CA2603015C - Mass spectrometer - Google Patents
Mass spectrometer Download PDFInfo
- Publication number
- CA2603015C CA2603015C CA2603015A CA2603015A CA2603015C CA 2603015 C CA2603015 C CA 2603015C CA 2603015 A CA2603015 A CA 2603015A CA 2603015 A CA2603015 A CA 2603015A CA 2603015 C CA2603015 C CA 2603015C
- Authority
- CA
- Canada
- Prior art keywords
- ions
- ion source
- ion
- mass
- mass spectrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 329
- 239000012491 analyte Substances 0.000 claims abstract description 80
- 238000002485 combustion reaction Methods 0.000 claims abstract description 72
- 239000002904 solvent Substances 0.000 claims abstract description 47
- 238000001871 ion mobility spectroscopy Methods 0.000 claims abstract description 34
- 238000000132 electrospray ionisation Methods 0.000 claims abstract description 10
- 230000002238 attenuated effect Effects 0.000 claims abstract description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 66
- 239000007789 gas Substances 0.000 claims description 52
- 239000001569 carbon dioxide Substances 0.000 claims description 33
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 33
- 230000005684 electric field Effects 0.000 claims description 30
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 24
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 17
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 239000001301 oxygen Substances 0.000 claims description 15
- 229910052760 oxygen Inorganic materials 0.000 claims description 15
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
- 238000004811 liquid chromatography Methods 0.000 claims description 10
- 238000001698 laser desorption ionisation Methods 0.000 claims description 8
- 238000004458 analytical method Methods 0.000 claims description 7
- 238000003795 desorption Methods 0.000 claims description 7
- 238000000766 differential mobility spectroscopy Methods 0.000 claims description 7
- 239000001307 helium Substances 0.000 claims description 7
- 229910052734 helium Inorganic materials 0.000 claims description 7
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 7
- 230000004323 axial length Effects 0.000 claims description 6
- 239000003054 catalyst Substances 0.000 claims description 6
- 238000000688 desorption electrospray ionisation Methods 0.000 claims description 6
- 238000010265 fast atom bombardment Methods 0.000 claims description 6
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 6
- 238000009616 inductively coupled plasma Methods 0.000 claims description 6
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 5
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims description 5
- 239000005751 Copper oxide Substances 0.000 claims description 5
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 5
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 5
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 5
- 229910000431 copper oxide Inorganic materials 0.000 claims description 5
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims description 4
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000001133 acceleration Effects 0.000 claims description 4
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 4
- 238000000451 chemical ionisation Methods 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 239000010703 silicon Substances 0.000 claims description 4
- 238000005040 ion trap Methods 0.000 claims description 3
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 claims description 3
- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 238000004150 penning trap Methods 0.000 claims description 2
- 238000001962 electrophoresis Methods 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 abstract description 22
- 239000000203 mixture Substances 0.000 description 20
- 238000005259 measurement Methods 0.000 description 11
- 239000000523 sample Substances 0.000 description 11
- 239000007788 liquid Substances 0.000 description 9
- 238000000926 separation method Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000011144 upstream manufacturing Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000004807 desolvation Methods 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 230000000737 periodic effect Effects 0.000 description 5
- 238000005251 capillar electrophoresis Methods 0.000 description 4
- 238000004817 gas chromatography Methods 0.000 description 4
- 239000011368 organic material Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- -1 tetrapropylammonium ion Chemical class 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- 229910001882 dioxygen Inorganic materials 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 229910002804 graphite Inorganic materials 0.000 description 3
