CA2621057A1 - Ikk inhibitors for the treatment of endometriosis - Google Patents
Ikk inhibitors for the treatment of endometriosis Download PDFInfo
- Publication number
- CA2621057A1 CA2621057A1 CA002621057A CA2621057A CA2621057A1 CA 2621057 A1 CA2621057 A1 CA 2621057A1 CA 002621057 A CA002621057 A CA 002621057A CA 2621057 A CA2621057 A CA 2621057A CA 2621057 A1 CA2621057 A1 CA 2621057A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- aryl
- group
- alkyl
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003458 I kappa b kinase inhibitor Substances 0.000 title claims abstract description 57
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71464505P | 2005-09-07 | 2005-09-07 | |
| US60/714,645 | 2005-09-07 | ||
| EP05109450.6 | 2005-10-11 | ||
| EP05109450 | 2005-10-11 | ||
| PCT/US2006/033686 WO2007030362A1 (en) | 2005-09-07 | 2006-08-28 | Ikk inhibitors for the treatment of endometriosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2621057A1 true CA2621057A1 (en) | 2007-03-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002621057A Abandoned CA2621057A1 (en) | 2005-09-07 | 2006-08-28 | Ikk inhibitors for the treatment of endometriosis |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100069387A1 (https=) |
| EP (2) | EP1931322B1 (https=) |
| JP (1) | JP2009507073A (https=) |
| KR (1) | KR20080052650A (https=) |
| CN (1) | CN101304736A (https=) |
| AU (1) | AU2006287767B2 (https=) |
| CA (1) | CA2621057A1 (https=) |
| EA (1) | EA200800755A1 (https=) |
| IL (1) | IL189659A0 (https=) |
| WO (1) | WO2007030362A1 (https=) |
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| WO2010009166A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Oxindolyl inhibitor compounds |
| JP5640005B2 (ja) | 2008-07-14 | 2014-12-10 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物 |
| NZ602832A (en) | 2008-07-14 | 2014-04-30 | Gilead Sciences Inc | Fused heterocyclic hdac inhibitor compounds |
| JP2011529504A (ja) | 2008-07-28 | 2011-12-08 | ギリアード サイエンシーズ， インコーポレイテッド | シクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物およびヘテロシクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物 |
| CN101503402B (zh) * | 2009-03-10 | 2014-06-25 | 沈阳药科大学 | 2-苯胺嘧啶衍生物及其制备和用途 |
| KR20120031170A (ko) | 2009-06-08 | 2012-03-30 | 길리애드 사이언시즈, 인코포레이티드 | 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물 |
| WO2010144378A2 (en) | 2009-06-08 | 2010-12-16 | Gilead Colorado, Inc. | Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds |
| US9046522B2 (en) * | 2009-07-24 | 2015-06-02 | Geadic Biotec, Aie | Markers for endometrial cancer |
| PT2576541T (pt) | 2010-06-04 | 2016-07-08 | Hoffmann La Roche | Derivados de aminopirimidina como moduladores de lrrk2 |
| HRP20172006T1 (hr) | 2010-11-10 | 2018-02-09 | Genentech, Inc. | Derivati pirazol-aminopiridina kao lrrk2-modulatori |
| US10729693B2 (en) | 2018-03-02 | 2020-08-04 | Ponce Medical School Foundation, Inc. | Compositions and methods for the treatment of endometriosis |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
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| EP0578328B1 (en) | 1983-11-02 | 1999-12-29 | Applied Research Systems ARS Holding N.V. | Material and methods for the production of a heterodimeric human LH with a Met42 Val55 alpha subunit |
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| JP2002193938A (ja) | 2000-12-01 | 2002-07-10 | Bayer Ag | ４−アリールピリジン誘導体 |
| US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US20030134836A1 (en) * | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| MXPA03006817A (es) * | 2001-02-01 | 2003-11-13 | Bristol Myers Squibb Co | Metodo de tratamiento de enfermedades inflamatorias e inmunes usando inhibidores de la ikb cinasa (ikk). |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| DE60239207D1 (de) * | 2001-08-10 | 2011-03-31 | Takeda Pharmaceutical | Gnrh-agonistische kombinationsmittel |
| DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| BR0316680A (pt) * | 2002-11-28 | 2005-10-18 | Schering Ag | Pirimidinas inibidoras de chk, pdk e akt, sua produção e uso como agentes farmacêuticos |
| CA2540775A1 (en) * | 2003-10-02 | 2005-04-21 | Xantos Biomedicine Ag | Medical use of tbk-1 or of inhibitors thereof |
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- 2006-08-28 EP EP06813899A patent/EP1931322B1/en active Active
- 2006-08-28 EA EA200800755A patent/EA200800755A1/ru unknown
- 2006-08-28 JP JP2008530093A patent/JP2009507073A/ja active Pending
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- 2006-08-28 CA CA002621057A patent/CA2621057A1/en not_active Abandoned
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- 2006-08-28 US US11/991,578 patent/US20100069387A1/en not_active Abandoned
- 2006-08-28 EP EP10184024A patent/EP2266561A3/en not_active Withdrawn
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2008
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| WO2007030362A1 (en) | 2007-03-15 |
| EA200800755A1 (ru) | 2008-10-30 |
| IL189659A0 (en) | 2008-08-07 |
| US20100069387A1 (en) | 2010-03-18 |
| EP1931322A1 (en) | 2008-06-18 |
| EP2266561A2 (en) | 2010-12-29 |
| EP2266561A3 (en) | 2011-05-18 |
| JP2009507073A (ja) | 2009-02-19 |
| CN101304736A (zh) | 2008-11-12 |
| AU2006287767B2 (en) | 2010-05-13 |
| KR20080052650A (ko) | 2008-06-11 |
| AU2006287767A1 (en) | 2007-03-15 |
| EP1931322B1 (en) | 2012-08-15 |
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