CA2617319A1 - Radiolabeled-pegylation of ligands for use as imaging agents - Google Patents
Radiolabeled-pegylation of ligands for use as imaging agents Download PDFInfo
- Publication number
- CA2617319A1 CA2617319A1 CA002617319A CA2617319A CA2617319A1 CA 2617319 A1 CA2617319 A1 CA 2617319A1 CA 002617319 A CA002617319 A CA 002617319A CA 2617319 A CA2617319 A CA 2617319A CA 2617319 A1 CA2617319 A1 CA 2617319A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- hydrogen
- group
- hydroxy
- instance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003446 ligand Substances 0.000 title claims abstract description 85
- 239000012216 imaging agent Substances 0.000 title claims abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 157
- 238000000034 method Methods 0.000 claims abstract description 109
- 238000003384 imaging method Methods 0.000 claims abstract description 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 241000124008 Mammalia Species 0.000 claims abstract description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 236
- 229910052739 hydrogen Inorganic materials 0.000 claims description 180
- 239000001257 hydrogen Substances 0.000 claims description 178
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 120
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 115
- 125000005843 halogen group Chemical group 0.000 claims description 90
- 229910052736 halogen Inorganic materials 0.000 claims description 69
- 150000002367 halogens Chemical group 0.000 claims description 69
- 229910052757 nitrogen Inorganic materials 0.000 claims description 54
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 52
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 45
- 125000002034 haloarylalkyl group Chemical group 0.000 claims description 43
- 125000000623 heterocyclic group Chemical group 0.000 claims description 42
- -1 hydroxy, amino, methylamino, dimethylamino Chemical group 0.000 claims description 41
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 39
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- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 30
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- 150000003839 salts Chemical class 0.000 claims description 23
- 229910052717 sulfur Inorganic materials 0.000 claims description 22
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 229910052702 rhenium Inorganic materials 0.000 claims description 17
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 15
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 6
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- 125000003545 alkoxy group Chemical group 0.000 description 30
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- 101150041968 CDC13 gene Proteins 0.000 description 25
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 25
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- 238000006243 chemical reaction Methods 0.000 description 23
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- 230000015572 biosynthetic process Effects 0.000 description 17
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- 239000002738 chelating agent Substances 0.000 description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 12
- 239000002253 acid Substances 0.000 description 12
- KPMVHELZNRNSMN-UHFFFAOYSA-N chembl1985849 Chemical compound N1=CC=C2NCCN21 KPMVHELZNRNSMN-UHFFFAOYSA-N 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 12
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- 238000003786 synthesis reaction Methods 0.000 description 11
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 10
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 10
