y sulfonamidas amido espirocíclicas
CN102600073B (zh) * 2012-03-31 2014-01-01 莱普德制药有限公司 以乳酸酯为基础的氟维司群或其衍生物油性制剂及其制备方法
NZ701324A (en) 2012-05-04 2016-09-30 Pfizer Prostate-associated antigens and vaccine-based immunotherapy regimens
KR20160006168A (ko) 2013-03-18 2016-01-18 바이오서오엑스 프로덕스 비.브이. 인간화 항-cd134(ox40) 항체 및 이의 용도
WO2014169462A1 (zh) * 2013-04-18 2014-10-23 西安力邦医药科技有限责任公司 具有抗癌活性的7-α-[9-(4,4,5,5,-五氟戊基亚硫酰基)壬基]-雌甾-1,3,5(10)-三烯-3,17β-二醇的酯类衍生物及其制备方法
WO2019036855A1 (en) 2017-08-21 2019-02-28 Adagene Inc. Anti-cd137 molecules and use thereof
WO2019148445A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Precision/context-dependent activatable antibodies, and methods of making and using the same
WO2019148444A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Anti-ctla4 antibodies and methods of making and using the same
WO2021228178A1 (en) 2020-05-13 2021-11-18 Adagene Ag Compositions and methods for treating cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0008172D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Therapy
BR0113625A (pt) * 2000-09-08 2003-07-22 Pharmacia Italia Spa Exemestano como agente de quimioprevenção
WO2002072106A2 (en) 2001-01-26 2002-09-19 Pharmacia Italia Spa Combined method for treating hormono-dependent disorders with exemestane
US8088737B2 (en) * 2003-04-04 2012-01-03 Incyte Corporation Compositions, methods and kits relating to Her-2 cleavage
WO2004096139A2 (en) * 2003-04-24 2004-11-11 Incyte Corporation Aza spiro alkane derivatives as inhibitors of metalloproteases
MXPA06004191A (es) 2003-10-17 2007-01-19 Incyte Corp Hidroxamatos ciclicos sustituidos en la forma inhibidores de metaloproteinasas de matriz.
WO2005117882A2 (en) 2004-04-20 2005-12-15 Incyte Corporation Hydroxamic acid derivatives as metalloprotease inhibitors
WO2007143600A2 (en) * 2006-06-05 2007-12-13 Incyte Corporation Sheddase inhibitors combined with cd30-binding immunotherapeutics for the treatment of cd30 positive diseases

Also Published As

Publication number Publication date
WO2007062093A3 (en) 2008-10-23
JP2009516747A (ja) 2009-04-23
US8324194B2 (en) 2012-12-04
US20070117809A1 (en) 2007-05-24
JP5256042B2 (ja) 2013-08-07
EP1951242A2 (en) 2008-08-06
WO2007062093A2 (en) 2007-05-31
CA2628747A1 (en) 2007-05-31

Similar Documents

Publication Publication Date Title
CA2628747C (en) Combinations of hormone therapy agents and metalloprotease inhibitors for the treatment of cancer
JP5707518B2 (ja) 置換型キノリン化合物及び使用方法
JP2022500381A (ja) 組み合わせ療法
JP6902682B2 (ja) 性ホルモン依存性疾患を治療するためのnk−1/nk−3受容体デュアルアンタゴニスト
WO2000035455A1 (en) Heteroaryl-aryl ureas as igf-1 receptor antagonists
JP2022500379A (ja) 組み合わせ療法
TWI285550B (en) s for combating menopausal hot flushes Use of CGRP antagonists and CGRP release inhibitor
JP2022500388A (ja) 組み合わせ療法
JP2024537136A (ja) KRAS G12D阻害剤と汎ErbBファミリー阻害剤との併用療法
WO2017040982A1 (en) Her3 ligands and uses thereof
CN118647379A (zh) 用于治疗癌症的包含cdk2抑制剂和cdk4抑制剂的方法和给药方案
AU2017264839B2 (en) 2-Anilinopyrimidine derivatives as therapeutic agents for treatment of brain cancers
US20230000876A1 (en) Treating cancers with a cyclin-dependent kinase inhibitor
JPWO2004035089A1 (ja) ホルモン依存性癌の治療剤
CN102227227A (zh) 包含吡啶并[4,3-d]嘧啶衍生的HSP90抑制剂和HER2抑制剂的药物组合
US20220162200A1 (en) Pkm2 modulators and methods for their use
AU2008309562A1 (en) Isoxazole compound for the treatment of cancer
EP4398904A1 (en) Selected compounds for targeted degradation of brd9
AU2017285609A1 (en) Compositions for treating or preventing vasomotor symptoms
JP7130180B2 (ja) 子宮内膜症の処置のためのインドールの新規誘導体
AU2020215684B2 (en) 2h-indazole derivatives as therapeutic agents for brain cancers and brain metastases
CN111356478A (zh) Ezh2抑制剂组合疗法
TW200902028A (en) Combination of progesterone-receptor antagonist together with an aromatase inhibitor for use in BRCA mediated diseases
US20130267512A1 (en) Jnk inhibitors for the treatment of endometriosis
WO2024206147A1 (en) Dosage regimens of estrogen receptor degraders

Legal Events

Date Code Title Description
EEER Examination request