- 239000010439 graphite Substances 0.000 description 3
- 238000002307 isotope ratio mass spectrometry Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 3
- 210000000689 upper leg Anatomy 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 230000000155 isotopic effect Effects 0.000 description 2
- 238000004808 supercritical fluid chromatography Methods 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- UDWPONKAYSRBTJ-UHFFFAOYSA-N [He].[N] Chemical compound [He].[N] UDWPONKAYSRBTJ-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 230000003446 memory effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910000048 titanium hydride Inorganic materials 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
- 230000002034 xenobiotic effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8447—Nebulising, aerosol formation or ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8868—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample elemental analysis, e.g. isotope dilution analysis
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0506665.9 | 2005-04-01 | ||
| GBGB0506665.9A GB0506665D0 (en) | 2005-04-01 | 2005-04-01 | Mass spectrometer |
| US67136405P | 2005-04-14 | 2005-04-14 | |
| US60/671,364 | 2005-04-14 | ||
| PCT/GB2006/001207 WO2006103465A2 (en) | 2005-04-01 | 2006-04-03 | Mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2603015A1 CA2603015A1 (en) | 2006-10-05 |
| CA2603015C true CA2603015C (en) | 2014-05-20 |
Family
ID=36939199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2603015A Expired - Fee Related CA2603015C (en) | 2005-04-01 | 2006-04-03 | Mass spectrometer |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1864315B1 (enExample) |
| JP (1) | JP5219274B2 (enExample) |
| CA (1) | CA2603015C (enExample) |
| WO (1) | WO2006103465A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2685169C (en) * | 2007-02-01 | 2016-12-13 | Sionex Corporation | Differential mobility spectrometer pre-filter assembly for a mass spectrometer |
| US7772548B2 (en) * | 2008-05-12 | 2010-08-10 | Shimadzu Corporation | “Droplet pickup ion source” coupled to mobility analyzer apparatus and method |
| JP4699535B2 (ja) * | 2009-03-05 | 2011-06-15 | 公立大学法人首都大学東京 | インターフェイス |
| US8809769B2 (en) * | 2012-11-29 | 2014-08-19 | Bruker Daltonics, Inc. | Apparatus and method for cross-flow ion mobility spectrometry |
| KR101470363B1 (ko) * | 2012-12-26 | 2014-12-10 | 한국표준과학연구원 | 연소전처리-동위원소희석질량분석법 |
| CN114527187B (zh) * | 2020-11-02 | 2025-01-07 | 岛津分析技术研发（上海）有限公司 | 离子分析装置和方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6120860A (ja) * | 1984-07-09 | 1986-01-29 | Shimadzu Corp | 同位体比測定装置 |
| US5012052A (en) * | 1988-03-22 | 1991-04-30 | Indiana University Foundation | Isotope-ratio-monitoring gas chromatography-mass spectrometry apparatus and method |
| JPH08122317A (ja) * | 1994-10-27 | 1996-05-17 | Shimadzu Corp | ガス分析システム |
| US5811059A (en) * | 1995-10-16 | 1998-09-22 | The United States Of America As Represented By The Secretary Of The Army | Automated, on-demand ion mobility spectrometry analysis of gas chromatograph effluents |
| ES2264148T3 (es) * | 1995-12-23 | 2006-12-16 | The Queen's University Of Belfast | Sistema de entrada de gas. |
| AU745236B2 (en) * | 1997-02-14 | 2002-03-14 | George Washington University, The | An assay for the measurement of DNA synthesis rates |
| EP1008167A4 (en) * | 1997-03-14 | 2006-08-23 | Univ George Washington | DEVICE FOR THE CONTINUOUS CONTROL OF THE ISOTOPIC RATIO AFTER FLUORINE CHEMICAL REACTIONS |
| JP2000009694A (ja) * | 1998-06-29 | 2000-01-14 | Kawasaki Steel Corp | 定量分析方法および定量分析装置 |
| CA2260572A1 (en) * | 1998-08-05 | 2000-02-05 | Randy W. Purves | Apparatus and method for atmospheric pressure 3-dimensional ion trapping |
| US6815668B2 (en) * | 1999-07-21 | 2004-11-09 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry |
| CA2444257A1 (en) * | 2001-04-17 | 2002-10-24 | The Charles Stark Draper Laboratory, Inc. | Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
| US7019291B2 (en) * | 2002-10-12 | 2006-03-28 | Sionex Corporation | NOx monitor using differential mobility spectrometry |
-
2006
- 2006-04-03 EP EP06726611.4A patent/EP1864315B1/en not_active Expired - Lifetime
- 2006-04-03 CA CA2603015A patent/CA2603015C/en not_active Expired - Fee Related
- 2006-04-03 JP JP2008503596A patent/JP5219274B2/ja not_active Expired - Fee Related
- 2006-04-03 WO PCT/GB2006/001207 patent/WO2006103465A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1864315A2 (en) | 2007-12-12 |
| EP1864315B1 (en) | 2016-03-30 |
| WO2006103465A2 (en) | 2006-10-05 |
| WO2006103465A3 (en) | 2007-10-25 |
| JP5219274B2 (ja) | 2013-06-26 |
| JP2008535170A (ja) | 2008-08-28 |
| CA2603015A1 (en) | 2006-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200831 |