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 10
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- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 10
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- 229940056501 technetium 99m Drugs 0.000 description 10
- 239000003638 chemical reducing agent Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 8
- 238000013459 approach Methods 0.000 description 8
- 239000002953 phosphate buffered saline Substances 0.000 description 8
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 8
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- 241000699670 Mus sp. Species 0.000 description 7
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- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 7
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 6
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 5
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69350105P | 2005-06-24 | 2005-06-24 | |
| US60/693,501 | 2005-06-24 | ||
| PCT/US2006/024707 WO2007002540A2 (en) | 2005-06-24 | 2006-06-26 | Radiolabeled-pegylation of ligands for use as imaging agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2617319A1 true CA2617319A1 (en) | 2007-01-04 |
Family
ID=37595934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002617319A Abandoned CA2617319A1 (en) | 2005-06-24 | 2006-06-26 | Radiolabeled-pegylation of ligands for use as imaging agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070031328A1 (de) |
| EP (1) | EP1893245A4 (de) |
| JP (1) | JP2008546804A (de) |
| AU (1) | AU2006261917A1 (de) |
| CA (1) | CA2617319A1 (de) |
| WO (1) | WO2007002540A2 (de) |
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| EP1838298A4 (de) * | 2004-12-17 | 2009-03-04 | Univ Pennsylvania | Stilben-derivate und ihre verwendung zur bindung und bilddarstellung von amyloid-plaque |
| CN101522624B (zh) | 2006-03-30 | 2013-11-06 | 宾夕法尼亚大学理事会 | 苯乙烯基吡啶衍生物及其用于结合和成像淀粉样蛋白斑的用途 |
| WO2007148755A1 (ja) * | 2006-06-21 | 2007-12-27 | Nihon Medi-Physics Co., Ltd. | 新規アミロイド親和性化合物 |
| BRPI0716583A2 (pt) * | 2006-08-24 | 2013-10-01 | Australian Nuclear Science Tec | ligandos fluorados para marcar recptores de benzodiazepina perifÉricos |
| JP5319121B2 (ja) * | 2007-01-30 | 2013-10-16 | 株式会社東芝 | 診療支援システム及び診療支援装置 |
| JP2010524857A (ja) * | 2007-04-10 | 2010-07-22 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | フェン−ナフタレン及びフェン−キノリン誘導体、及びアミロイドプラークに結合させ、そして造影するための使用 |
| EP2144507A4 (de) * | 2007-04-19 | 2010-05-26 | Univ Pennsylvania | Diphenyl-heteroaryl-derivate und ihre verwendung zur bindung und abbildung von amyloider plaque |
| WO2008151003A2 (en) * | 2007-05-30 | 2008-12-11 | Children's Medical Center Corporation | Novel fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography |
| EP2172444A4 (de) * | 2007-07-04 | 2010-12-22 | Univ Tohoku | Pet-sonde mit fluorsubstituierter alkoxygruppe und hydroxygruppe |
| EP2182988B1 (de) * | 2007-08-30 | 2014-04-16 | GE Healthcare Limited | Radiopharmazeutische zusammensetzung |
| CA2703649A1 (en) | 2007-10-24 | 2009-04-30 | Shigeyuki Tanifuji | Novel compound having affinity for amyloid |
| AU2008314871A1 (en) | 2007-10-26 | 2009-04-30 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| US20100249419A1 (en) | 2007-10-30 | 2010-09-30 | Nihon Medi-Physics Co., Ltd. | Utilization of novel compounds with amyloid affinity and method of producing the same |
| LT2247558T (lt) * | 2008-02-14 | 2022-04-11 | Eli Lilly And Company | Nauji vizualizavimo agentai neurologinės disfunkcijos aptikimui |
| US8932557B2 (en) | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| EP2247944A1 (de) * | 2008-02-27 | 2010-11-10 | Avid Radiopharmaceuticals, Inc. | Nachweis von amyloider plaque mittels gamma-sonde anhand von radioaktiv markierten a-beta-bindenden verbindungen |
| US8557222B2 (en) * | 2008-04-04 | 2013-10-15 | Avid Radiopharmaceuticals, Inc. | Radiopharmaceutical imaging of neurodegenerative diseases |
| WO2009155017A2 (en) | 2008-05-30 | 2009-12-23 | Merck & Co., Inc. | Novel substituted azabenzoxazoles |
| AU2009253046A1 (en) * | 2008-05-30 | 2009-12-03 | Foster Wheeler Energia Oy | Method of and system for generating power by oxyfuel combustion |
| PT2307381T (pt) | 2008-06-09 | 2021-03-15 | Univ Muenchen Ludwig Maximilians | Novas drogas para inibir a agregação de proteínas envolvidas em doenças relacionadas com a agregação de proteínas e/ou doenças neurodegenerativas |
| JP2012508889A (ja) * | 2008-11-13 | 2012-04-12 | アビッド レディオファーマシューティカルズ、インク． | 神経変性疾患の検出と診断のためのヒストグラムに基づいた分析方法 |
| EP2218464A1 (de) * | 2009-02-11 | 2010-08-18 | Technische Universität München | Verbindungen zur nichtinvasiven Messung von Aggregaten von Amyloidpeptiden |
| EP2400992B1 (de) * | 2009-02-27 | 2015-07-22 | Genentech, Inc. | Verfahren und zusammensetzungen zur kennzeichnung von proteinen |
| KR101123178B1 (ko) * | 2009-04-09 | 2012-06-13 | (주)에스메디 | 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
| PL2449379T3 (pl) | 2009-07-02 | 2017-12-29 | Sloan-Kettering Institute For Cancer Research | Fluorescencyjne nanocząstki na bazie krzemionki |
| JP2012532164A (ja) * | 2009-07-10 | 2012-12-13 | バイエル ファーマ アクチエンゲゼルシャフト | 放射性トレーサーの精製のための低‐中圧液体クロマトグラフィーの使用 |
| WO2011066521A2 (en) * | 2009-11-30 | 2011-06-03 | Stc. Unm | Compounds with reduced ring size for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same |
| EP2575898B8 (de) | 2010-06-04 | 2021-04-21 | Life Molecular Imaging SA | Verfahren zur herstellung von f-18-markierten amyloid-beta-liganden |
| JP5825608B2 (ja) * | 2010-08-06 | 2015-12-02 | 国立大学法人京都大学 | ピリジルベンゾフラン誘導体 |
| US9259495B2 (en) | 2010-10-12 | 2016-02-16 | Mayo Foundation For Medical Education And Research | Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives |
| JPWO2013027694A1 (ja) * | 2011-08-24 | 2015-03-19 | 国立大学法人京都大学 | コンフォメーション病診断用分子イメージングプローブ |
| JP6037330B2 (ja) * | 2012-03-03 | 2016-12-07 | 国立研究開発法人理化学研究所 | １１ｃ−標識チアミン及びその誘導体、１１ｃ−標識フルスルチアミン、チアミン前駆体、並びにｐｅｔ用プローブ及びそれらを用いたイメージング方法 |
| EP2657213A1 (de) * | 2012-04-24 | 2013-10-30 | Institut National de la Santé et de la Recherche Medicale | Markierte Chinoxalin-Derivate als multimodale Radiopharmazeutika und ihre Vorläufer |
| CN104540835B (zh) | 2012-04-26 | 2017-08-08 | 百时美施贵宝公司 | 用于治疗血小板聚集的作为蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑衍生物 |
| JP6101343B2 (ja) | 2012-04-26 | 2017-03-22 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 血小板凝集を治療するためのプロテアーゼ活性化受容体４（ｐａｒ４）阻害剤としてのイミダゾチアジアゾールおよびイミダゾピリダジン誘導体 |
| HUE060743T2 (hu) | 2012-04-26 | 2023-04-28 | Bristol Myers Squibb Co | Gyógyszerészeti kompozíciók, amelyek tartalmaznak imidazothiadiazol- és imidazopiridazinszármazékokat mint proteáz aktívált receptor 4 (PAR4) inhibitorokat trombocitaaggregációk kezelésére |
| WO2014004664A2 (en) | 2012-06-27 | 2014-01-03 | Mayo Foundation For Medical Education And Research | Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives |
| WO2014109296A1 (ja) * | 2013-01-09 | 2014-07-17 | 国立大学法人滋賀医科大学 | 神経難病のmr画像診断薬 |
| EP2957556B1 (de) * | 2013-02-12 | 2020-01-15 | Osaka University | Aromatisches aminosäurederivat und positronenemissionstopografie (pet)-sonde damit |
| CN105307687A (zh) | 2013-03-15 | 2016-02-03 | 索隆-基特林癌症研究协会 | 多模态的基于二氧化硅的纳米粒子 |
| JP2014218454A (ja) * | 2013-05-07 | 2014-11-20 | 日本メジフィジックス株式会社 | スチリルピリジン誘導体化合物 |
