CA2621809A1 - Alkoxy indolinone based protein kinase inhibitors - Google Patents

Alkoxy indolinone based protein kinase inhibitors Download PDF

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Publication number
CA2621809A1
CA2621809A1 CA002621809A CA2621809A CA2621809A1 CA 2621809 A1 CA2621809 A1 CA 2621809A1 CA 002621809 A CA002621809 A CA 002621809A CA 2621809 A CA2621809 A CA 2621809A CA 2621809 A1 CA2621809 A1 CA 2621809A1
Authority
CA
Canada
Prior art keywords
compound
tautomer
salt
represented
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002621809A
Other languages
English (en)
French (fr)
Inventor
Congxin Liang
Yangbo Feng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2621809A1 publication Critical patent/CA2621809A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA002621809A 2005-09-22 2006-09-21 Alkoxy indolinone based protein kinase inhibitors Abandoned CA2621809A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71947405P 2005-09-22 2005-09-22
US60/719,474 2005-09-22
PCT/US2006/036946 WO2007038251A1 (en) 2005-09-22 2006-09-21 Alkoxy indolinone based protein kinase inhibitors

Publications (1)

Publication Number Publication Date
CA2621809A1 true CA2621809A1 (en) 2007-04-05

Family

ID=37900093

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002621809A Abandoned CA2621809A1 (en) 2005-09-22 2006-09-21 Alkoxy indolinone based protein kinase inhibitors

Country Status (10)

Country Link
US (2) US20090305382A1 (https=)
EP (1) EP1926725A4 (https=)
JP (1) JP2009508971A (https=)
KR (1) KR20080046701A (https=)
CN (1) CN101282965A (https=)
AU (1) AU2006294600A1 (https=)
BR (1) BRPI0616378A2 (https=)
CA (1) CA2621809A1 (https=)
RU (1) RU2008110083A (https=)
WO (1) WO2007038251A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009508971A (ja) * 2005-09-22 2009-03-05 ザ スクリプス リサーチ インスティテュート アルコキシインドリノン系プロテインキナーゼ阻害剤
JP2010502741A (ja) * 2006-09-11 2010-01-28 キュリス，インコーポレイテッド Ｐｔｋインヒビターとしての亜鉛結合部分を含む置換２−インドリノン
ES2565683T3 (es) * 2006-09-15 2016-04-06 Xcovery, Inc. Compuestos inhibidores de quinasa
IN2014MN02105A (https=) 2012-04-20 2015-09-11 Annji Pharm Co Ltd
AU2015226206B2 (en) 2014-03-07 2017-03-16 F. Hoffmann-La Roche Ag Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection
CA2979490C (en) 2015-03-16 2023-07-18 F. Hoffmann-La Roche Ag Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
EP3512556B1 (en) 2016-09-13 2021-08-18 F. Hoffmann-La Roche AG Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
CN110016052B (zh) * 2018-01-08 2021-09-28 四川海思科制药有限公司 N-去乙基舒尼替尼的磷酰胺衍生物及其制备方法
JP2022525522A (ja) 2019-03-25 2022-05-17 エフ．ホフマン－ラ ロシュ アーゲー Ｈｂｖコアタンパク質アロステリック修飾剤の化合物の固体形態

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US72934A (en) * 1867-12-31 Improvement in marking-gauge fob sswim-mgohines
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
TWI259081B (en) * 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
MXPA06006049A (es) * 2003-11-26 2007-05-24 Scripps Research Inst Inhibidores de proteina quinasa avanzados a base de indolinona.
JP2009508971A (ja) * 2005-09-22 2009-03-05 ザ スクリプス リサーチ インスティテュート アルコキシインドリノン系プロテインキナーゼ阻害剤

Also Published As

Publication number Publication date
AU2006294600A1 (en) 2007-04-05
WO2007038251A1 (en) 2007-04-05
BRPI0616378A2 (pt) 2011-06-21
CN101282965A (zh) 2008-10-08
EP1926725A4 (en) 2010-10-06
EP1926725A1 (en) 2008-06-04
US7629339B2 (en) 2009-12-08
US20070072934A1 (en) 2007-03-29
JP2009508971A (ja) 2009-03-05
KR20080046701A (ko) 2008-05-27
US20090305382A1 (en) 2009-12-10
RU2008110083A (ru) 2009-10-27

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Legal Events

Date Code Title Description
FZDE Discontinued