CA2602946A1 - Systemes et methodes d'administration pour le diagnostic et le traitement de maladies cardio-vasculaires - Google Patents

Systemes et methodes d'administration pour le diagnostic et le traitement de maladies cardio-vasculaires Download PDF

Info

Publication number
CA2602946A1
CA2602946A1 CA002602946A CA2602946A CA2602946A1 CA 2602946 A1 CA2602946 A1 CA 2602946A1 CA 002602946 A CA002602946 A CA 002602946A CA 2602946 A CA2602946 A CA 2602946A CA 2602946 A1 CA2602946 A1 CA 2602946A1
Authority
CA
Canada
Prior art keywords
agent
receptor
biological system
atherosclerotic
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002602946A
Other languages
English (en)
Inventor
Stephen E. Epstein
Mary Susan Burnett
Martin A. Mullins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Medstar Health Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2602946A1 publication Critical patent/CA2602946A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/14Peptides, e.g. proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/221Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by the targeting agent or modifying agent linked to the acoustically-active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Acoustics & Sound (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA002602946A 2005-03-22 2006-03-22 Systemes et methodes d'administration pour le diagnostic et le traitement de maladies cardio-vasculaires Abandoned CA2602946A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66430005P 2005-03-22 2005-03-22
US60/664,300 2005-03-22
PCT/US2006/010371 WO2006102395A2 (fr) 2005-03-22 2006-03-22 Systemes et methodes d'administration pour le diagnostic et le traitement de maladies cardio-vasculaires

Publications (1)

Publication Number Publication Date
CA2602946A1 true CA2602946A1 (fr) 2006-09-28

Family

ID=36930417

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002602946A Abandoned CA2602946A1 (fr) 2005-03-22 2006-03-22 Systemes et methodes d'administration pour le diagnostic et le traitement de maladies cardio-vasculaires

Country Status (6)

Country Link
EP (1) EP1866416A2 (fr)
JP (1) JP2008534508A (fr)
CN (1) CN101189339A (fr)
AU (1) AU2006227133A1 (fr)
CA (1) CA2602946A1 (fr)
WO (1) WO2006102395A2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
ATE555801T1 (de) * 2007-03-01 2012-05-15 Csl Ltd Behandlung von endothelialer dysfunktion bei diabetes-patienten
US7956035B2 (en) 2007-03-01 2011-06-07 Csl Limited Treatment of endothelial dysfunction in diabetic patients
EP2144600A4 (fr) * 2007-04-04 2011-03-16 Massachusetts Inst Technology Fractions de ciblage de poly (acide aminé)
CN101688252A (zh) * 2007-07-11 2010-03-31 皇家飞利浦电子股份有限公司 使用超声诱导的报道分子构建体转染的体内表达分析
EP2019318A1 (fr) * 2007-07-27 2009-01-28 Erasmus University Medical Center Rotterdam Marqueurs de protéines pour événements cardio-vasculaires
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010128090A1 (fr) * 2009-05-05 2010-11-11 Stefan Andersson-Engels Système, procédé, et marqueur luminescent pour imagerie luminescente diffuse améliorée ou tomographie dans un milieu de diffusion
WO2010138192A2 (fr) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Nanotransporteurs dont les composants présentent des vitesses de libération différentes
JP5463549B2 (ja) * 2009-09-08 2014-04-09 学校法人福岡大学 超音波治療用リポソーム及び超音波治療促進用リポソーム
WO2011133685A2 (fr) * 2010-04-21 2011-10-27 President And Fellows Of Harvard College Nanoparticule ciblant l'ischémie à des fins d'imagerie et de traitement
WO2011135397A1 (fr) * 2010-04-29 2011-11-03 University Of Calcutta Antiagrégant plaquettaire et procédés d'utilisation de celui-ci
EP3388081A1 (fr) 2010-05-26 2018-10-17 Selecta Biosciences, Inc. Vaccins à nanovecteurs synthétiques multivalents
WO2012047584A2 (fr) 2010-09-27 2012-04-12 Janssen Biotech, Inc. Macaca fascicularis ccl17
BR112014002139A2 (pt) 2011-07-29 2017-02-21 Selecta Biosciences Inc nanotransportadores sintéticos que geram respostas imunes humorais e de linfócitos t citotóxicos (ctl)
CN102657875B (zh) * 2012-04-11 2013-09-04 中国人民解放军第三军医大学第二附属医院 基于ant1基因的靶向型免疫脂质体及其制备方法和应用
CN103006538A (zh) * 2012-11-09 2013-04-03 叶琳 一种用于关节炎治疗的超声微泡及其用途
US9693958B2 (en) * 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
EP3000827B1 (fr) * 2013-05-22 2020-04-22 Seoul National University Hospital Anticorps à double cible anti-tnf-alpha/cxcl10 et son utilisation
US9637542B2 (en) * 2013-08-21 2017-05-02 Boehringer Ingelheim International Gmbh CX3CR1-targeting imaging agents and their use in the diagnosis and treatment of disease
CN105950660B (zh) * 2016-06-27 2019-11-01 姚陈 一种特异性抑制平滑肌细胞增殖和迁移的腺病毒载体及其应用
CN106474487A (zh) * 2016-11-14 2017-03-08 中国人民解放军总医院 一种靶向荧光载药纳米分子探针及其制备方法和应用
JP7158740B2 (ja) * 2016-12-15 2022-10-24 タレンゲン インターナショナル リミテッド 冠状動脈アテローム性硬化症およびその合併症を治療するための方法
EP3556385A4 (fr) * 2016-12-15 2020-12-30 Talengen International Limited Procédé pour atténuer une maladie cardiaque
EP3556379A4 (fr) 2016-12-15 2020-08-19 Talengen International Limited Méthode et médicament pour la prévention et le traitement de l'obésité
WO2019215300A1 (fr) 2018-05-09 2019-11-14 Medirista Biotechnologies Ab Anticorps destinés à être utilisés en polythérapie
CN109061139A (zh) * 2018-06-19 2018-12-21 温州医科大学附属第医院 血清炎性生物标志物在防治急性缺血性脑梗死中的应用
US20220305143A1 (en) * 2019-06-05 2022-09-29 Microvascular Therapeutics, Llc Compositions and methods of detecting and treating thrombosis and vascular plaques
CN110201194A (zh) * 2019-07-23 2019-09-06 山东百多安医疗器械有限公司 一种治疗动脉粥样硬化斑块的载药显影微泡及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955584A (en) * 1986-03-31 1999-09-21 Charter Ventures Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof
US5632991A (en) * 1988-11-14 1997-05-27 Brigham & Women's Hospital Antibodies specific for E-selectin and the uses thereof
US5326559A (en) * 1991-05-16 1994-07-05 Miller D Douglas Treatment of accelerated atheosclerosis with interleukin-2 receptor targeted molecules
FR2704556B1 (fr) * 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
FR2731229B1 (fr) * 1995-03-02 1997-04-30 Rhone Poulenc Rorer Sa Therapie genique de l'atherosclerose par production de hdl par les lignees monocytaires
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US7157418B1 (en) * 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
CA2335105C (fr) * 1998-07-22 2010-05-11 Osprey Pharmaceuticals Limited Methodes et compositions de traitement des dommages tissulaires secondaires et autres conditions et troubles inflammatoires
AU6522400A (en) * 1999-08-10 2001-03-05 Imarx Therapeutics, Inc. Targeted thrombolytic agents
WO2001032070A2 (fr) * 1999-10-26 2001-05-10 The Regents Of The University Of California Reactifs et procedes de diagnostic, d'imagerie et de traitement d'une maladie atherosclereuse
JP2004505029A (ja) * 2000-08-01 2004-02-19 ザ・ユニバーシティ・オブ・カンザス 細胞内に取り込まれるペプチド−薬剤複合体
GB0209893D0 (en) * 2002-04-30 2002-06-05 Molmed Spa Conjugate
NO20035748D0 (no) * 2003-12-19 2003-12-19 Amersham Health As Optisk avbildning av sårbar arteriosklerose

Also Published As

Publication number Publication date
EP1866416A2 (fr) 2007-12-19
WO2006102395A3 (fr) 2007-05-10
AU2006227133A1 (en) 2006-09-28
WO2006102395A2 (fr) 2006-09-28
JP2008534508A (ja) 2008-08-28
CN101189339A (zh) 2008-05-28

Similar Documents

Publication Publication Date Title
CA2602946A1 (fr) Systemes et methodes d'administration pour le diagnostic et le traitement de maladies cardio-vasculaires
US20080138277A1 (en) Delivery systems and methods for diagnosing and treating cardiovascular diseases
Brodsky et al. Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells
Jiménez Calvente et al. Specific hepatic delivery of procollagen α1 (I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis
Sluimer et al. Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis
Ásgeirsdóttir et al. Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes
Ninichuk et al. Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3–deficient mice with Alport disease
Zhang et al. Liver-targeted siRNA lipid nanoparticles treat hepatic cirrhosis by dual antifibrotic and anti-inflammatory activities
Duivenvoorden et al. Nanoimmunotherapy to treat ischaemic heart disease
Murciano et al. ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface: Presented in part as posters at the American Thoracic Society (ATS) Meeting, May 5-10, 2000, Toronto, ON, Canada.
van Rooij et al. Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy
Pasqualini Vascular targeting with phage peptide libraries
Winter et al. Molecular imaging of angiogenic therapy in peripheral vascular disease with ανβ3‐integrin‐targeted nanoparticles
KR101838763B1 (ko) 인테그린 αⅤβ8 중화 항체
Brekken et al. MINI REVIEW-Strategies for vascular targeting in tumors
Brenner et al. Endothelial nanomedicine for the treatment of pulmonary disease
Kiaie et al. A new approach to the diagnosis and treatment of atherosclerosis: the era of the liposome
Cicha et al. Nanomedicine in diagnostics and therapy of cardiovascular diseases: Beyond atherosclerotic plaque imaging
Peters et al. Nanomaterials to resolve atherosclerosis
Ahluwalia et al. Progress on antiangiogenic therapy for patients with malignant glioma
Li et al. Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia
Metghalchi et al. Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet
Zadelaar et al. Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer
Leus et al. VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression
Qin et al. Enhanced delivery of rituximab into brain and lymph nodes using timed-release nanocapsules in non-human primates

Legal Events

Date Code Title Description
FZDE Dead