| JP6041751B2 (ja) * | 2013-05-07 | 2016-12-14 | 日本メジフィジックス株式会社 | スチリルピリジン誘導体化合物 |
| SI2999701T1 (sl) | 2013-05-23 | 2017-08-31 | F. Hoffmann-La Roche Ag | 2-fenilimidazo(1,2-a)pirimidini kot sredstva za slikanje |
| MX2016003422A (es) * | 2013-09-26 | 2016-06-28 | Hoffmann La Roche | Imidazo[1,2-a]piridina-7-aminas como herramientas de imagen. |
| WO2015051188A1 (en) * | 2013-10-02 | 2015-04-09 | Washington University | Heterocyclic molecules for biomedical imaging and therapeutic applications |
| CN113349707A (zh) | 2013-12-31 | 2021-09-07 | 纪念斯隆-凯特琳癌症中心 | 用于荧光源实时多通道成像的系统、方法和设备 |
| WO2015183882A1 (en) | 2014-05-29 | 2015-12-03 | Memorial Sloan Kettering Cancer Center | Nanoparticle drug conjugates |
| KR20180012299A (ko) | 2015-05-29 | 2018-02-05 | 메모리얼 슬로안-케터링 캔서 센터 | 초소형 나노입자를 사용하여 페로토시스를 통해 영양분-결핍 암 세포의 세포 사멸을 유도하는 치료 방법 |
| EP3634500B1 (de) | 2017-05-25 | 2023-10-25 | Memorial Sloan-Kettering Cancer Center | Mit zirkonium -89 markierte ultrakleine nanopartikel und verfahren dafür |
| EP3793619A4 (de) * | 2018-05-16 | 2022-01-12 | Emory University | Styrylbenzothiazolderivate und ihre verwendung in der bilderzeugung |
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|---|---|---|---|---|
| US5252632A (en) * | 1992-11-19 | 1993-10-12 | Savin Roland R | Low cost cathodic and conductive coating compositions comprising lightweight hollow glass microspheres and a conductive phase |
| US6168776B1 (en) * | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| US5601801A (en) * | 1994-08-02 | 1997-02-11 | Merck Frosst Canada, Inc. | Radiolabelled angiotensin converting enzyme inhibitors |
| AU1529297A (en) * | 1996-01-24 | 1997-08-20 | Warner-Lambert Company | Method of imaging amyloid deposits |
| US5869500A (en) * | 1996-12-13 | 1999-02-09 | Hoffmann-La Roche Inc. | Pyridone compounds useful in treating Alzheimer's disease |
| US6037473A (en) * | 1997-11-13 | 2000-03-14 | Haarmann & Reimer Gmbh | Use of substituted benzazoles as UV absorbers, new benzazoles and processes for their preparation |
| US7311893B2 (en) * | 2000-07-25 | 2007-12-25 | Neurochem (International) Limited | Amyloid targeting imaging agents and uses thereof |
| TWI245764B (en) * | 2001-04-23 | 2005-12-21 | Hank F Kung | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
| DK1432453T3 (da) * | 2001-08-27 | 2013-11-18 | Univ Pennsylvania | Stilbenderivater og anvendelse heraf til binding og billeddannelse af amyloid-plaques |
| TW200413009A (en) * | 2002-10-04 | 2004-08-01 | Univ Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
| US20050043523A1 (en) * | 2003-08-22 | 2005-02-24 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| EP1838298A4 (de) * | 2004-12-17 | 2009-03-04 | Univ Pennsylvania | Stilben-derivate und ihre verwendung zur bindung und bilddarstellung von amyloid-plaque |
| US7858072B2 (en) * | 2004-12-17 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
-
2006
- 2006-06-26 EP EP06785541A patent/EP1893245A4/de not_active Withdrawn
- 2006-06-26 US US11/474,489 patent/US20070031328A1/en not_active Abandoned
- 2006-06-26 CA CA002617319A patent/CA2617319A1/en not_active Abandoned
- 2006-06-26 JP JP2008518480A patent/JP2008546804A/ja active Pending
- 2006-06-26 AU AU2006261917A patent/AU2006261917A1/en not_active Abandoned
- 2006-06-26 WO PCT/US2006/024707 patent/WO2007002540A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP1893245A2 (de) | 2008-03-05 |
| WO2007002540A2 (en) | 2007-01-04 |
| WO2007002540A3 (en) | 2007-10-25 |
| EP1893245A4 (de) | 2009-06-24 |
| JP2008546804A (ja) | 2008-12-25 |
| US20070031328A1 (en) | 2007-02-08 |
| AU2006261917A1 (en) | 2007-01-04 |
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