CA2602926C - Non-protein stabilized clostridial toxin pharmaceutical compositions - Google Patents

Non-protein stabilized clostridial toxin pharmaceutical compositions Download PDF

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Publication number
CA2602926C
CA2602926C CA2602926A CA2602926A CA2602926C CA 2602926 C CA2602926 C CA 2602926C CA 2602926 A CA2602926 A CA 2602926A CA 2602926 A CA2602926 A CA 2602926A CA 2602926 C CA2602926 C CA 2602926C
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CA
Canada
Prior art keywords
botulinum toxin
protein
potency
pharmaceutical composition
toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2602926A
Other languages
English (en)
French (fr)
Other versions
CA2602926A1 (en
Inventor
Terrence J. Hunt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37527018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2602926(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CA2602926A1 publication Critical patent/CA2602926A1/en
Application granted granted Critical
Publication of CA2602926C publication Critical patent/CA2602926C/en
Anticipated expiration legal-status Critical
Active legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA2602926A 2005-10-06 2006-10-04 Non-protein stabilized clostridial toxin pharmaceutical compositions Active CA2602926C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72512605P 2005-10-06 2005-10-06
US60/725,126 2005-10-06
US11/524,683 US8137677B2 (en) 2005-10-06 2006-09-21 Non-protein stabilized clostridial toxin pharmaceutical compositions
US11/524,683 2006-09-21
PCT/US2006/038913 WO2007041664A1 (en) 2005-10-06 2006-10-04 Non-protein stabilized clostridial toxin pharmaceutical compositions

Publications (2)

Publication Number Publication Date
CA2602926A1 CA2602926A1 (en) 2007-04-12
CA2602926C true CA2602926C (en) 2010-12-21

Family

ID=37527018

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2602926A Active CA2602926C (en) 2005-10-06 2006-10-04 Non-protein stabilized clostridial toxin pharmaceutical compositions

Country Status (16)

Country Link
US (5) US8137677B2 (enExample)
EP (2) EP1931306B2 (enExample)
JP (4) JP5140595B2 (enExample)
KR (1) KR101314952B1 (enExample)
AU (1) AU2006299366B2 (enExample)
CA (1) CA2602926C (enExample)
CY (1) CY1117727T1 (enExample)
DK (1) DK2679217T3 (enExample)
ES (1) ES2580010T3 (enExample)
HU (1) HUE027810T2 (enExample)
MX (1) MX2007012062A (enExample)
NZ (1) NZ562033A (enExample)
PL (1) PL2679217T3 (enExample)
PT (1) PT2679217T (enExample)
SI (1) SI2679217T1 (enExample)
WO (1) WO2007041664A1 (enExample)

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Also Published As

Publication number Publication date
JP2012197320A (ja) 2012-10-18
US20100279953A1 (en) 2010-11-04
JP2017088611A (ja) 2017-05-25
JP5140595B2 (ja) 2013-02-06
US20120141619A1 (en) 2012-06-07
MX2007012062A (es) 2007-12-04
US8642047B2 (en) 2014-02-04
ES2580010T3 (es) 2016-08-18
EP1931306A1 (en) 2008-06-18
EP2679217A1 (en) 2014-01-01
PT2679217T (pt) 2016-07-15
JP2009511485A (ja) 2009-03-19
JP6235176B2 (ja) 2017-11-22
NZ562033A (en) 2011-12-22
AU2006299366B2 (en) 2012-01-12
EP1931306B1 (en) 2013-07-31
JP2014139229A (ja) 2014-07-31
CY1117727T1 (el) 2017-05-17
JP5758856B2 (ja) 2015-08-05
KR20080052510A (ko) 2008-06-11
US20200330564A1 (en) 2020-10-22
HK1192710A1 (en) 2014-08-29
HUE027810T2 (en) 2016-11-28
WO2007041664A1 (en) 2007-04-12
SI2679217T1 (sl) 2016-08-31
US8137677B2 (en) 2012-03-20
EP2679217B1 (en) 2016-04-06
EP1931306B2 (en) 2021-09-22
US20240226252A1 (en) 2024-07-11
CA2602926A1 (en) 2007-04-12
DK2679217T3 (en) 2016-07-25
US20140112908A1 (en) 2014-04-24
KR101314952B1 (ko) 2013-10-04
PL2679217T3 (pl) 2016-11-30
AU2006299366A1 (en) 2007-04-12

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