CA2609150A1 - Compositions, methods and kits for real-time nucleic acid analysis in live cells - Google Patents
Compositions, methods and kits for real-time nucleic acid analysis in live cells Download PDFInfo
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- CA2609150A1 CA2609150A1 CA002609150A CA2609150A CA2609150A1 CA 2609150 A1 CA2609150 A1 CA 2609150A1 CA 002609150 A CA002609150 A CA 002609150A CA 2609150 A CA2609150 A CA 2609150A CA 2609150 A1 CA2609150 A1 CA 2609150A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/72—Fusion polypeptide containing domain for protein-protein interaction containing SH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/85—Fusion polypeptide containing an RNA binding domain
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07006—DNA-directed RNA polymerase (2.7.7.6)
Landscapes
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- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
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| US60/682,334 | 2005-05-18 | ||
| PCT/US2006/019107 WO2006125012A2 (en) | 2005-05-18 | 2006-05-17 | Compositions, methods and kits for real-time nucleic acid analysis in live cells |
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| CA2609150A1 true CA2609150A1 (en) | 2006-11-23 |
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| GB0804495D0 (en) * | 2008-03-11 | 2008-04-16 | Iti Scotland Ltd | Surface attachment |
| WO2010129019A2 (en) | 2009-04-27 | 2010-11-11 | Pacific Biosciences Of California, Inc. | Real-time sequencing methods and systems |
| WO2010144150A2 (en) | 2009-06-12 | 2010-12-16 | Pacific Biosciences Of California, Inc. | Real-time analytical methods and systems |
| JP7588391B2 (ja) | 2017-06-30 | 2024-11-22 | コデクシス， インコーポレイテッド | Ｔ７ ｒｎａポリメラーゼバリアント |
| CN111417724A (zh) | 2017-06-30 | 2020-07-14 | 科德克希思公司 | T7 rna聚合酶变体 |
| US20230062612A1 (en) * | 2020-01-17 | 2023-03-02 | Sana Biotechnology, Inc. | Safety switches for regulation of gene expression |
| WO2022084748A1 (en) * | 2020-10-23 | 2022-04-28 | Spindle Biotech, Inc. | Compositions and methods for rna synthesis |
| WO2025038950A1 (en) * | 2023-08-16 | 2025-02-20 | Spotlight Therapeutics | Cell-penetrating peptide compositions and uses thereof |
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| EP0714980A1 (en) * | 1994-12-02 | 1996-06-05 | Institut Pasteur | Hypermutagenesis |
| US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
| US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6251303B1 (en) | 1998-09-18 | 2001-06-26 | Massachusetts Institute Of Technology | Water-soluble fluorescent nanocrystals |
| US6426513B1 (en) | 1998-09-18 | 2002-07-30 | Massachusetts Institute Of Technology | Water-soluble thiol-capped nanocrystals |
| KR20020086508A (ko) * | 2000-02-08 | 2002-11-18 | 상가모 바이오사이언스 인코포레이티드 | 약물 발견용 세포 |
| US20020025317A1 (en) * | 2000-07-20 | 2002-02-28 | Schering Ag | Bispecific monoclonal antibodies to IL-12 and IL-18 |
| US6576291B2 (en) | 2000-12-08 | 2003-06-10 | Massachusetts Institute Of Technology | Preparation of nanocrystallites |
| US20030165434A1 (en) * | 2001-04-20 | 2003-09-04 | Chiron Corporation | Delivery of polynucleotide agents to the central nervous system |
| JP2003061684A (ja) * | 2001-06-11 | 2003-03-04 | Nippon Genetech Co Ltd | Ｄｎａの塩基配列決定法 |
| JP2005504275A (ja) * | 2001-09-18 | 2005-02-10 | ユー．エス． ジェノミクス， インコーポレイテッド | 高分解能線形解析用のポリマーの差示的タグ付け |
| WO2004007692A2 (en) * | 2002-07-17 | 2004-01-22 | U.S.Genomics, Inc. | Methods and compositions for analyzing polymers using chimeric tags |
| US7343249B2 (en) * | 2005-03-23 | 2008-03-11 | International Business Machines Corporational | Vectorization of sequence alignment computation using distance matrix reshaping |
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| Publication number | Publication date |
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| US20160168558A1 (en) | 2016-06-16 |
| EP1882047A2 (en) | 2008-01-30 |
| AU2006247215B2 (en) | 2012-09-13 |
| WO2006125012A2 (en) | 2006-11-23 |
| AU2006247215A1 (en) | 2006-11-23 |
| US9260703B2 (en) | 2016-02-16 |
| US10093917B2 (en) | 2018-10-09 |
| JP2008545394A (ja) | 2008-12-18 |
| WO2006125012A3 (en) | 2007-05-03 |
| EP1882047A4 (en) | 2009-10-28 |
| US20100041025A1 (en) | 2010-02-18 |
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