CA2609271C - Novel substrate for rpn 11 enzymatic activity - Google Patents

Novel substrate for rpn 11 enzymatic activity Download PDF

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Publication number
CA2609271C
CA2609271C CA2609271A CA2609271A CA2609271C CA 2609271 C CA2609271 C CA 2609271C CA 2609271 A CA2609271 A CA 2609271A CA 2609271 A CA2609271 A CA 2609271A CA 2609271 C CA2609271 C CA 2609271C
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Prior art keywords
peptide
agent
proteasome
amino acid
seq
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Expired - Lifetime
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CA2609271A
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English (en)
French (fr)
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CA2609271A1 (en
Inventor
Francesco Parlati
Monette Aujay
Mark K. Bennett
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Onyx Therapeutics Inc
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Onyx Therapeutics Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • A—HUMAN NECESSITIES
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
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CA2609271A 2005-05-27 2006-05-30 Novel substrate for rpn 11 enzymatic activity Expired - Lifetime CA2609271C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68542605P 2005-05-27 2005-05-27
US60/685,426 2005-05-27
US70965905P 2005-08-19 2005-08-19
US60/709,659 2005-08-19
PCT/US2006/021080 WO2006128196A2 (en) 2005-05-27 2006-05-30 Novel substrate for rpn 11 enzymatic activity

Publications (2)

Publication Number Publication Date
CA2609271A1 CA2609271A1 (en) 2006-11-30
CA2609271C true CA2609271C (en) 2014-02-25

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ID=37055744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2609271A Expired - Lifetime CA2609271C (en) 2005-05-27 2006-05-30 Novel substrate for rpn 11 enzymatic activity

Country Status (9)

Country Link
US (2) US7741432B2 (enExample)
EP (1) EP1885744B1 (enExample)
JP (2) JP5311209B2 (enExample)
AT (1) ATE483725T1 (enExample)
AU (1) AU2006251941B2 (enExample)
CA (1) CA2609271C (enExample)
DE (1) DE602006017359D1 (enExample)
IL (1) IL187489A (enExample)
WO (1) WO2006128196A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006017359D1 (de) * 2005-05-27 2010-11-18 Proteolix Inc Substrat für die rpn-11-enzymaktivität
US20110118274A1 (en) * 2007-08-23 2011-05-19 Cornell Research Foundation, Inc. Proteasome inhibitors and their use in treating pathogen infection and cancer
GB201009941D0 (en) * 2010-06-14 2010-07-21 Medical Res Council Deubiquitinase assay
WO2013123071A1 (en) * 2012-02-13 2013-08-22 Cleave Biosciences, Inc. Methods and compositions for jamm protease inhibition
NZ705040A (en) 2012-07-20 2017-07-28 Cleave Biosciences Inc Fused pyrimidines as inhibitors of p97 complex
WO2014066506A2 (en) 2012-10-23 2014-05-01 Cleave Biosciences, Inc. Compositions and methods for jamm protein inhibition
US9828363B2 (en) 2014-01-20 2017-11-28 Cleave Biosciences, Inc. Fused pyrimidines as inhibitors of P97 complex

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340736A (en) 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
JP3650632B2 (ja) * 1994-06-16 2005-05-25 株式会社林原生物化学研究所 マルトースをトレハロースに変換する組換え型酵素
JPH09263A (ja) * 1995-06-21 1997-01-07 Sagami Chem Res Center ポリユビキチンｃＤＮＡおよび標識ユビキチンの製造方法
WO1998010779A1 (en) 1996-09-13 1998-03-19 New York University Method for treating parasitic diseases with proteasome inhibitors
WO1999001567A2 (en) * 1997-07-01 1999-01-14 The University Of Utah Methods and compositions for a deubiquitinating enzyme and variants thereof
US7279317B2 (en) 2001-01-12 2007-10-09 California Institute Of Technology Modulation of COP9 signalsome isopeptidase activity
EP1349922A4 (en) 2001-01-12 2005-09-07 California Inst Of Techn REGULATING THE ACTIVITY OF A TARGET PROTEIN THROUGH MODIFIED PROTEINS
US6903238B2 (en) 2001-12-13 2005-06-07 Wyeth Substituted indenones as estrogenic agents
WO2003060476A2 (en) 2002-01-14 2003-07-24 California Institute Of Technology Modulation of cop9 signalsome isopeptidase activity
JP2005006637A (ja) * 2003-05-29 2005-01-13 National Institute Of Advanced Industrial & Technology ユビキチン化タンパク質からユビキチンを外しタンパク質を回収する方法
DE602006017359D1 (de) * 2005-05-27 2010-11-18 Proteolix Inc Substrat für die rpn-11-enzymaktivität

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Publication number Publication date
CA2609271A1 (en) 2006-11-30
US20100196346A1 (en) 2010-08-05
US7741432B2 (en) 2010-06-22
ATE483725T1 (de) 2010-10-15
IL187489A0 (en) 2008-02-09
WO2006128196A3 (en) 2007-04-12
DE602006017359D1 (de) 2010-11-18
EP1885744B1 (en) 2010-10-06
US8697837B2 (en) 2014-04-15
IL187489A (en) 2014-01-30
JP5311209B2 (ja) 2013-10-09
JP2008545719A (ja) 2008-12-18
WO2006128196A2 (en) 2006-11-30
AU2006251941A1 (en) 2006-11-30
JP2012167092A (ja) 2012-09-06
AU2006251941B2 (en) 2012-02-09
US20060280731A1 (en) 2006-12-14
EP1885744A2 (en) 2008-02-13

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