CA2610416A1 - Tubulin inhibitor and process for its preparation - Google Patents
Tubulin inhibitor and process for its preparation Download PDFInfo
- Publication number
- CA2610416A1 CA2610416A1 CA002610416A CA2610416A CA2610416A1 CA 2610416 A1 CA2610416 A1 CA 2610416A1 CA 002610416 A CA002610416 A CA 002610416A CA 2610416 A CA2610416 A CA 2610416A CA 2610416 A1 CA2610416 A1 CA 2610416A1
- Authority
- CA
- Canada
- Prior art keywords
- trifluoro
- pyrazin
- process according
- phenyl
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69001605P | 2005-06-13 | 2005-06-13 | |
US60/690,016 | 2005-06-13 | ||
US80278106P | 2006-05-24 | 2006-05-24 | |
US60/802,781 | 2006-05-24 | ||
PCT/US2006/022574 WO2006138180A1 (en) | 2005-06-13 | 2006-06-08 | Tubulin inhibitor and process for its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2610416A1 true CA2610416A1 (en) | 2006-12-28 |
Family
ID=37074929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002610416A Abandoned CA2610416A1 (en) | 2005-06-13 | 2006-06-08 | Tubulin inhibitor and process for its preparation |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1891052A1 (ja) |
JP (1) | JP2008543838A (ja) |
AR (1) | AR054392A1 (ja) |
AU (1) | AU2006259663A1 (ja) |
BR (1) | BRPI0612145A2 (ja) |
CA (1) | CA2610416A1 (ja) |
GT (1) | GT200600257A (ja) |
MX (1) | MX2007015718A (ja) |
PE (1) | PE20070114A1 (ja) |
SV (1) | SV2007002573A (ja) |
TW (1) | TW200716613A (ja) |
WO (1) | WO2006138180A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011057805A1 (en) | 2009-11-12 | 2011-05-19 | R&D Biopharmaceuticals Gmbh | Tubulin inhibitors |
EP2903436B1 (en) * | 2012-09-19 | 2019-07-17 | The Trustees Of The University Of Pennsylvania | Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies |
WO2017181974A1 (zh) * | 2016-04-20 | 2017-10-26 | 苏州苏领生物医药有限公司 | 五元杂环类化合物及其制备方法、药物组合物和用途 |
US11623927B2 (en) | 2018-03-02 | 2023-04-11 | The Trustees Of The University Of Pennsylvania | Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1680425E (pt) * | 2003-09-24 | 2007-02-28 | Wyeth Corp | 6 - [fenil (substituído)] triazolopirimidinas como agentes contra o cancro. |
RU2006107578A (ru) * | 2003-09-24 | 2007-10-27 | Вайет Холдингз Корпорейшн (Us) | 6-арилпиримидин, применяемый в качестве противоракового агента |
-
2006
- 2006-06-08 AU AU2006259663A patent/AU2006259663A1/en not_active Abandoned
- 2006-06-08 BR BRPI0612145-4A patent/BRPI0612145A2/pt not_active Application Discontinuation
- 2006-06-08 MX MX2007015718A patent/MX2007015718A/es not_active Application Discontinuation
- 2006-06-08 JP JP2008516956A patent/JP2008543838A/ja not_active Withdrawn
- 2006-06-08 EP EP06784720A patent/EP1891052A1/en not_active Withdrawn
- 2006-06-08 CA CA002610416A patent/CA2610416A1/en not_active Abandoned
- 2006-06-08 WO PCT/US2006/022574 patent/WO2006138180A1/en active Application Filing
- 2006-06-12 TW TW095120855A patent/TW200716613A/zh unknown
- 2006-06-12 AR ARP060102470A patent/AR054392A1/es unknown
- 2006-06-13 PE PE2006000657A patent/PE20070114A1/es not_active Application Discontinuation
- 2006-06-13 GT GT200600257A patent/GT200600257A/es unknown
- 2006-06-13 SV SV2006002573A patent/SV2007002573A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AR054392A1 (es) | 2007-06-20 |
TW200716613A (en) | 2007-05-01 |
BRPI0612145A2 (pt) | 2010-10-19 |
SV2007002573A (es) | 2007-01-03 |
WO2006138180A1 (en) | 2006-12-28 |
PE20070114A1 (es) | 2007-02-03 |
EP1891052A1 (en) | 2008-02-27 |
GT200600257A (es) | 2007-02-14 |
JP2008543838A (ja) | 2008-12-04 |
MX2007015718A (es) | 2008-02-21 |
AU2006259663A1 (en) | 2006-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2759480T3 (es) | Nuevos derivados de hidroxiéster, un proceso para su preparación y composiciones farmacéuticas que los contienen | |
US5856481A (en) | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative | |
AU2019204745A1 (en) | Antimicrobial compounds and methods of making and using the same | |
EP3173412B1 (en) | 2,4-disubstituted 7h-pyrrolo[2,3-d]pyrimidine derivative, preparation method and medicinal use thereof | |
EP0303697A1 (en) | Derivatives of physiologically active substance k-252 | |
US20230250087A1 (en) | Solid forms of apol1 inhibitor and methods of using same | |
IL114735A (en) | L-Monvalin Aster of 2-) 2-Amino-1,6-Dihydro-6-Oxopurin-9-Il (3-Hydroxy-1-propanol) preparations, preparation | |
CN115141215A (zh) | Kras g12d蛋白抑制剂和其用途 | |
EA025863B1 (ru) | Карбазолкарбоксамидные соединения | |
EP2889287B1 (en) | Dolastatin-10 derivative, method of producing same and anticancer drug composition containing same | |
US20180370948A1 (en) | P-toluenesulfonate for mek kinase inhibitor, method of preparation thereof, and method of use thereof | |
US9458165B2 (en) | DOT1L inhibitors | |
CA2610416A1 (en) | Tubulin inhibitor and process for its preparation | |
KR20060098368A (ko) | 항암제로서의 6-[(치환된)페닐]트리아졸로피리미딘 | |
US7501423B2 (en) | Tubulin inhibitor and process for its preparation | |
US11964987B2 (en) | Isoidide derivatives and methods of making and using same | |
US20050124635A1 (en) | Process for the preparation of tubulin inhibitors | |
US20240158404A1 (en) | Modulators of alpha-1 antitrypsin | |
RU2817349C1 (ru) | Производные аминопиримидинила | |
US10617706B2 (en) | Compounds for cancer chemotherapeutic sensitization | |
TW202208371A (zh) | 胺基嘧啶基衍生物 | |
JP2024510935A (ja) | 甲状腺ホルモン受容体ベータアゴニスト化合物 | |
CN113354590A (zh) | 拮抗nod1/2受体信号通路的喹唑啉酮类化合物 | |
WO2022229986A1 (en) | Indirubin compounds and methods thereof | |
WO2021257669A1 (en) | Synthesis of substituted arylmethylureas, analogues, and crystalline forms thereof and methods of using same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |