AU2006251941B2 - Novel substrate for Rpn11 enzymatic activity - Google Patents

Novel substrate for Rpn11 enzymatic activity Download PDF

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Publication number
AU2006251941B2
AU2006251941B2 AU2006251941A AU2006251941A AU2006251941B2 AU 2006251941 B2 AU2006251941 B2 AU 2006251941B2 AU 2006251941 A AU2006251941 A AU 2006251941A AU 2006251941 A AU2006251941 A AU 2006251941A AU 2006251941 B2 AU2006251941 B2 AU 2006251941B2
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peptide
agent
proteasome
amino acid
seq
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AU2006251941A
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AU2006251941A1 (en
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Monette Aujay
Mark K. Bennett
Francesco Parlati
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Onyx Therapeutics Inc
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Onyx Therapeutics Inc
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Priority to AU2012202284A priority Critical patent/AU2012202284B2/en
Assigned to ONYX THERAPEUTICS, INC. reassignment ONYX THERAPEUTICS, INC. Request to Amend Deed and Register Assignors: PROTEOLIX, INC.
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875Nucleoproteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Neurology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Physics & Mathematics (AREA)
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AU2006251941A 2005-05-27 2006-05-30 Novel substrate for Rpn11 enzymatic activity Active AU2006251941B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012202284A AU2012202284B2 (en) 2005-05-27 2012-04-19 Novel substrate for Rpn11 enzymatic activity

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68542605P 2005-05-27 2005-05-27
US60/685,426 2005-05-27
US70965905P 2005-08-19 2005-08-19
US60/709,659 2005-08-19
PCT/US2006/021080 WO2006128196A2 (en) 2005-05-27 2006-05-30 Novel substrate for rpn 11 enzymatic activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012202284A Division AU2012202284B2 (en) 2005-05-27 2012-04-19 Novel substrate for Rpn11 enzymatic activity

Publications (2)

Publication Number Publication Date
AU2006251941A1 AU2006251941A1 (en) 2006-11-30
AU2006251941B2 true AU2006251941B2 (en) 2012-02-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006251941A Active AU2006251941B2 (en) 2005-05-27 2006-05-30 Novel substrate for Rpn11 enzymatic activity

Country Status (9)

Country Link
US (2) US7741432B2 (enExample)
EP (1) EP1885744B1 (enExample)
JP (2) JP5311209B2 (enExample)
AT (1) ATE483725T1 (enExample)
AU (1) AU2006251941B2 (enExample)
CA (1) CA2609271C (enExample)
DE (1) DE602006017359D1 (enExample)
IL (1) IL187489A (enExample)
WO (1) WO2006128196A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE483725T1 (de) * 2005-05-27 2010-10-15 Proteolix Inc Substrat für die rpn-11-enzymaktivität
US20110118274A1 (en) * 2007-08-23 2011-05-19 Cornell Research Foundation, Inc. Proteasome inhibitors and their use in treating pathogen infection and cancer
GB201009941D0 (en) * 2010-06-14 2010-07-21 Medical Res Council Deubiquitinase assay
WO2013123071A1 (en) * 2012-02-13 2013-08-22 Cleave Biosciences, Inc. Methods and compositions for jamm protease inhibition
NZ705040A (en) 2012-07-20 2017-07-28 Cleave Biosciences Inc Fused pyrimidines as inhibitors of p97 complex
WO2014066506A2 (en) 2012-10-23 2014-05-01 Cleave Biosciences, Inc. Compositions and methods for jamm protein inhibition
CN106458996B (zh) 2014-01-20 2020-11-03 克里弗生物科学公司 作为p97复合物的抑制剂的稠合嘧啶

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340736A (en) 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
JP3650632B2 (ja) * 1994-06-16 2005-05-25 株式会社林原生物化学研究所 マルトースをトレハロースに変換する組換え型酵素
JPH09263A (ja) * 1995-06-21 1997-01-07 Sagami Chem Res Center ポリユビキチンcDNAおよび標識ユビキチンの製造方法
WO1998010779A1 (en) 1996-09-13 1998-03-19 New York University Method for treating parasitic diseases with proteasome inhibitors
WO1999001567A2 (en) * 1997-07-01 1999-01-14 The University Of Utah Methods and compositions for a deubiquitinating enzyme and variants thereof
AU2002245255A1 (en) 2001-01-12 2002-07-24 California Institute Of Technology Pasadena, Ca 91125 Regulation of target protein activity through modified proteins
US7279317B2 (en) 2001-01-12 2007-10-09 California Institute Of Technology Modulation of COP9 signalsome isopeptidase activity
US6903238B2 (en) 2001-12-13 2005-06-07 Wyeth Substituted indenones as estrogenic agents
WO2003060476A2 (en) 2002-01-14 2003-07-24 California Institute Of Technology Modulation of cop9 signalsome isopeptidase activity
JP2005006637A (ja) * 2003-05-29 2005-01-13 National Institute Of Advanced Industrial & Technology ユビキチン化タンパク質からユビキチンを外しタンパク質を回収する方法
ATE483725T1 (de) 2005-05-27 2010-10-15 Proteolix Inc Substrat für die rpn-11-enzymaktivität

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Publication number Publication date
ATE483725T1 (de) 2010-10-15
EP1885744A2 (en) 2008-02-13
WO2006128196A3 (en) 2007-04-12
US8697837B2 (en) 2014-04-15
WO2006128196A2 (en) 2006-11-30
US20060280731A1 (en) 2006-12-14
JP2012167092A (ja) 2012-09-06
US20100196346A1 (en) 2010-08-05
US7741432B2 (en) 2010-06-22
IL187489A (en) 2014-01-30
CA2609271A1 (en) 2006-11-30
CA2609271C (en) 2014-02-25
JP5311209B2 (ja) 2013-10-09
IL187489A0 (en) 2008-02-09
EP1885744B1 (en) 2010-10-06
DE602006017359D1 (de) 2010-11-18
JP2008545719A (ja) 2008-12-18
AU2006251941A1 (en) 2006-11-30

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