CA2621345A1 - Single receptor assays for immunosuppressive drugs - Google Patents

Single receptor assays for immunosuppressive drugs Download PDF

Info

Publication number
CA2621345A1
CA2621345A1 CA002621345A CA2621345A CA2621345A1 CA 2621345 A1 CA2621345 A1 CA 2621345A1 CA 002621345 A CA002621345 A CA 002621345A CA 2621345 A CA2621345 A CA 2621345A CA 2621345 A1 CA2621345 A1 CA 2621345A1
Authority
CA
Canada
Prior art keywords
rapamycin
immunosuppressive drug
drug
immunophilin
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002621345A
Other languages
English (en)
French (fr)
Inventor
Gerald Sigler
Mitali Ghoshal
Allan Dorn
Shaker Rashid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2621345A1 publication Critical patent/CA2621345A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002621345A 2005-09-07 2006-09-06 Single receptor assays for immunosuppressive drugs Abandoned CA2621345A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71471205P 2005-09-07 2005-09-07
US60/714,712 2005-09-07
PCT/EP2006/008664 WO2007028580A2 (en) 2005-09-07 2006-09-06 Single receptor assays for immunosuppressive drugs

Publications (1)

Publication Number Publication Date
CA2621345A1 true CA2621345A1 (en) 2007-03-15

Family

ID=37116004

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002621345A Abandoned CA2621345A1 (en) 2005-09-07 2006-09-06 Single receptor assays for immunosuppressive drugs

Country Status (6)

Country Link
US (1) US7642059B2 (enExample)
EP (1) EP1946122A2 (enExample)
JP (1) JP2009507234A (enExample)
CN (1) CN101300492A (enExample)
CA (1) CA2621345A1 (enExample)
WO (1) WO2007028580A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007054714A2 (en) * 2005-11-12 2007-05-18 Platform Diagnostics Limited Agglutination assay
US20080081379A1 (en) * 2006-07-13 2008-04-03 Sigler Gerald F Homogeneous double receptor agglutination assay for immunosuppressant drugs
KR101433331B1 (ko) * 2007-08-17 2014-08-22 한국과학기술원 물질의 상호작용 검출 방법
US8133743B2 (en) * 2007-10-19 2012-03-13 Roche Diagnostics Operations, Inc. Phenobarbital derivatives useful in immunoassay
JP6211680B2 (ja) * 2014-03-07 2017-10-11 日本全薬工業株式会社 プルランゲルならびにその製造方法および利用
CN107073066B (zh) 2014-09-11 2021-09-17 加利福尼亚大学董事会 mTORC1抑制剂
US11958863B2 (en) * 2018-11-02 2024-04-16 Siemens Healthcare Diagnostics Inc. Binding competitors for use in macrophilin-binding pharmaceutical assays and methods of use thereof
CN115308328A (zh) * 2022-08-08 2022-11-08 江苏格诺生物科技有限公司 一种检测人全血中多种免疫抑制剂药物的预处理试剂盒及其使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU630901B2 (en) * 1988-12-02 1992-11-12 Children's Research Institute Cyclosporine binding protein and use in an assay for biologically-active cyclosporine
US5698448A (en) 1988-12-02 1997-12-16 Soldin; Steven J. Immunosuppressive drug binding proteins and use
US5196352A (en) 1989-01-19 1993-03-23 Merck & Co., Inc. New FK-506 cytosolic binding protein
WO1991004321A1 (en) 1989-09-25 1991-04-04 President And Fellows Of Harvard College Receptor for fk-506
JP3240135B2 (ja) * 1990-05-09 2001-12-17 チルドレンズ・リサーチ・インスティチュート Ｆｋ―５０６のレセプター分析法
US5322772A (en) 1991-04-09 1994-06-21 Children's Research Institute Rapamycin assay
US5498597A (en) 1992-01-17 1996-03-12 Dana-Farber Cancer Institute, Inc. FKBP-13, an FK506-binding immunophilin
US5354845A (en) 1993-04-21 1994-10-11 Children's Research Institute FK-506 and rapamycin specific binding immunophilin
US5457182A (en) 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6
US6410340B1 (en) 2000-08-23 2002-06-25 Children's Research Institute Use of an 8.4 kDa protein as an immunophilin reagent in protein binding assays for immunosuppressive drugs
EP1239285A1 (en) * 2001-03-07 2002-09-11 Roche Diagnostics GmbH Improved homogeneous immunoassay method
JP4540704B2 (ja) * 2004-03-10 2010-09-08 セラディン インコーポレイテッド エベロリムスの測定方法および測定キット

Also Published As

Publication number Publication date
WO2007028580A2 (en) 2007-03-15
US7642059B2 (en) 2010-01-05
EP1946122A2 (en) 2008-07-23
WO2007028580A3 (en) 2007-05-10
US20070054338A1 (en) 2007-03-08
JP2009507234A (ja) 2009-02-19
CN101300492A (zh) 2008-11-05

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130205